{"id":"https://openalex.org/W3083399692","doi":"https://doi.org/10.1158/1538-7445.am2020-4806","title":"Abstract 4806: SIRT5 inhibition causes increased oxidative stress and impairs tumor progression and metastasis","display_name":"Abstract 4806: SIRT5 inhibition causes increased oxidative stress and impairs tumor progression and metastasis","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083399692","doi":"https://doi.org/10.1158/1538-7445.am2020-4806","mag":"3083399692"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-4806","doi":"https://doi.org/10.1158/1538-7445.am2020-4806","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-4806","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040958718","display_name":"Irma R. Fernandez","orcid":"https://orcid.org/0000-0003-0063-4612","observed_orcids":["https://orcid.org/0000-0003-0063-4612"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irma Fernandez","raw_affiliation_strings":["Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057991607","display_name":"Yashira L. Negr\u00f3n Abril","orcid":"https://orcid.org/0000-0002-5922-9999","observed_orcids":["https://orcid.org/0000-0002-5922-9999"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yashira N. Abril","raw_affiliation_strings":["Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037484762","display_name":"Jun Young Hong","orcid":"https://orcid.org/0000-0002-5257-6525","observed_orcids":["https://orcid.org/0000-0002-5257-6525"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Y. Hong","raw_affiliation_strings":["Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Yang","raw_affiliation_strings":["Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079033898","display_name":"Sushabhan Sadhukhan","orcid":"https://orcid.org/0000-0002-3302-5875","observed_orcids":["https://orcid.org/0000-0002-3302-5875"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sushabhan Sadhukhan","raw_affiliation_strings":["Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001339258","display_name":"Hening Lin","orcid":"https://orcid.org/0000-0002-0255-2701","observed_orcids":["https://orcid.org/0000-0002-0255-2701"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hening Lin","raw_affiliation_strings":["Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103044276","display_name":"Robert S. Weiss","orcid":"https://orcid.org/0000-0003-3327-1379","observed_orcids":["https://orcid.org/0000-0003-3327-1379"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Weiss","raw_affiliation_strings":["Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"4806","last_page":"4806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt5","display_name":"SIRT5","score":0.9900000095367432},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.753000020980835},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5440000295639038},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9350000023841858},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.734000027179718},{"id":"https://openalex.org/keywords/mmtv-pymt-mice","display_name":"MMTV-PyMT mice","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nadph","display_name":"NADPH","score":0.7239999771118164},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.47200000286102295},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.640999972820282},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.43299999833106995},{"id":"https://openalex.org/keywords/succinylation","display_name":"succinylation","score":0.5099999904632568},{"id":"https://openalex.org/keywords/malonylation","display_name":"malonylation","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.7260558605194092},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5639714002609253},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5497737526893616},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5481751561164856},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.5252102017402649},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5170117616653442},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.49825239181518555},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.48293325304985046},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.45126959681510925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42740559577941895},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4208980202674866},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3766661286354065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28692203760147095},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.27851641178131104},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1345522105693817},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.08545544743537903},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-4806","doi":"https://doi.org/10.1158/1538-7445.am2020-4806","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-4806","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1499339123","https://openalex.org/W2487824964","https://openalex.org/W2318647057","https://openalex.org/W2065690661","https://openalex.org/W4304116770","https://openalex.org/W4283771460","https://openalex.org/W2154708791","https://openalex.org/W2044067914","https://openalex.org/W2003068239","https://openalex.org/W3009956259"],"abstract_inverted_index":{"Abstract":[0],"Cancer":[1,312,324],"cells":[2,92,153,179],"undergo":[3],"metabolic":[4,19,53,85,204],"reprogramming,":[5],"producing":[6],"energy":[7],"through":[8,197],"aerobic":[9],"glycolysis":[10],"followed":[11],"by":[12,55,83,194],"lactic":[13],"acid":[14],"fermentation.":[15],"Consequently,":[16],"targeting":[17],"key":[18,203],"enzymes":[20,54],"has":[21,37],"emerged":[22],"as":[23,142,169,262],"a":[24,263],"potential":[25,210],"avenue":[26],"to":[27,121,144,183],"selectively":[28],"inhibit":[29],"tumor":[30,136,229,296],"growth.":[31],"The":[32,44],"sirtuin":[33,46],"family":[34],"of":[35,59,157,165,201,211,225,303,307],"deacylases":[36],"roles":[38],"in":[39,68,89,111,231],"both":[40,232],"metabolism":[41],"and":[42,62,124,138,161,171,217,234,294,298,318],"cancer.":[43,73,269],"mitochondrial":[45],"SIRT5":[47,65,78,87,107,127,145,150,177,188,212,221,226,261,288],"regulates":[48],"protein":[49],"post-translational":[50],"modifications":[51],"on":[52,101],"catalyzing":[56],"the":[57,208,304,308],"removal":[58],"succinyl,":[60],"malonyl,":[61],"glutaryl":[63],"moieties.":[64],"is":[66],"over-expressed":[67],"many":[69],"cancers,":[70],"including":[71],"breast":[72,80,192,236,268],"Therefore,":[74],"we":[75,113,214],"hypothesized":[76],"that":[77,176,187,246],"promotes":[79],"cancer":[81,91,152,193,237],"progression":[82,297],"facilitating":[84],"reprogramming.":[86],"knockdown":[88],"human":[90,235],"inhibited":[93],"anchorage":[94],"independent":[95],"growth":[96,230],"but":[97],"had":[98,132,154],"little":[99],"effect":[100],"non-transformed":[102],"cells.":[103],"To":[104,206],"examine":[105],"how":[106],"loss":[108],"impacts":[109],"tumorigenesis":[110],"vivo,":[112],"utilized":[114],"MMTV-PyMT":[115,130,148],"transgenic":[116,233],"mice,":[117],"which":[118],"are":[119,180,250],"prone":[120],"mammary":[122,228],"adenocarcinoma":[123],"lung":[125,140],"metastasis.":[126],"knockout":[128,248],"(KO)":[129],"mice":[131,249],"increased":[133,291],"survival,":[134],"decreased":[135],"size,":[137],"reduced":[139],"metastases,":[141],"compared":[143],"wild-type":[146],"(WT)":[147],"controls.":[149],"KO":[151,178],"higher":[155],"levels":[156,164],"reactive":[158],"oxygen":[159],"species":[160],"displayed":[162],"lower":[163],"important":[166],"antioxidants":[167],"such":[168],"NADPH":[170],"GSH.":[172],"These":[173],"results":[174],"suggest":[175],"more":[181,200],"susceptible":[182],"oxidative":[184,292],"stress,":[185],"hinting":[186],"may":[189],"be":[190],"promoting":[191],"mitigating":[195],"ROS":[196],"one":[198],"or":[199],"its":[202],"substrates.":[205],"determine":[207],"therapeutic":[209],"inhibition,":[213],"created":[215],"potent":[216],"specific":[218],"small":[219],"molecule":[220],"inhibitors.":[222],"Pharmacological":[223],"inhibition":[224,289],"impaired":[227],"xenograft":[238],"mouse":[239],"models,":[240],"with":[241,253],"no":[242],"apparent":[243],"toxicity.":[244],"Considering":[245],"Sirt5":[247],"generally":[251],"normal,":[252],"only":[254],"mild":[255],"phenotypes":[256],"observed,":[257],"these":[258],"data":[259],"establish":[260],"promising":[264],"target":[265],"for":[266,311],"treating":[267],"Citation":[270],"Format:":[271],"Irma":[272],"Fernandez,":[273],"Yashira":[274],"N.":[275],"Abril,":[276],"Jun":[277,319],"Y.":[278],"Hong,":[279],"Min":[280],"Yang,":[281],"Sushabhan":[282],"Sadhukhan,":[283],"Hening":[284],"Lin,":[285],"Robert":[286],"Weiss.":[287],"causes":[290],"stress":[293],"impairs":[295],"metastasis":[299],"[abstract].":[300],"In:":[301],"Proceedings":[302],"Annual":[305],"Meeting":[306],"American":[309],"Association":[310],"Research":[313],"2020;":[314],"2020":[315],"Apr":[316],"27-28":[317],"22-24.":[320],"Philadelphia":[321],"(PA):":[322],"AACR;":[323],"Res":[325],"2020;80(16":[326],"Suppl):Abstract":[327],"nr":[328],"4806.":[329]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}
