{"id":"https://openalex.org/W3084418924","doi":"https://doi.org/10.1111/1759-7714.13653","title":"MicroRNA \u2010200b is a potential biomarker of the expression of PD\u2010L1 in patients with lung cancer","display_name":"MicroRNA \u2010200b is a potential biomarker of the expression of PD\u2010L1 in patients with lung cancer","publication_year":2020,"publication_date":"2020-09-07","ids":{"openalex":"https://openalex.org/W3084418924","doi":"https://doi.org/10.1111/1759-7714.13653","mag":"3084418924","pmid":"https://pubmed.ncbi.nlm.nih.gov/32893980"},"language":"en","primary_location":{"id":"doi:10.1111/1759-7714.13653","doi":"https://doi.org/10.1111/1759-7714.13653","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1759-7714.13653","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.13653","source":{"id":"https://openalex.org/S37904752","display_name":"Thoracic Cancer","issn_l":"1759-7706","issn":["1759-7706","1759-7714"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","medline"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.13653","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082837675","display_name":"Seigo Katakura","orcid":"https://orcid.org/0000-0003-4851-3377","observed_orcids":["https://orcid.org/0000-0003-4851-3377"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seigo Katakura","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017323255","display_name":"Nobuaki Kobayashi","orcid":"https://orcid.org/0000-0002-7064-320X","observed_orcids":["https://orcid.org/0000-0002-7064-320X"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Nobuaki Kobayashi","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":"https://orcid.org/0000-0002-7064-320X","affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102861958","display_name":"Hisashi Hashimoto","orcid":"https://orcid.org/0000-0001-9495-3811","observed_orcids":["https://orcid.org/0000-0001-9495-3811"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi Hashimoto","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017918319","display_name":"Chisato Kamimaki","orcid":"https://orcid.org/0000-0003-4497-7051","observed_orcids":["https://orcid.org/0000-0003-4497-7051"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chisato Kamimaki","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006272329","display_name":"Katsushi Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsushi Tanaka","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112722660","display_name":"Sousuke Kubo","orcid":"https://orcid.org/0009-0004-8071-5299","observed_orcids":["https://orcid.org/0009-0004-8071-5299"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sousuke Kubo","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068530089","display_name":"Kentaro Nakashima","orcid":"https://orcid.org/0000-0002-4633-110X","observed_orcids":["https://orcid.org/0000-0002-4633-110X"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Nakashima","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023700895","display_name":"Shuhei Teranishi","orcid":"https://orcid.org/0000-0003-2365-144X","observed_orcids":["https://orcid.org/0000-0003-2365-144X"]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]},{"id":"https://openalex.org/I4210099218","display_name":"Yokohama City University Hospital","ror":"https://ror.org/010hfy465","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099218"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuhei Teranishi","raw_affiliation_strings":["Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan","Respiratory Disease Center Yokohama City University Medical Center Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan","institution_ids":["https://openalex.org/I2802180866","https://openalex.org/I4210099218"]},{"raw_affiliation_string":"Respiratory Disease Center Yokohama City University Medical Center Yokohama Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108300646","display_name":"Saki Manabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]},{"id":"https://openalex.org/I4210099218","display_name":"Yokohama City University Hospital","ror":"https://ror.org/010hfy465","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099218"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saki Manabe","raw_affiliation_strings":["Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan","Respiratory Disease Center Yokohama City University Medical Center Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan","institution_ids":["https://openalex.org/I2802180866","https://openalex.org/I4210099218"]},{"raw_affiliation_string":"Respiratory Disease Center Yokohama City University Medical Center Yokohama Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056285113","display_name":"Keisuke Watanabe","orcid":"https://orcid.org/0000-0001-9623-1492","observed_orcids":["https://orcid.org/0000-0001-9623-1492"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Watanabe","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":"https://orcid.org/0000-0001-9623-1492","affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059987560","display_name":"Nobuyuki Horita","orcid":"https://orcid.org/0000-0002-8200-0340","observed_orcids":["https://orcid.org/0000-0002-8200-0340"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Horita","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":"https://orcid.org/0000-0002-8200-0340","affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073290799","display_name":"Yu Hara","orcid":"https://orcid.org/0000-0002-2574-2516","observed_orcids":["https://orcid.org/0000-0002-2574-2516"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Hara","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":"https://orcid.org/0000-0002-2574-2516","affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023838708","display_name":"Masaki Yamamoto","orcid":"https://orcid.org/0000-0001-7056-4192","observed_orcids":["https://orcid.org/0000-0001-7056-4192"]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]},{"id":"https://openalex.org/I4210099218","display_name":"Yokohama City University Hospital","ror":"https://ror.org/010hfy465","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099218"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Yamamoto","raw_affiliation_strings":["Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan","Respiratory Disease Center Yokohama City University Medical Center Yokohama Japan"],"raw_orcid":"https://orcid.org/0000-0001-7056-4192","affiliations":[{"raw_affiliation_string":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan","institution_ids":["https://openalex.org/I2802180866","https://openalex.org/I4210099218"]},{"raw_affiliation_string":"Respiratory Disease Center Yokohama City University Medical Center Yokohama Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047669455","display_name":"Makoto Kudo","orcid":"https://orcid.org/0000-0002-1837-0267","observed_orcids":["https://orcid.org/0000-0002-1837-0267"]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]},{"id":"https://openalex.org/I4210099218","display_name":"Yokohama City University Hospital","ror":"https://ror.org/010hfy465","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099218"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Kudo","raw_affiliation_strings":["Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan","Respiratory Disease Center Yokohama City University Medical Center Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan","institution_ids":["https://openalex.org/I2802180866","https://openalex.org/I4210099218"]},{"raw_affiliation_string":"Respiratory Disease Center Yokohama City University Medical Center Yokohama Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101638105","display_name":"Hongmei Piao","orcid":"https://orcid.org/0000-0001-6950-8353","observed_orcids":["https://orcid.org/0000-0001-6950-8353"]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]},{"id":"https://openalex.org/I4210131149","display_name":"Yanbian University Hospital","ror":"https://ror.org/037ve0v69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131149"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongmei Piao","raw_affiliation_strings":["Department of Respiratory Medicine Affiliated Hospital of Yanbian University  Yanji China","Department of Respiratory Medicine Affiliated Hospital of Yanbian University Yanji China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine Affiliated Hospital of Yanbian University  Yanji China","institution_ids":["https://openalex.org/I1793135","https://openalex.org/I4210131149"]},{"raw_affiliation_string":"Department of Respiratory Medicine Affiliated Hospital of Yanbian University Yanji China","institution_ids":["https://openalex.org/I1793135","https://openalex.org/I4210131149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054367448","display_name":"Takeshi Kaneko","orcid":"https://orcid.org/0000-0001-9292-307X","observed_orcids":["https://orcid.org/0000-0001-9292-307X"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Kaneko","raw_affiliation_strings":["Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan","institution_ids":["https://openalex.org/I89630735"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017323255"],"corresponding_institution_ids":["https://openalex.org/I89630735"],"apc_list":{"value":2420,"currency":"USD","value_usd":2420},"apc_paid":{"value":2420,"currency":"USD","value_usd":2420},"fwci":0.8902,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.7547596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"10","first_page":"2975","last_page":"2982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.2207999974489212,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-200b","display_name":"miR-200b","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.9129999876022339},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/surrogate-markers","display_name":"surrogate markers","score":0.7379999756813049},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.6669999957084656},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6010000109672546},{"id":"https://openalex.org/keywords/tumor-proportion-score","display_name":"tumor proportion score","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8019710779190063},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7704463601112366},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6970527172088623},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6351742744445801},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6169033646583557},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5650491118431091},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5180090069770813},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4903874397277832},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.4376617968082428},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.42635613679885864},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.42344754934310913},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.382312148809433},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.35118067264556885},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.32678401470184326},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3120570778846741},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29789823293685913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27338147163391113},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14631140232086182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.129866361618042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/1759-7714.13653","doi":"https://doi.org/10.1111/1759-7714.13653","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1759-7714.13653","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.13653","source":{"id":"https://openalex.org/S37904752","display_name":"Thoracic Cancer","issn_l":"1759-7706","issn":["1759-7706","1759-7714"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","medline"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic Cancer","raw_type":"journal-article"},{"id":"pmid:32893980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32893980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7529545","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7529545","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thorac Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:16617066622c41d597b7c6fc08914603","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/16617066622c41d597b7c6fc08914603","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thoracic Cancer, Vol 11, Iss 10, Pp 2975-2982 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/1759-7714.13653","doi":"https://doi.org/10.1111/1759-7714.13653","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1759-7714.13653","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.13653","source":{"id":"https://openalex.org/S37904752","display_name":"Thoracic Cancer","issn_l":"1759-7706","issn":["1759-7706","1759-7714"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","medline"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8899999856948853}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4831279096","display_name":null,"funder_award_id":"JP1426830111","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3084418924.pdf","grobid_xml":"https://content.openalex.org/works/W3084418924.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W581597897","https://openalex.org/W1519739419","https://openalex.org/W1976903466","https://openalex.org/W1996863944","https://openalex.org/W2057329290","https://openalex.org/W2086809547","https://openalex.org/W2102059693","https://openalex.org/W2103328194","https://openalex.org/W2111662961","https://openalex.org/W2132157071","https://openalex.org/W2132870547","https://openalex.org/W2159514748","https://openalex.org/W2164758046","https://openalex.org/W2404282441","https://openalex.org/W2527905628","https://openalex.org/W2554492310","https://openalex.org/W2560717039","https://openalex.org/W2626459434","https://openalex.org/W2743419024","https://openalex.org/W2760639821","https://openalex.org/W2763137975","https://openalex.org/W2766149732","https://openalex.org/W2770366458","https://openalex.org/W2796582438","https://openalex.org/W2799733004","https://openalex.org/W2805354595","https://openalex.org/W2883922109","https://openalex.org/W2892640821","https://openalex.org/W2948461995","https://openalex.org/W2952299848","https://openalex.org/W2966672100","https://openalex.org/W2978375556","https://openalex.org/W2981291970","https://openalex.org/W2994755653"],"related_works":["https://openalex.org/W3103789129","https://openalex.org/W4386799875","https://openalex.org/W4213065871","https://openalex.org/W4361818220","https://openalex.org/W4361818978","https://openalex.org/W4361818627","https://openalex.org/W3157667906","https://openalex.org/W2800322456","https://openalex.org/W3157549915","https://openalex.org/W4388856884"],"abstract_inverted_index":{"BACKGROUND:":[0],"Advanced":[1],"non-small":[2],"cell":[3,84,140],"lung":[4,82,199,225,256,289],"cancer":[5,83,200,226,257,269,290],"(NSCLC)":[6],"has":[7],"a":[8,41,71,125,158,217,282],"high":[9,251],"mortality":[10],"rate":[11],"and":[12,57,90,96,177,202],"poor":[13],"prognosis.":[14],"However,":[15],"outcomes":[16],"have":[17],"gradually":[18],"improved":[19],"after":[20,122],"the":[21,66,80,171,277],"introduction":[22],"of":[23,48,54,68,99,146,279],"novel":[24],"immunotherapies,":[25],"including":[26],"immune":[27],"checkpoint":[28],"inhibitors":[29],"(ICIs).":[30],"Although":[31],"programmed":[32],"death-ligand":[33],"1":[34],"(PD-L1)":[35],"expression":[36,93,111,132,137,151,169,197,204,223,237,247,253,267,287],"in":[37,94,112,117,138,152,170,198,205,224,254,268,288],"tumor":[38,118,160,187],"tissues":[39],"is":[40],"known":[42],"biomarker":[43,73,220,284],"for":[44,74,221,285],"guiding":[45],"ICI":[46],"treatment":[47,61],"NSCLC,":[49],"challenges":[50],"such":[51],"as":[52,70,114,116,281],"difficulty":[53],"liquid":[55],"biopsy":[56],"heterogeneous":[58],"results":[59],"during":[60],"persist.":[62],"This":[63],"study":[64,273],"evaluated":[65,103,121],"potential":[67,278],"miR200b":[69,92,127,131,147,168,193,203,214,242,252,260,280],"surrogate":[72,219,283],"PD-L1":[75,110,136,150,159,186,196,211,222,236,246,266,286],"expression.":[76,212],"METHODS:":[77],"We":[78,275],"used":[79],"human":[81,255],"lines":[85],"H226,":[86],"H460,":[87],"H520,":[88],"A549,":[89],"H1975.":[91],"blood":[95],"bronchoscopy":[97,172],"specimens":[98,173,207],"NSCLC":[100],"patients":[101],"was":[102,120,238,248],"using":[104],"reverse-transcription-quantitative":[105],"PCR.":[106],"Using":[107],"flow":[108],"cytometry,":[109],"vitro,":[113],"well":[115],"tissues,":[119],"transfection":[123],"with":[124,135,157,185,210],"mimic":[126],"or":[128,144,262],"siRNA.":[129],"RESULTS:":[130],"negatively":[133,208],"correlated":[134,209],"all":[139],"lines.":[141],"The":[142,154],"induction":[143],"knockdown":[145],"also":[148],"altered":[149],"vitro.":[153],"patient":[155],"group":[156],"proportion":[161,188],"score":[162,189],"\u2265":[163],"50%":[164],"had":[165],"significantly":[166],"lower":[167],"(P":[174,180],"=":[175,181],"0.025)":[176],"serum-derived":[178],"exosomes":[179],"0.022)":[182],"than":[183],"that":[184],"<":[190],"50%.":[191],"CONCLUSIONS:":[192],"can":[194,264],"regulate":[195],"cells,":[201],"clinical":[206],"Thus,":[213,259],"may":[215],"be":[216],"useful":[218],"patients.":[227,258,291],"KEY":[228],"POINTS:":[229],"SIGNIFICANT":[230],"FINDINGS":[231],"OF":[232],"THE":[233],"STUDY:":[234],"High":[235],"linked":[239,249],"to":[240,250],"low":[241,245],"expression,":[243],"whereas":[244],"overexpression":[261],"silencing":[263],"control":[265],"cells.":[270],"What":[271],"this":[272],"adds":[274],"demonstrated":[276]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2020-09-14T00:00:00"}