{"id":"https://openalex.org/W3084060423","doi":"https://doi.org/10.1038/s12276-020-0473-2","title":"Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics","display_name":"Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W3084060423","doi":"https://doi.org/10.1038/s12276-020-0473-2","mag":"3084060423","pmid":"https://pubmed.ncbi.nlm.nih.gov/32908211","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8080820"},"language":"en","primary_location":{"id":"doi:10.1038/s12276-020-0473-2","doi":"https://doi.org/10.1038/s12276-020-0473-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-020-0473-2","pdf_url":"https://www.nature.com/articles/s12276-020-0473-2.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s12276-020-0473-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079689480","display_name":"John Chulhoon Park","orcid":"https://orcid.org/0000-0001-5705-2862","observed_orcids":["https://orcid.org/0000-0001-5705-2862"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"John Chulhoon Park","raw_affiliation_strings":["Department of Life Sciences, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5705-2862","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018682015","display_name":"Sin\u2010Hyeog Im","orcid":"https://orcid.org/0000-0002-3173-1856","observed_orcids":["https://orcid.org/0000-0002-3173-1856"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I4405259430","display_name":"ImmunoBiome, Inc. (Korea)","ror":"https://ror.org/027pp3z40","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405259430"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sin-Hyeog Im","raw_affiliation_strings":["Department of Life Sciences, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea. iimsh@postech.ac.kr","ImmunoBiome Inc. POSTECH Biotech Center, Pohang, 37673, Republic of Korea. iimsh@postech.ac.kr","Department of Life Sciences, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3173-1856","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea. iimsh@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"ImmunoBiome Inc. POSTECH Biotech Center, Pohang, 37673, Republic of Korea. iimsh@postech.ac.kr","institution_ids":["https://openalex.org/I123900574","https://openalex.org/I4405259430"]},{"raw_affiliation_string":"Department of Life Sciences, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018682015"],"corresponding_institution_ids":["https://openalex.org/I123900574","https://openalex.org/I4405259430"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":{"value":3150,"currency":"USD","value_usd":3150},"fwci":2.1389,"has_fulltext":true,"cited_by_count":233,"citation_normalized_percentile":{"value":0.90958269,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"52","issue":"9","first_page":"1383","last_page":"1396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9160000085830688},{"id":"https://openalex.org/keywords/microbiome-based-therapy","display_name":"microbiota-based therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.8880000114440918},{"id":"https://openalex.org/keywords/donor-selection","display_name":"donor selection","score":0.5590000152587891},{"id":"https://openalex.org/keywords/mouse-genetic-background","display_name":"mouse genetic background","score":0.9240000247955322},{"id":"https://openalex.org/keywords/microbial-colonization","display_name":"microbial colonization","score":0.7149999737739563},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.750027596950531},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.7343822717666626},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.728896975517273},{"id":"https://openalex.org/C137923570","wikidata":"https://www.wikidata.org/wiki/Q2121103","display_name":"Fecal bacteriotherapy","level":4,"score":0.7168498635292053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6749982833862305},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6576073169708252},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.542801022529602},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.48784661293029785},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4637499451637268},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44060370326042175},{"id":"https://openalex.org/C190944805","wikidata":"https://www.wikidata.org/wiki/Q3922751","display_name":"Human Microbiome Project","level":4,"score":0.4268534779548645},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4245252311229706},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3258751630783081},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.24853596091270447},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23876869678497314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21906903386116028},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.20814025402069092},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17863917350769043},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14403414726257324},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0850709080696106},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068617","descriptor_name":"Genetic Background","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069467","descriptor_name":"Fecal Microbiota Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005856","descriptor_name":"Germ-Free Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s12276-020-0473-2","doi":"https://doi.org/10.1038/s12276-020-0473-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-020-0473-2","pdf_url":"https://www.nature.com/articles/s12276-020-0473-2.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:32908211","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32908211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8080820","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8080820/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Mol Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0e6700604255461e924ce0f40e2369d2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0e6700604255461e924ce0f40e2369d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1383-1396 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s12276-020-0473-2","doi":"https://doi.org/10.1038/s12276-020-0473-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-020-0473-2","pdf_url":"https://www.nature.com/articles/s12276-020-0473-2.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3084060423.pdf","grobid_xml":"https://content.openalex.org/works/W3084060423.grobid-xml"},"referenced_works_count":137,"referenced_works":["https://openalex.org/W1577148670","https://openalex.org/W1591032344","https://openalex.org/W1685305421","https://openalex.org/W1908532873","https://openalex.org/W1971415551","https://openalex.org/W1974509836","https://openalex.org/W1975807766","https://openalex.org/W1982203245","https://openalex.org/W1982278487","https://openalex.org/W1982281296","https://openalex.org/W1999906527","https://openalex.org/W2001851999","https://openalex.org/W2002084799","https://openalex.org/W2003342633","https://openalex.org/W2012289680","https://openalex.org/W2014437629","https://openalex.org/W2023506796","https://openalex.org/W2030500910","https://openalex.org/W2031983303","https://openalex.org/W2033236889","https://openalex.org/W2033294077","https://openalex.org/W2034123898","https://openalex.org/W2035742252","https://openalex.org/W2036791620","https://openalex.org/W2037347206","https://openalex.org/W2039571306","https://openalex.org/W2060185417","https://openalex.org/W2063890406","https://openalex.org/W2071841602","https://openalex.org/W2073332363","https://openalex.org/W2080883470","https://openalex.org/W2082565310","https://openalex.org/W2087278385","https://openalex.org/W2087292184","https://openalex.org/W2087897706","https://openalex.org/W2092609776","https://openalex.org/W2096515456","https://openalex.org/W2097478615","https://openalex.org/W2098163072","https://openalex.org/W2102207995","https://openalex.org/W2107369528","https://openalex.org/W2108865848","https://openalex.org/W2109127169","https://openalex.org/W2109798971","https://openalex.org/W2109943216","https://openalex.org/W2109963121","https://openalex.org/W2113455571","https://openalex.org/W2113678392","https://openalex.org/W2114368506","https://openalex.org/W2115256784","https://openalex.org/W2117029190","https://openalex.org/W2117178300","https://openalex.org/W2118695222","https://openalex.org/W2118971714","https://openalex.org/W2119698477","https://openalex.org/W2121104191","https://openalex.org/W2125484216","https://openalex.org/W2125664451","https://openalex.org/W2131536322","https://openalex.org/W2135952951","https://openalex.org/W2136552678","https://openalex.org/W2142536690","https://openalex.org/W2146666438","https://openalex.org/W2147296837","https://openalex.org/W2147726663","https://openalex.org/W2147790901","https://openalex.org/W2148103005","https://openalex.org/W2148171446","https://openalex.org/W2148493668","https://openalex.org/W2151241623","https://openalex.org/W2151798187","https://openalex.org/W2152289100","https://openalex.org/W2155395286","https://openalex.org/W2162088497","https://openalex.org/W2165067288","https://openalex.org/W2165795251","https://openalex.org/W2165971615","https://openalex.org/W2166562121","https://openalex.org/W2167062509","https://openalex.org/W2167257083","https://openalex.org/W2167519234","https://openalex.org/W2170925079","https://openalex.org/W2171804370","https://openalex.org/W2182173958","https://openalex.org/W2204185518","https://openalex.org/W2232220193","https://openalex.org/W2235498129","https://openalex.org/W2283572643","https://openalex.org/W2287246374","https://openalex.org/W2288139400","https://openalex.org/W2295140408","https://openalex.org/W2360231252","https://openalex.org/W2394792025","https://openalex.org/W2484230073","https://openalex.org/W2571820890","https://openalex.org/W2581406049","https://openalex.org/W2590640589","https://openalex.org/W2601727535","https://openalex.org/W2613870203","https://openalex.org/W2663374310","https://openalex.org/W2749700969","https://openalex.org/W2766903152","https://openalex.org/W2767590364","https://openalex.org/W2770212191","https://openalex.org/W2770938408","https://openalex.org/W2782982995","https://openalex.org/W2790004059","https://openalex.org/W2791323504","https://openalex.org/W2799865318","https://openalex.org/W2808213961","https://openalex.org/W2808824631","https://openalex.org/W2810559782","https://openalex.org/W2886557383","https://openalex.org/W2886596673","https://openalex.org/W2890289370","https://openalex.org/W2898372197","https://openalex.org/W2902029737","https://openalex.org/W2921966151","https://openalex.org/W2939130206","https://openalex.org/W2949529851","https://openalex.org/W2949947154","https://openalex.org/W2952930415","https://openalex.org/W2953115794","https://openalex.org/W2959398154","https://openalex.org/W2961079136","https://openalex.org/W2961678354","https://openalex.org/W2964321778","https://openalex.org/W2971231411","https://openalex.org/W2976599382","https://openalex.org/W2979208099","https://openalex.org/W2998016835","https://openalex.org/W2998369522","https://openalex.org/W3002511970","https://openalex.org/W3003752356","https://openalex.org/W3156918339","https://openalex.org/W4244529347","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3166737844","https://openalex.org/W2023430279","https://openalex.org/W4238808075","https://openalex.org/W2971291130","https://openalex.org/W4400323355","https://openalex.org/W2964530914","https://openalex.org/W2885752935","https://openalex.org/W4387517835","https://openalex.org/W3195831312","https://openalex.org/W7155187345"],"abstract_inverted_index":{"Considerable":[0],"evidence":[1],"points":[2],"to":[3,34,44,76,100,103,118,123,128,187],"the":[4,8,60,78,97,104,112,120,147,164,169,178],"critical":[5,117],"role":[6],"of":[7,17,53,64,125,135,142,171,177],"gut":[9,180],"microbiota":[10,47,62],"in":[11,87,138],"physiology":[12],"and":[13,38,73,132,151,182],"disease.":[14],"The":[15,51],"administration":[16],"live":[18],"microbes":[19,110],"as":[20,32,92,186],"a":[21,54,90,130,172],"therapeutic":[22],"modality":[23],"is":[24,116,141],"increasingly":[25],"being":[26],"considered.":[27],"However,":[28,82],"key":[29,165],"questions":[30],"such":[31,89,193],"how":[33,109,188],"identify":[35],"candidate":[36],"microorganisms":[37],"which":[39],"preclinical":[40],"models":[41,194],"are":[42,85,157],"relevant":[43],"recapitulate":[45],"human":[46,65,79,101,126,136,179],"remain":[48],"largely":[49],"unanswered.":[50],"establishment":[52],"humanized":[55,173],"gnotobiotic":[56],"mouse":[57,105,174],"model":[58,175],"through":[59],"fecal":[61],"transplantation":[63],"feces":[66],"into":[67,159],"germ-free":[68],"mice":[69],"provides":[70],"an":[71],"innovative":[72],"powerful":[74],"tool":[75],"mimic":[77],"microbial":[80],"system.":[81],"numerous":[83],"considerations":[84],"required":[86],"designing":[88],"model,":[91],"various":[93],"elements,":[94],"ranging":[95],"from":[96],"factors":[98,166],"pertaining":[99],"donors":[102,127],"genetic":[106],"background,":[107],"affect":[108,168],"colonize":[111],"gut.":[113],"Thus,":[114],"it":[115],"match":[119],"murine":[121],"context":[122],"that":[124,167],"provide":[129],"continuous":[131],"faithful":[133],"progression":[134],"flora":[137,181],"mice.":[139],"This":[140],"even":[143],"greater":[144],"importance":[145],"when":[146],"need":[148],"for":[149,195],"accuracy":[150],"reproducibility":[152],"across":[153],"global":[154],"research":[155],"groups":[156],"taken":[158],"account.":[160],"Here,":[161],"we":[162],"review":[163],"formulation":[170],"representative":[176],"propose":[183],"several":[184],"approaches":[185],"researchers":[189],"can":[190],"effectively":[191],"design":[192],"clinical":[196],"relevance.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":46},{"year":2025,"cited_by_count":47},{"year":2024,"cited_by_count":48},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-09-14T00:00:00"}