{"id":"https://openalex.org/W3083781677","doi":"https://doi.org/10.1038/s41598-020-71636-0","title":"Transcriptional analysis of cleft palate in TGF\u03b23 mutant mice","display_name":"Transcriptional analysis of cleft palate in TGF\u03b23 mutant mice","publication_year":2020,"publication_date":"2020-09-10","ids":{"openalex":"https://openalex.org/W3083781677","doi":"https://doi.org/10.1038/s41598-020-71636-0","mag":"3083781677","pmid":"https://pubmed.ncbi.nlm.nih.gov/32913205","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7483747"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-71636-0","doi":"https://doi.org/10.1038/s41598-020-71636-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-71636-0","pdf_url":"https://www.nature.com/articles/s41598-020-71636-0.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-71636-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Liu","raw_affiliation_strings":["Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 68583, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 68583, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082982828","display_name":"Sree Krishna Chanumolu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. K. Chanumolu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. M. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. M. White","raw_affiliation_strings":["Department of Growth and Development, College of Dentistry, University of Nebraska Medical Center College of Dentistry, Lincoln, NE, 68583, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Growth and Development, College of Dentistry, University of Nebraska Medical Center College of Dentistry, Lincoln, NE, 68583, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079488315","display_name":"Mustafa Albahrani","orcid":"https://orcid.org/0000-0002-4532-6018","observed_orcids":["https://orcid.org/0000-0002-4532-6018"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Albahrani","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000992292","display_name":"Hasan H. Otu","orcid":"https://orcid.org/0000-0002-9253-8152","observed_orcids":["https://orcid.org/0000-0002-9253-8152"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. H. Otu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028209651","display_name":"Ali Nawshad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Nawshad","raw_affiliation_strings":["Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 68583, USA. anawshad@unmc.edu","Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 68583, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 68583, USA. anawshad@unmc.edu","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 68583, USA","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028209651"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.5858,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64570667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"10","issue":"1","first_page":"14940","last_page":"14940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cleft-palate","display_name":"cleft palate","score":1.0},{"id":"https://openalex.org/keywords/tgfbeta3","display_name":"TGF-beta3","score":0.906000018119812},{"id":"https://openalex.org/keywords/palatogenesis","display_name":"palatogenesis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/congenital-craniofacial-anomalies","display_name":"congenital craniofacial anomalies","score":0.8899999856948853},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6349999904632568},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8539999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.671999990940094},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7504904270172119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.424673855304718},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.422496497631073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3969063460826874},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36691465973854065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2713678479194641},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21583089232444763}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053782","descriptor_name":"Transforming Growth Factor beta3","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-020-71636-0","doi":"https://doi.org/10.1038/s41598-020-71636-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-71636-0","pdf_url":"https://www.nature.com/articles/s41598-020-71636-0.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7483747","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7483747","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:32913205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32913205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.unl.edu:electricalengineeringfacpub-1608","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unl.edu/electricalengineeringfacpub/618","pdf_url":null,"source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Electrical and Computer Engineering: Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-71636-0","doi":"https://doi.org/10.1038/s41598-020-71636-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-71636-0","pdf_url":"https://www.nature.com/articles/s41598-020-71636-0.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5918059070","display_name":"TGFbeta3 SIGNALING IN DEVELOPMENT OF PALATE","funder_award_id":"R01DE017986","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320309137","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083781677.pdf","grobid_xml":"https://content.openalex.org/works/W3083781677.grobid-xml"},"referenced_works_count":157,"referenced_works":["https://openalex.org/W63859702","https://openalex.org/W857980410","https://openalex.org/W1429628591","https://openalex.org/W1480422180","https://openalex.org/W1509198290","https://openalex.org/W1568568674","https://openalex.org/W1714807130","https://openalex.org/W1855100791","https://openalex.org/W1870324945","https://openalex.org/W1880027388","https://openalex.org/W1889990950","https://openalex.org/W1963641861","https://openalex.org/W1964596167","https://openalex.org/W1965222408","https://openalex.org/W1966298489","https://openalex.org/W1967509367","https://openalex.org/W1968818047","https://openalex.org/W1975204154","https://openalex.org/W1975774017","https://openalex.org/W1975853332","https://openalex.org/W1978576534","https://openalex.org/W1985113333","https://openalex.org/W1986247145","https://openalex.org/W1990794205","https://openalex.org/W1993793653","https://openalex.org/W1994132006","https://openalex.org/W1995070233","https://openalex.org/W1997573197","https://openalex.org/W1998487623","https://openalex.org/W1999405745","https://openalex.org/W1999916489","https://openalex.org/W2000099153","https://openalex.org/W2002795447","https://openalex.org/W2004877225","https://openalex.org/W2006174445","https://openalex.org/W2010434757","https://openalex.org/W2010923321","https://openalex.org/W2011471567","https://openalex.org/W2012678527","https://openalex.org/W2013737089","https://openalex.org/W2016191016","https://openalex.org/W2019535129","https://openalex.org/W2023869001","https://openalex.org/W2025363689","https://openalex.org/W2025893644","https://openalex.org/W2027829948","https://openalex.org/W2028046051","https://openalex.org/W2028892293","https://openalex.org/W2031111711","https://openalex.org/W2032279931","https://openalex.org/W2032468149","https://openalex.org/W2032745397","https://openalex.org/W2034883364","https://openalex.org/W2037450317","https://openalex.org/W2037910321","https://openalex.org/W2039690398","https://openalex.org/W2040073656","https://openalex.org/W2043872733","https://openalex.org/W2044531433","https://openalex.org/W2044848239","https://openalex.org/W2044931254","https://openalex.org/W2046004620","https://openalex.org/W2047076201","https://openalex.org/W2048929388","https://openalex.org/W2049811345","https://openalex.org/W2052370925","https://openalex.org/W2053791637","https://openalex.org/W2054935891","https://openalex.org/W2055429850","https://openalex.org/W2062072171","https://openalex.org/W2063501462","https://openalex.org/W2064050439","https://openalex.org/W2067595547","https://openalex.org/W2068390416","https://openalex.org/W2072759027","https://openalex.org/W2074040064","https://openalex.org/W2074144064","https://openalex.org/W2075087690","https://openalex.org/W2075176705","https://openalex.org/W2081601075","https://openalex.org/W2084144217","https://openalex.org/W2089789625","https://openalex.org/W2091821419","https://openalex.org/W2093107372","https://openalex.org/W2093733104","https://openalex.org/W2094632087","https://openalex.org/W2095253978","https://openalex.org/W2097130546","https://openalex.org/W2098039703","https://openalex.org/W2099436279","https://openalex.org/W2101297553","https://openalex.org/W2102856571","https://openalex.org/W2103017472","https://openalex.org/W2110114807","https://openalex.org/W2110937334","https://openalex.org/W2115475818","https://openalex.org/W2115548867","https://openalex.org/W2116495755","https://openalex.org/W2120168331","https://openalex.org/W2121390608","https://openalex.org/W2128954494","https://openalex.org/W2129168468","https://openalex.org/W2130410032","https://openalex.org/W2131271579","https://openalex.org/W2132728547","https://openalex.org/W2138305701","https://openalex.org/W2139231790","https://openalex.org/W2141541691","https://openalex.org/W2141853544","https://openalex.org/W2142707412","https://openalex.org/W2145812384","https://openalex.org/W2146306557","https://openalex.org/W2147489768","https://openalex.org/W2148178820","https://openalex.org/W2148248939","https://openalex.org/W2148982122","https://openalex.org/W2155935761","https://openalex.org/W2158217645","https://openalex.org/W2158450020","https://openalex.org/W2159482845","https://openalex.org/W2159552267","https://openalex.org/W2160225627","https://openalex.org/W2162143298","https://openalex.org/W2162534812","https://openalex.org/W2163344736","https://openalex.org/W2164768668","https://openalex.org/W2165035888","https://openalex.org/W2165061154","https://openalex.org/W2166355659","https://openalex.org/W2166541157","https://openalex.org/W2172098727","https://openalex.org/W2181981870","https://openalex.org/W2200999931","https://openalex.org/W2217419101","https://openalex.org/W2253060366","https://openalex.org/W2258772674","https://openalex.org/W2276515708","https://openalex.org/W2280125680","https://openalex.org/W2310118138","https://openalex.org/W2321872593","https://openalex.org/W2397931275","https://openalex.org/W2419413427","https://openalex.org/W2425966091","https://openalex.org/W2528684781","https://openalex.org/W2531099443","https://openalex.org/W2574281994","https://openalex.org/W2582527207","https://openalex.org/W2586672263","https://openalex.org/W2592054416","https://openalex.org/W2592811885","https://openalex.org/W2593298786","https://openalex.org/W2605800216","https://openalex.org/W2613751522","https://openalex.org/W2626234955","https://openalex.org/W2798084948","https://openalex.org/W2979722175","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2084144217","https://openalex.org/W2774969697","https://openalex.org/W2117637286","https://openalex.org/W2074144064","https://openalex.org/W2159072111","https://openalex.org/W2031104876","https://openalex.org/W3037626657","https://openalex.org/W2460279376","https://openalex.org/W4417177363","https://openalex.org/W4243627252"],"abstract_inverted_index":{"Cleft":[0],"palate":[1,29,37],"(CP)":[2],"is":[3,183],"one":[4],"of":[5,49,65,130,142,169,171,180,187,196],"the":[6,19,61,85,101,167,172,178],"most":[7],"common":[8],"craniofacial":[9],"birth":[10],"defects,":[11],"impacting":[12],"about":[13],"1":[14],"in":[15,18,26,84,107,162],"800":[16],"births":[17],"USA.":[20],"Tgf-\u03b23":[21,32,54,163],"plays":[22],"a":[23],"critical":[24],"role":[25],"regulating":[27],"murine":[28],"development,":[30],"and":[31,53,67,75,87,128,132,140,152,177],"null":[33],"mutants":[34],"develop":[35],"cleft":[36],"with":[38,119,199],"100%":[39],"penetrance.":[40],"In":[41],"this":[42],"study,":[43],"we":[44],"compared":[45],"global":[46],"palatal":[47],"transcriptomes":[48],"wild":[50],"type":[51],"(WT)":[52],"-/-":[55],"homozygous":[56],"(HM)":[57],"mouse":[58],"embryos":[59],"at":[60,80,111],"crucial":[62],"palatogenesis":[63],"stages":[64],"E14.5,":[66],"E16.5,":[68],"using":[69,175],"RNA-seq":[70,188],"data.":[71],"We":[72,98,147,165],"found":[73],"1,809":[74],"2,127":[76],"differentially":[77],"expressed":[78],"genes":[79,102,117,135,156,174,197],"E16.5":[81,112],"vs.":[82,113],"E14.5":[83,114],"WT":[86,108,131,154],"HM":[88,110,133,150],"groups,":[89],"respectively":[90],"(adjusted":[91],"p":[92],"<":[93],"0.05;":[94],"|fold":[95],"change|>":[96],"2.0).":[97],"focused":[99],"on":[100],"that":[103,157,186,201],"were":[104],"uniquely":[105],"up/downregulated":[106],"or":[109,204],"to":[115,125,144,185],"identify":[116],"associated":[118,198],"CP.":[120],"Systems":[121],"biology":[122],"analysis":[123],"relating":[124],"cell":[126],"behaviors":[127],"function":[129],"specific":[134,151,155],"identified":[136,148],"functional":[137],"non-Smad":[138],"pathways":[139],"preference":[141],"apoptosis":[143],"epithelial-mesenchymal":[145],"transition.":[146],"24":[149],"11":[153],"are":[158,202],"CP-related":[159],"and/or":[160],"involved":[161],"signaling.":[164],"validated":[166],"expression":[168,182],"29":[170],"35":[173],"qRT-PCR":[176],"trend":[179],"mRNA":[181],"similar":[184],"data":[189],".":[190],"Our":[191],"results":[192],"enrich":[193],"our":[194],"understanding":[195],"CP":[200],"directly":[203],"indirectly":[205],"regulated":[206],"via":[207],"TGF-\u03b2.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-14T00:00:00"}
