{"id":"https://openalex.org/W3084031980","doi":"https://doi.org/10.1161/hyp.76.suppl_1.p011","title":"Abstract P011: Novel Roles Of Global, Intestinal, And Kidney Proximal Tubule Sodium And Hydrogen Exchanger 3 In Angiotensin Ii-induced Hypertension","display_name":"Abstract P011: Novel Roles Of Global, Intestinal, And Kidney Proximal Tubule Sodium And Hydrogen Exchanger 3 In Angiotensin Ii-induced Hypertension","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W3084031980","doi":"https://doi.org/10.1161/hyp.76.suppl_1.p011","mag":"3084031980"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.76.suppl_1.p011","doi":"https://doi.org/10.1161/hyp.76.suppl_1.p011","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.76.suppl_1.p011","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018156590","display_name":"Jia L. Zhuo","orcid":"https://orcid.org/0000-0001-9477-9075","observed_orcids":["https://orcid.org/0000-0001-9477-9075"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia L Zhuo","raw_affiliation_strings":["Tulane Univ Sch of Medicine, NEW ORLEANS, LA","Jia L Zhuo Tulane Univ Sch of Medicine, NEW ORLEANS, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ Sch of Medicine, NEW ORLEANS, LA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Jia L Zhuo Tulane Univ Sch of Medicine, NEW ORLEANS, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425151","display_name":"Liang Zhang","orcid":"https://orcid.org/0000-0001-8448-6754","observed_orcids":["https://orcid.org/0000-0001-8448-6754"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liang Zhang","raw_affiliation_strings":["Tulane Univ Sch of Medicin, New Orleans, LA","Liang Zhang Tulane Univ Sch of Medicin, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ Sch of Medicin, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Liang Zhang Tulane Univ Sch of Medicin, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008700459","display_name":"Ana Isabel Bento Ferreira Leite","orcid":"https://orcid.org/0009-0008-5902-4214","observed_orcids":["https://orcid.org/0009-0008-5902-4214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Leite","raw_affiliation_strings":["Ana Leite"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ana Leite","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086302701","display_name":"Xiao C. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao C Li","raw_affiliation_strings":["Tulane Univ Sch of Medicine, New Orleans, LA","Xiao C Li Tulane Univ Sch of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ Sch of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Xiao C Li Tulane Univ Sch of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-hydrogen-exchanger-3","display_name":"sodium-hydrogen exchanger 3","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nhe3","display_name":"NHE3","score":0.9789999723434448},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8989999890327454},{"id":"https://openalex.org/keywords/angiotensin-ii-induced-hypertension","display_name":"angiotensin II-induced hypertension","score":0.8980000019073486},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.8640000224113464},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.41999998688697815},{"id":"https://openalex.org/keywords/salt-wasting","display_name":"salt wasting","score":0.5580000281333923},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.5699999928474426},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.7900000214576721},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.6740000247955322},{"id":"https://openalex.org/keywords/diuresis","display_name":"diuresis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/renal-sodium-reabsorption","display_name":"renal sodium reabsorption","score":0.4569999873638153},{"id":"https://openalex.org/keywords/pathogenesis-of-hypertension","display_name":"hypertension pathogenesis","score":0.34700000286102295},{"id":"https://openalex.org/keywords/gene-targeting","display_name":"gene targeting","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C114574056","wikidata":"https://www.wikidata.org/wiki/Q7553395","display_name":"Sodium\u2013hydrogen antiporter","level":3,"score":0.8427863121032715},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7635550498962402},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7537363767623901},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6362414360046387},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6234594583511353},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5910689830780029},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.5877318978309631},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4692782163619995},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4610298275947571},{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.44808757305145264},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4449707865715027},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.4238305985927582},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36918890476226807},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.3409196138381958},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.76.suppl_1.p011","doi":"https://doi.org/10.1161/hyp.76.suppl_1.p011","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.76.suppl_1.p011","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2241481600","https://openalex.org/W2622878392","https://openalex.org/W2971804596","https://openalex.org/W2964593755","https://openalex.org/W2955574347","https://openalex.org/W2167926723","https://openalex.org/W2109192627","https://openalex.org/W3166854305","https://openalex.org/W4224237317","https://openalex.org/W2317664612"],"abstract_inverted_index":{"The":[0,144],"present":[1],"study":[2],"used":[3],"global":[4,57,111,149,245],"(":[5,175,213,235,259,292],"Nhe3":[6,11,26,58,63,68,112,117,122,150,155,196,200,246,251,256,277,285,313,317,322],"-/-":[7,12,27,59,64,69,113,118,123,151,156,197,201,247,252,257,278,281,286,314,318,323],"),":[8,13],"kidney-selective":[9,61,115,153,249],"(tg":[10],"and":[14,65,99,119,131,152,172,187,194,206,254,283,304,320,341,356,370],"proximal":[15,66,120,343],"tubule-specific":[16,67,121],"Na":[17,169,189],"+":[18,20,170,190],"/H":[19],"exchanger":[21],"3":[22,140],"(NHE3)-deficient":[23],"mice":[24,70,124,137,157,202,212,258,291,324],"(PT-":[25],")":[28],"to":[29,267,308],"test":[30],"the":[31,38,239,263,302,331,338,342,346,358],"hypothesis":[32],"that":[33,335],"NHE3":[34,336],"is":[35,348],"required":[36,349],"for":[37,88,102,350,357],"full":[39],"development":[40,359],"of":[41,51,218,333,345,360],"angiotensin":[42],"II":[43,78,83,98,220,270,310],"(Ang":[44],"II)-induced":[45],"hypertension":[46],"in":[47,147,184,226,230,244,276,311,337],"mice.":[48,198],"Four":[49],"groups":[50],"adult":[52],"male,":[53],"age-matched":[54],"wild-type":[55,136,193,211,231,290],"(WT),":[56],",":[60,114,248,253,279,282,315,319],"tg":[62,116,154,250,316],"were":[71,181],"infused":[72],"with:":[73],"a)":[74],"saline;":[75],"b)":[76],"Ang":[77,82,97,219,269,309,361],"(10":[79],"pmol/min,":[80],"i.v.);":[81],"via":[84],"an":[85],"osmotic":[86],"minipump":[87],"2":[89,103],"weeks":[90,104],"(1.5":[91],"mg/kg/day,":[92,106],"i.p.);":[93],"or":[94],"treated":[95],"with":[96,160,210,289,298],"losartan":[100,299],"concurrently":[101],"(20":[105],"p.o.).":[107],"Under":[108],"basal":[109,352],"conditions,":[110],"all":[125],"showed":[126,203],"significantly":[127,274],"lower":[128],"systolic,":[129],"diastolic,":[130],"mean":[132],"arterial":[133,223],"pressure":[134,225,240,354],"than":[135],"(~15":[138],"\u00b1":[139],"mmHg,":[141],"P":[142,176,214,236,260,293],"<0.01).":[143,177,215,261,294],"hypotensive":[145],"phenotype":[146],"both":[148],"was":[158,242,272],"associated":[159],"abnormal":[161],"intestinal":[162,185],"structures,":[163],"diarrhea,":[164],"increased":[165,222],"24":[166],"h":[167],"fecal":[168,188],"excretion,":[171],"salt":[173],"wasting":[174],"By":[178],"contrast,":[179],"there":[180],"no":[182],"differences":[183],"structures":[186],"excretion":[191],"between":[192],"PT-":[195,199,255,284,321],"significant":[204],"diuretic":[205],"natriuretic":[207],"responses":[208,307],"compared":[209,288],"Acute":[216],"infusion":[217,271],"markedly":[221],"blood":[224,353],"a":[227],"time-dependent":[228],"manner":[229],"mice,":[232,287],"as":[233],"expected":[234],"<0.01),":[237],"but":[238],"response":[241,266],"attenuated":[243,275],"Furthermore,":[262],"chronic":[264,305],"pressor":[265,306],"2-week":[268],"also":[273],"tgNhe3":[280],"Finally,":[295],"concurrent":[296],"treatment":[297],"completely":[300],"blocked":[301],"acute":[303],"wild-type,":[312],"(p<0.01).":[325],"Taken":[326],"together,":[327],"these":[328],"data":[329],"support":[330],"proof":[332],"concept":[334],"small":[339],"intestines":[340],"tubules":[344],"kidney":[347],"maintaining":[351],"homeostasis":[355],"II-induced":[362],"hypertension.":[363],"Supported":[364],"by":[365],"NIH":[366],"grants,":[367],"2R01DK102429-03A1,":[368],"1R56HL130988-01,":[369],"2R01DK067299-10A1.":[371]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2020-09-14T00:00:00"}
