{"id":"https://openalex.org/W3083430232","doi":"https://doi.org/10.1158/1538-7445.am2020-3662","title":"Abstract 3662: FiTAc-seq: Fixed-Tissue ChIP-seq for H3K27Ac profiling and super-enhancer analysis on FFPE tissues","display_name":"Abstract 3662: FiTAc-seq: Fixed-Tissue ChIP-seq for H3K27Ac profiling and super-enhancer analysis on FFPE tissues","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083430232","doi":"https://doi.org/10.1158/1538-7445.am2020-3662","mag":"3083430232"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-3662","doi":"https://doi.org/10.1158/1538-7445.am2020-3662","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-3662","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005699273","display_name":"Alba Font\u2010Tello","orcid":"https://orcid.org/0000-0002-7501-2888","observed_orcids":["https://orcid.org/0000-0002-7501-2888"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alba Font-Tello","raw_affiliation_strings":["1Dana Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061194798","display_name":"Nikolas Kesten","orcid":"https://orcid.org/0000-0002-9183-8778","observed_orcids":["https://orcid.org/0000-0002-9183-8778"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolas Kesten","raw_affiliation_strings":["1Dana Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059400884","display_name":"Yingtian Xie","orcid":"https://orcid.org/0000-0003-0206-457X","observed_orcids":["https://orcid.org/0000-0003-0206-457X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingtian Xie","raw_affiliation_strings":["1Dana Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055277353","display_name":"Len Taing","orcid":"https://orcid.org/0000-0001-7453-5372","observed_orcids":["https://orcid.org/0000-0001-7453-5372"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Len Taing","raw_affiliation_strings":["1Dana Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074756323","display_name":"Joaquim Bellmunt B","orcid":"https://orcid.org/0000-0003-2328-3421","observed_orcids":["https://orcid.org/0000-0003-2328-3421","https://orcid.org/0000-0001-7569-7074"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joaquim Bellmunt","raw_affiliation_strings":["2Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033532061","display_name":"Myles A Brown","orcid":"https://orcid.org/0000-0002-8213-1658","observed_orcids":["https://orcid.org/0000-0002-8213-1658"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myles Brown","raw_affiliation_strings":["1Dana Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006519575","display_name":"Paloma Cejas","orcid":"https://orcid.org/0000-0002-2090-7748","observed_orcids":["https://orcid.org/0000-0002-2090-7748"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paloma Cejas","raw_affiliation_strings":["1Dana Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066070097","display_name":"Henry W. Long","orcid":"https://orcid.org/0000-0001-6849-6629","observed_orcids":["https://orcid.org/0000-0001-6849-6629"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Long","raw_affiliation_strings":["1Dana Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"3662","last_page":"3662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.8949999809265137},{"id":"https://openalex.org/keywords/super-enhancers","display_name":"super-enhancers","score":0.8309999704360962},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.6759999990463257},{"id":"https://openalex.org/keywords/tissue-homogenization","display_name":"tissue homogenization","score":0.7070000171661377},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/tumor-classification","display_name":"tumor classification","score":0.44999998807907104},{"id":"https://openalex.org/keywords/lineage-specific-transcription-factors","display_name":"lineage-specific transcription factors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/breast-cancer-brain-metastases","display_name":"breast cancer brain metastasis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.9169999957084656},{"id":"https://openalex.org/keywords/seminoma","display_name":"seminoma","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.7680282592773438},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6133853793144226},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.595636785030365},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5855608582496643},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.5456737279891968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5401280522346497},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5383582711219788},{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.4428461492061615},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3737655282020569},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.354015976190567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3121371269226074},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.252713143825531},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17500248551368713},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15365815162658691}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-3662","doi":"https://doi.org/10.1158/1538-7445.am2020-3662","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-3662","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3037973483","https://openalex.org/W4406722544","https://openalex.org/W2710305884","https://openalex.org/W2344070705","https://openalex.org/W3201022833","https://openalex.org/W6959034113","https://openalex.org/W3157891465","https://openalex.org/W3181465891","https://openalex.org/W6977650963","https://openalex.org/W6977082039"],"abstract_inverted_index":{"Abstract":[0],"FiTAc-seq":[1,104,124,183],"is":[2,19,60,113,184],"an":[3],"epigenetic":[4,191],"method":[5,187],"for":[6,44,55,126,175,189,241,261],"profiling":[7,46,243],"of":[8,130,151,193,204,253,257],"active":[9],"enhancers":[10],"and":[11,77,99,111,119,145,154,207,217,244,268],"promoters":[12],"in":[13,47,87,94],"FFPE":[14,28,195,248],"clinical":[15,196],"samples.":[16,179,197],"The":[17,147,198],"protocol":[18,43],"optimized":[20,62],"to":[21,63,115,163],"generate":[22,116],"high-quality":[23,51,106],"H3K27Ac":[24,65,109,157,242],"ChIP-seq":[25,42,240],"maps":[26],"from":[27],"macrodissected":[29],"or":[30],"cored":[31],"tissues":[32,249],"within":[33],"4":[34],"days.":[35],"We":[36,122,180],"previously":[37],"developed":[38],"FiT-seq,":[39],"a":[40,127,185],"modified":[41,73],"chromatin":[45,52],"FFPE.":[48],"FiT-seq":[49,88],"produces":[50,105],"profiles":[53],"particularly":[54],"methylated":[56],"histone":[57],"marks":[58],"but":[59],"not":[61],"resolve":[64],"signal.":[66],"To":[67],"overcome":[68],"this":[69],"limitation,":[70],"we":[71],"have":[72],"the":[74,82,101,164,176,190,202,254,258],"tissue":[75],"homogenization":[76],"sonication":[78,102],"steps":[79],"by":[80],"replacing":[81],"proteinase":[83],"K":[84],"digestion":[85],"applied":[86],"with":[89,210],"extended":[90],"heating":[91],"at":[92],"65\u00b0C":[93],"more":[95],"stringent":[96],"detergent":[97],"conditions":[98],"minimizing":[100],"step.":[103],"genome":[107],"wide":[108,128],"profiles,":[110],"it":[112],"suitable":[114,188],"enhancer":[117,153,206],"landscapes":[118],"super-enhancer":[120,155,169,245],"annotation.":[121],"demonstrate":[123,181],"applicability":[125],"variety":[129],"human":[131],"tumor":[132,166,178],"types,":[133],"including":[134],"bladder":[135],"cancers,":[136],"breast":[137],"cancer":[138],"brain":[139],"metastasis,":[140],"melanomas,":[141],"pancreatic":[142],"neuroendocrine":[143],"tumors":[144],"seminomas.":[146],"unsupervised":[148],"hierarchical":[149],"analyses":[150],"both":[152],"only":[156],"signal":[158],"clearly":[159],"identify":[160],"clusters":[161],"according":[162],"different":[165],"types.":[167],"Moreover,":[168],"annotation":[170],"shows":[171],"lineage-specific":[172],"transcription":[173],"factors":[174],"distinct":[177],"that":[182],"robust":[186],"interrogation":[192],"archived":[194],"results":[199],"generated":[200],"allow":[201],"identification":[203],"tissue-specific":[205],"SE":[208],"landscapes,":[209],"potential":[211],"immediate":[212],"impact":[213],"on":[214,247],"ongoing":[215],"basic":[216],"translational":[218],"research.":[219],"Citation":[220],"Format:":[221],"Alba":[222],"Font-Tello,":[223],"Nikolas":[224],"Kesten,":[225],"Yingtian":[226],"Xie,":[227],"Len":[228],"Taing,":[229],"Joaquim":[230],"Bellmunt,":[231],"Myles":[232],"Brown,":[233],"Paloma":[234],"Cejas,":[235],"Henry":[236],"Long.":[237],"FiTAc-seq:":[238],"Fixed-Tissue":[239],"analysis":[246],"[abstract].":[250],"In:":[251],"Proceedings":[252],"Annual":[255],"Meeting":[256],"American":[259],"Association":[260],"Cancer":[262,274],"Research":[263],"2020;":[264],"2020":[265],"Apr":[266],"27-28":[267],"Jun":[269],"22-24.":[270],"Philadelphia":[271],"(PA):":[272],"AACR;":[273],"Res":[275],"2020;80(16":[276],"Suppl):Abstract":[277],"nr":[278],"3662.":[279]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2020-09-11T00:00:00"}
