{"id":"https://openalex.org/W3083495448","doi":"https://doi.org/10.2217/fon-2020-0538","title":"Niraparib in the Treatment of Previously Treated Advanced Ovarian, Fallopian Tube or Primary Peritoneal Cancer","display_name":"Niraparib in the Treatment of Previously Treated Advanced Ovarian, Fallopian Tube or Primary Peritoneal Cancer","publication_year":2020,"publication_date":"2020-09-03","ids":{"openalex":"https://openalex.org/W3083495448","doi":"https://doi.org/10.2217/fon-2020-0538","mag":"3083495448","pmid":"https://pubmed.ncbi.nlm.nih.gov/32880196"},"language":"en","primary_location":{"id":"doi:10.2217/fon-2020-0538","doi":"https://doi.org/10.2217/fon-2020-0538","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fon-2020-0538","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084800083","display_name":"B.J. Rimel","orcid":"https://orcid.org/0000-0003-4808-3805","observed_orcids":["https://orcid.org/0000-0003-4808-3805"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BJ Rimel","raw_affiliation_strings":["Cedars-Sinai Medical Center,Department of Obstetrics &amp; Gynecology,Division of Gynecologic Oncology, \rLos Angeles,CA90048,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center,Department of Obstetrics &amp; Gynecology,Division of Gynecologic Oncology, \rLos Angeles,CA90048,USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077115315","display_name":"Lauren Dockery","orcid":"https://orcid.org/0000-0002-4883-750X","observed_orcids":["https://orcid.org/0000-0002-4883-750X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Dockery","raw_affiliation_strings":["University of North Carolina at Chapel Hill,Department of Obstetrics &amp; Gynecology, Division of Gynecologic Oncology, \rChapel Hill,NC27599,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill,Department of Obstetrics &amp; Gynecology, Division of Gynecologic Oncology, \rChapel Hill,NC27599,USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071527937","display_name":"Leslie M. Randall","orcid":"https://orcid.org/0000-0003-3790-4858","observed_orcids":["https://orcid.org/0000-0003-3790-4858"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie M Randall","raw_affiliation_strings":["Massey Cancer Center, Virginia Commonwealth University, \rRichmond,VA23298,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massey Cancer Center, Virginia Commonwealth University, \rRichmond,VA23298,USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069337573","display_name":"Kathleen N. Moore","orcid":"https://orcid.org/0000-0002-5803-0718","observed_orcids":["https://orcid.org/0000-0002-5803-0718"]},"institutions":[{"id":"https://openalex.org/I4390039380","display_name":"OU Health Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039271","https://openalex.org/I4390039380"]},{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathleen Moore","raw_affiliation_strings":["The Stephenson Cancer Center,The University of Oklahoma, \rOklahoma City,OK73104,USA"],"raw_orcid":"https://orcid.org/0000-0002-5803-0718","affiliations":[{"raw_affiliation_string":"The Stephenson Cancer Center,The University of Oklahoma, \rOklahoma City,OK73104,USA","institution_ids":["https://openalex.org/I4390039380","https://openalex.org/I8692664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5069337573"],"corresponding_institution_ids":["https://openalex.org/I4390039380","https://openalex.org/I8692664"],"apc_list":null,"apc_paid":null,"fwci":0.0903,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4236426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"16","issue":"33","first_page":"2701","last_page":"2711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niraparib","display_name":"niraparib","score":1.0},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.9049999713897705},{"id":"https://openalex.org/keywords/advanced-ovarian-cancer","display_name":"advanced ovarian cancer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/fallopian-tube-cancer","display_name":"fallopian tube cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/primary-peritoneal-cancer","display_name":"primary peritoneal cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/parp-inhibitor-combination","display_name":"PARP inhibitor combination","score":0.6679999828338623},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.675000011920929},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.8916404247283936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.833081841468811},{"id":"https://openalex.org/C2775883341","wikidata":"https://www.wikidata.org/wiki/Q1233836","display_name":"Fallopian tube","level":2,"score":0.6553864479064941},{"id":"https://openalex.org/C2777249960","wikidata":"https://www.wikidata.org/wiki/Q4818922","display_name":"Fallopian tube cancer","level":4,"score":0.6099739074707031},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5434792637825012},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.4812566936016083},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4489714503288269},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43822306394577026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41525799036026},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.40348905324935913},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.21789896488189697},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1581287384033203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10441052913665771},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005185","descriptor_name":"Fallopian Tube Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2217/fon-2020-0538","doi":"https://doi.org/10.2217/fon-2020-0538","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fon-2020-0538","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},{"id":"pmid:32880196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32880196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future oncology (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313690","display_name":"Novocure","ror":"https://ror.org/018ec2p66"},{"id":"https://openalex.org/F4320316932","display_name":"Mersana Therapeutics","ror":"https://ror.org/05jyg6z06"},{"id":"https://openalex.org/F4320317892","display_name":"GOG Foundation","ror":"https://ror.org/04x187e69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W2070528300","https://openalex.org/W2074730941","https://openalex.org/W2075491707","https://openalex.org/W2106247280","https://openalex.org/W2110691972","https://openalex.org/W2128746885","https://openalex.org/W2132720619","https://openalex.org/W2136689090","https://openalex.org/W2137708206","https://openalex.org/W2160399783","https://openalex.org/W2173456459","https://openalex.org/W2179105349","https://openalex.org/W2528228811","https://openalex.org/W2587333476","https://openalex.org/W2597062310","https://openalex.org/W2608211931","https://openalex.org/W2761228804","https://openalex.org/W2761888485","https://openalex.org/W2762680603","https://openalex.org/W2763728669","https://openalex.org/W2767170869","https://openalex.org/W2768434280","https://openalex.org/W2802480234","https://openalex.org/W2804717005","https://openalex.org/W2805187906","https://openalex.org/W2884001607","https://openalex.org/W2891811633","https://openalex.org/W2892812402","https://openalex.org/W2898088739","https://openalex.org/W2901506506","https://openalex.org/W2903876972","https://openalex.org/W2908639608","https://openalex.org/W2914850591","https://openalex.org/W2921991537","https://openalex.org/W2935541805","https://openalex.org/W2943183669","https://openalex.org/W2970135300","https://openalex.org/W2975141952","https://openalex.org/W2981585441","https://openalex.org/W2982985448","https://openalex.org/W3011212154","https://openalex.org/W3013350468","https://openalex.org/W3031903430","https://openalex.org/W4211006558"],"related_works":["https://openalex.org/W2809674778","https://openalex.org/W4386484207","https://openalex.org/W6986285075","https://openalex.org/W4390240116","https://openalex.org/W2902886329","https://openalex.org/W2905681190","https://openalex.org/W3049483319","https://openalex.org/W2944085998","https://openalex.org/W3133613692","https://openalex.org/W2990332687"],"abstract_inverted_index":{"Homologous":[0],"recombination":[1],"deficiency":[2],"is":[3,23,82],"a":[4,24],"critical":[5],"biologic":[6],"feature":[7],"of":[8,63,68,74,94],"ovarian":[9,39,75,104],"cancer.":[10,105],"This":[11,86],"weakness":[12],"in":[13,36,45,51,103],"DNA":[14],"damage":[15],"repair":[16],"relies":[17],"on":[18],"functional":[19],"poly(ADP-ribose)":[20,25],"polymerase.":[21],"Niraparib":[22],"polymerase":[26],"inhibitor,":[27],"orally":[28],"available":[29],"and":[30,47,100],"initially":[31],"approved":[32],"for":[33,53],"maintenance":[34],"therapy":[35],"women":[37],"with":[38],"cancer":[40,58,76],"by":[41,48],"the":[42,49,54,60,72,89],"US":[43],"FDA":[44],"2017":[46,52],"EMA":[50],"same":[55],"indication.":[56],"Ovarian":[57],"represents":[59],"most":[61],"lethal":[62],"gynecologic":[64],"malignancies.":[65],"The":[66],"efficacy":[67,99],"niraparib":[69,92],"has":[70],"changed":[71],"landscape":[73],"treatment,":[77],"but":[78],"overall":[79],"survival":[80],"data":[81,90],"still":[83],"to":[84],"come.":[85],"review":[87],"summarizes":[88],"regarding":[91],"mechanism":[93],"action,":[95],"toxicities,":[96],"single":[97],"agent":[98],"novel":[101],"combinations":[102]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-11T00:00:00"}
