{"id":"https://openalex.org/W3084396808","doi":"https://doi.org/10.1007/978-3-030-50621-6_1","title":"Introduction: Druggable Lipid Signaling Pathways","display_name":"Introduction: Druggable Lipid Signaling Pathways","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3084396808","doi":"https://doi.org/10.1007/978-3-030-50621-6_1","mag":"3084396808","pmid":"https://pubmed.ncbi.nlm.nih.gov/32894504"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-030-50621-6_1","doi":"https://doi.org/10.1007/978-3-030-50621-6_1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-030-50621-6_1","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4231298739","display_name":"Druggable Lipid Signaling Pathways"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006952722","display_name":"Yasuyuki Kihara","orcid":"https://orcid.org/0000-0001-7462-3006","observed_orcids":["https://orcid.org/0000-0001-7462-3006"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yasuyuki Kihara","raw_affiliation_strings":["Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. kihara-yasuyuki@umin.net","Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. kihara-yasuyuki@umin.net","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006952722"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":null,"apc_paid":null,"fwci":1.0131,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.78107263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"1274","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingosine-1-phosphate-receptor-modulator","display_name":"sphingosine-1-phosphate receptor modulator","score":0.9409999847412109},{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.8970000147819519},{"id":"https://openalex.org/keywords/siponimod","display_name":"siponimod","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ozanimod","display_name":"ozanimod","score":0.9990000128746033},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibitors","display_name":"cyclooxygenase inhibitors","score":0.859000027179718},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8820000290870667},{"id":"https://openalex.org/keywords/leukotrienes","display_name":"leukotrienes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/epoxy-fatty-acids","display_name":"epoxy fatty acids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lysophospholipids","display_name":"lysophospholipids","score":0.9660000205039978},{"id":"https://openalex.org/keywords/endocannabinoids","display_name":"endocannabinoids","score":0.8899999856948853},{"id":"https://openalex.org/keywords/phosphoinositides","display_name":"phosphoinositides","score":0.9380000233650208},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/lysophospholipid-acyltransferase","display_name":"lysophospholipid acyltransferase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.7607841491699219},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.5816493630409241},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5787222981452942},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5158054828643799},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.4768734574317932},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4462399482727051},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4227280616760254},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.4151882529258728},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3986327648162842},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3743059039115906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36883652210235596},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35703909397125244},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3517886996269226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29861879348754883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-030-50621-6_1","doi":"https://doi.org/10.1007/978-3-030-50621-6_1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-030-50621-6_1","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:32894504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32894504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1549006420","https://openalex.org/W1936798053","https://openalex.org/W1971584499","https://openalex.org/W1973617509","https://openalex.org/W1985551319","https://openalex.org/W1993918137","https://openalex.org/W2007187686","https://openalex.org/W2014046188","https://openalex.org/W2036904501","https://openalex.org/W2037182281","https://openalex.org/W2037549849","https://openalex.org/W2076822925","https://openalex.org/W2081521523","https://openalex.org/W2085046768","https://openalex.org/W2101134096","https://openalex.org/W2108812575","https://openalex.org/W2116687544","https://openalex.org/W2120276871","https://openalex.org/W2120377931","https://openalex.org/W2129935236","https://openalex.org/W2158743336","https://openalex.org/W2162392926","https://openalex.org/W2236997873","https://openalex.org/W2316741846","https://openalex.org/W2524528574","https://openalex.org/W2765945432","https://openalex.org/W2768617092","https://openalex.org/W2809905001","https://openalex.org/W2887053881","https://openalex.org/W2896089314","https://openalex.org/W2908927563","https://openalex.org/W2909092545","https://openalex.org/W2914966474","https://openalex.org/W2976604399","https://openalex.org/W2983287708"],"related_works":["https://openalex.org/W1985551319","https://openalex.org/W7131619168","https://openalex.org/W1566845866","https://openalex.org/W2037371747","https://openalex.org/W4231298739","https://openalex.org/W2565664571","https://openalex.org/W2522895431","https://openalex.org/W2016949590","https://openalex.org/W3162784420","https://openalex.org/W4250191838"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-14T00:00:00"}
