{"id":"https://openalex.org/W3083556913","doi":"https://doi.org/10.3390/pharmaceutics12090846","title":"Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice","display_name":"Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice","publication_year":2020,"publication_date":"2020-09-04","ids":{"openalex":"https://openalex.org/W3083556913","doi":"https://doi.org/10.3390/pharmaceutics12090846","mag":"3083556913","pmid":"https://pubmed.ncbi.nlm.nih.gov/32899642","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7557591"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics12090846","doi":"https://doi.org/10.3390/pharmaceutics12090846","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics12090846","pdf_url":"https://www.mdpi.com/1999-4923/12/9/846/pdf?version=1600395262","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/12/9/846/pdf?version=1600395262","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072980356","display_name":"Malavika Deodhar","orcid":"https://orcid.org/0000-0002-1661-6518","observed_orcids":["https://orcid.org/0000-0002-1661-6518"]},"institutions":[{"id":"https://openalex.org/I4405271950","display_name":"Tabula Rasa HealthCare (United States)","ror":"https://ror.org/03akc2z91","country_code":"US","type":"company","lineage":["https://openalex.org/I4405271950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malavika Deodhar","raw_affiliation_strings":["Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I4405271950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037434877","display_name":"Sweilem B. Al Rihani","orcid":"https://orcid.org/0000-0003-2415-4664","observed_orcids":["https://orcid.org/0000-0003-2415-4664"]},"institutions":[{"id":"https://openalex.org/I4405271950","display_name":"Tabula Rasa HealthCare (United States)","ror":"https://ror.org/03akc2z91","country_code":"US","type":"company","lineage":["https://openalex.org/I4405271950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sweilem B Al Rihani","raw_affiliation_strings":["Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA"],"raw_orcid":"https://orcid.org/0000-0003-2415-4664","affiliations":[{"raw_affiliation_string":"Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I4405271950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089709417","display_name":"Meghan J. Arwood","orcid":"https://orcid.org/0000-0003-3117-7450","observed_orcids":["https://orcid.org/0000-0003-3117-7450"]},"institutions":[{"id":"https://openalex.org/I4405271950","display_name":"Tabula Rasa HealthCare (United States)","ror":"https://ror.org/03akc2z91","country_code":"US","type":"company","lineage":["https://openalex.org/I4405271950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan J. Arwood","raw_affiliation_strings":["Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I4405271950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001579402","display_name":"Lucy I. Darakjian","orcid":"https://orcid.org/0000-0001-9310-1668","observed_orcids":["https://orcid.org/0000-0001-9310-1668"]},"institutions":[{"id":"https://openalex.org/I4405271950","display_name":"Tabula Rasa HealthCare (United States)","ror":"https://ror.org/03akc2z91","country_code":"US","type":"company","lineage":["https://openalex.org/I4405271950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy Darakjian","raw_affiliation_strings":["Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I4405271950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075497355","display_name":"Pamela Dow","orcid":"https://orcid.org/0000-0002-9983-8545","observed_orcids":["https://orcid.org/0000-0002-9983-8545"]},"institutions":[{"id":"https://openalex.org/I4405271950","display_name":"Tabula Rasa HealthCare (United States)","ror":"https://ror.org/03akc2z91","country_code":"US","type":"company","lineage":["https://openalex.org/I4405271950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela Dow","raw_affiliation_strings":["Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA"],"raw_orcid":"https://orcid.org/0000-0002-9983-8545","affiliations":[{"raw_affiliation_string":"Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I4405271950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080359453","display_name":"Jacques Turgeon","orcid":"https://orcid.org/0000-0002-7978-9280","observed_orcids":["https://orcid.org/0000-0002-7978-9280"]},"institutions":[{"id":"https://openalex.org/I4405271950","display_name":"Tabula Rasa HealthCare (United States)","ror":"https://ror.org/03akc2z91","country_code":"US","type":"company","lineage":["https://openalex.org/I4405271950"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Jacques Turgeon","raw_affiliation_strings":["Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3C 3J7, Canada","Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA"],"raw_orcid":"https://orcid.org/0000-0002-7978-9280","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3C 3J7, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I4405271950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101655185","display_name":"V\u00e9ronique Michaud","orcid":"https://orcid.org/0000-0002-1399-6447","observed_orcids":["https://orcid.org/0000-0002-1399-6447","https://orcid.org/0000-0002-0504-5502"]},"institutions":[{"id":"https://openalex.org/I4405271950","display_name":"Tabula Rasa HealthCare (United States)","ror":"https://ror.org/03akc2z91","country_code":"US","type":"company","lineage":["https://openalex.org/I4405271950"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Veronique Michaud","raw_affiliation_strings":["Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3C 3J7, Canada","Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3C 3J7, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I4405271950"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101655185"],"corresponding_institution_ids":["https://openalex.org/I4405271950","https://openalex.org/I70931966"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1901},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1901},"fwci":3.108,"has_fulltext":true,"cited_by_count":288,"citation_normalized_percentile":{"value":0.95031056,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"12","issue":"9","first_page":"846","last_page":"846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450-inhibition","display_name":"cytochrome P450 inhibition","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mechanism-based-inhibition","display_name":"mechanism-based inhibition","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9890000224113464},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8159999847412109},{"id":"https://openalex.org/keywords/irreversible-enzyme-inhibition","display_name":"irreversible enzyme inhibition","score":0.7200000286102295},{"id":"https://openalex.org/keywords/omeprazole","display_name":"omeprazole","score":0.8370000123977661},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/macrolide-antibiotics","display_name":"macrolide antibiotics","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mirabegron","display_name":"mirabegron","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.7940609455108643},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7883679866790771},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.640770673751831},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5930806994438171},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.49417784810066223},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.44964516162872314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4221077263355255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3022315800189972},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13273891806602478},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics12090846","doi":"https://doi.org/10.3390/pharmaceutics12090846","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics12090846","pdf_url":"https://www.mdpi.com/1999-4923/12/9/846/pdf?version=1600395262","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:32899642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32899642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7557591","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7557591/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b38bec820b2a4390b61925519b1d0cd9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b38bec820b2a4390b61925519b1d0cd9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 12, Iss 9, p 846 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics12090846","doi":"https://doi.org/10.3390/pharmaceutics12090846","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics12090846","pdf_url":"https://www.mdpi.com/1999-4923/12/9/846/pdf?version=1600395262","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083556913.pdf","grobid_xml":"https://content.openalex.org/works/W3083556913.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W633405694","https://openalex.org/W1558276030","https://openalex.org/W1934270266","https://openalex.org/W1947994548","https://openalex.org/W1968407153","https://openalex.org/W1968887991","https://openalex.org/W1970648957","https://openalex.org/W1972816241","https://openalex.org/W1980002210","https://openalex.org/W1980474768","https://openalex.org/W1981611138","https://openalex.org/W1983687170","https://openalex.org/W1984624729","https://openalex.org/W2008998473","https://openalex.org/W2010241890","https://openalex.org/W2016322604","https://openalex.org/W2031205523","https://openalex.org/W2032247889","https://openalex.org/W2056623900","https://openalex.org/W2060761223","https://openalex.org/W2062754756","https://openalex.org/W2071687773","https://openalex.org/W2100332460","https://openalex.org/W2103481781","https://openalex.org/W2103946220","https://openalex.org/W2104278118","https://openalex.org/W2105005467","https://openalex.org/W2107450474","https://openalex.org/W2108129761","https://openalex.org/W2129258287","https://openalex.org/W2132733182","https://openalex.org/W2143777566","https://openalex.org/W2151471516","https://openalex.org/W2152376036","https://openalex.org/W2154808644","https://openalex.org/W2157227177","https://openalex.org/W2158389123","https://openalex.org/W2161781272","https://openalex.org/W2163711771","https://openalex.org/W2166042365","https://openalex.org/W2167323824","https://openalex.org/W2172775913","https://openalex.org/W2221708339","https://openalex.org/W2269419715","https://openalex.org/W2316375735","https://openalex.org/W2342801766","https://openalex.org/W2412800873","https://openalex.org/W2416578975","https://openalex.org/W2563278367","https://openalex.org/W2570328141","https://openalex.org/W2756738310","https://openalex.org/W2765908685","https://openalex.org/W2892026465","https://openalex.org/W3026513964","https://openalex.org/W6640460636","https://openalex.org/W6675577123","https://openalex.org/W6676150899"],"related_works":["https://openalex.org/W2495611317","https://openalex.org/W2003237988","https://openalex.org/W4241121983","https://openalex.org/W1456489090","https://openalex.org/W2156273681","https://openalex.org/W2075309894","https://openalex.org/W1994904603","https://openalex.org/W4239528205","https://openalex.org/W2160645071","https://openalex.org/W1989145752"],"abstract_inverted_index":{"In":[0],"an":[1],"ageing":[2],"society,":[3],"polypharmacy":[4,31],"has":[5],"become":[6],"a":[7,123,137,140,144,214],"major":[8,24],"public":[9],"health":[10,25],"and":[11,88,100,117,176,235],"economic":[12],"issue.":[13],"Overuse":[14],"of":[15,30,36,46,78,90,97,102,107,119,155,173,205,207,217,221,228],"medications,":[16],"especially":[17,69],"in":[18],"patients":[19],"with":[20,160,225],"chronic":[21],"diseases,":[22],"carries":[23],"risks.":[26],"One":[27],"common":[28],"consequence":[29],"is":[32,180,190],"the":[33,95,98,203,208,218],"increased":[34],"emergence":[35],"adverse":[37],"drug":[38],"events,":[39],"mainly":[40],"from":[41],"drug-drug":[42],"interactions.":[43],"The":[44,76],"majority":[45],"currently":[47],"available":[48],"drugs":[49,66,161,186],"are":[50,67,187],"metabolized":[51],"by":[52,182,201],"CYP450":[53,74,103,108],"enzymes.":[54],"Interactions":[55],"due":[56],"to":[57,192],"shared":[58],"CYP450-mediated":[59],"metabolic":[60],"pathways":[61],"for":[62],"two":[63],"or":[64,72,168],"more":[65],"frequent,":[68],"through":[70],"reversible":[71],"irreversible":[73],"inhibition.":[75,104],"magnitude":[77],"these":[79,120],"interactions":[80,118,159],"depends":[81],"on":[82,131],"several":[83],"factors,":[84],"including":[85],"varying":[86],"affinity":[87],"concentration":[89],"substrates,":[91],"time":[92,204],"delay":[93],"between":[94],"administration":[96,206],"drugs,":[99],"mechanisms":[101],"Various":[105],"types":[106,121,220],"inhibition":[109,156,175,195,231],"(competitive,":[110],"non-competitive,":[111],"mechanism-based)":[112],"have":[113],"been":[114],"observed":[115],"clinically,":[116],"require":[122],"distinct":[124],"clinical":[125,178,236],"management":[126,179],"strategy.":[127],"This":[128,153],"review":[129],"focuses":[130],"mechanism-based":[132,174,194,222,230],"inhibition,":[133,223],"which":[134],"occurs":[135],"when":[136,184],"substrate":[138],"forms":[139],"reactive":[141],"intermediate,":[142],"creating":[143],"stable":[145],"enzyme-intermediate":[146],"complex":[147],"that":[148],"irreversibly":[149],"reduces":[150],"enzyme":[151],"activity.":[152],"type":[154],"can":[157],"cause":[158],"such":[162,185],"as":[163],"omeprazole,":[164],"paroxetine,":[165],"macrolide":[166],"antibiotics,":[167],"mirabegron.":[169],"A":[170],"good":[171],"understanding":[172],"proper":[177],"needed":[181],"clinicians":[183],"prescribed.":[188],"It":[189],"important":[191],"recognize":[193],"since":[196],"it":[197],"cannot":[198],"be":[199],"prevented":[200],"separating":[202],"interacting":[209],"drugs.":[210],"Here,":[211],"we":[212],"provide":[213],"comprehensive":[215],"overview":[216],"different":[219],"along":[224],"illustrative":[226],"examples":[227],"how":[229],"might":[232],"affect":[233],"prescribing":[234],"behaviors.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":59},{"year":2025,"cited_by_count":80},{"year":2024,"cited_by_count":61},{"year":2023,"cited_by_count":43},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":15},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-09-11T00:00:00"}
