{"id":"https://openalex.org/W3083383019","doi":"https://doi.org/10.1158/1538-7445.am2020-1766","title":"Abstract 1766: Targeting epigenetic regulation in clear cell renal cell carcinoma reveals PRMT1 as a novel target","display_name":"Abstract 1766: Targeting epigenetic regulation in clear cell renal cell carcinoma reveals PRMT1 as a novel target","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083383019","doi":"https://doi.org/10.1158/1538-7445.am2020-1766","mag":"3083383019"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-1766","doi":"https://doi.org/10.1158/1538-7445.am2020-1766","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-1766","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1158/1538-7445.am2020-1766","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032932437","display_name":"Joseph Walton","orcid":"https://orcid.org/0000-0002-4654-4404","observed_orcids":["https://orcid.org/0000-0002-4654-4404"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joseph Paul Walton","raw_affiliation_strings":["1University of Toronto, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Toronto, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056028238","display_name":"Anthony J. Apostoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anthony Apostoli","raw_affiliation_strings":["2Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044640197","display_name":"Jalna Meens","orcid":"https://orcid.org/0000-0001-5274-3744","observed_orcids":["https://orcid.org/0000-0001-5274-3744"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jalna Meens","raw_affiliation_strings":["2Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007077453","display_name":"Julia Dmytryshyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julia Dmytryshyn","raw_affiliation_strings":["2Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012117525","display_name":"C.H. Arrowsmith","orcid":"https://orcid.org/0000-0002-4971-3250","observed_orcids":["https://orcid.org/0000-0002-4971-3250"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cheryl Arrowsmith","raw_affiliation_strings":["2Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080821714","display_name":"Laurie Ailles","orcid":"https://orcid.org/0000-0001-7289-8882","observed_orcids":["https://orcid.org/0000-0001-7289-8882"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laurie AIlles","raw_affiliation_strings":["2Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"1766","last_page":"1766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prmt1","display_name":"PRMT1","score":0.968999981880188},{"id":"https://openalex.org/keywords/protein-arginine-methyltransferase","display_name":"protein arginine methyltransferase","score":0.878000020980835},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/vhl-inactivation","display_name":"VHL inactivation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6769999861717224},{"id":"https://openalex.org/keywords/epigenetic-drug-targets","display_name":"epigenetic drug targets","score":0.6039999723434448},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.6079999804496765},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7352785468101501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6935921311378479},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.670857846736908},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6436211466789246},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6284305453300476},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4410891532897949},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4219260513782501},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4101848900318146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31032341718673706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27257221937179565},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.22953438758850098},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13140326738357544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1266009509563446}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-1766","doi":"https://doi.org/10.1158/1538-7445.am2020-1766","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-1766","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1158/1538-7445.am2020-1766","doi":"https://doi.org/10.1158/1538-7445.am2020-1766","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-1766","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3183542265","https://openalex.org/W3173338137","https://openalex.org/W3195373684","https://openalex.org/W3173679061","https://openalex.org/W4367186701","https://openalex.org/W3190422440","https://openalex.org/W2083693850","https://openalex.org/W4232240465","https://openalex.org/W2361888356","https://openalex.org/W2320661246"],"abstract_inverted_index":{"Abstract":[0],"Sporadic":[1],"Renal":[2],"Cell":[3],"Carcinoma":[4],"(RCC)":[5],"is":[6,48,187,196,324,366],"dominated":[7],"by":[8,205,213,357],"the":[9,22,32,102,138,197,269,276,306,331,339,381,390,423,463,467],"clear":[10,448],"cell":[11,165,180,192,235,242,265,332,449,451],"subtype":[12],"(ccRCC)":[13],"and":[14,35,42,149,159,168,173,185,253,318,351,393,477],"overwhelmingly":[15],"associated":[16],"with":[17,134,237,248,288,343,422],"a":[18,93,109,132,214,327,456],"biallelic":[19],"inactivation":[20,46],"of":[21,31,73,101,111,120,203,210,218,228,272,278,283,294,301,308,330,364,383,389,396,413,462,466],"von":[23],"Hippel-Lindau":[24],"(VHL)":[25],"gene,":[26],"leading":[27],"to":[28,38,50,85,155,177,291,346,360,372,400,408,410,420],"constitutive":[29],"activation":[30],"hypoxia":[33],"response":[34],"deleterious":[36],"alterations":[37,75],"gene":[39,163],"expression,":[40,164],"metabolism":[41],"growth.":[43],"However,":[44],"VHL":[45],"alone":[47],"insufficient":[49],"cause":[51],"cancer.":[52],"Other":[53],"key":[54],"genetic":[55,354],"players":[56],"identified":[57],"through":[58],"patient":[59,97],"cohort":[60],"sequencing":[61],"include":[62],"frequent":[63],"inactivating":[64],"mutations":[65],"in":[66,76,96,182,190,251,254,262,275,297,305,338,368,380,447],"epigenetic":[67,79,121,445],"regulatory":[68],"enzymes.":[69],"The":[70],"high":[71],"frequency":[72],"these":[74,273],"ccRCC":[77,99,179,204,234,264,286,303,421],"implicate":[78],"vulnerabilities":[80],"that":[81,321,362],"may":[82],"be":[83],"exploited":[84],"develop":[86],"new":[87],"therapies.Accordingly,":[88],"our":[89,183,263,302,348,373,386],"lab":[90],"has":[91,312],"completed":[92],"proliferative":[94,270],"screen":[95],"derived":[98],"models":[100,304],"Structural":[103],"Genomics":[104],"Consortium's":[105],"(SGC)":[106],"epiprobe":[107],"library,":[108],"panel":[110],"high-quality,":[112],"small":[113],"molecule":[114],"inhibitors":[115,175],"directed":[116,240],"against":[117,137],"an":[118,405],"array":[119],"targets.":[122],"A":[123],"particularly":[124],"favorable":[125],"inhibition":[126,202,293],"profile":[127],"was":[128,244],"noted":[129],"for":[130,200,425,470],"MS023,":[131],"probe":[133,323],"potent":[135,328],"activity":[136],"type":[139],"I":[140],"protein":[141],"arginine":[142,397],"methytransferase":[143],"family":[144],"(PRMT1,":[145],"3,":[146],"4,":[147],"6":[148,174],"8).":[150],"PRMTs":[151],"transfer":[152],"methyl":[153],"groups":[154],"both":[156,250],"nuclear":[157],"histones":[158],"cytoplasmic":[160],"targets,":[161],"influencing":[162],"signaling,":[166],"growth":[167,181,201,215,296],"viability.":[169],"Specific":[170],"PRMT3,":[171],"4":[172,231],"failed":[176],"inhibit":[178],"screen,":[184],"PRMT8":[186],"not":[188],"expressed":[189],"this":[191,322,402,411],"type,":[193],"thus":[194],"PRMT1":[195,211,239,257,365,454],"primary":[198],"target":[199,458],"MS023.":[206],"Upon":[207],"CRISPR-mediated":[208],"knockout":[209],"followed":[212],"competition":[216],"assay":[217],"knock-out":[219],"vs":[220,310],"control":[221,311],"cells,":[222],"all":[223],"PRMT1-knockout":[224],"cells":[225,274],"dropped":[226],"out":[227],"culture":[229],"within":[230],"passages.":[232],"In":[233],"lines":[236],"tetracycline-inducible":[238],"shRNAs,":[241],"proliferation":[243],"inhibited":[245],"upon":[246],"induction":[247],"doxycycline":[249],"vitro":[252],"vivo.":[255,298],"Additionally,":[256],"over":[258],"expression":[259],"vectors":[260],"introduced":[261],"lines,":[266],"successfully":[267],"rescued":[268],"phenotype":[271],"presence":[277,307],"MS023":[279,289,309,344],"treatment.":[280],"Finally,":[281],"treatment":[282,345],"mice":[284],"bearing":[285],"xenografts":[287],"led":[290],"significant":[292],"tumor":[295],"Transcriptomic":[299],"profiling":[300],"been":[313,378],"performed":[314,379],"via":[315],"RNA":[316],"Seq":[317],"results":[319],"suggest":[320],"acting":[325],"as":[326,455],"regulator":[329],"cycle.":[333],"We":[334],"are":[335],"mapping":[336],"changes":[337],"H4R3me2a":[340],"histone":[341],"mark":[342],"complement":[347],"transcriptomic":[349],"data":[350],"identify":[352],"direct":[353],"targets":[355],"regulated":[356],"PRMT1.Evidence":[358],"continues":[359,399],"mount":[361],"dysregulation":[363],"implicated":[367],"cancer":[369],"biology,":[370],"but":[371],"knowledge,":[374,414],"no":[375],"investigations":[376],"have":[377],"context":[382],"ccRCC.":[384],"As":[385],"nascent":[387],"understanding":[388],"regulation,":[391],"function":[392],"clinical":[394,427],"relevance":[395],"methylation":[398],"expand,":[401],"project":[403],"represents":[404],"exciting":[406],"opportunity":[407],"contribute":[409],"body":[412],"while":[415],"describing":[416],"novel":[417,457],"therapeutic":[418],"approaches":[419],"potential":[424],"rapid":[426],"translation.":[428],"Citation":[429],"Format:":[430],"Joseph":[431],"Paul":[432],"Walton,":[433],"Anthony":[434],"Apostoli,":[435],"Jalna":[436],"Meens,":[437],"Julia":[438],"Dmytryshyn,":[439],"Cheryl":[440],"Arrowsmith,":[441],"Laurie":[442],"AIlles.":[443],"Targeting":[444],"regulation":[446],"renal":[450],"carcinoma":[452],"reveals":[453],"[abstract].":[459],"In:":[460],"Proceedings":[461],"Annual":[464],"Meeting":[465],"American":[468],"Association":[469],"Cancer":[471,483],"Research":[472],"2020;":[473],"2020":[474],"Apr":[475],"27-28":[476],"Jun":[478],"22-24.":[479],"Philadelphia":[480],"(PA):":[481],"AACR;":[482],"Res":[484],"2020;80(16":[485],"Suppl):Abstract":[486],"nr":[487],"1766.":[488]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}