{"id":"https://openalex.org/W3083655604","doi":"https://doi.org/10.1080/13697137.2020.1804545","title":"Lessons from KEEPS: the Kronos Early Estrogen Prevention Study","display_name":"Lessons from KEEPS: the Kronos Early Estrogen Prevention Study","publication_year":2020,"publication_date":"2020-09-03","ids":{"openalex":"https://openalex.org/W3083655604","doi":"https://doi.org/10.1080/13697137.2020.1804545","mag":"3083655604","pmid":"https://pubmed.ncbi.nlm.nih.gov/32880220","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8108428"},"language":"en","primary_location":{"id":"doi:10.1080/13697137.2020.1804545","doi":"https://doi.org/10.1080/13697137.2020.1804545","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13697137.2020.1804545","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13697137.2020.1804545?needAccess=true","source":{"id":"https://openalex.org/S110024640","display_name":"Climacteric","issn_l":"1369-7137","issn":["1369-7137","1473-0804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Climacteric","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/13697137.2020.1804545?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084106664","display_name":"V. M. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V. M. Miller","raw_affiliation_strings":["Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA;","Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA;","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073212927","display_name":"Hugh Stott Taylor","orcid":"https://orcid.org/0000-0003-1720-8310","observed_orcids":["https://orcid.org/0000-0003-1720-8310"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. S. Taylor","raw_affiliation_strings":["Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030184373","display_name":"Frederick Nicholas Naftolin","orcid":"https://orcid.org/0000-0002-9447-6266","observed_orcids":["https://orcid.org/0000-0002-9447-6266"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Naftolin","raw_affiliation_strings":["Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049411008","display_name":"JoAnn E. Manson","orcid":"https://orcid.org/0000-0002-9426-7595","observed_orcids":["https://orcid.org/0000-0002-9426-7595"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. E. Manson","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020416642","display_name":"Carey Elizabeth Gleason","orcid":"https://orcid.org/0000-0001-6210-4671","observed_orcids":["https://orcid.org/0000-0001-6210-4671"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210132596","display_name":"University of Wisconsin Health","ror":"https://ror.org/03e3qgk42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. E. Gleason","raw_affiliation_strings":["Division of Geriatrics, Department of Medicine, Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatrics, Department of Medicine, Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210132596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020230532","display_name":"Eliot A. Brinton","orcid":"https://orcid.org/0000-0002-9807-4010","observed_orcids":["https://orcid.org/0000-0002-9807-4010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. A. Brinton","raw_affiliation_strings":["Utah Lipid Center, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utah Lipid Center, Salt Lake City, UT, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070158356","display_name":"Juliana M. Kling","orcid":"https://orcid.org/0000-0001-9898-8405","observed_orcids":["https://orcid.org/0000-0001-9898-8405"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Kling","raw_affiliation_strings":["Department of Internal Medicine, Division of Women\u2019s Health Internal Medicine, Mayo Clinic, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Women\u2019s Health Internal Medicine, Mayo Clinic, AZ, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074289517","display_name":"Marcelle Ivonne Cedars","orcid":"https://orcid.org/0000-0003-3682-6907","observed_orcids":["https://orcid.org/0000-0003-3682-6907"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. I. Cedars","raw_affiliation_strings":["Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089170421","display_name":"N. Maritza Dowling","orcid":"https://orcid.org/0000-0001-8642-7299","observed_orcids":["https://orcid.org/0000-0001-8642-7299"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. M. Dowling","raw_affiliation_strings":["Department of Acute & Chronic Care, School of Nursing, Department of Epidemiology & Biostatistics, Milken Institute School of Public Health, The George Washington University, Washington DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Acute & Chronic Care, School of Nursing, Department of Epidemiology & Biostatistics, Milken Institute School of Public Health, The George Washington University, Washington DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077933873","display_name":"Kejal Kantarci","orcid":"https://orcid.org/0000-0002-8001-2081","observed_orcids":["https://orcid.org/0000-0002-8001-2081"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Kantarci","raw_affiliation_strings":["Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079428284","display_name":"Sherman Mitchell Harman","orcid":"https://orcid.org/0000-0002-8806-8178","observed_orcids":["https://orcid.org/0000-0002-8806-8178"]},"institutions":[{"id":"https://openalex.org/I4210113157","display_name":"Phoenix VA Health Care System","ror":"https://ror.org/024b7e967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210113157","https://openalex.org/I4210138663"]},{"id":"https://openalex.org/I4210144491","display_name":"Kronos Longevity Research Institute","ror":"https://ror.org/04anb9w92","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210144491"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. Harman","raw_affiliation_strings":["Kronos Longevity Research Institute, Phoenix, AZ, USA;","Phoenix Veterans Administration Health Care System, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kronos Longevity Research Institute, Phoenix, AZ, USA;","institution_ids":["https://openalex.org/I4210144491"]},{"raw_affiliation_string":"Phoenix Veterans Administration Health Care System, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210113157"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5084106664"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":1.4653,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.82618517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"2","first_page":"139","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/conjugated-equine-estrogens","display_name":"conjugated equine estrogens","score":0.8939999938011169},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.7400000095367432},{"id":"https://openalex.org/keywords/menopausal-symptoms","display_name":"menopausal symptoms","score":0.843999981880188},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mood-and-anxiety","display_name":"mood and anxiety","score":0.7369999885559082},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.9559999704360962},{"id":"https://openalex.org/keywords/sexual-function","display_name":"sexual function","score":0.9940000176429749},{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8942549228668213},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7395936250686646},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.651185929775238},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5870900750160217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5324813723564148},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.5302583575248718},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45540177822113037},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.43372684717178345},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41677114367485046},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3641791343688965},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.1356356143951416},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004966","descriptor_name":"Estrogens, Conjugated (USP)","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015914","descriptor_name":"Estrogen Replacement Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059168","descriptor_name":"Carotid Intima-Media Thickness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/13697137.2020.1804545","doi":"https://doi.org/10.1080/13697137.2020.1804545","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13697137.2020.1804545","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13697137.2020.1804545?needAccess=true","source":{"id":"https://openalex.org/S110024640","display_name":"Climacteric","issn_l":"1369-7137","issn":["1369-7137","1473-0804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Climacteric","raw_type":"journal-article"},{"id":"pmid:32880220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32880220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Climacteric : the journal of the International Menopause Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8108428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8108428","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Climacteric","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1080/13697137.2020.1804545","doi":"https://doi.org/10.1080/13697137.2020.1804545","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13697137.2020.1804545","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13697137.2020.1804545?needAccess=true","source":{"id":"https://openalex.org/S110024640","display_name":"Climacteric","issn_l":"1369-7137","issn":["1369-7137","1473-0804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Climacteric","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1068201143","display_name":null,"funder_award_id":"UL1 RR02413","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1071432574","display_name":"Effects of estrogen on brain morphology and neuronal integrity in early menopause","funder_award_id":"R21NS066147","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G142564060","display_name":"Sex-specific Risk for Vascular Dysfunction and Cognitive Decline","funder_award_id":"P50AG044170","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1478994338","display_name":null,"funder_award_id":"Ul1 RR024150, Ul1 RR024139, Ul1 RR02413","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1651394900","display_name":"Clinical and Translational Science Institute","funder_award_id":"UL1RR024131","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2140019763","display_name":"Estrogen, Platelets, and Artherosclerosis","funder_award_id":"R01HL090639","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G653985792","display_name":"Prevention of Alzheimer's disease in women: risks and benefits of hormone therapy","funder_award_id":"RF1AG057547","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8046583106","display_name":"Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease","funder_award_id":"U54AG044170","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8052269359","display_name":"Yale University Clinical and Translational Science Award Program","funder_award_id":"UL1RR024139","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8875974309","display_name":"Mayo Clinic Center for Translational Science Activities","funder_award_id":"UL1RR024150","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320316597","display_name":"Aurora Foundation","ror":"https://ror.org/05r252d24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3083655604.pdf"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W578040726","https://openalex.org/W1593442063","https://openalex.org/W1799533495","https://openalex.org/W2001265632","https://openalex.org/W2018515170","https://openalex.org/W2032431489","https://openalex.org/W2033896075","https://openalex.org/W2042606981","https://openalex.org/W2051028982","https://openalex.org/W2061334317","https://openalex.org/W2072453475","https://openalex.org/W2087841827","https://openalex.org/W2089203471","https://openalex.org/W2091232445","https://openalex.org/W2107604419","https://openalex.org/W2110885050","https://openalex.org/W2112997260","https://openalex.org/W2119183883","https://openalex.org/W2126199983","https://openalex.org/W2137482825","https://openalex.org/W2143935302","https://openalex.org/W2153259010","https://openalex.org/W2167703944","https://openalex.org/W2201390437","https://openalex.org/W2204745425","https://openalex.org/W2220931894","https://openalex.org/W2289584781","https://openalex.org/W2290627980","https://openalex.org/W2330799317","https://openalex.org/W2378845778","https://openalex.org/W2417618181","https://openalex.org/W2425009053","https://openalex.org/W2537817634","https://openalex.org/W2553744529","https://openalex.org/W2593778355","https://openalex.org/W2604251408","https://openalex.org/W2747429217","https://openalex.org/W2749066814","https://openalex.org/W2756138584","https://openalex.org/W2772812157","https://openalex.org/W2802220258","https://openalex.org/W2893321534","https://openalex.org/W2916541037","https://openalex.org/W2926696917","https://openalex.org/W2966500580","https://openalex.org/W2981262520","https://openalex.org/W2982582678","https://openalex.org/W3000415516","https://openalex.org/W3005482948","https://openalex.org/W3142319369","https://openalex.org/W4245166850"],"related_works":["https://openalex.org/W2926696917","https://openalex.org/W2042606981","https://openalex.org/W2091232445","https://openalex.org/W2179902922","https://openalex.org/W2204745425","https://openalex.org/W2133863156","https://openalex.org/W4404573179","https://openalex.org/W2009752367","https://openalex.org/W4388869204","https://openalex.org/W2521569258"],"abstract_inverted_index":{"The":[0],"Kronos":[1],"Early":[2],"Estrogen":[3],"Prevention":[4],"Study":[5],"(KEEPS)":[6],"was":[7],"a":[8,46],"randomized,":[9],"double-blind,":[10],"placebo-controlled":[11],"trial":[12],"designed":[13],"to":[14],"determine":[15],"the":[16,26,101,119,142,156],"effects":[17],"of":[18,28,48,121,139,153,158,163,172,182,184],"hormone":[19,22,194],"treatments":[20,23],"(menopausal":[21],"[MHTs])":[24],"on":[25,200],"progression":[27],"carotid":[29],"intima-medial":[30],"thickness":[31],"(CIMT)":[32],"in":[33,104,130,141,147,174,193],"recently":[34,186],"menopausal":[35,122],"women.":[36],"Participants":[37],"less":[38],"than":[39],"3":[40],"years":[41],"from":[42],"menopause":[43],"and":[44,59,91,124,137,151,180,189],"without":[45],"history":[47],"overt":[49],"cardiovascular":[50],"disease":[51],"(CVD),":[52],"defined":[53],"as":[54],"no":[55],"clinical":[56,175],"CVD":[57],"events":[58],"coronary":[60],"artery":[61],"calcium":[62],"<":[63],"50":[64],"Agatston":[65],"units,":[66],"received":[67],"either":[68],"oral":[69],"conjugated":[70],"equine":[71],"estrogens":[72],"(0.45":[73],"mg/day)":[74],"or":[75,88],"transdermal":[76],"17\u03b2-estradiol":[77],"(50":[78],"\u00b5g/day),":[79],"both":[80],"with":[81],"progesterone":[82],"(200":[83],"mg/day":[84],"for":[85,93,149,160,170],"12":[86],"days/month),":[87],"placebo":[89,117],"pills":[90],"patches":[92],"4":[94],"years.":[95],"Although":[96],"MHT":[97,112,159,173,185,198],"did":[98],"not":[99],"decrease":[100],"age-related":[102],"increase":[103],"CIMT,":[105],"KEEPS":[106,166],"provided":[107],"other":[108],"important":[109,168],"insights":[110],"about":[111],"effects.":[113],"Both":[114],"MHTs":[115],"versus":[116],"reduced":[118],"severity":[120],"symptoms":[123],"maintained":[125],"bone":[126],"density,":[127],"but":[128],"differed":[129],"efficacy":[131,157,199],"regarding":[132],"mood/anxiety,":[133],"sleep,":[134],"sexual":[135],"function,":[136],"deposition":[138],"\u03b2-amyloid":[140],"brain.":[143],"Additionally,":[144],"genetic":[145,191],"variants":[146,192],"enzymes":[148],"metabolism":[150,195],"uptake":[152],"estrogen":[154],"affected":[155],"some":[161],"aspects":[162],"symptom":[164],"relief.":[165],"provides":[167],"information":[169],"use":[171],"practice,":[176],"including":[177],"type,":[178],"dose,":[179],"mode":[181],"delivery":[183],"after":[187],"menopause,":[188],"how":[190],"may":[196],"affect":[197],"specific":[201],"outcomes.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-11T00:00:00"}
