{"id":"https://openalex.org/W3083550605","doi":"https://doi.org/10.1158/1538-7445.am2020-1273","title":"Abstract 1273: RASSF1 promoter hypermethylation is associated with activated CTNNB1 pathways in hepatocellular carcinoma","display_name":"Abstract 1273: RASSF1 promoter hypermethylation is associated with activated CTNNB1 pathways in hepatocellular carcinoma","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083550605","doi":"https://doi.org/10.1158/1538-7445.am2020-1273","mag":"3083550605"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-1273","doi":"https://doi.org/10.1158/1538-7445.am2020-1273","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-1273","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028096127","display_name":"Sandi Alexander Kwee","orcid":"https://orcid.org/0000-0002-4624-8787","observed_orcids":["https://orcid.org/0000-0002-4624-8787"]},"institutions":[{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandi Alexander Kwee","raw_affiliation_strings":["1The Queen's Medical Center, Honolulu, HI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Queen's Medical Center, Honolulu, HI;","institution_ids":["https://openalex.org/I4210104115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007388657","display_name":"Karolina Peplowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karolina Peplowska","raw_affiliation_strings":["2University of Hawaii Cancer Center, Honolulu, HI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Hawaii Cancer Center, Honolulu, HI;","institution_ids":["https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070952451","display_name":"Christine E. Farrar","orcid":"https://orcid.org/0000-0001-8561-2257","observed_orcids":["https://orcid.org/0000-0001-8561-2257"]},"institutions":[{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Farrar","raw_affiliation_strings":["2University of Hawaii Cancer Center, Honolulu, HI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Hawaii Cancer Center, Honolulu, HI;","institution_ids":["https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069748932","display_name":"Linda L. Wong","orcid":"https://orcid.org/0000-0003-3143-5384","observed_orcids":["https://orcid.org/0000-0003-3143-5384"]},"institutions":[{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Wong","raw_affiliation_strings":["2University of Hawaii Cancer Center, Honolulu, HI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Hawaii Cancer Center, Honolulu, HI;","institution_ids":["https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002573985","display_name":"Min\u2010Ae Song","orcid":"https://orcid.org/0000-0002-2864-0224","observed_orcids":["https://orcid.org/0000-0002-2864-0224"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min-ae Song","raw_affiliation_strings":["3Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014295522","display_name":"Maarit Tiirikainen","orcid":"https://orcid.org/0000-0002-8124-3818","observed_orcids":["https://orcid.org/0000-0002-8124-3818"]},"institutions":[{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maarit Tiirikainen","raw_affiliation_strings":["2University of Hawaii Cancer Center, Honolulu, HI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Hawaii Cancer Center, Honolulu, HI;","institution_ids":["https://openalex.org/I4390039246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"1273","last_page":"1273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.36910000443458557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ctnnb1","display_name":"CTNNB1","score":0.7720000147819519},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.7609999775886536},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.9670000076293945},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.6489999890327454},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.5350000262260437},{"id":"https://openalex.org/keywords/ctnnb1-mutation","display_name":"CTNNB1 mutation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tumor-suppressor-inactivation","display_name":"tumor suppressor inactivation","score":0.47600001096725464},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.492000013589859},{"id":"https://openalex.org/keywords/resectability","display_name":"resectability","score":0.4269999861717224},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7699011564254761},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6439881324768066},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6406307816505432},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6292585730552673},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.47825729846954346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47590622305870056},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4290015697479248},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3376975655555725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3283967077732086},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3251776695251465},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20882990956306458},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09483197331428528}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-1273","doi":"https://doi.org/10.1158/1538-7445.am2020-1273","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-1273","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005655114","https://openalex.org/W2381456232","https://openalex.org/W3104835935","https://openalex.org/W1537112530","https://openalex.org/W2387247803","https://openalex.org/W2306227551","https://openalex.org/W2042644795","https://openalex.org/W2385317588","https://openalex.org/W2080560721","https://openalex.org/W6939551327"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND:":[1],"The":[2,142,400],"promoter-region":[3],"of":[4,30,177,224,312,444,448],"the":[5,64,161,208,248,323,406,445,449],"Ras":[6],"association":[7],"domain":[8],"family":[9],"member":[10],"1":[11],"(RASSF1)":[12],"gene":[13,156,183,388],"is":[14,53,432],"frequently":[15],"hypermethylated":[16],"in":[17,50,76,87,108,119,219,231,247,255,309,358,366,398,438],"several":[18],"solid":[19],"tumors,":[20],"including":[21],"hepatocellular":[22,439],"carcinoma":[23,440],"(HCC).":[24],"Wnt-pathway":[25],"deregulation":[26],"and":[27,40,59,70,100,306,345,386,405,459],"increased":[28],"accumulation":[29],"nuclear":[31],"catenin-beta-1":[32],"(CTNNB1)":[33],"has":[34],"been":[35],"associated":[36,272,393,433],"with":[37,43,115,273,368,394,434],"RASSF1":[38,67,84,214,225,249,281,319,355,395,429],"inactivation,":[39],"more":[41],"recently,":[42],"diminished":[44],"response":[45],"to":[46,82,151,190,235,259,286,335,375],"immune":[47],"checkpoint":[48],"blockade":[49],"HCC.":[51,77,399],"There":[52],"limited":[54,175],"data":[55],"from":[56,89,104,112,147,160,198],"clinical":[57,123,401],"tumor":[58,140,163,221,232,359],"liquid":[60,300,369],"biopsy":[61,301,370],"samples":[62,106,128,135,179,315,326],"on":[63,173],"relationship":[65],"between":[66],"promoter":[68,85,215,226,250,282,320,356,396,430],"methylation":[69,86,144,227,283,307,321,357],"Wnt":[71,274],"beta-catenin":[72,275],"pathway":[73,154,276],"activation":[74,155,277],"status":[75],"METHODS:":[78],"Pyrosequencing":[79],"was":[80,170,205,217,362],"performed":[81,172,206],"assess":[83],"DNA":[88,98,103,143,167,238,261,304,325,361],"paired":[90],"HCC":[91,117,200],"tumor/adjacent-liver":[92],"tissues":[93],"as":[94,96,233,257,284,333,373],"well":[95],"cell-free":[97,324],"(cfDNA)":[99],"buffy":[101],"coat":[102],"blood":[105,127,314],"collected":[107,130,137],"Streck":[109],"cfDNA":[110,178,256],"tubes":[111],"40":[113],"patients":[114,367],"surgically-resectable":[116],"participating":[118],"an":[120],"IRB-approved":[121],"diagnostic":[122],"trial":[124],"(NCT01395030).":[125],"All":[126],"were":[129,136,149,228,251],"pre-operatively":[131],"while":[132],"all":[133],"tissue":[134,237,360],"upon":[138],"surgical":[139],"resection.":[141],"analysis":[145,308],"results":[146],"tumors":[148,287],"compared":[150,234,258,285,334,374],"a":[152,174,181,310],"CTNNB1":[153,195,329,384,436],"expression":[157,389],"signature":[158],"obtained":[159],"same":[162],"samples.":[164,222],"Targeted":[165],"next-generation":[166],"sequencing":[168],"(NGS)":[169],"also":[171,252,316,363],"number":[176],"using":[180,207],"56":[182],"Oncology":[184],"Panel":[185],"(56G":[186],"v2,":[187],"Swift":[188],"Bioscience)":[189],"obtain":[191],"mutational":[192],"profiles":[193],"(including":[194],"mutation":[196],"status)":[197],"each":[199],"case.":[201],"Allele":[202],"variant":[203],"detection":[204],"ERASE-Seq":[209],"algorithm":[210],"(Fluxion":[211],"Biosciences).":[212],"RESULTS:":[213],"hypermethylation":[216,397,431],"detected":[218,371],"35/40":[220],"Levels":[223],"significantly":[229,253,279,364],"higher":[230,254,280,318,365],"liver":[236],"(55.2%":[239],"vs.":[240,263,293,339,349],"23.5%,":[241],"p":[242,265,296,342,352,380],"<":[243,266],"0.0001).":[244,267],"Methylation":[245],"levels":[246],"buffy-coat":[260],"(7.5%":[262],"0.4%,":[264],"Tumors":[268],"enriched":[269,288],"for":[270,289,403,452],"genes":[271,291],"demonstrated":[278],"immune/interferon-related":[290],"(63%":[292],"20%,":[294],"Tukey":[295,341,351],"=":[297,343,353,381],"0.0004).":[298],"Pilot":[299],"studies":[302],"involving":[303],"NGS":[305],"subset":[311],"pre-operative":[313],"revealed":[317],"among":[322],"carrying":[327],"activating":[328],"exon":[330],"3":[331],"mutations":[332,337,347,385],"p53":[336],"(23.4%":[338,348],"1.4%,":[340],"0.009)":[344],"PIK3":[346],"1.5%,":[350],"0.031).":[354],"CTNNB1-mutations":[372],"p53-mutations":[376],"(65.5%":[377],"versus":[378],"37%,":[379],"0.030).":[382],"CONCLUSION:":[383],"related":[387],"patterns":[390],"may":[391],"be":[392],"implications":[402],"immunotherapy":[404],"mechanisms":[407],"underlying":[408],"these":[409],"associations":[410],"deserve":[411],"further":[412],"investigation.":[413],"Citation":[414],"Format:":[415],"Sandi":[416],"Alexander":[417],"Kwee,":[418],"Karolina":[419],"Peplowska,":[420],"Christine":[421],"Farrar,":[422],"Linda":[423],"Wong,":[424],"Min-ae":[425],"Song,":[426],"Maarit":[427],"Tiirikainen.":[428],"activated":[435],"pathways":[437],"[abstract].":[441],"In:":[442],"Proceedings":[443],"Annual":[446],"Meeting":[447],"American":[450],"Association":[451],"Cancer":[453,465],"Research":[454],"2020;":[455],"2020":[456],"Apr":[457],"27-28":[458],"Jun":[460],"22-24.":[461],"Philadelphia":[462],"(PA):":[463],"AACR;":[464],"Res":[466],"2020;80(16":[467],"Suppl):Abstract":[468],"nr":[469],"1273.":[470]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2020-09-11T00:00:00"}
