{"id":"https://openalex.org/W3083813629","doi":"https://doi.org/10.1073/pnas.1921473117","title":"Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome","display_name":"Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome","publication_year":2020,"publication_date":"2020-09-08","ids":{"openalex":"https://openalex.org/W3083813629","doi":"https://doi.org/10.1073/pnas.1921473117","mag":"3083813629","pmid":"https://pubmed.ncbi.nlm.nih.gov/32900925","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7519349"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1921473117","doi":"https://doi.org/10.1073/pnas.1921473117","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1921473117","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.1921473117","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065317184","display_name":"Minhyung Cho","orcid":"https://orcid.org/0000-0003-3436-9909","observed_orcids":["https://orcid.org/0000-0003-3436-9909"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min-Hyung Cho","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, MD 21218;"],"raw_orcid":"https://orcid.org/0000-0003-3436-9909","affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, MD 21218;","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060577949","display_name":"James O. Wrabl","orcid":"https://orcid.org/0000-0001-7679-0158","observed_orcids":["https://orcid.org/0000-0001-7679-0158"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James O. Wrabl","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, MD 21218;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, MD 21218;","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025611053","display_name":"James Taylor","orcid":"https://orcid.org/0000-0001-5079-840X","observed_orcids":["https://orcid.org/0000-0001-5079-840X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Taylor","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, MD 21218;","Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, MD 21218;","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218;","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023619981","display_name":"Vincent J. Hilser","orcid":"https://orcid.org/0000-0002-7173-0073","observed_orcids":["https://orcid.org/0000-0002-7173-0073"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vincent J. Hilser","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, MD 21218;","T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, MD 21218;","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023619981"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.6408,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.61791805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"117","issue":"38","first_page":"23606","last_page":"23616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.9359999895095825},{"id":"https://openalex.org/keywords/conformational-fluctuations","display_name":"conformational fluctuations","score":0.753000020980835},{"id":"https://openalex.org/keywords/kinase-substrate-recognition","display_name":"kinase substrate recognition","score":0.7110000252723694},{"id":"https://openalex.org/keywords/phosphorylation-site-prediction","display_name":"phosphorylation site prediction","score":0.9390000104904175},{"id":"https://openalex.org/keywords/statistical-mechanics","display_name":"statistical mechanics","score":0.843999981880188},{"id":"https://openalex.org/keywords/sequence-classification","display_name":"sequence classification","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.5431709289550781},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4973137676715851},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.485103964805603},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.44210365414619446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4114754796028137},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36872684955596924},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.353016197681427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3213755786418915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23491519689559937},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13118183612823486},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1921473117","doi":"https://doi.org/10.1073/pnas.1921473117","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1921473117","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/866558","doi":"https://doi.org/10.1101/866558","is_oa":true,"landing_page_url":"https://doi.org/10.1101/866558","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/12/05/866558.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7519349","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7519349","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:32900925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32900925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1921473117","doi":"https://doi.org/10.1073/pnas.1921473117","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1921473117","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6423263503","display_name":"The Experimental Energy Landscape and Protein Function","funder_award_id":"R01GM063747","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6639181074","display_name":"Democratization of Data Analysis in Life Sciences Through Galaxy","funder_award_id":"U41HG006620","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8931902250","display_name":"Allostery in an intrinsically disordered transcription factor","funder_award_id":"R01GM126130","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337397","display_name":"Division of Molecular and Cellular Biosciences","ror":"https://ror.org/002jdaq33"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083813629.pdf","grobid_xml":"https://content.openalex.org/works/W3083813629.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W24553703","https://openalex.org/W124178974","https://openalex.org/W349770100","https://openalex.org/W1600192536","https://openalex.org/W1756401784","https://openalex.org/W1762366815","https://openalex.org/W1965092590","https://openalex.org/W1975667302","https://openalex.org/W1984099313","https://openalex.org/W2000299206","https://openalex.org/W2004069111","https://openalex.org/W2013853442","https://openalex.org/W2019858779","https://openalex.org/W2023919356","https://openalex.org/W2034818379","https://openalex.org/W2038163496","https://openalex.org/W2041788773","https://openalex.org/W2043308634","https://openalex.org/W2043338013","https://openalex.org/W2044195587","https://openalex.org/W2044573154","https://openalex.org/W2053921361","https://openalex.org/W2054461892","https://openalex.org/W2069478616","https://openalex.org/W2074120362","https://openalex.org/W2075053787","https://openalex.org/W2076742999","https://openalex.org/W2080736062","https://openalex.org/W2086445965","https://openalex.org/W2092006899","https://openalex.org/W2093067883","https://openalex.org/W2101234009","https://openalex.org/W2102025585","https://openalex.org/W2103404876","https://openalex.org/W2103842182","https://openalex.org/W2107270569","https://openalex.org/W2112907786","https://openalex.org/W2120167569","https://openalex.org/W2131322954","https://openalex.org/W2139319441","https://openalex.org/W2143210482","https://openalex.org/W2152891198","https://openalex.org/W2162172965","https://openalex.org/W2165967770","https://openalex.org/W2170678561","https://openalex.org/W2171742422","https://openalex.org/W2205194111","https://openalex.org/W2228302324","https://openalex.org/W2277107447","https://openalex.org/W2297784337","https://openalex.org/W2300545781","https://openalex.org/W2345490732","https://openalex.org/W2410771071","https://openalex.org/W2418196617","https://openalex.org/W2418657672","https://openalex.org/W2547162692","https://openalex.org/W2583310064","https://openalex.org/W2612542354","https://openalex.org/W2743015141","https://openalex.org/W2749051295","https://openalex.org/W2756821926","https://openalex.org/W2762370213","https://openalex.org/W2766510537","https://openalex.org/W2768290498","https://openalex.org/W2787894218","https://openalex.org/W2791221265","https://openalex.org/W2800697076","https://openalex.org/W2901496107","https://openalex.org/W2912820434","https://openalex.org/W2955338246","https://openalex.org/W2966687748","https://openalex.org/W4232640445","https://openalex.org/W4245552814"],"related_works":["https://openalex.org/W2010961422","https://openalex.org/W3168424926","https://openalex.org/W7171724634","https://openalex.org/W2582424167","https://openalex.org/W2062114704","https://openalex.org/W1993240415","https://openalex.org/W4391928409","https://openalex.org/W2611764439","https://openalex.org/W2737403359","https://openalex.org/W2248525918"],"abstract_inverted_index":{"Phosphorylation":[0],"sites":[1,102],"are":[2,64,161],"hyperabundant":[3],"in":[4,17,103,181,230],"the":[5,40,44,53,58,68,86,96,104,162,170,177,185,203,208],"eukaryotic":[6],"disordered":[7,105,186],"proteome,":[8,209],"suggesting":[9],"that":[10,61,135,150,159],"conformational":[11,59,133,151,231],"fluctuations":[12,90,152],"play":[13,153],"a":[14,22,26,76,112,154,213],"major":[15,155],"role":[16,156],"determining":[18],"to":[19,83,91,98,108,165,198],"what":[20],"extent":[21],"kinase":[23,45,125],"interacts":[24],"with":[25],"particular":[27],"substrate.":[28],"In":[29,168,196],"biophysical":[30],"terms,":[31],"substrate":[32,115,132,166,172],"selectivity":[33,175],"may":[34],"be":[35],"determined":[36],"not":[37,140,148],"just":[38],"by":[39,52,67,95],"structural-chemical":[41,224],"complementarity":[42,225],"between":[43,57],"and":[46,128,226],"its":[47],"protein":[48],"substrates":[49],"but":[50,138,157],"also":[51,158],"free":[54],"energy":[55],"difference":[56],"ensembles":[60],"are,":[62],"or":[63],"not,":[65],"recognized":[66],"kinase.":[69],"To":[70],"test":[71],"this":[72,109],"hypothesis,":[73],"we":[74],"developed":[75],"statistical-thermodynamics-based":[77],"informatics":[78],"framework,":[79],"which":[80],"allows":[81],"us":[82],"probe":[84],"for":[85,216],"contribution":[87,164],"of":[88,114,179,184,190,205],"equilibrium":[89,134],"phosphorylation,":[92],"as":[93],"evaluated":[94],"ability":[97],"predict":[99],"Ser/Thr/Tyr":[100],"phosphorylation":[101,189,206],"proteome.":[106],"Essential":[107],"framework":[110],"is":[111,136,176],"decomposition":[113],"sequence":[116],"information":[117,122,130],"into":[118,202,221],"two":[119],"types:":[120],"vertical":[121],"encoding":[123,131],"conserved":[124],"specificity":[126],"motifs":[127],"horizontal":[129],"embedded,":[137],"often":[139],"apparent,":[141],"within":[142],"position-specific":[143],"conservation":[144],"patterns.":[145],"We":[146],"find":[147],"only":[149],"they":[160],"dominant":[163],"selectivity.":[167],"fact,":[169],"main":[171],"classifier":[173],"distinguishing":[174],"magnitude":[178],"change":[180],"local":[182],"compaction":[183],"chain":[187],"upon":[188],"these":[191],"mostly":[192],"singly":[193],"phosphorylated":[194],"sites.":[195],"addition":[197],"providing":[199],"fundamental":[200],"insights":[201],"consequences":[204],"across":[207],"our":[210],"approach":[211],"provides":[212],"statistical-thermodynamic":[214],"strategy":[215],"partitioning":[217],"any":[218],"sequence-based":[219],"search":[220],"contributions":[222],"from":[223,228],"those":[227],"changes":[229],"equilibrium.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-14T00:00:00"}
