{"id":"https://openalex.org/W3083461972","doi":"https://doi.org/10.1021/acschembio.0c00495","title":"Advancements in Assay Technologies and Strategies to Enable Drug Discovery","display_name":"Advancements in Assay Technologies and Strategies to Enable Drug Discovery","publication_year":2020,"publication_date":"2020-09-03","ids":{"openalex":"https://openalex.org/W3083461972","doi":"https://doi.org/10.1021/acschembio.0c00495","mag":"3083461972","pmid":"https://pubmed.ncbi.nlm.nih.gov/32880443"},"language":"en","primary_location":{"id":"doi:10.1021/acschembio.0c00495","doi":"https://doi.org/10.1021/acschembio.0c00495","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.0c00495","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058863432","display_name":"Scott A. Busby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott A. Busby","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072311415","display_name":"Seth Carbonneau","orcid":"https://orcid.org/0000-0002-0827-3850","observed_orcids":["https://orcid.org/0000-0002-0827-3850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seth Carbonneau","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063436470","display_name":"John B. Concannon","orcid":"https://orcid.org/0000-0001-6727-0265","observed_orcids":["https://orcid.org/0000-0001-6727-0265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Concannon","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005847343","display_name":"Christoph E. Dumelin","orcid":"https://orcid.org/0009-0004-1687-0964","observed_orcids":["https://orcid.org/0009-0004-1687-0964"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christoph E. Dumelin","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054893291","display_name":"YounKyoung Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YounKyoung Lee","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037427036","display_name":"Shin Numao","orcid":"https://orcid.org/0000-0002-6204-7117","observed_orcids":["https://orcid.org/0000-0002-6204-7117"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Shin Numao","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6204-7117","affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077087082","display_name":"Nicole Renaud","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Renaud","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044471951","display_name":"Thomas M. Smith","orcid":"https://orcid.org/0000-0001-6343-2490","observed_orcids":["https://orcid.org/0000-0001-6343-2490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas M. Smith","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005522334","display_name":"Douglas S. Auld","orcid":"https://orcid.org/0000-0002-8164-9375","observed_orcids":["https://orcid.org/0000-0002-8164-9375"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Douglas S. Auld","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0002-8164-9375","affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, Massachusetts, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005522334"],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.325,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.34733894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"15","issue":"10","first_page":"2636","last_page":"2648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.18490000069141388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.875},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.7570000290870667},{"id":"https://openalex.org/keywords/microtiter-plates","display_name":"microplates","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cell-based-assays","display_name":"cell-based assays","score":0.40799999237060547},{"id":"https://openalex.org/keywords/biochemical-tests","display_name":"biochemical tests","score":0.796999990940094},{"id":"https://openalex.org/keywords/lead-identification","display_name":"lead compound identification","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.8505719304084778},{"id":"https://openalex.org/C2778810118","wikidata":"https://www.wikidata.org/wiki/Q534260","display_name":"Microtiter plate","level":2,"score":0.6373632550239563},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.5672997236251831},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5244688987731934},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5064090490341187},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48781755566596985},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4858243465423584},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.45602530241012573},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.44776424765586853},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4339714050292969},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.36758238077163696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2762144207954407},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.24925574660301208},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16507312655448914},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1181880533695221},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acschembio.0c00495","doi":"https://doi.org/10.1021/acschembio.0c00495","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.0c00495","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},{"id":"pmid:32880443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32880443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:oak.novartis.com:42877","doi":null,"is_oa":false,"landing_page_url":"https://oak.novartis.com/42877/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400709","display_name":"The Novartis Repository (Novartis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1283582996","host_organization_name":"Novartis (Switzerland)","host_organization_lineage":["https://openalex.org/I1283582996"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W1496719976","https://openalex.org/W1752612204","https://openalex.org/W1965300532","https://openalex.org/W1970877840","https://openalex.org/W1987877938","https://openalex.org/W1992843052","https://openalex.org/W1993096939","https://openalex.org/W1996929582","https://openalex.org/W1997952190","https://openalex.org/W2000212055","https://openalex.org/W2010993054","https://openalex.org/W2011922425","https://openalex.org/W2011987685","https://openalex.org/W2013614403","https://openalex.org/W2013655852","https://openalex.org/W2045048112","https://openalex.org/W2046398049","https://openalex.org/W2046588282","https://openalex.org/W2059292790","https://openalex.org/W2063061148","https://openalex.org/W2065915163","https://openalex.org/W2106776993","https://openalex.org/W2108236403","https://openalex.org/W2123061071","https://openalex.org/W2146851716","https://openalex.org/W2149761888","https://openalex.org/W2150886255","https://openalex.org/W2165137909","https://openalex.org/W2226712470","https://openalex.org/W2254560754","https://openalex.org/W2315050993","https://openalex.org/W2322059219","https://openalex.org/W2335877792","https://openalex.org/W2340102874","https://openalex.org/W2340749976","https://openalex.org/W2341721391","https://openalex.org/W2399229449","https://openalex.org/W2461509262","https://openalex.org/W2468923062","https://openalex.org/W2498090354","https://openalex.org/W2530737230","https://openalex.org/W2544638187","https://openalex.org/W2560677837","https://openalex.org/W2573369749","https://openalex.org/W2593430295","https://openalex.org/W2597045666","https://openalex.org/W2604618525","https://openalex.org/W2729885816","https://openalex.org/W2742751028","https://openalex.org/W2743877237","https://openalex.org/W2752127712","https://openalex.org/W2754886024","https://openalex.org/W2774836366","https://openalex.org/W2783268592","https://openalex.org/W2794011199","https://openalex.org/W2794301983","https://openalex.org/W2796931681","https://openalex.org/W2799435340","https://openalex.org/W2805554722","https://openalex.org/W2806044795","https://openalex.org/W2809247499","https://openalex.org/W2888598609","https://openalex.org/W2903061871","https://openalex.org/W2903559391","https://openalex.org/W2903979853","https://openalex.org/W2907810295","https://openalex.org/W2910480257","https://openalex.org/W2921000810","https://openalex.org/W2927939151","https://openalex.org/W2941297394","https://openalex.org/W2944727022","https://openalex.org/W2944838708","https://openalex.org/W2944922217","https://openalex.org/W2949862037","https://openalex.org/W2950206253","https://openalex.org/W2955168413","https://openalex.org/W2955373190","https://openalex.org/W2959350436","https://openalex.org/W2967052368","https://openalex.org/W2967228716","https://openalex.org/W2980809860","https://openalex.org/W2990669650","https://openalex.org/W2998120965","https://openalex.org/W3002840490","https://openalex.org/W3003178516","https://openalex.org/W3005037397","https://openalex.org/W3006420827","https://openalex.org/W3043969900"],"related_works":["https://openalex.org/W2092399057","https://openalex.org/W4246707311","https://openalex.org/W4235875277","https://openalex.org/W2038792302","https://openalex.org/W2046588282","https://openalex.org/W2069812548","https://openalex.org/W2567632938","https://openalex.org/W1491966819","https://openalex.org/W2182809905","https://openalex.org/W2019023166"],"abstract_inverted_index":{"Assays":[0],"drive":[1],"drug":[2,13,26,106,141,160],"discovery":[3,27],"from":[4,46],"the":[5,9,71,84,96],"exploratory":[6],"phases":[7],"to":[8,24,56,69,136,154],"clinical":[10],"testing":[11,72],"of":[12,33,73,86,98,100,121],"candidates.":[14],"As":[15],"such,":[16],"numerous":[17],"assay":[18,133,152],"technologies":[19,134],"and":[20,31,40,43],"methodologies":[21],"have":[22,53],"arisen":[23],"support":[25,70,95],"efforts.":[28],"Robust":[29],"identification":[30],"characterization":[32],"tractable":[34],"chemical":[35],"matter":[36],"requires":[37],"biochemical,":[38],"biophysical,":[39],"cellular":[41],"approaches":[42],"often":[44],"benefits":[45],"high-throughput":[47,132],"methods.":[48],"To":[49],"increase":[50],"throughput,":[51],"efforts":[52,81],"been":[54,83],"made":[55],"provide":[57,145],"assays":[58],"in":[59,66,131],"miniaturized":[60],"volumes":[61],"which":[62],"can":[63,94],"be":[64],"arrayed":[65],"microtiter":[67,87],"plates":[68],"as":[74,76,108,110],"many":[75],"100,000":[77],"samples/day.":[78],"Alongside":[79],"these":[80],"has":[82],"growth":[85],"plate-free":[88],"formats":[89,116],"with":[90],"encoded":[91],"libraries":[92],"that":[93],"screening":[97],"billions":[99],"compounds,":[101],"a":[102],"hunt":[103],"for":[104,140,149,159],"new":[105],"modalities,":[107],"well":[109],"emphasis":[111],"on":[112,128,147],"more":[113],"disease":[114,122],"relevant":[115],"using":[117],"complex":[118],"cell":[119],"models":[120],"states.":[123],"This":[124],"review":[125],"will":[126],"focus":[127],"recent":[129],"developments":[130],"applied":[135],"identify":[137],"starting":[138],"points":[139],"discovery.":[142],"We":[143],"also":[144],"recommendations":[146],"strategies":[148],"implementing":[150],"various":[151],"types":[153],"select":[155],"high":[156],"quality":[157],"leads":[158],"development.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-09-11T00:00:00"}