{"id":"https://openalex.org/W3084084725","doi":"https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-22","title":"Identification of Structural-Activity Features of Long Chain Polyunsaturated Fatty Acid Epoxides in Angiogenesis","display_name":"Identification of Structural-Activity Features of Long Chain Polyunsaturated Fatty Acid Epoxides in Angiogenesis","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3084084725","doi":"https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-22","mag":"3084084725"},"language":"en","primary_location":{"id":"doi:10.1254/jpssuppl.wcp2018.0_po1-8-22","doi":"https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-22","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-22","pdf_url":"https://www.jstage.jst.go.jp/article/jpssuppl/WCP2018/0/WCP2018_PO1-8-22/_pdf","source":{"id":"https://openalex.org/S4210239061","display_name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","issn_l":"2435-4953","issn":["2435-4953"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/jpssuppl/WCP2018/0/WCP2018_PO1-8-22/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000439321","display_name":"Rebekah Marie Betts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebekah Betts","raw_affiliation_strings":["Pharmacology and Toxicology, Michigan State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology, Michigan State University, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064274524","display_name":"Kin Sing Stephen Lee","orcid":"https://orcid.org/0000-0003-4541-3063","observed_orcids":["https://orcid.org/0000-0003-4541-3063"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kin Sing Lee","raw_affiliation_strings":["Pharmacology and Toxicology, Michigan State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology, Michigan State University, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019924991","display_name":"Maris A. Cinelli","orcid":"https://orcid.org/0000-0002-5887-7038","observed_orcids":["https://orcid.org/0000-0002-5887-7038"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maris Cinelli","raw_affiliation_strings":["Pharmacology and Toxicology, Michigan State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology, Michigan State University, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031436489","display_name":"Joe Luca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe Luca","raw_affiliation_strings":["Pharmacology and Toxicology, Michigan State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology, Michigan State University, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002628534","display_name":"Nick Confer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nick Confer","raw_affiliation_strings":["Pharmacology and Toxicology, Michigan State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology, Michigan State University, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18755053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"WCP2018","issue":"0","first_page":"PO1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-epoxides","display_name":"fatty acid epoxides","score":0.8920000195503235},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/soluble-epoxide-hydrolase","display_name":"soluble epoxide hydrolase","score":0.843999981880188},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.6460000276565552},{"id":"https://openalex.org/keywords/omega-6-fatty-acids","display_name":"omega-6 fatty acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.8299999833106995},{"id":"https://openalex.org/keywords/docosapentaenoic-acid","display_name":"docosapentaenoic acid","score":0.9610000252723694},{"id":"https://openalex.org/keywords/epoxyeicosatrienoic-acids","display_name":"epoxyeicosatrienoic acids","score":0.9589999914169312},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8579999804496765},{"id":"https://openalex.org/keywords/regioisomers","display_name":"regioisomers","score":0.6899999976158142},{"id":"https://openalex.org/keywords/stereoisomers","display_name":"stereoisomers","score":0.9869999885559082},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bioactive-lipids","display_name":"bioactive lipids","score":0.7139999866485596},{"id":"https://openalex.org/keywords/seh-inhibitors","display_name":"sEH inhibitors","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C18605011","wikidata":"https://www.wikidata.org/wiki/Q17916975","display_name":"Epoxide hydrolase 2","level":3,"score":0.7788795232772827},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.6373205184936523},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.618982195854187},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6133908033370972},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5732048749923706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5411710739135742},{"id":"https://openalex.org/C2781349093","wikidata":"https://www.wikidata.org/wiki/Q17177300","display_name":"Docosapentaenoic acid","level":5,"score":0.5213302969932556},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.50374835729599},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.4942012131214142},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4729951322078705},{"id":"https://openalex.org/C187921627","wikidata":"https://www.wikidata.org/wiki/Q2469470","display_name":"Stereospecificity","level":3,"score":0.4341534376144409},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.42390698194503784},{"id":"https://openalex.org/C101819947","wikidata":"https://www.wikidata.org/wiki/Q87444516","display_name":"Epoxide hydrolase","level":4,"score":0.41617342829704285},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.4106304943561554},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3798549771308899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3361794948577881},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32228827476501465},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06928303837776184},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1254/jpssuppl.wcp2018.0_po1-8-22","doi":"https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-22","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-22","pdf_url":"https://www.jstage.jst.go.jp/article/jpssuppl/WCP2018/0/WCP2018_PO1-8-22/_pdf","source":{"id":"https://openalex.org/S4210239061","display_name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","issn_l":"2435-4953","issn":["2435-4953"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1254/jpssuppl.wcp2018.0_po1-8-22","doi":"https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-22","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-22","pdf_url":"https://www.jstage.jst.go.jp/article/jpssuppl/WCP2018/0/WCP2018_PO1-8-22/_pdf","source":{"id":"https://openalex.org/S4210239061","display_name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","issn_l":"2435-4953","issn":["2435-4953"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3084084725.pdf","grobid_xml":"https://content.openalex.org/works/W3084084725.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1653032051","https://openalex.org/W2233828936","https://openalex.org/W2025122196","https://openalex.org/W2112628603","https://openalex.org/W4389008106","https://openalex.org/W4320006792","https://openalex.org/W3083862941","https://openalex.org/W4406699323","https://openalex.org/W7159979952","https://openalex.org/W2606516348"],"abstract_inverted_index":{"The":[0],"cytochrome":[1],"P450-derived":[2],"fatty":[3,66,179],"acid":[4,67,92,99,180,202],"epoxides":[5,123,134,181,195],"are":[6,24,93,147],"bioactive":[7],"lipids":[8],"with":[9],"regulatory":[10,239],"roles":[11],"in":[12,58,124,135,186,237,256],"a":[13,53,128,136],"wide":[14],"range":[15],"of":[16,38,52,55,77,118,130,151,174,209,226,229,234,244,253],"homeostatic":[17],"and":[18,108,132,143,149,177,199,215,220,224,259],"pathophysiological":[19],"events.":[20],"These":[21],"lipid":[22],"mediators":[23],"efficiently":[25],"metabolized":[26],"by":[27],"mammalian":[28],"soluble":[29],"epoxide":[30,69,213],"hydrolase":[31],"enzyme":[32],"(sEH)":[33],"to":[34,43,46,218],"corresponding":[35],"1,2-diols.":[36],"Inhibition":[37],"sEH":[39,78,235,246],"has":[40],"been":[41],"shown":[42,83],"be":[44,184],"beneficial":[45,251],"human":[47,257],"health":[48,258],"via":[49],"increasing":[50],"concentrations":[51],"variety":[54],"short-lived":[56],"epoxylipids":[57],"vivo":[59],"(2).":[60],"Identifying":[61],"the":[62,75,85,96,116,153,171,189,192,206,210,222,250],"most":[63,211],"potent":[64,212],"polyunsaturated":[65],"(PUFA)":[68],"species":[70,214],"will":[71,241],"provide":[72],"insight":[73],"on":[74],"effects":[76,146,252],"inhibition.":[79],"Recent":[80],"studies":[81],"have":[82],"that":[84,182,248],"omega-6":[86,133,178,200],"epoxyeicosatrienoic":[87],"acids":[88,102],"(EETs)":[89],"from":[90,188,196],"arachidonic":[91],"pro-angiogenic,":[94],"while":[95],"omega-3":[97,131,176,198],"docosahexaenoic":[98],"(DHA)-derived":[100],"epoxydocosapentaenoic":[101],"(EDPs)":[103],"inhibit":[104],"angiogenesis,":[105],"tumor":[106],"growth,":[107],"metastasis":[109],"(1).":[110],"Given":[111],"these":[112],"findings,":[113],"we":[114,169],"explore":[115],"role":[117],"various":[119],"long":[120],"chain":[121],"PUFA":[122,254],"angiogenesis.":[125],"We":[126,204],"tested":[127],"library":[129],"newly":[137],"developed":[138],"high-throughput":[139],"tube":[140,159],"formation":[141,160],"assay":[142],"found":[144],"their":[145],"regiospecific":[148],"stereospecific;":[150],"note,":[152],"19(S),20(R)-EDP":[154],"stereoisomer":[155],"inhibited":[156],"endothelial":[157],"cell":[158],"less":[161,193],"effectively":[162],"than":[163],"its":[164],"respective":[165],"racemic":[166],"mixture.":[167],"Here,":[168],"report":[170],"angiogenic":[172],"activities":[173,233],"diverse":[175],"could":[183],"present":[185,216],"mammals":[187],"diet,":[190],"including":[191],"explored":[194],"both":[197],"docosapentaenoic":[201],"(DPA).":[203],"discuss":[205],"structure-activtity":[207],"features":[208],"methodology":[217],"synthesize":[219],"purify":[221],"regioisomers":[223],"stereoisomers":[225],"each":[227],"series":[228],"epoxides.":[230],"Ultimately,":[231],"understanding":[232],"substrates":[236],"specific":[238],"environments":[240],"guide":[242],"development":[243],"targeted":[245],"modulators":[247],"promote":[249],"metabolites":[255],"disease.":[260]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2020-09-14T00:00:00"}