{"id":"https://openalex.org/W3084876802","doi":"https://doi.org/10.1016/j.ncl.2020.08.001","title":"A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy","display_name":"A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy","publication_year":2020,"publication_date":"2020-09-12","ids":{"openalex":"https://openalex.org/W3084876802","doi":"https://doi.org/10.1016/j.ncl.2020.08.001","mag":"3084876802","pmid":"https://pubmed.ncbi.nlm.nih.gov/33040871"},"language":"en","primary_location":{"id":"doi:10.1016/j.ncl.2020.08.001","doi":"https://doi.org/10.1016/j.ncl.2020.08.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ncl.2020.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S62844684","display_name":"Neurologic Clinics","issn_l":"0733-8619","issn":["0733-8619","1557-9875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologic Clinics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035529864","display_name":"Michael W. Ruff","orcid":"https://orcid.org/0000-0001-8513-9615","observed_orcids":["https://orcid.org/0000-0001-8513-9615"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Ruff","raw_affiliation_strings":["T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003521951","display_name":"Elizabeth L. Siegler","orcid":"https://orcid.org/0000-0002-8336-4373","observed_orcids":["https://orcid.org/0000-0002-8336-4373"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth L. Siegler","raw_affiliation_strings":["T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054196868","display_name":"Saad S. Kenderian","orcid":"https://orcid.org/0000-0003-2767-3830","observed_orcids":["https://orcid.org/0000-0003-2767-3830"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saad S. Kenderian","raw_affiliation_strings":["T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Molecular Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: Kenderian.saad@mayo.edu","Department of Immunology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","Department of Molecular Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Molecular Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: Kenderian.saad@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Immunology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"T Cell Engineering, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054196868"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":1.4134,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.83803874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"38","issue":"4","first_page":"953","last_page":"963"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.6230000257492065},{"id":"https://openalex.org/keywords/neurological-complications","display_name":"neurological complications","score":0.7910000085830688},{"id":"https://openalex.org/keywords/immune-effector-cell-associated-neurotoxicity-syndrome","display_name":"immune effector cell-associated neurotoxicity syndrome","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/encephalopathy","display_name":"encephalopathy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/focal-neurological-deficits","display_name":"focal neurological deficits","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9078185558319092},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.8542253971099854},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7213003635406494},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40656399726867676},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24139297008514404}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ncl.2020.08.001","doi":"https://doi.org/10.1016/j.ncl.2020.08.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ncl.2020.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S62844684","display_name":"Neurologic Clinics","issn_l":"0733-8619","issn":["0733-8619","1557-9875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologic Clinics","raw_type":"journal-article"},{"id":"pmid:33040871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33040871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologic clinics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320315663","display_name":"Sunesis","ror":"https://ror.org/0187pm092"},{"id":"https://openalex.org/F4320328062","display_name":"MorphoSys","ror":"https://ror.org/00ew7rg06"},{"id":"https://openalex.org/F4320333647","display_name":"Kite Pharma","ror":"https://ror.org/05waa9105"},{"id":"https://openalex.org/F4320333670","display_name":"Juno Therapeutics","ror":"https://ror.org/02dq5dx40"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1619537825","https://openalex.org/W1985579610","https://openalex.org/W2082708772","https://openalex.org/W2099570622","https://openalex.org/W2105400883","https://openalex.org/W2118796952","https://openalex.org/W2167550136","https://openalex.org/W2285239684","https://openalex.org/W2602369513","https://openalex.org/W2735691291","https://openalex.org/W2754562068","https://openalex.org/W2763751953","https://openalex.org/W2773804840","https://openalex.org/W2775369717","https://openalex.org/W2787621143","https://openalex.org/W2791660181","https://openalex.org/W2803430447","https://openalex.org/W2804159084","https://openalex.org/W2805523469","https://openalex.org/W2884386651","https://openalex.org/W2889777858","https://openalex.org/W2905654445","https://openalex.org/W2914996705","https://openalex.org/W2924908514","https://openalex.org/W2944288721","https://openalex.org/W2959588651","https://openalex.org/W2987812087"],"related_works":["https://openalex.org/W4323566731","https://openalex.org/W3138940124","https://openalex.org/W3207850203","https://openalex.org/W4292707568","https://openalex.org/W3081687748","https://openalex.org/W4385798954","https://openalex.org/W2963067921","https://openalex.org/W4225625907","https://openalex.org/W3032974738","https://openalex.org/W4287009494"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-21T00:00:00"}