{"id":"https://openalex.org/W3083461696","doi":"https://doi.org/10.1158/1538-7445.am2020-4163","title":"Abstract 4163: Clinical proteomics for patient stratification - a GCLP quantitative mass spectrometry workflow for multiplexed measurement of protein biomarkers in FFPE tissues","display_name":"Abstract 4163: Clinical proteomics for patient stratification - a GCLP quantitative mass spectrometry workflow for multiplexed measurement of protein biomarkers in FFPE tissues","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083461696","doi":"https://doi.org/10.1158/1538-7445.am2020-4163","mag":"3083461696"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-4163","doi":"https://doi.org/10.1158/1538-7445.am2020-4163","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-4163","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113787504","display_name":"Maxim Isabelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100264","display_name":"Caprion (Canada)","ror":"https://ror.org/017d1a722","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210100264"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Maxim Isabelle","raw_affiliation_strings":["Caprion Biosciences, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caprion Biosciences, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210100264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011910804","display_name":"Michael Schirm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100264","display_name":"Caprion (Canada)","ror":"https://ror.org/017d1a722","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210100264"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Schirm","raw_affiliation_strings":["Caprion Biosciences, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caprion Biosciences, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210100264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046748776","display_name":"Gw\u00ebna\u00ebl Pottiez","orcid":"https://orcid.org/0000-0001-8485-4510","observed_orcids":["https://orcid.org/0000-0001-8485-4510"]},"institutions":[{"id":"https://openalex.org/I4210100264","display_name":"Caprion (Canada)","ror":"https://ror.org/017d1a722","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210100264"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gwenael Pottiez","raw_affiliation_strings":["Caprion Biosciences, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caprion Biosciences, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210100264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085472948","display_name":"Rudolf Guilbaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100264","display_name":"Caprion (Canada)","ror":"https://ror.org/017d1a722","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210100264"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rudolf Guilbaud","raw_affiliation_strings":["Caprion Biosciences, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caprion Biosciences, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210100264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007396674","display_name":"Lorella Di Donato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100264","display_name":"Caprion (Canada)","ror":"https://ror.org/017d1a722","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210100264"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lorella Di Donato","raw_affiliation_strings":["Caprion Biosciences, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caprion Biosciences, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210100264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210100264"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"4163","last_page":"4163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinical-proteomics","display_name":"clinical proteomics","score":0.7139999866485596},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.8659999966621399},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.800000011920929},{"id":"https://openalex.org/keywords/breast-tumors","display_name":"breast tumors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/biomarker-driven-clinical-trials","display_name":"biomarker-driven clinical trials","score":0.6029999852180481},{"id":"https://openalex.org/keywords/targeted-proteomics","display_name":"targeted proteomics","score":0.3490000069141388},{"id":"https://openalex.org/keywords/analytical-method-validation","display_name":"analytical method validation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/macrodissection","display_name":"macrodissection","score":0.7919999957084656},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.7059999704360962},{"id":"https://openalex.org/keywords/assay-sensitivity-and-precision","display_name":"assay sensitivity and precision","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7529502511024475},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.6565873026847839},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.5915209054946899},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5013101100921631},{"id":"https://openalex.org/C71043704","wikidata":"https://www.wikidata.org/wiki/Q17144692","display_name":"Selected reaction monitoring","level":4,"score":0.5003290176391602},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.47548186779022217},{"id":"https://openalex.org/C154020017","wikidata":"https://www.wikidata.org/wiki/Q520171","display_name":"Repeatability","level":2,"score":0.44077083468437195},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4236501455307007},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.3653848171234131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3412349224090576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3355891704559326},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2881855368614197},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25340932607650757},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.24591010808944702},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08325314521789551},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-4163","doi":"https://doi.org/10.1158/1538-7445.am2020-4163","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-4163","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3105595935","https://openalex.org/W2076138205","https://openalex.org/W4296984496","https://openalex.org/W2486429036","https://openalex.org/W2989956260","https://openalex.org/W1992396342","https://openalex.org/W2922526544","https://openalex.org/W3088602607","https://openalex.org/W2907760340","https://openalex.org/W2132095517"],"abstract_inverted_index":{"Abstract":[0],"a)":[1],"The":[2],"advent":[3],"of":[4,19,23,55,98,160,178,207,235,250,258,288,295,334,350,367,378,409,418,422],"precision":[5,292],"oncology":[6],"has":[7,77],"led":[8],"a":[9,175,248,255,291,400],"shift":[10],"towards":[11],"biomarker-driven":[12],"clinical":[13,42,84,108,332,376],"trial":[14],"designs":[15],"and":[16,65,95,155,214,233,293,344,347,373,433],"molecular":[17],"profiling":[18],"individual":[20],"patients.":[21],"Identification":[22],"patients":[24],"with":[25,196,204,254,268,290],"the":[26,91,132,271,304,419,423],"target":[27,170],"biomarker":[28,56,105,125,151],"profile":[29],"may":[30],"be":[31,129,361],"useful":[32],"in":[33,58,107,136,163,270,312,339,412],"guiding":[34],"patient":[35,364,397],"selection":[36],"as":[37,143,174,324],"an":[38,118],"enrichment":[39],"strategy":[40],"for":[41,52,103,157,201,363,396,406,426],"trials.":[43,85],"Targeted":[44],"multiple":[45],"reaction":[46],"monitoring":[47],"mass":[48,403],"spectrometry":[49,404],"(MRM-MS)":[50],"analysis":[51,113,333],"multiplexed":[53,100,158,330,407],"quantitation":[54,159,349],"proteins":[57,126,351],"FFPE":[59,109,137,184,318,340,413],"tissue":[60,185,341],"provides":[61],"direct,":[62],"more":[63],"accurate":[64,348],"precise":[66,346],"quantification":[67,106],"over":[68,283,297],"current":[69],"\u2018gold":[70],"standard'":[71],"immunohistochemistry":[72],"(IHC)":[73],"methods.":[74],"However,":[75],"MRM-MS":[76,101,150,305,338],"not":[78],"yet":[79],"been":[80],"broadly":[81],"applied":[82],"to":[83,198,285,309,374],"In":[86,301],"this":[87],"study,":[88],"we":[89],"demonstrate":[90],"systematic":[92],"development,":[93],"optimization":[94,366],"analytical":[96],"validation":[97,219],"quantitative,":[99],"assays":[102],"robust":[104],"tissues,":[110,246],"including":[111,131,226,247],"sample":[112,302],"under":[114],"GCLP.":[115],"Results":[116],"from":[117,168,183,317],"MRM":[119],"panel":[120],"targeting":[121],"8":[122],"clinically":[123],"relevant":[124],"will":[127],"also":[128],"shown,":[130],"measured":[133],"HER2":[134,259,311],"levels":[135,206],"breast":[138,251,319],"tumors":[139],"classified":[140,321],"by":[141,216,322,337],"IHC":[142,323,353],"0,":[144],"1+,":[145],"2+":[146],"or":[147,192,357],"3+.":[148],"b)":[149],"panels":[152],"were":[153,172,187,265],"developed":[154],"optimized":[156],"\u226412":[161],"proteins,":[162],"which":[164],"unique":[165],"peptides":[166,200],"derived":[167],"each":[169],"protein":[171,179,275,316,335,410],"monitored":[173],"surrogate":[176],"measure":[177],"levels.":[180],"Tumor":[181],"regions":[182],"sections":[186],"dissected":[188],"using":[189,242],"laser":[190],"capture":[191],"macrodissection,":[193],"solubilized,":[194],"digested":[195],"trypsin":[197],"generate":[199],"analysis,":[202,303],"spiked":[203],"fixed":[205],"stable":[208],"isotope":[209],"labeled":[210],"(SIL)":[211],"peptide":[212],"standards,":[213],"analyzed":[215],"MRM-MS.":[217],"Analytical":[218],"was":[220,240,281,306],"performed":[221],"per":[222],"NCI":[223],"CPTAC":[224],"guidelines,":[225],"response":[227],"curves,":[228],"assay":[229,279],"repeatability,":[230],"selectivity,":[231],"stability,":[232],"reproducibility":[234],"endogenous":[236],"detection.":[237],"Clinical":[238,394],"performance":[239,263],"assessed":[241],"commercially":[243],"sourced":[244],"FFPE-tumor":[245],"cohort":[249],"tumor":[252,320],"tissues":[253,414],"wide":[256],"range":[257],"expression.":[260],"c)":[261],"Assay":[262],"results":[264],"protein/peptide":[266],"dependent,":[267],"sensitivity":[269],"low":[272],"pg/\u03bcg":[273],"total":[274,315],"range.":[276],"For":[277],"HER2,":[278],"linearity":[280],"demonstrated":[282],"2.5":[284],"3":[286,298],"orders":[287],"magnitude,":[289],"accuracy":[294],"<15%":[296],"independent":[299],"runs.":[300],"sufficiently":[307],"sensitive":[308],"detect":[310],"1":[313],"\u03bcg":[314],"negative":[325],"(0).":[326],"d)":[327],"GCLP-compliant":[328],"quantitative":[329,402],"large-scale":[331],"biomarkers":[336,411],"is":[342],"feasible":[343],"enables":[345],"when":[352],"methods":[354],"are":[355],"unsuitable":[356],"unavailable.":[358],"Data":[359],"can":[360],"used":[362],"stratification,":[365],"treatment":[368],"outcomes,":[369],"drug":[370],"resistance":[371],"prediction,":[372],"support":[375],"development":[377],"novel":[379],"therapies.":[380],"Citation":[381],"Format:":[382],"Maxim":[383],"Isabelle,":[384],"Michael":[385],"Schirm,":[386],"Gwenael":[387],"Pottiez,":[388],"Rudolf":[389],"Guilbaud,":[390],"Lorella":[391],"Di":[392],"Donato.":[393],"proteomics":[395],"stratification":[398],"-":[399],"GCLP":[401],"workflow":[405],"measurement":[408],"[abstract].":[415],"In:":[416],"Proceedings":[417],"Annual":[420],"Meeting":[421],"American":[424],"Association":[425],"Cancer":[427,439],"Research":[428],"2020;":[429],"2020":[430],"Apr":[431],"27-28":[432],"Jun":[434],"22-24.":[435],"Philadelphia":[436],"(PA):":[437],"AACR;":[438],"Res":[440],"2020;80(16":[441],"Suppl):Abstract":[442],"nr":[443],"4163.":[444]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2020-09-11T00:00:00"}
