{"id":"https://openalex.org/W3084722364","doi":"https://doi.org/10.1080/09553002.2020.1820606","title":"The New Zealand white rabbit animal model of acute radiation syndrome: hematopoietic and coagulation-based parameters by radiation dose following supportive care","display_name":"The New Zealand white rabbit animal model of acute radiation syndrome: hematopoietic and coagulation-based parameters by radiation dose following supportive care","publication_year":2020,"publication_date":"2020-09-10","ids":{"openalex":"https://openalex.org/W3084722364","doi":"https://doi.org/10.1080/09553002.2020.1820606","mag":"3084722364","pmid":"https://pubmed.ncbi.nlm.nih.gov/32909860"},"language":"en","primary_location":{"id":"doi:10.1080/09553002.2020.1820606","doi":"https://doi.org/10.1080/09553002.2020.1820606","is_oa":true,"landing_page_url":"https://doi.org/10.1080/09553002.2020.1820606","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1080/09553002.2020.1820606","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020926039","display_name":"Andre D. Paredes","orcid":"https://orcid.org/0000-0001-6949-9549","observed_orcids":["https://orcid.org/0000-0001-6949-9549"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andre Paredes","raw_affiliation_strings":["Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0001-6949-9549","affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064484750","display_name":"Matthew O. Lindeblad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Lindeblad","raw_affiliation_strings":["Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109650466","display_name":"Rachana Vinay Patil","orcid":"https://orcid.org/0000-0002-9918-5564","observed_orcids":["https://orcid.org/0000-0002-9918-5564"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachana Patil","raw_affiliation_strings":["Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029058133","display_name":"Matthew D. Neal","orcid":"https://orcid.org/0000-0001-8931-6236","observed_orcids":["https://orcid.org/0000-0001-8931-6236"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Neal","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062573724","display_name":"Yuanfan Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanfan Hong","raw_affiliation_strings":["Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brett Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Smith","raw_affiliation_strings":["Department of Radiation Oncology, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008372661","display_name":"Joy P. Nanda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joy P. Nanda","raw_affiliation_strings":["Community Research Advisory Council for Clinical and Translational Research, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Community Research Advisory Council for Clinical and Translational Research, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003659963","display_name":"Vasileios Mousafeiris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasileios Mousafeiris","raw_affiliation_strings":["Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039613923","display_name":"John E. Moulder","orcid":"https://orcid.org/0000-0002-6217-9611","observed_orcids":["https://orcid.org/0000-0002-6217-9611"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Moulder","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":"https://orcid.org/0000-0002-6217-9611","affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083370667","display_name":"Maarten C. Bosland","orcid":"https://orcid.org/0000-0002-0023-6975","observed_orcids":["https://orcid.org/0000-0002-0023-6975"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maarten C. Bosland","raw_affiliation_strings":["Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047034211","display_name":"Alexander V. Lyubimov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Lyubimov","raw_affiliation_strings":["Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112803953","display_name":"Amelia M. Bartholomew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amelia Bartholomew","raw_affiliation_strings":["Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020926039"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":0.243,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.53882426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"97","issue":"sup1","first_page":"S45","last_page":"S62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-radiation-syndrome","display_name":"radiation sickness","score":0.9559999704360962},{"id":"https://openalex.org/keywords/new-zealand-white-rabbits","display_name":"New Zealand White rabbits","score":0.8059999942779541},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.5649999976158142},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/radiation-dose-response","display_name":"radiation dose-response","score":0.7519999742507935},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8090000152587891},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.5809999704360962},{"id":"https://openalex.org/keywords/supportive-care","display_name":"supportive care","score":0.4429999887943268},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.8920000195503235},{"id":"https://openalex.org/keywords/fentanyl-patch","display_name":"fentanyl patch","score":0.7509999871253967},{"id":"https://openalex.org/keywords/ld50","display_name":"LD50","score":0.4410000145435333},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7450291514396667},{"id":"https://openalex.org/C2778880498","wikidata":"https://www.wikidata.org/wiki/Q1986672","display_name":"Total body irradiation","level":4,"score":0.5214956998825073},{"id":"https://openalex.org/C2908890008","wikidata":"https://www.wikidata.org/wiki/Q275459","display_name":"Acute Radiation Syndrome","level":4,"score":0.49823760986328125},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4866126477718353},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.4796191155910492},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4374355375766754},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.41470324993133545},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.3850212097167969},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3836449384689331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13416579365730286},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13413575291633606},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.09697800874710083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D054508","descriptor_name":"Acute Radiation Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/09553002.2020.1820606","doi":"https://doi.org/10.1080/09553002.2020.1820606","is_oa":true,"landing_page_url":"https://doi.org/10.1080/09553002.2020.1820606","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},{"id":"pmid:32909860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32909860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/09553002.2020.1820606","doi":"https://doi.org/10.1080/09553002.2020.1820606","is_oa":true,"landing_page_url":"https://doi.org/10.1080/09553002.2020.1820606","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W111670544","https://openalex.org/W156672560","https://openalex.org/W398166368","https://openalex.org/W561797155","https://openalex.org/W1452635382","https://openalex.org/W1487959040","https://openalex.org/W1572037829","https://openalex.org/W1573832590","https://openalex.org/W1601066507","https://openalex.org/W1819664549","https://openalex.org/W1858310449","https://openalex.org/W1870470294","https://openalex.org/W1978154805","https://openalex.org/W1985502949","https://openalex.org/W1989937057","https://openalex.org/W1991141821","https://openalex.org/W1997641597","https://openalex.org/W2008348417","https://openalex.org/W2008457722","https://openalex.org/W2019851850","https://openalex.org/W2028137929","https://openalex.org/W2030938835","https://openalex.org/W2031783394","https://openalex.org/W2038979492","https://openalex.org/W2041461587","https://openalex.org/W2044351980","https://openalex.org/W2045203382","https://openalex.org/W2046993793","https://openalex.org/W2049271043","https://openalex.org/W2058157135","https://openalex.org/W2060522841","https://openalex.org/W2061969835","https://openalex.org/W2076546514","https://openalex.org/W2077788306","https://openalex.org/W2080844075","https://openalex.org/W2085842200","https://openalex.org/W2087574280","https://openalex.org/W2093816432","https://openalex.org/W2096484869","https://openalex.org/W2097364950","https://openalex.org/W2103486381","https://openalex.org/W2119543049","https://openalex.org/W2130927464","https://openalex.org/W2133910024","https://openalex.org/W2141076439","https://openalex.org/W2151362823","https://openalex.org/W2175492577","https://openalex.org/W2194267477","https://openalex.org/W2197197107","https://openalex.org/W2208919004","https://openalex.org/W2331193783","https://openalex.org/W2331744475","https://openalex.org/W2463833592","https://openalex.org/W2597243982","https://openalex.org/W2609808352","https://openalex.org/W2623339269","https://openalex.org/W2775688828","https://openalex.org/W2791461560","https://openalex.org/W2795806743","https://openalex.org/W2901306538","https://openalex.org/W4242171500"],"related_works":["https://openalex.org/W6958707719","https://openalex.org/W3086854338","https://openalex.org/W58626942","https://openalex.org/W2335568026","https://openalex.org/W4412403275","https://openalex.org/W2044229897","https://openalex.org/W2090775560","https://openalex.org/W151503666","https://openalex.org/W7095202494","https://openalex.org/W7099696645"],"abstract_inverted_index":{"PURPOSE:":[0],"Animal":[1],"models":[2],"that":[3],"accurately":[4],"reflect":[5],"human":[6,87],"responses":[7],"to":[8,65,86,184,207,248,265,352,355],"radiation":[9,79,387],"injury":[10],"are":[11],"needed":[12],"for":[13,33,53,180,359,381],"advanced":[14],"mechanistic":[15,383],"investigation":[16,384],"and":[17,48,90,118,168,177,197,218,232,239,260,275,288,324,364,389],"development":[18,41,50],"of":[19,35,42,45,51,61,77,82,104,111,126,136,186,229,257,292,295,317,330,342,376,385],"effective":[20],"therapeutics.":[21],"The":[22,59],"rabbit":[23,379],"is":[24],"an":[25],"established":[26,84],"animal":[27],"model":[28,73,76,380],"accepted":[29],"by":[30,270],"the":[31,40,49,67,192,296,328,356,374,377],"FDA":[32],"studies":[34,98],"cardiovascular":[36],"disease,":[37],"lipid":[38],"metabolism,":[39],"anticoagulants,":[43],"testing":[44],"bone":[46],"implants,":[47],"treatments":[52],"infectious":[54],"diseases":[55],"such":[56],"as":[57,74],"HIV.":[58],"purpose":[60],"this":[62],"study":[63,225],"was":[64],"investigate":[66],"New":[68],"Zealand":[69],"White":[70],"(NZW)":[71],"Rabbit":[72],"a":[75,102,123,141,227,299],"acute":[78,386],"exposure":[80,388],"because":[81],"its":[83],"similarity":[85],"vascular,":[88],"immune,":[89],"coagulation":[91,231],"responses.":[92],"MATERIALS":[93],"AND":[94],"METHODS:":[95],"Two":[96],"sequential":[97],"were":[99,152,178,235],"performed":[100,236],"in":[101,268,304],"total":[103,137],"81":[105],"male":[106],"NZW":[107,378],"rabbits,":[108],"16-20":[109],"weeks":[110],"age.":[112],"All":[113],"animals":[114,246,281,307],"underwent":[115],"clinical":[116],"observations":[117],"peripheral":[119],"blood":[120,230,242,318],"analyses":[121],"following":[122],"single":[124],"dose":[125],"0,":[127],"6,":[128],"7,":[129,249],"8,":[130,250],"8.5,":[131],"9,":[132],"or":[133,183,251,285,301,338],"10":[134,252],"Gy":[135,344],"body":[138],"irradiation":[139],"via":[140],"6":[142],"MV":[143],"Linear":[144],"accelerator":[145],"photon":[146],"source":[147],"on":[148,334],"day":[149,271],"0.":[150],"Animals":[151],"treated":[153],"with":[154,199,348,368],"timed":[155],"release":[156],"fentanyl":[157],"patch":[158],"(days":[159,175],"0-30),":[160],"subcutaneous":[161],"hydration":[162],"(day":[163],"1,":[164],"Study":[165,189],"2":[166],"only),":[167],"oral":[169],"sulfamethoxazole/trimethoprim":[170],"30":[171,181,205],"mg/kg":[172],"once":[173],"daily":[174],"3-30)":[176],"followed":[179],"days":[182,206],"time":[185,238,291,329],"mortality.":[187],"RESULTS:":[188],"1":[190],"revealed":[191],"estimated":[193],"LD30,":[194],"-50,":[195],"-70,":[196],"-90":[198],"95%":[200],"confidence":[201],"intervals":[202],"(CI)":[203],"at":[204,290,327],"be":[208,353],"6.7":[209],"(CI:":[210,213,216,220],"5.9-7.4),":[211],"7.3":[212],"6.7-7.8),":[214],"7.9":[215],"7.3-8.4),":[217],"8.8":[219],"7.9-9.7)":[221],"Gy,":[222,253],"respectively.":[223],"In":[224],"2,":[226],"survey":[228],"biochemical":[233],"parameters":[234],"over":[237],"necropsy.":[240],"Complete":[241],"counts":[243,263,277],"taken":[244],"from":[245,313],"exposed":[247],"demonstrated":[254,282,308,336],"dose-dependent":[255],"depletion":[256],"lymphocytes,":[258],"neutrophils,":[259],"platelets.":[261],"Platelet":[262],"recovered":[264],"baseline":[266,315],"levels":[267,316,326],"survivors":[269,333],"30,":[272],"whereas":[273,332],"lymphocyte":[274],"neutrophil":[276],"did":[278],"not.":[279],"Decedent":[280,306],"grade":[283],"3":[284],"4":[286],"neutropenia":[287],"lymphopenia":[289],"death;":[293],"64%":[294],"decedents":[297],"experienced":[298],"30%":[300],"greater":[302],"drop":[303],"hematocrit.":[305],"more":[309],"than":[310],"100%":[311],"increases":[312],"serum":[314],"urea":[319],"nitrogen,":[320],"creatinine,":[321],"aspartate":[322],"aminotransferase,":[323],"triglyceride":[325],"death":[331],"average":[335],"modest":[337],"no":[339],"elevation.":[340],"CONCLUSION:":[341],"7.8":[343],"(95%":[345],"CI:":[346],"6.6-8.4)":[347],"supportive":[349,369],"care":[350],"appears":[351],"close":[354],"ranges":[357],"reported":[358],"rhesus":[360],"macaques":[361],"(5.25-7.44":[362],"Gy)":[363,367],"humans":[365],"(6-8":[366],"care.":[370],"These":[371],"findings":[372],"support":[373],"utility":[375],"further":[382],"medical":[390],"countermeasure":[391],"testing.":[392]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-21T00:00:00"}