{"id":"https://openalex.org/W3083467148","doi":"https://doi.org/10.1158/1538-7445.am2020-ct191","title":"Abstract CT191: Interim results from CLASSICAL-Lung, phase 1b/2 study of pepinemab (VX15/2503) in combination with avelumab in advanced NSCLC","display_name":"Abstract CT191: Interim results from CLASSICAL-Lung, phase 1b/2 study of pepinemab (VX15/2503) in combination with avelumab in advanced NSCLC","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083467148","doi":"https://doi.org/10.1158/1538-7445.am2020-ct191","mag":"3083467148"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-ct191","doi":"https://doi.org/10.1158/1538-7445.am2020-ct191","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-ct191","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036134937","display_name":"Jonathan Wade Goldman","orcid":"https://orcid.org/0000-0002-4925-8243","observed_orcids":["https://orcid.org/0000-0002-4925-8243"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan W. Goldman","raw_affiliation_strings":["1UCLA, Santa Monica, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA, Santa Monica, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022624265","display_name":"Terrence Lee Fisher","orcid":"https://orcid.org/0000-0001-9326-6606","observed_orcids":["https://orcid.org/0000-0001-9326-6606"]},"institutions":[{"id":"https://openalex.org/I4210141595","display_name":"Vaccinex (United States)","ror":"https://ror.org/047jxj944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210141595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terrence L. Fisher","raw_affiliation_strings":["2Vaccinex, Inc., Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vaccinex, Inc., Rochester, NY;","institution_ids":["https://openalex.org/I4210141595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001292309","display_name":"Elizabeth E. Evans","orcid":"https://orcid.org/0000-0002-9287-9221","observed_orcids":["https://orcid.org/0000-0002-9287-9221"]},"institutions":[{"id":"https://openalex.org/I4210141595","display_name":"Vaccinex (United States)","ror":"https://ror.org/047jxj944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210141595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Evans","raw_affiliation_strings":["2Vaccinex, Inc., Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vaccinex, Inc., Rochester, NY;","institution_ids":["https://openalex.org/I4210141595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001835930","display_name":"John E. Leonard","orcid":"https://orcid.org/0000-0003-2154-750X","observed_orcids":["https://orcid.org/0000-0003-2154-750X"]},"institutions":[{"id":"https://openalex.org/I4210141595","display_name":"Vaccinex (United States)","ror":"https://ror.org/047jxj944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210141595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Leonard","raw_affiliation_strings":["2Vaccinex, Inc., Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vaccinex, Inc., Rochester, NY;","institution_ids":["https://openalex.org/I4210141595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030373204","display_name":"Desa Rae E. Pastore","orcid":"https://orcid.org/0009-0007-7840-8099","observed_orcids":["https://orcid.org/0009-0007-7840-8099"]},"institutions":[{"id":"https://openalex.org/I4210141595","display_name":"Vaccinex (United States)","ror":"https://ror.org/047jxj944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210141595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Desa Rae Pastore","raw_affiliation_strings":["2Vaccinex, Inc., Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vaccinex, Inc., Rochester, NY;","institution_ids":["https://openalex.org/I4210141595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114035061","display_name":"Crystal L. Mallow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141595","display_name":"Vaccinex (United States)","ror":"https://ror.org/047jxj944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210141595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal Mallow","raw_affiliation_strings":["2Vaccinex, Inc., Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vaccinex, Inc., Rochester, NY;","institution_ids":["https://openalex.org/I4210141595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112620955","display_name":"Ernest Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141595","display_name":"Vaccinex (United States)","ror":"https://ror.org/047jxj944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210141595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernest Smith","raw_affiliation_strings":["2Vaccinex, Inc., Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vaccinex, Inc., Rochester, NY;","institution_ids":["https://openalex.org/I4210141595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113937895","display_name":"Andreas Schr\u00f6eder","orcid":"https://orcid.org/0000-0002-3568-1358","observed_orcids":["https://orcid.org/0000-0002-3568-1358"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Schr\u00f6eder","raw_affiliation_strings":["3Merck KGaA, Darmstadt, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Merck KGaA, Darmstadt, Germany;","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050974773","display_name":"Kevin M. Chin","orcid":"https://orcid.org/0000-0002-5062-4159","observed_orcids":["https://orcid.org/0000-0002-5062-4159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Chin","raw_affiliation_strings":["4EMD Serono, Billerica, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4EMD Serono, Billerica, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036970226","display_name":"Michael Rahman Shafique","orcid":"https://orcid.org/0000-0003-4232-7629","observed_orcids":["https://orcid.org/0000-0003-4232-7629"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Shafique","raw_affiliation_strings":["5Moffitt Cancer Center, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Moffitt Cancer Center, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065056301","display_name":"Thaddeus Beck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107699","display_name":"Highlands Oncology Group","ror":"https://ror.org/01k1j7593","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210107699"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thaddeus Beck","raw_affiliation_strings":["6Highlands Oncology Group, Fayetteville, AR;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Highlands Oncology Group, Fayetteville, AR;","institution_ids":["https://openalex.org/I4210107699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019666128","display_name":"Megan Ann Baumgart","orcid":"https://orcid.org/0000-0002-1122-3934","observed_orcids":["https://orcid.org/0000-0002-1122-3934"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan A. Baumgart","raw_affiliation_strings":["7University of Rochester, Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7University of Rochester, Rochester, NY;","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068824818","display_name":"Ramaswamy Govindan","orcid":"https://orcid.org/0000-0002-6964-9612","observed_orcids":["https://orcid.org/0000-0002-6964-9612"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramaswamy Govindan","raw_affiliation_strings":["8Washington University School of Medicine, St. Louis, MO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Washington University School of Medicine, St. Louis, MO;","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111512954","display_name":"Nashat Y. Gabrail","orcid":"https://orcid.org/0009-0007-3885-3622","observed_orcids":["https://orcid.org/0009-0007-3885-3622"]},"institutions":[{"id":"https://openalex.org/I4210100169","display_name":"Gabrail Cancer Center","ror":"https://ror.org/015hpqr35","country_code":"US","type":"other","lineage":["https://openalex.org/I4210100169"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nashat Gabrail","raw_affiliation_strings":["9Gabrail Cancer Center, Canton, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Gabrail Cancer Center, Canton, OH;","institution_ids":["https://openalex.org/I4210100169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005462156","display_name":"Rachel E. Sanborn","orcid":"https://orcid.org/0000-0003-0542-6054","observed_orcids":["https://orcid.org/0000-0003-0542-6054"]},"institutions":[{"id":"https://openalex.org/I2801670537","display_name":"Providence Portland Medical Center","ror":"https://ror.org/015tmw922","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801670537","https://openalex.org/I4210160466","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel E. Sanborn","raw_affiliation_strings":["10Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR;","institution_ids":["https://openalex.org/I2801670537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044613951","display_name":"Alexander I. Spira","orcid":"https://orcid.org/0000-0003-1303-0447","observed_orcids":["https://orcid.org/0000-0003-1303-0447"]},"institutions":[{"id":"https://openalex.org/I4210122908","display_name":"Virginia Cancer Specialists","ror":"https://ror.org/03tbabt10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122908"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander I. Spira","raw_affiliation_strings":["11Virginia Cancer Center Specialists, Fairfax, VA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Virginia Cancer Center Specialists, Fairfax, VA;","institution_ids":["https://openalex.org/I4210122908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020651485","display_name":"Nagashree Seetharamu","orcid":"https://orcid.org/0000-0002-3282-7622","observed_orcids":["https://orcid.org/0000-0002-3282-7622"]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nagashree Seetharamu","raw_affiliation_strings":["12Feinstein Institutes for Medical Research, Northwell Health, Lake Success, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Feinstein Institutes for Medical Research, Northwell Health, Lake Success, NY;","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034847496","display_name":"Yanyan Lou","orcid":"https://orcid.org/0000-0001-6207-9461","observed_orcids":["https://orcid.org/0000-0001-6207-9461"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanyan Lou","raw_affiliation_strings":["13Mayo Clinic, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Mayo Clinic, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron S. Mansfield","raw_affiliation_strings":["14Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089699061","display_name":"Maurice Zauderer","orcid":"https://orcid.org/0000-0002-4253-9165","observed_orcids":["https://orcid.org/0000-0002-4253-9165"]},"institutions":[{"id":"https://openalex.org/I4210141595","display_name":"Vaccinex (United States)","ror":"https://ror.org/047jxj944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210141595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurice Zauderer","raw_affiliation_strings":["2Vaccinex, Inc., Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vaccinex, Inc., Rochester, NY;","institution_ids":["https://openalex.org/I4210141595"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"CT191","last_page":"CT191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sema4d","display_name":"Sema4D","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cd100","display_name":"CD100","score":0.8870000243186951},{"id":"https://openalex.org/keywords/avelumab","display_name":"avelumab","score":0.9950000047683716},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.7609999775886536},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.6370000243186951},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.7139999866485596},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.968999981880188},{"id":"https://openalex.org/keywords/immune-exclusion","display_name":"immune exclusion","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C2777381376","wikidata":"https://www.wikidata.org/wiki/Q21083261","display_name":"Avelumab","level":5,"score":0.8310142755508423},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.773991584777832},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5978724956512451},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5921266078948975},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.584489107131958},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5688799023628235},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.564862072467804},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.5216184854507446},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.46229785680770874},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2900059223175049},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2320738136768341},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22157350182533264}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-ct191","doi":"https://doi.org/10.1158/1538-7445.am2020-ct191","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-ct191","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3004737080","https://openalex.org/W2947632533","https://openalex.org/W2955938239","https://openalex.org/W3030070008","https://openalex.org/W3139770254","https://openalex.org/W3023170783","https://openalex.org/W2912605442","https://openalex.org/W4388047857","https://openalex.org/W2954569329","https://openalex.org/W4220706025"],"abstract_inverted_index":{"Abstract":[0],"Despite":[1],"progress":[2],"of":[3,9,25,34,42,78,92,104,109,132,218,246,264,280,308,320,332,399,412,416],"immune":[4,35,84,95],"checkpoint":[5,87],"therapies,":[6],"many":[7],"cases":[8],"non-small":[10],"cell":[11,49,255],"lung":[12],"cancer":[13],"(NSCLC)":[14],"are":[15],"refractory":[16],"or":[17,156,262,273,285,294],"acquire":[18],"resistance":[19,32,196],"to":[20,54,82,125,175,197,289],"current":[21],"therapies.":[22],"Antibody":[23],"blockade":[24],"semaphorin":[26],"4D":[27],"(SEMA4D,":[28],"CD100)":[29],"can":[30],"overcome":[31],"mechanisms":[33],"exclusion":[36],"and":[37,51,130,150,167,190,209,230,248,301,315,335,427],"myeloid":[38,337],"suppression.":[39],"Importantly,":[40],"combinations":[41],"anti-SEMA4D":[43],"with":[44,80,89,136,141,188,200,258,260,271,292,404],"various":[45],"immunotherapies":[46],"enhanced":[47],"T":[48,254],"infiltration":[50],"activity,":[52],"leading":[53],"durable":[55,215],"tumor":[56,94,192,265],"regression":[57],"in":[58,134,138,266,402,406],"preclinical":[59],"models.":[60],"Pepinemab":[61],"(VX15/2503)":[62,401],"is":[63,123,299,312],"a":[64],"first-in-class":[65],"humanized":[66],"monoclonal":[67],"antibody":[68],"targeting":[69],"SEMA4D.":[70],"The":[71,239],"CLASSICAL-Lung":[72,111],"clinical":[73,216,234,318,324],"trial":[74],"tests":[75],"the":[76,93,105,110,127,306,413,417],"combination":[77,121,135,307,403],"pepinemab":[79,133,309,400],"avelumab":[81,137,311,405],"couple":[83],"activation":[85],"via":[86,97],"inhibition":[88],"beneficial":[90],"modifications":[91],"microenvironment":[96],"pepinemab.":[98],"Here,":[99],"we":[100],"present":[101],"interim":[102,303],"results":[103,393],"Phase":[106],"2":[107,182],"portion":[108],"study.":[112],"This":[113],"phase":[114,396],"1b/2,":[115],"open":[116],"label,":[117],"single":[118],"arm,":[119],"first-in-human":[120],"study":[122,398],"designed":[124],"evaluate":[126],"safety,":[128],"tolerability":[129],"efficacy":[131],"62":[139],"subjects":[140,270],"advanced":[142,407],"stage":[143],"(IIIB/IV)":[144],"NSCLC,":[145],"including":[146],"immunotherapy-na\u00efve":[147],"(ION)":[148],"patients":[149,151,204,213,232,281],"whose":[152],"tumors":[153,291],"progressed":[154],"during":[155],"following":[157,194],"immunotherapy":[158],"(IOF).":[159],"Dose":[160],"escalation":[161],"was":[162,243,276],"successfully":[163],"completed,":[164],"presented":[165],"previously,":[166],"no":[168],"concerning":[169],"safety":[170],"signals":[171,319],"have":[172,290],"been":[173],"identified":[174],"date.":[176],"Among":[177,222],"29":[178],"evaluable":[179,224],"IOF":[180],"patients,":[181,226],"experienced":[183,205,228,283],"confirmed":[184],"partial":[185],"response":[186,325],"(PR)":[187],"66%":[189],"52%":[191],"reduction":[193,261],"acquired":[195],"prior":[198],"treatment":[199],"pembrolizumab,":[201],"15":[202],"additional":[203,330],"stable":[206],"disease":[207,240],"(SD),":[208],"at":[210],"least":[211],"7":[212],"had":[214,233],"benefit":[217,235],"\u2265":[219,236],"23":[220],"weeks.":[221],"21":[223],"ION":[225],"5":[227],"PR,":[229],"3":[231],"1":[237],"year.":[238],"control":[241],"rate":[242],"81%.":[244],"Analysis":[245],"pre-":[247],"on-treatment":[249],"biopsies":[250,268],"demonstrated":[251],"increased":[252],"CD8+":[253],"density":[256],"correlating":[257],"response,":[259],"elimination":[263],"10/11":[267],"from":[269,394],"PR":[272,284],"SD.":[274],"It":[275],"notable":[277],"that":[278],"79%":[279],"who":[282],"SD":[286],"were":[287],"reported":[288],"negative":[293],"low":[295],"PD-L1":[296],"expression.":[297],"Enrollment":[298],"complete":[300],"this":[302],"analysis":[304],"suggest":[305],"plus":[310],"well":[313,328],"tolerated":[314],"shows":[316],"initial":[317],"antitumor":[321],"activity.":[322],"Updated":[323],"data,":[326],"as":[327,329],"immunophenotyping":[331],"both":[333],"inflammatory":[334],"suppressive":[336],"cells":[338],"will":[339],"be":[340],"presented.":[341],"Citation":[342],"Format:":[343],"Jonathan":[344],"W.":[345],"Goldman,":[346],"Terrence":[347],"L.":[348],"Fisher,":[349],"Elizabeth":[350],"Evans,":[351],"John":[352],"E.":[353,378],"Leonard,":[354],"Desa":[355],"Rae":[356],"Pastore,":[357],"Crystal":[358],"Mallow,":[359],"Ernest":[360],"Smith,":[361],"Andreas":[362],"Schr\u00f6eder,":[363],"Kevin":[364],"Chin,":[365],"Michael":[366],"Shafique,":[367],"Thaddeus":[368],"Beck,":[369],"Megan":[370],"A.":[371],"Baumgart,":[372],"Ramaswamy":[373],"Govindan,":[374],"Nashat":[375],"Gabrail,":[376],"Rachel":[377],"Sanborn,":[379],"Alexander":[380],"I.":[381],"Spira,":[382],"Nagashree":[383],"Seetharamu,":[384],"Yanyan":[385],"Lou,":[386],"Aaron":[387],"S.":[388],"Mansfield,":[389],"Maurice":[390],"Zauderer.":[391],"Interim":[392],"CLASSICAL-Lung,":[395],"1b/2":[397],"NSCLC":[408],"[abstract].":[409],"In:":[410],"Proceedings":[411],"Annual":[414],"Meeting":[415],"American":[418],"Association":[419],"for":[420],"Cancer":[421,433],"Research":[422],"2020;":[423],"2020":[424],"Apr":[425],"27-28":[426],"Jun":[428],"22-24.":[429],"Philadelphia":[430],"(PA):":[431],"AACR;":[432],"Res":[434],"2020;80(16":[435],"Suppl):Abstract":[436],"nr":[437],"CT191.":[438]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2020-09-11T00:00:00"}