{"id":"https://openalex.org/W3085705141","doi":"https://doi.org/10.1002/btpr.3081","title":"Cross\u2010scale quality assessment of a mechanistic cation exchange chromatography model","display_name":"Cross\u2010scale quality assessment of a mechanistic cation exchange chromatography model","publication_year":2020,"publication_date":"2020-09-25","ids":{"openalex":"https://openalex.org/W3085705141","doi":"https://doi.org/10.1002/btpr.3081","mag":"3085705141","pmid":"https://pubmed.ncbi.nlm.nih.gov/32926575"},"language":"en","primary_location":{"id":"doi:10.1002/btpr.3081","doi":"https://doi.org/10.1002/btpr.3081","is_oa":true,"landing_page_url":"https://doi.org/10.1002/btpr.3081","pdf_url":"https://aiche.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btpr.3081","source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://aiche.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btpr.3081","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057217680","display_name":"David Saleh","orcid":"https://orcid.org/0000-0002-1212-3679","observed_orcids":["https://orcid.org/0000-0002-1212-3679"]},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]},{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"David Saleh","raw_affiliation_strings":["Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany","Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Karlsruhe, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1212-3679","affiliations":[{"raw_affiliation_string":"Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany","institution_ids":["https://openalex.org/I1330995197"]},{"raw_affiliation_string":"Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100367477","display_name":"Gang Wang","orcid":"https://orcid.org/0009-0000-8262-2951","observed_orcids":["https://orcid.org/0009-0000-8262-2951"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gang Wang","raw_affiliation_strings":["Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039455986","display_name":"Benedict Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benedict Mueller","raw_affiliation_strings":["Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019854562","display_name":"Federico Rischawy","orcid":"https://orcid.org/0000-0002-2267-0019","observed_orcids":["https://orcid.org/0000-0002-2267-0019"]},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]},{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Federico Rischawy","raw_affiliation_strings":["Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany","Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany","institution_ids":["https://openalex.org/I1330995197"]},{"raw_affiliation_string":"Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041695743","display_name":"Simon Kluters","orcid":"https://orcid.org/0000-0002-3619-6821","observed_orcids":["https://orcid.org/0000-0002-3619-6821"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simon Kluters","raw_affiliation_strings":["Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019556076","display_name":"Joey Studts","orcid":"https://orcid.org/0000-0001-7793-1514","observed_orcids":["https://orcid.org/0000-0001-7793-1514"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joey Studts","raw_affiliation_strings":["Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Late Stage DSP Development Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074124976","display_name":"J\u00fcrgen J. Hubbuch","orcid":"https://orcid.org/0000-0003-0839-561X","observed_orcids":["https://orcid.org/0000-0003-0839-561X"]},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J\u00fcrgen Hubbuch","raw_affiliation_strings":["Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057217680","https://openalex.org/A5074124976"],"corresponding_institution_ids":["https://openalex.org/I102335020","https://openalex.org/I1330995197"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":{"value":3700,"currency":"USD","value_usd":3700},"fwci":1.1416,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.74789691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"37","issue":"1","first_page":"e3081","last_page":"e3081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cation-exchange-chromatography","display_name":"cation exchange chromatography","score":0.996999979019165},{"id":"https://openalex.org/keywords/monoclonal-antibody-purification","display_name":"monoclonal antibody purification","score":0.8889999985694885},{"id":"https://openalex.org/keywords/scale-down-model","display_name":"scale-down model","score":0.8999999761581421},{"id":"https://openalex.org/keywords/model-qualification","display_name":"model qualification","score":0.5619999766349792},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.6340000033378601},{"id":"https://openalex.org/keywords/equivalence-testing","display_name":"equivalence testing","score":0.6240000128746033},{"id":"https://openalex.org/keywords/dispersion-effects","display_name":"dispersion effects","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.531956672668457},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5029472708702087},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5000126361846924},{"id":"https://openalex.org/C2777874358","wikidata":"https://www.wikidata.org/wiki/Q7389060","display_name":"SCALE-UP","level":2,"score":0.47547903656959534},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.45765483379364014},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.41727566719055176},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.37754517793655396},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3438207507133484},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1379423439502716},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09441283345222473},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002411","descriptor_name":"Cation Exchange Resins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002852","descriptor_name":"Chromatography, Ion Exchange","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/btpr.3081","doi":"https://doi.org/10.1002/btpr.3081","is_oa":true,"landing_page_url":"https://doi.org/10.1002/btpr.3081","pdf_url":"https://aiche.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btpr.3081","source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},{"id":"pmh:oai:EVASTAR-Karlsruhe.de:1000125352","doi":null,"is_oa":true,"landing_page_url":"https://publikationen.bibliothek.kit.edu/1000125352","pdf_url":null,"source":{"id":"https://openalex.org/S4306401992","display_name":"Repository KITopen (Karlsruhe Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102335020","host_organization_name":"Karlsruhe Institute of Technology","host_organization_lineage":["https://openalex.org/I102335020"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology progress, 37 (1), Art.Nr. e3081","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:32926575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32926575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology progress","raw_type":"Journal Article"},{"id":"doi:10.5445/ir/1000125352","doi":"https://doi.org/10.5445/ir/1000125352","is_oa":true,"landing_page_url":"https://doi.org/10.5445/ir/1000125352","pdf_url":null,"source":{"id":"https://openalex.org/S7407052948","display_name":"KITopen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102335020","host_organization_name":"Karlsruhe Institute of Technology","host_organization_lineage":["https://openalex.org/I102335020"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1002/btpr.3081","doi":"https://doi.org/10.1002/btpr.3081","is_oa":true,"landing_page_url":"https://doi.org/10.1002/btpr.3081","pdf_url":"https://aiche.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btpr.3081","source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3085705141.pdf","grobid_xml":"https://content.openalex.org/works/W3085705141.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1139758729","https://openalex.org/W1583202152","https://openalex.org/W1592512006","https://openalex.org/W1723459026","https://openalex.org/W1862464699","https://openalex.org/W1968913285","https://openalex.org/W1971420682","https://openalex.org/W1991285584","https://openalex.org/W1995246013","https://openalex.org/W1998377044","https://openalex.org/W2001671969","https://openalex.org/W2002308830","https://openalex.org/W2010948143","https://openalex.org/W2021076065","https://openalex.org/W2029950347","https://openalex.org/W2037698344","https://openalex.org/W2039831100","https://openalex.org/W2047389923","https://openalex.org/W2071095038","https://openalex.org/W2093173249","https://openalex.org/W2106060404","https://openalex.org/W2108112008","https://openalex.org/W2119770416","https://openalex.org/W2121357942","https://openalex.org/W2149818636","https://openalex.org/W2166365991","https://openalex.org/W2171254431","https://openalex.org/W2218282836","https://openalex.org/W2287979679","https://openalex.org/W2338153244","https://openalex.org/W2480937959","https://openalex.org/W2581513883","https://openalex.org/W2585609993","https://openalex.org/W2884856839","https://openalex.org/W2902697606","https://openalex.org/W2913499731","https://openalex.org/W2915483287","https://openalex.org/W2968060382","https://openalex.org/W2972056158","https://openalex.org/W2995764973","https://openalex.org/W3000186006","https://openalex.org/W3007248139","https://openalex.org/W3010715253","https://openalex.org/W3017045680","https://openalex.org/W4244264040","https://openalex.org/W6759233995","https://openalex.org/W6826359500"],"related_works":["https://openalex.org/W3007248139","https://openalex.org/W4322498364","https://openalex.org/W2176564148","https://openalex.org/W7156031274","https://openalex.org/W2047389923","https://openalex.org/W2039831100","https://openalex.org/W4414361883","https://openalex.org/W4296435752","https://openalex.org/W2941210608","https://openalex.org/W2809394092"],"abstract_inverted_index":{"Cation":[0],"exchange":[1],"chromatography":[2,33,84,203,231],"(CEX)":[3],"is":[4],"an":[5],"essential":[6],"part":[7],"of":[8,21,121,145,195,207,213,229],"most":[9],"monoclonal":[10],"antibody":[11],"(mAb)":[12],"purification":[13],"platforms.":[14],"Process":[15],"characterization":[16],"and":[17,59,75,97,129,170,181,220],"root":[18],"cause":[19],"investigation":[20],"chromatographic":[22],"unit":[23],"operations":[24],"are":[25],"performed":[26],"using":[27,191],"scale":[28],"down":[29],"models":[30,89,232],"(SDM).":[31],"SDM":[32,104,180,209,239],"columns":[34],"typically":[35],"have":[36],"the":[37,42,83,119,138,167,173,182,192,196,208,227],"identical":[38,193],"bed":[39,214],"height":[40],"as":[41,233],"respective":[43],"manufacturing-scale,":[44,137],"but":[45],"a":[46,109,122,234],"significantly":[47],"reduced":[48],"inner":[49],"diameter.":[50],"While":[51],"SDMs":[52],"enable":[53],"process":[54],"development":[55],"demanding":[56],"less":[57],"material":[58],"time,":[60],"their":[61],"comparability":[62],"to":[63,92,102,118,136,165,171,237],"manufacturing-scale":[64],"can":[65,90],"be":[66],"affected":[67],"by":[68,210],"variability":[69],"in":[70,183],"feed":[71,218],"composition,":[72,219],"mobile":[73,221],"phase":[74,222],"resin":[76],"properties,":[77],"or":[78,154],"dispersion":[79,152],"effects":[80,153,212],"depending":[81],"on":[82,127],"system":[85,151],"at":[86],"hand.":[87],"Mechanistic":[88],"help":[91],"close":[93],"gaps":[94],"between":[95,147],"scales":[96],"reduce":[98],"experimental":[99,103,179],"efforts":[100],"compared":[101],"applications.":[105],"In":[106],"this":[107],"study,":[108],"multicomponent":[110],"steric":[111],"mass-action":[112],"(SMA)":[113],"adsorption":[114],"model":[115,160,168,185,204],"was":[116,163],"applied":[117],"scale-up":[120],"CEX":[123],"polishing":[124],"step.":[125],"Based":[126],"chromatograms":[128],"elution":[130],"pool":[131],"data":[132,190],"ranging":[133],"from":[134],"laboratory-":[135],"proposed":[139],"modeling":[140],"workflow":[141],"enabled":[142],"early":[143],"identification":[144],"differences":[146],"scales,":[148],"for":[149],"example,":[150],"ionic":[155],"capacity":[156],"variability.":[157],"A":[158],"multistage":[159],"qualification":[161],"approach":[162],"introduced":[164],"measure":[166],"quality":[169],"understand":[172],"model's":[174],"limitations":[175,206],"across":[176],"scales.":[177],"The":[178,201,224],"silico":[184],"were":[186],"qualified":[187],"against":[188],"large-scale":[189],"state":[194],"art":[197],"equivalence":[198],"testing":[199],"procedure.":[200],"mechanistic":[202,230],"avoided":[205],"capturing":[211],"height,":[215],"loading":[216],"density,":[217],"properties.":[223],"results":[225],"demonstrate":[226],"applicability":[228],"possible":[235],"alternative":[236],"conventional":[238],"approaches.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-09-21T00:00:00"}
