{"id":"https://openalex.org/W3083388079","doi":null,"title":"Gene polymorphisms of uric acid related proteins and the Angiotensin Receptor IV (AT4) in Pre-eclampsia.","display_name":"Gene polymorphisms of uric acid related proteins and the Angiotensin Receptor IV (AT4) in Pre-eclampsia.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3083388079","mag":"3083388079"},"language":"en","primary_location":{"id":"pmh:oai:researchspace.ukzn.ac.za:10413/18644","doi":null,"is_oa":true,"landing_page_url":"https://researchspace.ukzn.ac.za/handle/10413/18644","pdf_url":"https://researchspace.ukzn.ac.za/bitstreams/94a73b0b-9aad-4a60-9c5e-bdc54023abf7/download","source":{"id":"https://openalex.org/S4306402416","display_name":"ResearchSpace (University of KwaZulu-Natal)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95023434","host_organization_name":"University of KwaZulu-Natal","host_organization_lineage":["https://openalex.org/I95023434"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://researchspace.ukzn.ac.za/bitstreams/94a73b0b-9aad-4a60-9c5e-bdc54023abf7/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039888900","display_name":"Olive Pearl Khaliq","orcid":"https://orcid.org/0000-0002-9742-4525","observed_orcids":["https://orcid.org/0000-0002-9742-4525"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Olive P. Khaliq","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9742-4525","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039888900"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.8539999723434448},{"id":"https://openalex.org/keywords/uric-acid-transporters","display_name":"uric acid transporters","score":0.6549999713897705},{"id":"https://openalex.org/keywords/urat1","display_name":"URAT1","score":0.5590000152587891},{"id":"https://openalex.org/keywords/angiotensin-iv-receptor","display_name":"angiotensin IV receptor","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cd13","display_name":"CD13","score":0.8980000019073486},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7739999890327454},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hypertensive-disorders-of-pregnancy","display_name":"hypertensive disorders of pregnancy","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2781276381","wikidata":"https://www.wikidata.org/wiki/Q552348","display_name":"Eclampsia","level":3,"score":0.7215431928634644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49746444821357727},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.46717506647109985},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41675493121147156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36957257986068726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36567187309265137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34417301416397095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32835087180137634},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1247008740901947}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:researchspace.ukzn.ac.za:10413/18644","doi":null,"is_oa":true,"landing_page_url":"https://researchspace.ukzn.ac.za/handle/10413/18644","pdf_url":"https://researchspace.ukzn.ac.za/bitstreams/94a73b0b-9aad-4a60-9c5e-bdc54023abf7/download","source":{"id":"https://openalex.org/S4306402416","display_name":"ResearchSpace (University of KwaZulu-Natal)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95023434","host_organization_name":"University of KwaZulu-Natal","host_organization_lineage":["https://openalex.org/I95023434"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3083388079","doi":null,"is_oa":false,"landing_page_url":"https://researchspace.ukzn.ac.za/handle/10413/18644","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:researchspace.ukzn.ac.za:10413/18644","doi":null,"is_oa":true,"landing_page_url":"https://researchspace.ukzn.ac.za/handle/10413/18644","pdf_url":"https://researchspace.ukzn.ac.za/bitstreams/94a73b0b-9aad-4a60-9c5e-bdc54023abf7/download","source":{"id":"https://openalex.org/S4306402416","display_name":"ResearchSpace (University of KwaZulu-Natal)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95023434","host_organization_name":"University of KwaZulu-Natal","host_organization_lineage":["https://openalex.org/I95023434"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5901762629","display_name":null,"funder_award_id":"DEL-15- 006","funder_id":"https://openalex.org/F4320327323","funder_display_name":"African Academy of Sciences"},{"id":"https://openalex.org/G6617178558","display_name":null,"funder_award_id":"DEL-15-006","funder_id":"https://openalex.org/F4320314707","funder_display_name":"Government of the United Kingdom"},{"id":"https://openalex.org/G6620436759","display_name":null,"funder_award_id":"2020.","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G6675272361","display_name":null,"funder_award_id":"DEL-15-006","funder_id":"https://openalex.org/F4320320672","funder_display_name":"South African Medical Research Council"},{"id":"https://openalex.org/G8547154903","display_name":null,"funder_award_id":"DEL-15-006","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320314707","display_name":"Government of the United Kingdom","ror":"https://ror.org/05wnh3t63"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320672","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320322812","display_name":"Inyuvesi Yakwazulu-Natali","ror":"https://ror.org/04qzfn040"},{"id":"https://openalex.org/F4320323315","display_name":"University of Fukui","ror":"https://ror.org/00msqp585"},{"id":"https://openalex.org/F4320327323","display_name":"African Academy of Sciences","ror":"https://ror.org/05px9k635"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083388079.pdf","grobid_xml":"https://content.openalex.org/works/W3083388079.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W88937860","https://openalex.org/W1485204010","https://openalex.org/W1578063175","https://openalex.org/W1969503055","https://openalex.org/W1976773608","https://openalex.org/W1979372524","https://openalex.org/W1980280179","https://openalex.org/W1984412550","https://openalex.org/W1984960406","https://openalex.org/W1987215808","https://openalex.org/W1989472146","https://openalex.org/W2007257475","https://openalex.org/W2008752479","https://openalex.org/W2014522878","https://openalex.org/W2020938124","https://openalex.org/W2021943936","https://openalex.org/W2033311273","https://openalex.org/W2037320667","https://openalex.org/W2050449537","https://openalex.org/W2054601887","https://openalex.org/W2054625921","https://openalex.org/W2055852713","https://openalex.org/W2057035903","https://openalex.org/W2062965113","https://openalex.org/W2064785203","https://openalex.org/W2070795176","https://openalex.org/W2076002484","https://openalex.org/W2080041227","https://openalex.org/W2082029763","https://openalex.org/W2086526747","https://openalex.org/W2091923451","https://openalex.org/W2092155853","https://openalex.org/W2094275557","https://openalex.org/W2096851082","https://openalex.org/W2100579230","https://openalex.org/W2119906300","https://openalex.org/W2120569080","https://openalex.org/W2123419318","https://openalex.org/W2128934212","https://openalex.org/W2137423632","https://openalex.org/W2139649412","https://openalex.org/W2140665078","https://openalex.org/W2142459107","https://openalex.org/W2144745785","https://openalex.org/W2156980794","https://openalex.org/W2158162966","https://openalex.org/W2161485764","https://openalex.org/W2163926219","https://openalex.org/W2166174569","https://openalex.org/W2169731574","https://openalex.org/W2177303388","https://openalex.org/W2300801594","https://openalex.org/W2306627506","https://openalex.org/W2309194703","https://openalex.org/W2319952567","https://openalex.org/W2329232548","https://openalex.org/W2334720710","https://openalex.org/W2407973961","https://openalex.org/W2411383862","https://openalex.org/W2463603475","https://openalex.org/W2469295949","https://openalex.org/W2505818654","https://openalex.org/W2551625368","https://openalex.org/W2552113214","https://openalex.org/W2557977204","https://openalex.org/W2559229196","https://openalex.org/W2577233327","https://openalex.org/W2614959045","https://openalex.org/W2745175723","https://openalex.org/W2789539482","https://openalex.org/W2791073931","https://openalex.org/W2795490606","https://openalex.org/W2804692877","https://openalex.org/W2895485272","https://openalex.org/W2898385279","https://openalex.org/W2900212853","https://openalex.org/W2900916100","https://openalex.org/W2902051656","https://openalex.org/W2916697167","https://openalex.org/W2916851491","https://openalex.org/W2939306837","https://openalex.org/W2943109517","https://openalex.org/W2955618051","https://openalex.org/W2964465125","https://openalex.org/W2977277006","https://openalex.org/W2990726108","https://openalex.org/W2992969074","https://openalex.org/W2994579297","https://openalex.org/W3021681863"],"related_works":["https://openalex.org/W3014997905","https://openalex.org/W3036849567","https://openalex.org/W2095867490","https://openalex.org/W7100987449","https://openalex.org/W2158938883","https://openalex.org/W2492847083","https://openalex.org/W4412560013","https://openalex.org/W2359614205","https://openalex.org/W2060799770","https://openalex.org/W2073473891"],"abstract_inverted_index":{"Background:":[0],"Hypertensive":[1],"disorders":[2],"of":[3,7,26,31,50,55,66,83,92,103,121,125,165,189,231,248,266,288,295,305,310,320],"pregnancy":[4,27],"remain":[5],"one":[6],"the":[8,19,40,52,56,61,71,81,89,96,104,151,172,183,197,222,243,249,282,286,303,321],"major":[9,46],"contributions":[10],"to":[11,87,109,203,217,238],"maternal":[12,41],"and":[13,16,63,70,100,113,130,139,177,201,221,242,254],"fetal":[14],"morbidity":[15],"mortality":[17],"around":[18],"globe.":[20],"Pre-eclampsia":[21,133],"is":[22,35,60,86],"a":[23,36,45,64,117,228,318],"hypertensive":[24],"disorder":[25,38],"which":[28,126],"complicates":[29],"3-10%":[30],"pregnancies":[32],"worldwide.":[33],"It":[34],"multi-organ":[37],"affecting":[39],"system,":[42],"thereby":[43],"creating":[44],"setback":[47],"in":[48,78,106,199,212,233,273,276,315,325],"terms":[49],"targeting":[51],"aetiology.":[53],"One":[54],"main":[57],"organs":[58],"disrupted":[59],"kidneys":[62],"dysregulation":[65,319],"uric":[67,93,166,296,388,515],"acid":[68,167,297,389,516],"levels":[69,102,188,265,283,309],"renin":[72,322,545],"angiotensin":[73,97,173,190,250,267,311,323,394,465,481,531,546],"system":[74,324,547],"have":[75],"been":[76],"implicated":[77],"pre-eclampsia.":[79,262,289,306,326,477],"Therefore,":[80],"aim":[82],"this":[84],"study":[85,119],"investigate":[88],"gene":[90,462],"polymorphisms":[91,164,247,294,386,463,513],"acid,":[94],"aminopeptidase-N,":[95],"receptor":[98,105,174,191,252,269,395,409,467,483],"IV,":[99],"plasma":[101,264,308],"pre-eclampsia":[107,142,200,215,220,236,241,274,435,440,451,456],"compared":[108,202,216,237],"normotensive":[110,223,244,459],"pregnancies.":[111],"\\nMaterials":[112],"Methods:":[114],"This":[115],"was":[116,134,145,210],"retrospective":[118],"consisting":[120],"637":[122,337],"blood":[123,148,156,377],"samples":[124,149],"280":[127,344],"were":[128,180,193,270],"normotensives":[129],"357":[131],"pre-eclamptic.":[132],"subdivided":[135],"into":[136],"early":[137,218,234,362,438],"(n=187)":[138,363],"late":[140,213,239,365,433,454],"onset":[141,214,219,235,240,366,434,439,450,455],"(n=170).":[143,367],"DNA":[144,158,379],"isolated":[146],"from":[147],"using":[150,182,196],"Thermo":[152,373],"Scientific":[153,374],"GeneJet":[154,375],"whole":[155,376],"Genomic":[157,378],"purification":[159,380],"mini":[160,381],"Kit.":[161,382],"Single":[162,384],"nucleotide":[163,293,385,512],"(rs505802,":[168,298,390,517],"rs1014290,":[169,391],"rs12129861,":[170,392],"rs2231142),":[171,393],"IV":[175,192,251,268,312,396,410,466,482,532],"(rs18059)":[176,253,397,468],"aminopeptidase-N":[178,255,399,471],"(rs6496603)":[179,256,400,472],"amplified":[181],"TaqMan":[184,404],"genotyping":[185,405],"assay.":[186,406],"Plasma":[187],"also":[194,226],"measured":[195],"ELISA":[198],"normotensives.":[204,277],"\\nResults:":[205],"We":[206,225],"found":[207,280],"that":[208,281],"rs505802":[209,430],"higher":[211],"group.":[224,245,460],"observed":[227],"significant":[229,259],"elevation":[230],"rs1014290":[232,448],"Gene":[246],"showed":[257],"no":[258],"association":[260],"with":[261,285,302],"However,":[263],"significantly":[271],"lower":[272],"than":[275],"Furthermore,":[278,307],"we":[279,464],"decreased":[284,314],"severity":[287],"\\nConclusion:":[290],"The":[291],"single":[292,511],"rs1014290)":[299,518],"are":[300,313],"associated":[301],"pathogenesis":[304],"pre-eclampsia,":[316],"indicating":[317],"\\n":[327],"\\nABSTRACT-ISIZULU":[328],"\\nAmathuluzi":[329],"asetshenzisiwe:":[330],"Lolucwaningo":[331],"lubizwa":[332],"nge-retrospective":[333],"lusebenzise":[334],"amagazi":[335],"awu":[336],"aphuma":[338],"kwabanomfutho":[339,415],"osesimweni":[340,422,495],"sempilo":[341,423,496],"(normotensives)":[342],"abangu":[343,351],"Kanye":[345,457,469],"nabanomfutho":[346,421],"ophakeme":[347,354,417,489,507,524,538,551],"wegazi":[348,355],"kubakhulelwe":[349],"(pre-eclamptic)":[350],"357.":[352],"Abanomfutho":[353],"baphinde":[356],"bahlukaniswa":[357],"izigaba":[358],"ezimbili,":[359],"ezibizwa":[360],"nge":[361],"ne":[364,437,441,453,458,470,476],"Ufuzo":[368],"egazini":[369,411,484,490,525,533,539,552],"lutholakale":[370],"ngokusebenzisa":[371,402,413],"I":[372,510],"Ama":[383,461],"e":[387,429],"nawe":[398],"acubulungwe":[401],"i-":[403],"Izinga":[407],"le-angiotensin":[408],"likalwe":[412],"i-ELISA":[414],"wamandla":[416],"kwabakhulelwe":[418,526],"(pre-eclamptics)":[419],"makuqhathaniswa":[420,452,492],"(normotensive).":[424,497],"\\nImiphumela:":[425],"Sithole":[426],"ukuthi":[427,500],"amazinga":[428],"abephezulu":[431],"ku":[432],"makuqhataniswa":[436],"normotensive.":[442],"Siphinde":[443,498],"sabona":[444],"ukukhuphuka":[445],"kwenani":[446],"le":[447,480,530],"ku-early":[449],"awakhombisanga":[473],"mahluko":[474],"ekuhlobaneni":[475],"Kodwa,":[478],"inani":[479],"abehlile":[485],"kulabo":[486,535,548],"abanomfutho":[487,494,536,549],"wamadla":[488,506,523,537,550],"(pre-eclampsia)":[491],"nalabo":[493],"sathola":[499],"lokwehla":[501],"kuhambisana":[502],"nokubhebhetheka":[503],"kwesifo":[504,521],"somfutho":[505,522],"egazini.":[508],"\\nUkuvala:":[509],"ye":[514],"ihlobene":[519],"nokuqala":[520],"(pre-eclampsia).":[527,553],"Futhi,":[528],"izinga":[529],"lehlile":[534],"kwabakhululwe":[540],"(pre-eclampsia),":[541],"okukhombisa":[542],"ukungalawuleki":[543],"kwe":[544]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-09-11T00:00:00"}