{"id":"https://openalex.org/W3083378103","doi":"https://doi.org/10.1186/s40816-020-00204-w","title":"Bridelia ferruginea Benth leaves attenuates diabetes nephropathy in STZ-induced rats via targeting NGAL/KIM-1/cystatin c gene","display_name":"Bridelia ferruginea Benth leaves attenuates diabetes nephropathy in STZ-induced rats via targeting NGAL/KIM-1/cystatin c gene","publication_year":2020,"publication_date":"2020-09-04","ids":{"openalex":"https://openalex.org/W3083378103","doi":"https://doi.org/10.1186/s40816-020-00204-w","mag":"3083378103"},"language":"en","primary_location":{"id":"doi:10.1186/s40816-020-00204-w","doi":"https://doi.org/10.1186/s40816-020-00204-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40816-020-00204-w","pdf_url":"https://clinphytoscience.springeropen.com/track/pdf/10.1186/s40816-020-00204-w","source":{"id":"https://openalex.org/S2737755743","display_name":"Clinical Phytoscience","issn_l":"2199-1197","issn":["2199-1197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Phytoscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://clinphytoscience.springeropen.com/track/pdf/10.1186/s40816-020-00204-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061853767","display_name":"Damilola Alex Omoboyowa","orcid":"https://orcid.org/0000-0002-1740-9764","observed_orcids":["https://orcid.org/0000-0002-1740-9764"]},"institutions":[{"id":"https://openalex.org/I28653996","display_name":"Adekunle Ajasin University","ror":"https://ror.org/04e27p903","country_code":"NG","type":"education","lineage":["https://openalex.org/I28653996"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Damilola Alex Omoboyowa","raw_affiliation_strings":["Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria"],"raw_orcid":"https://orcid.org/0000-0002-1740-9764","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria","institution_ids":["https://openalex.org/I28653996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063678583","display_name":"Kayode Olayele Karigidi","orcid":"https://orcid.org/0000-0002-5394-430X","observed_orcids":["https://orcid.org/0000-0002-5394-430X"]},"institutions":[{"id":"https://openalex.org/I904009604","display_name":"Olusegun Agagu University of Science and Technology","ror":"https://ror.org/01y98tt60","country_code":"NG","type":"education","lineage":["https://openalex.org/I904009604"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Kayode Olayele Karigidi","raw_affiliation_strings":["Biochemistry Program, Department of Chemical Sciences, Olusegun Agagu University of Scince and Technology, Okitipupa, Ondo State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Program, Department of Chemical Sciences, Olusegun Agagu University of Scince and Technology, Okitipupa, Ondo State, Nigeria","institution_ids":["https://openalex.org/I904009604"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088699417","display_name":"Temitope Cosmas Aribigbola","orcid":"https://orcid.org/0000-0001-6567-248X","observed_orcids":["https://orcid.org/0000-0001-6567-248X"]},"institutions":[{"id":"https://openalex.org/I51783024","display_name":"Brandenburg University of Technology Cottbus-Senftenberg","ror":"https://ror.org/02wxx3e24","country_code":"DE","type":"education","lineage":["https://openalex.org/I51783024"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Temitope Cosmas Aribigbola","raw_affiliation_strings":["Biotechnology Block, Bradenburg University of Technology, Cottbus-Stenftenberg Campus, Cottbus, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Block, Bradenburg University of Technology, Cottbus-Stenftenberg Campus, Cottbus, Germany","institution_ids":["https://openalex.org/I51783024"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061853767"],"corresponding_institution_ids":["https://openalex.org/I28653996"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":1.2731,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80983898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.10329999774694443,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bridelia-ferruginea","display_name":"Bridelia ferruginea","score":1.0},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.906000018119812},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9779999852180481},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.6340000033378601},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.753000020980835},{"id":"https://openalex.org/keywords/kim-1","display_name":"KIM-1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.9940000176429749},{"id":"https://openalex.org/keywords/renal-biomarkers","display_name":"renal biomarkers","score":0.5339999794960022},{"id":"https://openalex.org/keywords/hypoglycemic-activity","display_name":"hypoglycemic activity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6010000109672546},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7490000128746033},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.8399999737739563},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.3779999911785126},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.640999972820282},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.7592009902000427},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.6605648398399353},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6402629613876343},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5848348736763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5624520778656006},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5041059255599976},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5009737014770508},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.491001158952713},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4846413731575012},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4777737855911255},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4714052677154541},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4580681622028351},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.4310426712036133},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3583427667617798},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21147596836090088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1509469747543335}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s40816-020-00204-w","doi":"https://doi.org/10.1186/s40816-020-00204-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40816-020-00204-w","pdf_url":"https://clinphytoscience.springeropen.com/track/pdf/10.1186/s40816-020-00204-w","source":{"id":"https://openalex.org/S2737755743","display_name":"Clinical Phytoscience","issn_l":"2199-1197","issn":["2199-1197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Phytoscience","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:af46cb536c4247b2a4bad05c223dfa11","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/af46cb536c4247b2a4bad05c223dfa11","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Phytoscience, Vol 6, Iss 1, Pp 1-10 (2020)","raw_type":"article"},{"id":"doi:10.60692/0wgyx-w1703","doi":"https://doi.org/10.60692/0wgyx-w1703","is_oa":true,"landing_page_url":"https://doi.org/10.60692/0wgyx-w1703","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/c52hy-8rx63","doi":"https://doi.org/10.60692/c52hy-8rx63","is_oa":true,"landing_page_url":"https://doi.org/10.60692/c52hy-8rx63","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s40816-020-00204-w","doi":"https://doi.org/10.1186/s40816-020-00204-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40816-020-00204-w","pdf_url":"https://clinphytoscience.springeropen.com/track/pdf/10.1186/s40816-020-00204-w","source":{"id":"https://openalex.org/S2737755743","display_name":"Clinical Phytoscience","issn_l":"2199-1197","issn":["2199-1197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Phytoscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083378103.pdf","grobid_xml":"https://content.openalex.org/works/W3083378103.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W178380885","https://openalex.org/W1491177125","https://openalex.org/W1506043065","https://openalex.org/W1540240022","https://openalex.org/W1608395573","https://openalex.org/W1964574933","https://openalex.org/W2022138253","https://openalex.org/W2028054489","https://openalex.org/W2043533197","https://openalex.org/W2061786959","https://openalex.org/W2077787784","https://openalex.org/W2082050968","https://openalex.org/W2124701053","https://openalex.org/W2130063532","https://openalex.org/W2130692402","https://openalex.org/W2138944374","https://openalex.org/W2151223245","https://openalex.org/W2170242625","https://openalex.org/W2175441329","https://openalex.org/W2323922832","https://openalex.org/W2504800334","https://openalex.org/W2768848330","https://openalex.org/W2791130056","https://openalex.org/W2807783307","https://openalex.org/W2954542061","https://openalex.org/W2955504961","https://openalex.org/W4245177871","https://openalex.org/W4302219957"],"related_works":["https://openalex.org/W2067811728","https://openalex.org/W2366253291","https://openalex.org/W2740358460","https://openalex.org/W2950138714","https://openalex.org/W2356539028","https://openalex.org/W2379548360","https://openalex.org/W2399110484","https://openalex.org/W3006406582","https://openalex.org/W4285675073","https://openalex.org/W2366581574"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Renal":[2],"failure":[3],"is":[4,17],"among":[5],"the":[6,18,28,111,120,124,189,219,234],"main":[7],"complications":[8],"of":[9,21,31,50,55,74,84,88,102,110,139,185,191,203,236],"diabetes":[10],"disorders":[11],"and":[12,71,81,135,141,157,177,210,238],"free":[13],"radical":[14],"from":[15],"hyperglycemia":[16,237],"major":[19],"cause":[20],"this":[22],"nephrotic":[23,36],"complication.":[24],"This":[25],"study":[26],"investigated":[27],"therapeutic":[29],"effects":[30],"Bridelia":[32],"ferruginea":[33,90,104,187,199],"Benth":[34],"on":[35,63,153],"damage":[37],"in":[38,58,149,194,233],"streptozotocin":[39],"(STZ)":[40],"induced":[41,47],"diabetic":[42,130,162,165,196],"rats.":[43,163,197],"Diabetes":[44],"mellitus":[45],"was":[46,65,92],"by":[48],"injection":[49],"50":[51],"mg/kg":[52,137],"b.":[53],"w.":[54],"STZ":[56],"(intraperitoneal)":[57],"rats":[59,166],"fasted":[60],"overnight.":[61],"Effect":[62],"nephropathy":[64],"assessed":[66],"using":[67],"biochemical,":[68],"histological":[69],"indices":[70],"gene":[72],"expression":[73],"kidney":[75,207],"tissue.":[76],"Results":[77],"The":[78,106,128],"total":[79],"flavonoids":[80],"phenolic":[82],"content":[83],"petroleum":[85],"ether":[86,100],"fraction":[87,101],"B.":[89,103,186,198],"(PEFBF)":[91],"observed":[93],"to":[94,98,123,160],"be":[95],"higher":[96],"compared":[97,122,159],"diethyl":[99],"(DEFBF).":[105],"1,1-diphenyl-2-picryl-hydrazyl":[107],"scavenging":[108],"activity":[109,223],"fractions":[112,184],"were":[113],"significantly":[114,167],"(P":[115,145,168],"<":[116,146,169],"0.05)":[117,147,170],"reduced":[118,188],"across":[119],"concentrations":[121],"standard":[125],"(gallic":[126],"acid).":[127],"STZ-induced":[129,164],"animals":[131],"treated":[132,195],"with":[133,182],"100":[134],"200":[136],"b.w.":[138],"PEFBF":[140],"DEFBF":[142],"showed":[143],"significant":[144],"reduction":[148],"blood":[150],"glucose":[151],"level":[152,179,190],"days":[154],"7,":[155],"11":[156],"14":[158],"untreated":[161],"exhibited":[171],"increase":[172],"plasma":[173],"urea,":[174],"creatinine,":[175],"protein":[176],"albumin":[178],"while":[180],"treatment":[181],"both":[183],"these":[192],"parameters":[193],"also":[200],"caused":[201],"down-regulation":[202],"neutrophil":[204],"gelatinase-associated":[205],"lipocalin,":[206],"injury":[208],"molecule-1":[209],"cystatin":[211],"c":[212],"genes.":[213],"Conclusion":[214],"These":[215],"results":[216],"revealed":[217],"that,":[218],"plant":[220],"has":[221],"hypoglycemic":[222],"therefore":[224],"provides":[225],"a":[226],"pharmacological":[227],"basis":[228],"for":[229],"its":[230,239],"folkloric":[231],"use":[232],"management":[235],"associated":[240],"renal":[241],"dysfunction.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}