{"id":"https://openalex.org/W3084336587","doi":"https://doi.org/10.1101/cshperspect.a038000","title":"Targeting Epigenetics in Lung Cancer","display_name":"Targeting Epigenetics in Lung Cancer","publication_year":2020,"publication_date":"2020-09-08","ids":{"openalex":"https://openalex.org/W3084336587","doi":"https://doi.org/10.1101/cshperspect.a038000","mag":"3084336587","pmid":"https://pubmed.ncbi.nlm.nih.gov/32900703","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8168531"},"language":"en","primary_location":{"id":"doi:10.1101/cshperspect.a038000","doi":"https://doi.org/10.1101/cshperspect.a038000","is_oa":true,"landing_page_url":"https://doi.org/10.1101/cshperspect.a038000","pdf_url":"http://perspectivesinmedicine.cshlp.org/content/early/2020/09/07/cshperspect.a038000.full.pdf","source":{"id":"https://openalex.org/S2479837110","display_name":"Cold Spring Harbor Perspectives in Medicine","issn_l":"2157-1422","issn":["2157-1422","2472-5412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Medicine","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://perspectivesinmedicine.cshlp.org/content/early/2020/09/07/cshperspect.a038000.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034222421","display_name":"Yvonne L. Chao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne L. Chao","raw_affiliation_strings":["Department of Medicine, Division of Hematology and Oncology, University of North Carolina, Chapel Hill, North Carolina 27514, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology and Oncology, University of North Carolina, Chapel Hill, North Carolina 27514, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017773172","display_name":"Chad Victor Pecot","orcid":"https://orcid.org/0000-0002-5250-2999","observed_orcids":["https://orcid.org/0000-0002-5250-2999"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad V. Pecot","raw_affiliation_strings":["Department of Medicine, Division of Hematology and Oncology, University of North Carolina, Chapel Hill, North Carolina 27514, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology and Oncology, University of North Carolina, Chapel Hill, North Carolina 27514, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"6","first_page":"a038000","last_page":"a038000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.8870000243186951},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.953000009059906},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6499999761581421},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.715277373790741},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6567283272743225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47548139095306396},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4305475950241089},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39064541459083557},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34166592359542847},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32613813877105713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30961477756500244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2476898431777954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14670899510383606},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042421","descriptor_name":"Histone Code","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1101/cshperspect.a038000","doi":"https://doi.org/10.1101/cshperspect.a038000","is_oa":true,"landing_page_url":"https://doi.org/10.1101/cshperspect.a038000","pdf_url":"http://perspectivesinmedicine.cshlp.org/content/early/2020/09/07/cshperspect.a038000.full.pdf","source":{"id":"https://openalex.org/S2479837110","display_name":"Cold Spring Harbor Perspectives in Medicine","issn_l":"2157-1422","issn":["2157-1422","2472-5412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8168531","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8168531","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harb Perspect Med","raw_type":"Text"},{"id":"pmid:32900703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32900703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor perspectives in medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/cshperspect.a038000","doi":"https://doi.org/10.1101/cshperspect.a038000","is_oa":true,"landing_page_url":"https://doi.org/10.1101/cshperspect.a038000","pdf_url":"http://perspectivesinmedicine.cshlp.org/content/early/2020/09/07/cshperspect.a038000.full.pdf","source":{"id":"https://openalex.org/S2479837110","display_name":"Cold Spring Harbor Perspectives in Medicine","issn_l":"2157-1422","issn":["2157-1422","2472-5412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7379453623","display_name":"Immune Regulation of Lung Squamous Metastasis","funder_award_id":"R01CA215075","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3084336587.pdf","grobid_xml":"https://content.openalex.org/works/W3084336587.grobid-xml"},"referenced_works_count":193,"referenced_works":["https://openalex.org/W1484293540","https://openalex.org/W1503744211","https://openalex.org/W1520121967","https://openalex.org/W1523117612","https://openalex.org/W1603797292","https://openalex.org/W1825543333","https://openalex.org/W1827923022","https://openalex.org/W1852761976","https://openalex.org/W1876877140","https://openalex.org/W1907661270","https://openalex.org/W1914929330","https://openalex.org/W1920450187","https://openalex.org/W1921397304","https://openalex.org/W1939365747","https://openalex.org/W1947520875","https://openalex.org/W1947959739","https://openalex.org/W1966131437","https://openalex.org/W1966411071","https://openalex.org/W1966485273","https://openalex.org/W1979818557","https://openalex.org/W1980497534","https://openalex.org/W1982162367","https://openalex.org/W1983501949","https://openalex.org/W1988323955","https://openalex.org/W1992862760","https://openalex.org/W1996863944","https://openalex.org/W2005253752","https://openalex.org/W2006871036","https://openalex.org/W2007283154","https://openalex.org/W2007506240","https://openalex.org/W2007881573","https://openalex.org/W2008130100","https://openalex.org/W2011667027","https://openalex.org/W2012372842","https://openalex.org/W2013149980","https://openalex.org/W2013253942","https://openalex.org/W2015723935","https://openalex.org/W2016700676","https://openalex.org/W2020966893","https://openalex.org/W2022093187","https://openalex.org/W2024139498","https://openalex.org/W2024187290","https://openalex.org/W2024645263","https://openalex.org/W2027324111","https://openalex.org/W2029300527","https://openalex.org/W2031593782","https://openalex.org/W2036982851","https://openalex.org/W2038444711","https://openalex.org/W2040237389","https://openalex.org/W2042386784","https://openalex.org/W2043841998","https://openalex.org/W2049662309","https://openalex.org/W2052265257","https://openalex.org/W2054240721","https://openalex.org/W2056750246","https://openalex.org/W2060459012","https://openalex.org/W2060940710","https://openalex.org/W2064165694","https://openalex.org/W2064442490","https://openalex.org/W2065477010","https://openalex.org/W2066027374","https://openalex.org/W2066151767","https://openalex.org/W2066772704","https://openalex.org/W2068394634","https://openalex.org/W2072039942","https://openalex.org/W2072191008","https://openalex.org/W2072378401","https://openalex.org/W2074310370","https://openalex.org/W2074411648","https://openalex.org/W2078564924","https://openalex.org/W2082854050","https://openalex.org/W2083898865","https://openalex.org/W2084242910","https://openalex.org/W2092260148","https://openalex.org/W2093188241","https://openalex.org/W2093468083","https://openalex.org/W2095125632","https://openalex.org/W2102059693","https://openalex.org/W2102844520","https://openalex.org/W2103177465","https://openalex.org/W2108040084","https://openalex.org/W2108927999","https://openalex.org/W2110511887","https://openalex.org/W2110666579","https://openalex.org/W2117244632","https://openalex.org/W2117692326","https://openalex.org/W2120920586","https://openalex.org/W2122450025","https://openalex.org/W2126504590","https://openalex.org/W2128211249","https://openalex.org/W2128779436","https://openalex.org/W2130027352","https://openalex.org/W2130497075","https://openalex.org/W2130979840","https://openalex.org/W2138428661","https://openalex.org/W2141476381","https://openalex.org/W2141978478","https://openalex.org/W2143658931","https://openalex.org/W2144038313","https://openalex.org/W2144154026","https://openalex.org/W2145809931","https://openalex.org/W2146653515","https://openalex.org/W2151571608","https://openalex.org/W2152207829","https://openalex.org/W2152853425","https://openalex.org/W2152995571","https://openalex.org/W2157814804","https://openalex.org/W2159798176","https://openalex.org/W2163999275","https://openalex.org/W2164296283","https://openalex.org/W2168018632","https://openalex.org/W2169354377","https://openalex.org/W2171836441","https://openalex.org/W2171937543","https://openalex.org/W2180481128","https://openalex.org/W2190723343","https://openalex.org/W2234443850","https://openalex.org/W2236897080","https://openalex.org/W2266356262","https://openalex.org/W2274757775","https://openalex.org/W2277491994","https://openalex.org/W2289445514","https://openalex.org/W2316171452","https://openalex.org/W2337756776","https://openalex.org/W2337962116","https://openalex.org/W2344250613","https://openalex.org/W2346025119","https://openalex.org/W2350443416","https://openalex.org/W2427007523","https://openalex.org/W2509963959","https://openalex.org/W2511592073","https://openalex.org/W2511667040","https://openalex.org/W2515970043","https://openalex.org/W2516648208","https://openalex.org/W2517463990","https://openalex.org/W2529451330","https://openalex.org/W2530380647","https://openalex.org/W2554694872","https://openalex.org/W2555340419","https://openalex.org/W2555747213","https://openalex.org/W2558017818","https://openalex.org/W2559239118","https://openalex.org/W2559620924","https://openalex.org/W2566097899","https://openalex.org/W2581769481","https://openalex.org/W2588632379","https://openalex.org/W2588654455","https://openalex.org/W2604414072","https://openalex.org/W2604585835","https://openalex.org/W2605295718","https://openalex.org/W2606377102","https://openalex.org/W2609243345","https://openalex.org/W2738946844","https://openalex.org/W2739174192","https://openalex.org/W2740038310","https://openalex.org/W2748237445","https://openalex.org/W2748570664","https://openalex.org/W2751143162","https://openalex.org/W2752258084","https://openalex.org/W2753729734","https://openalex.org/W2754970987","https://openalex.org/W2758733287","https://openalex.org/W2762129112","https://openalex.org/W2767204171","https://openalex.org/W2767898155","https://openalex.org/W2769177687","https://openalex.org/W2772672053","https://openalex.org/W2774935716","https://openalex.org/W2775062779","https://openalex.org/W2775863097","https://openalex.org/W2777953572","https://openalex.org/W2789783379","https://openalex.org/W2791017111","https://openalex.org/W2792204919","https://openalex.org/W2793789701","https://openalex.org/W2795210358","https://openalex.org/W2797823977","https://openalex.org/W2803008706","https://openalex.org/W2803891124","https://openalex.org/W2809301543","https://openalex.org/W2842676593","https://openalex.org/W2887100062","https://openalex.org/W2887652841","https://openalex.org/W2898806520","https://openalex.org/W2900850487","https://openalex.org/W2903579127","https://openalex.org/W2911595146","https://openalex.org/W2914398011","https://openalex.org/W2921804231","https://openalex.org/W2936025729","https://openalex.org/W2944674681","https://openalex.org/W2952308182","https://openalex.org/W3022782945"],"related_works":["https://openalex.org/W2084242910","https://openalex.org/W2996675584","https://openalex.org/W2740552644","https://openalex.org/W1976811466","https://openalex.org/W2899453387","https://openalex.org/W4407384275","https://openalex.org/W2367640319","https://openalex.org/W2509963959","https://openalex.org/W2398610718","https://openalex.org/W341769950"],"abstract_inverted_index":{"The":[0],"epigenetic":[1,39],"landscape,":[2],"which":[3],"in":[4,45,62],"part":[5],"includes":[6],"DNA":[7],"methylation,":[8],"chromatin":[9],"organization,":[10],"histone":[11],"modifications,":[12],"and":[13,51],"noncoding":[14],"RNA":[15],"regulation,":[16],"greatly":[17],"contributes":[18],"to":[19],"the":[20,38,63],"heterogeneity":[21],"that":[22,41],"makes":[23],"developing":[24],"effective":[25],"therapies":[26],"for":[27,59],"lung":[28,66],"cancer":[29,49],"challenging.":[30],"This":[31],"review":[32],"will":[33],"provide":[34],"an":[35],"overview":[36],"of":[37,48,65],"alterations":[40],"have":[42],"been":[43],"implicated":[44],"all":[46],"aspects":[47],"pathogenesis":[50],"progression":[52],"as":[53,55],"well":[54],"summarize":[56],"clinical":[57],"applications":[58],"targeting":[60],"epigenetics":[61],"treatment":[64],"cancer.":[67]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-14T00:00:00"}