{"id":"https://openalex.org/W3083920105","doi":"https://doi.org/10.2217/imt-2020-0220","title":"Cross-Neutralization Activity Against SARS-CoV-2 is Present in Currently Available Intravenous Immunoglobulins","display_name":"Cross-Neutralization Activity Against SARS-CoV-2 is Present in Currently Available Intravenous Immunoglobulins","publication_year":2020,"publication_date":"2020-09-08","ids":{"openalex":"https://openalex.org/W3083920105","doi":"https://doi.org/10.2217/imt-2020-0220","mag":"3083920105","pmid":"https://pubmed.ncbi.nlm.nih.gov/32900263","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7480323"},"language":"en","primary_location":{"id":"doi:10.2217/imt-2020-0220","doi":"https://doi.org/10.2217/imt-2020-0220","is_oa":true,"landing_page_url":"https://doi.org/10.2217/imt-2020-0220","pdf_url":null,"source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2217/imt-2020-0220","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jos\u00e9-Mar\u00eda D\u00edez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126725","display_name":"Grifols (Spain)","ror":"https://ror.org/02ed64f32","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210126725"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9-Mar\u00eda D\u00edez","raw_affiliation_strings":["Immunotherapies Unit, Bioscience Research and Development, Grifols, Barcelona, Spain","Bioscience Research & Development, Grifols, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunotherapies Unit, Bioscience Research and Development, Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]},{"raw_affiliation_string":"Bioscience Research & Development, Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052705995","display_name":"Carolina Soledad Romero","orcid":"https://orcid.org/0000-0002-2325-4463","observed_orcids":["https://orcid.org/0000-0002-2325-4463"]},"institutions":[{"id":"https://openalex.org/I4210126725","display_name":"Grifols (Spain)","ror":"https://ror.org/02ed64f32","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210126725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carolina Romero","raw_affiliation_strings":["Immunotherapies Unit, Bioscience Research and Development, Grifols, Barcelona, Spain","Bioscience Research & Development, Grifols, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunotherapies Unit, Bioscience Research and Development, Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]},{"raw_affiliation_string":"Bioscience Research & Development, Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079245484","display_name":"J\u00falia Vergara\u2010Alert","orcid":"https://orcid.org/0000-0001-7484-444X","observed_orcids":["https://orcid.org/0000-0001-7484-444X"]},"institutions":[{"id":"https://openalex.org/I4210100074","display_name":"Centre de Recerca en Sanitat Animal","ror":"https://ror.org/011jtr847","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210100074","https://openalex.org/I4210100913","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J\u00falia Vergara-Alert","raw_affiliation_strings":["IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain","institution_ids":["https://openalex.org/I4210100074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021265319","display_name":"Melissa Bell\u00f3-P\u00e9rez","orcid":"https://orcid.org/0000-0002-9212-083X","observed_orcids":["https://orcid.org/0000-0002-9212-083X"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Melissa Bell\u00f3-Perez","raw_affiliation_strings":["Laboratorio Coronavirus. Departamento de Biolog\u00eda Molecular y Celular, CNB-CSIC, Madrid. Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Coronavirus. Departamento de Biolog\u00eda Molecular y Celular, CNB-CSIC, Madrid. Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102901782","display_name":"Jordi Rodon","orcid":"https://orcid.org/0000-0002-1032-9091","observed_orcids":["https://orcid.org/0000-0002-1032-9091"]},"institutions":[{"id":"https://openalex.org/I4210100074","display_name":"Centre de Recerca en Sanitat Animal","ror":"https://ror.org/011jtr847","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210100074","https://openalex.org/I4210100913","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Rodon","raw_affiliation_strings":["IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain","institution_ids":["https://openalex.org/I4210100074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061898277","display_name":"Jos\u00e9 M. Honrubia","orcid":"https://orcid.org/0000-0003-1851-1143","observed_orcids":["https://orcid.org/0000-0003-1851-1143"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Manuel Honrubia","raw_affiliation_strings":["Laboratorio Coronavirus. Departamento de Biolog\u00eda Molecular y Celular, CNB-CSIC, Madrid. Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Coronavirus. Departamento de Biolog\u00eda Molecular y Celular, CNB-CSIC, Madrid. Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078514449","display_name":"Joaqu\u00edm Segal\u00e9s","orcid":"https://orcid.org/0000-0002-1539-7261","observed_orcids":["https://orcid.org/0000-0002-1539-7261"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210100074","display_name":"Centre de Recerca en Sanitat Animal","ror":"https://ror.org/011jtr847","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210100074","https://openalex.org/I4210100913","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4405254415","display_name":"Animal Health Research Center","ror":"https://ror.org/01sn0bt42","country_code":"ES","type":"government","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210100913","https://openalex.org/I4387153040","https://openalex.org/I4405254415"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joaquim Segal\u00e9s","raw_affiliation_strings":["Departament de Sanitat i Anatomia Animals, Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain","UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Aut\u00f2noma de Barcelona, Bellaterra, Barcelona, Spain","Departament de Sanitat i Anatomia Animals, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain","UAB, CReSA (IRTA-UAB), Campus de la Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Sanitat i Anatomia Animals, Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Aut\u00f2noma de Barcelona, Bellaterra, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210100074","https://openalex.org/I4405254415"]},{"raw_affiliation_string":"Departament de Sanitat i Anatomia Animals, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"UAB, CReSA (IRTA-UAB), Campus de la Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210100074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018873372","display_name":"Isabel Sola","orcid":"https://orcid.org/0000-0002-5704-1917","observed_orcids":["https://orcid.org/0000-0002-5704-1917"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabel Sola","raw_affiliation_strings":["Laboratorio Coronavirus. Departamento de Biolog\u00eda Molecular y Celular, CNB-CSIC, Madrid. Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Coronavirus. Departamento de Biolog\u00eda Molecular y Celular, CNB-CSIC, Madrid. Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059996554","display_name":"Luis Enjuanes","orcid":"https://orcid.org/0000-0002-0854-0226","observed_orcids":["https://orcid.org/0000-0002-0854-0226"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Enjuanes","raw_affiliation_strings":["Laboratorio Coronavirus. Departamento de Biolog\u00eda Molecular y Celular, CNB-CSIC, Madrid. Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Coronavirus. Departamento de Biolog\u00eda Molecular y Celular, CNB-CSIC, Madrid. Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089838478","display_name":"Rodrigo Gajardo","orcid":"https://orcid.org/0009-0000-2149-9507","observed_orcids":["https://orcid.org/0009-0000-2149-9507"]},"institutions":[{"id":"https://openalex.org/I4210126725","display_name":"Grifols (Spain)","ror":"https://ror.org/02ed64f32","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210126725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rodrigo Gajardo","raw_affiliation_strings":["Immunotherapies Unit, Bioscience Research and Development, Grifols, Barcelona, Spain","Bioscience Research & Development, Grifols, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunotherapies Unit, Bioscience Research and Development, Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]},{"raw_affiliation_string":"Bioscience Research & Development, Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210126725"],"apc_list":null,"apc_paid":null,"fwci":1.1727,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.89606917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"12","issue":"17","first_page":"1247","last_page":"1255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cross-neutralization","display_name":"cross-neutralization","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":1.0},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9120000004768372},{"id":"https://openalex.org/keywords/sars-cov","display_name":"SARS-CoV","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mers-cov","display_name":"MERS-CoV","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.781000018119812},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/plaque-reduction-neutralization-test","display_name":"plaque reduction neutralization test","score":0.656000018119812},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.9678646922111511},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7214179039001465},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6553680896759033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5978018641471863},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.586253821849823},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5262897610664368},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.5170758366584778},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.48476237058639526},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.47737666964530945},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4438628852367401},{"id":"https://openalex.org/C2775996393","wikidata":"https://www.wikidata.org/wiki/Q1149147","display_name":"Cytopathic effect","level":3,"score":0.4317683279514313},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.24844586849212646},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.09651553630828857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07423347234725952},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065207","descriptor_name":"Middle East Respiratory Syndrome Coronavirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065207","descriptor_name":"Middle East Respiratory Syndrome Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.2217/imt-2020-0220","doi":"https://doi.org/10.2217/imt-2020-0220","is_oa":true,"landing_page_url":"https://doi.org/10.2217/imt-2020-0220","pdf_url":null,"source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},{"id":"doi:10.1101/2020.06.19.160879","doi":"https://doi.org/10.1101/2020.06.19.160879","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.19.160879","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/19/2020.06.19.160879.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7480323","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7480323","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"Text"},{"id":"pmid:32900263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32900263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:ddd.uab.cat:232719","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/232719","pdf_url":null,"source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:digital.csic.es:10261/214919","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/214919","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_816b"},{"id":"pmh:oai:digital.csic.es:10261/220087","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/220087","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:dnet:uabarcelona_::0d8ed6c2ed3b92dd38699397ab579ce7","doi":null,"is_oa":true,"landing_page_url":"http://ddd.uab.cat/record/232719","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:recercat.cat:2072/441898","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2072/441898","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositori.irta.cat:20.500.12327/1093","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12327/1093","pdf_url":null,"source":{"id":"https://openalex.org/S4306401920","display_name":"IRTA (Institut de Recerca i Tecnologia Agroalimentaries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210100913","host_organization_name":"Institute of Agrifood Research and Technology","host_organization_lineage":["https://openalex.org/I4210100913"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2217/imt-2020-0220","doi":"https://doi.org/10.2217/imt-2020-0220","is_oa":true,"landing_page_url":"https://doi.org/10.2217/imt-2020-0220","pdf_url":null,"source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329568","display_name":"Grifols","ror":"https://ror.org/02ed64f32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083920105.pdf","grobid_xml":"https://content.openalex.org/works/W3083920105.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1862199182","https://openalex.org/W1933155703","https://openalex.org/W1934043894","https://openalex.org/W1970860163","https://openalex.org/W1978450899","https://openalex.org/W1982533785","https://openalex.org/W2025350760","https://openalex.org/W2067071280","https://openalex.org/W2069902539","https://openalex.org/W2113457186","https://openalex.org/W2114551787","https://openalex.org/W2117266879","https://openalex.org/W2138324310","https://openalex.org/W2171220431","https://openalex.org/W2306794997","https://openalex.org/W2487135296","https://openalex.org/W2612362616","https://openalex.org/W2626112069","https://openalex.org/W2920688815","https://openalex.org/W2995449088","https://openalex.org/W3004318991","https://openalex.org/W3007924766","https://openalex.org/W3011183720","https://openalex.org/W3012421327","https://openalex.org/W3012846954","https://openalex.org/W3013093478","https://openalex.org/W3013525829","https://openalex.org/W3013643030","https://openalex.org/W3015181278","https://openalex.org/W3015369767","https://openalex.org/W3015728312","https://openalex.org/W3016655948","https://openalex.org/W3017641594","https://openalex.org/W3019884833","https://openalex.org/W3021329917","https://openalex.org/W3022121885","https://openalex.org/W3025320502","https://openalex.org/W3025435356","https://openalex.org/W3025744748","https://openalex.org/W3033206251","https://openalex.org/W3109675431","https://openalex.org/W3143439963","https://openalex.org/W4210968071"],"related_works":["https://openalex.org/W3094419933","https://openalex.org/W3025435356","https://openalex.org/W3114231186","https://openalex.org/W3087074054","https://openalex.org/W4366224108","https://openalex.org/W4320491219","https://openalex.org/W4412784728","https://openalex.org/W4403382148","https://openalex.org/W3191070896","https://openalex.org/W4390579035"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"There":[2],"is":[3],"a":[4],"crucial":[5],"need":[6],"for":[7,52,107,184,197,270],"effective":[8],"therapies":[9],"that":[10],"are":[11,262],"immediately":[12,268],"available":[13,30,264],"to":[14,174,182,211,221],"counteract":[15],"COVID-19":[16,271],"disease.":[17],"Recently,":[18],"ELISA":[19],"binding":[20],"cross-reactivity":[21],"against":[22,55,79,230,248,258],"components":[23],"of":[24,71,75,113,167,206],"human":[25],"epidemic":[26],"coronaviruses":[27],"with":[28,176,192,244],"currently":[29,263],"intravenous":[31],"immunoglobulins":[32],"(IVIG)":[33],"Gamunex-C":[34],"and":[35,39,58,60,85,103,134,188,214,250,265],"Flebogamma":[36],"DIF":[37],"(5%":[38],"10%)":[40],"have":[41],"been":[42],"reported.":[43],"In":[44,233],"this":[45],"study,":[46],"the":[47,96,114,121,131,135,144,149,156,185,198,238],"same":[48],"products":[49,241],"were":[50],"tested":[51,239],"neutralization":[53,69,91,124,166,205,236,254],"activity":[54,229],"SARS-CoV-2,":[56],"SARS-CoV":[57,84,207],"MERS-CoV":[59,86],"their":[61],"potential":[62],"as":[63,148],"an":[64,193],"antiviral":[65],"therapy.":[66],"Methods":[67],"The":[68],"capacity":[70,247,255],"six":[72],"selected":[73],"lots":[74,110,203],"IVIG":[76,109,163,202,224,240],"was":[77,92,118,256],"assessed":[78],"SARS-CoV-2":[80,115,169,249],"(two":[81],"different":[82],"isolates),":[83],"in":[87,99,111,130,143],"cell":[88,234],"cultures.":[89],"Infectivity":[90],"measured":[93],"by":[94,104,159],"determining":[95],"percent":[97],"reduction":[98,123],"plaque-forming":[100],"units":[101],"(PFU)":[102],"cytopathic":[105,199],"effects":[106],"two":[108],"one":[112],"isolates.":[116],"Neutralization":[117],"quantified":[119],"using":[120],"plaque":[122],"test":[125],"50":[126,128,141,178,195,216],"(PRNT":[127],")":[129,142],"PFU":[132,186],"assay":[133],"half":[136],"maximal":[137],"inhibitory":[138],"concentration":[139],"(IC":[140],"cytopathic/cytotoxic":[145],"method":[146,187],"(calculated":[147],"minus":[150],"log":[151],"10":[152],"dilution":[153],"which":[154],"reduced":[155],"viral":[157],"titer":[158],"50%).":[160],"Results":[161],"All":[162,201],"preparations":[164,261],"showed":[165,226],"both":[168],"isolates,":[170],"ranging":[171,189,208,218],"from":[172,180,190,209,219],"79":[173],"89.5%":[175],"PRNT":[177,215],"titers":[179],"4.5":[181],">5":[183],"47.0%-64.7%":[191],"IC":[194],"~1":[196],"method.":[200],"produced":[204],"39.5":[210],"55.1":[212],"%":[213],"values":[217],"2.0":[220],"3.3.":[222],"No":[223],"preparation":[225],"significant":[227,245],"neutralizing":[228],"MERS-CoV.":[231,259],"Conclusion":[232],"culture":[235],"assays,":[237],"contain":[242],"antibodies":[243],"cross-neutralization":[246],"SARS-CoV.":[251],"However,":[252],"no":[253],"demonstrated":[257],"These":[260],"may":[266],"be":[267],"useful":[269],"management.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-09-14T00:00:00"}