{"id":"https://openalex.org/W3085191016","doi":"https://doi.org/10.1126/sciimmunol.aay9368","title":"Sympathetic nervous tone limits the development of myeloid-derived suppressor cells","display_name":"Sympathetic nervous tone limits the development of myeloid-derived suppressor cells","publication_year":2020,"publication_date":"2020-09-11","ids":{"openalex":"https://openalex.org/W3085191016","doi":"https://doi.org/10.1126/sciimmunol.aay9368","mag":"3085191016","pmid":"https://pubmed.ncbi.nlm.nih.gov/32917793"},"language":"en","primary_location":{"id":"doi:10.1126/sciimmunol.aay9368","doi":"https://doi.org/10.1126/sciimmunol.aay9368","is_oa":false,"landing_page_url":"https://doi.org/10.1126/sciimmunol.aay9368","pdf_url":null,"source":{"id":"https://openalex.org/S2764653179","display_name":"Science Immunology","issn_l":"2470-9468","issn":["2470-9468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015550061","display_name":"James Timothy Nevin","orcid":"https://orcid.org/0000-0001-6286-5622","observed_orcids":["https://orcid.org/0000-0001-6286-5622"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James T. Nevin","raw_affiliation_strings":["Department of Immunology and Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT, USA"],"raw_orcid":"https://orcid.org/0000-0001-6286-5622","affiliations":[{"raw_affiliation_string":"Department of Immunology and Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT, USA","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018308989","display_name":"Marmar R. Moussa","orcid":"https://orcid.org/0000-0003-0574-6656","observed_orcids":["https://orcid.org/0000-0003-0574-6656"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marmar Moussa","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Connecticut, Farmington, CT, USA"],"raw_orcid":"https://orcid.org/0000-0003-0574-6656","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Connecticut, Farmington, CT, USA","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111692970","display_name":"William L. Corwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L. Corwin","raw_affiliation_strings":["Department of Immunology and Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT, USA","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014788373","display_name":"Ion M\u0103ndoiu","orcid":"https://orcid.org/0000-0002-4818-0237","observed_orcids":["https://orcid.org/0000-0002-4818-0237"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ion I. Mandoiu","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Connecticut, Farmington, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-4818-0237","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Connecticut, Farmington, CT, USA","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015522784","display_name":"Pramod Kumar Srivastava","orcid":"https://orcid.org/0000-0003-2837-2861","observed_orcids":["https://orcid.org/0000-0003-2837-2861"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pramod K. Srivastava","raw_affiliation_strings":["Department of Immunology and Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT, USA"],"raw_orcid":"https://orcid.org/0000-0003-2837-2861","affiliations":[{"raw_affiliation_string":"Department of Immunology and Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT, USA","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015522784","https://openalex.org/A5015550061"],"corresponding_institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"],"apc_list":null,"apc_paid":null,"fwci":1.1172,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.76794073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"5","issue":"51","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.09189999848604202,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.9890000224113464},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.859000027179718},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8659999966621399},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/s100a8-a9","display_name":"S100A8/A9","score":0.9639999866485596},{"id":"https://openalex.org/keywords/alarmins","display_name":"alarmins","score":0.6700000166893005},{"id":"https://openalex.org/keywords/myeloid-cell-maturation","display_name":"myeloid cell maturation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/neuroimmune-regulation","display_name":"neuroimmune regulation","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.731865406036377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6315292716026306},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5241073369979858},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4951881468296051},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.47067245841026306},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.469461590051651},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42809703946113586},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4210089147090912},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3865576386451721},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37044557929039},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23007532954216003},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018674","descriptor_name":"Adrenergic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D040501","descriptor_name":"Calgranulin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D040502","descriptor_name":"Calgranulin B","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/sciimmunol.aay9368","doi":"https://doi.org/10.1126/sciimmunol.aay9368","is_oa":false,"landing_page_url":"https://doi.org/10.1126/sciimmunol.aay9368","pdf_url":null,"source":{"id":"https://openalex.org/S2764653179","display_name":"Science Immunology","issn_l":"2470-9468","issn":["2470-9468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Immunology","raw_type":"journal-article"},{"id":"pmid:32917793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32917793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1603852791","https://openalex.org/W1788753937","https://openalex.org/W1865326375","https://openalex.org/W1985339809","https://openalex.org/W1987703447","https://openalex.org/W1993340690","https://openalex.org/W2007143131","https://openalex.org/W2035025683","https://openalex.org/W2038624273","https://openalex.org/W2038918212","https://openalex.org/W2049959255","https://openalex.org/W2068815985","https://openalex.org/W2078132657","https://openalex.org/W2078502459","https://openalex.org/W2080315244","https://openalex.org/W2086243699","https://openalex.org/W2113845760","https://openalex.org/W2123900004","https://openalex.org/W2127107746","https://openalex.org/W2128957395","https://openalex.org/W2134444342","https://openalex.org/W2151356556","https://openalex.org/W2151940597","https://openalex.org/W2158175641","https://openalex.org/W2162560186","https://openalex.org/W2163825883","https://openalex.org/W2167160653","https://openalex.org/W2283665483","https://openalex.org/W2471500324","https://openalex.org/W2624530800","https://openalex.org/W2748524892","https://openalex.org/W2766437506","https://openalex.org/W2782485041","https://openalex.org/W2787894829","https://openalex.org/W2789630263","https://openalex.org/W2808305854","https://openalex.org/W2811245365","https://openalex.org/W2887766567","https://openalex.org/W2888894833","https://openalex.org/W2889719403","https://openalex.org/W2899194342","https://openalex.org/W2917646500","https://openalex.org/W2974417139","https://openalex.org/W2978526767","https://openalex.org/W3007604420"],"related_works":["https://openalex.org/W4313366289","https://openalex.org/W4313406859","https://openalex.org/W1971589629","https://openalex.org/W4391943927","https://openalex.org/W4404166440","https://openalex.org/W4323294673","https://openalex.org/W1970092944","https://openalex.org/W4393853799","https://openalex.org/W3006389441","https://openalex.org/W2029878362"],"abstract_inverted_index":{"Sympathetic":[0],"nerves":[1],"that":[2,14,29,51,92,103],"innervate":[3],"lymphoid":[4],"organs":[5],"regulate":[6],"immune":[7,18,47,142],"development":[8,137],"and":[9,40,71,96,140,144,150],"function":[10],"by":[11,17],"releasing":[12],"norepinephrine":[13],"is":[15],"sensed":[16],"cells":[19,68,90,112,143],"via":[20,113],"their":[21,122,146],"expression":[22],"of":[23,31,45,53,66,78,86,109,115,138],"adrenergic":[24],"receptors.":[25],"Here,":[26],"we":[27,41,101],"demonstrate":[28],"ablation":[30],"sympathetic":[32,133],"nervous":[33],"system":[34],"(SNS)":[35],"signaling":[36],"suppresses":[37],"tumor":[38,94,98],"immunity,":[39],"dissect":[42],"the":[43,54,79,84,116,136],"mechanism":[44],"such":[46],"suppression.":[48],"We":[49],"report":[50],"disruption":[52,77],"SNS":[55],"in":[56,69,131,148],"mice":[57],"removes":[58],"a":[59,128],"critical":[60],"\u03b1-adrenergic":[61,80],"signal":[62,81],"required":[63],"for":[64],"maturation":[65],"myeloid":[67],"normal":[70],"tumor-bearing":[72,75],"mice.":[73],"In":[74],"mice,":[76],"leads":[82],"to":[83],"accumulation":[85],"immature":[87],"myeloid-derived":[88],"suppressor":[89],"(MDSCs)":[91],"suppress":[93],"immunity":[95],"promote":[97],"growth.":[99],"Furthermore,":[100],"show":[102],"these":[104],"SNS-responsive":[105],"MDSCs":[106],"drive":[107],"expansion":[108],"regulatory":[110,129],"T":[111],"secretion":[114],"alarmin":[117],"heterodimer":[118],"S100A8/A9,":[119],"thereby":[120],"compounding":[121],"immunosuppressive":[123],"activity.":[124],"Our":[125],"results":[126],"describe":[127],"framework":[130],"which":[132],"tone":[134],"controls":[135],"innate":[139],"adaptive":[141],"influences":[145],"activity":[147],"health":[149],"disease.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-21T00:00:00"}
