{"id":"https://openalex.org/W3083369244","doi":"https://doi.org/10.1158/1538-7445.am2020-721","title":"Abstract 721: Analytical validation of a multi-cancer early detection test with tissue localization using a cell-free DNA-based targeted methylation assay","display_name":"Abstract 721: Analytical validation of a multi-cancer early detection test with tissue localization using a cell-free DNA-based targeted methylation assay","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083369244","doi":"https://doi.org/10.1158/1538-7445.am2020-721","mag":"3083369244"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-721","doi":"https://doi.org/10.1158/1538-7445.am2020-721","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-721","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007294683","display_name":"Gregory E. Alexander","orcid":"https://orcid.org/0000-0002-2442-206X","observed_orcids":["https://orcid.org/0000-0002-2442-206X"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Alexander","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088995429","display_name":"Wendy Lin","orcid":"https://orcid.org/0000-0002-4167-7072","observed_orcids":["https://orcid.org/0000-0002-4167-7072"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Lin","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103693332","display_name":"Madhuvanthi Ramaiah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhuvanthi Ramaiah","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109591595","display_name":"Byoungsok Jung","orcid":"https://orcid.org/0009-0006-1518-7826","observed_orcids":["https://orcid.org/0009-0006-1518-7826"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Byoungsok Jung","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080147925","display_name":"Lijuan Ji","orcid":"https://orcid.org/0000-0003-0678-6131","observed_orcids":["https://orcid.org/0000-0003-0678-6131"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lijuan Ji","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010961642","display_name":"Ekaterina Revenkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekaterina Revenkova","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103177760","display_name":"Payal Deepak Shah","orcid":"https://orcid.org/0009-0004-7225-1674","observed_orcids":["https://orcid.org/0009-0004-7225-1674"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Payal Shah","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040375262","display_name":"Christian Croiseti\u00e8re","orcid":"https://orcid.org/0000-0002-6174-4818","observed_orcids":["https://orcid.org/0000-0002-6174-4818"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Croisetiere","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Berman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Berman","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009635460","display_name":"Lane Eubank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lane Eubank","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gunjan Naik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunjan Naik","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053684349","display_name":"Jacqueline D. Brooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Brooks","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069336635","display_name":"Andrea Mich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Mich","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061717752","display_name":"Seyedmehdi Shojaee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seyedmehdi Shojaee","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037466720","display_name":"Neda Ronaghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Ronaghi","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067810274","display_name":"Hemanshi Chawla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hemanshi Chawla","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042040439","display_name":"Xinyi Hou","orcid":"https://orcid.org/0000-0002-3731-8499","observed_orcids":["https://orcid.org/0000-0002-3731-8499"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyi Hou","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069657399","display_name":"Qin\u2010Wen Liu","orcid":"https://orcid.org/0009-0000-0104-1718","observed_orcids":["https://orcid.org/0009-0000-0104-1718"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinwen Liu","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082272127","display_name":"Christopher Yakym","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Yakym","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112562615","display_name":"Patriss Wais Moradi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patriss Wais Moradi","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042935008","display_name":"Meredith Halks\u2010Miller","orcid":"https://orcid.org/0000-0002-9847-1331","observed_orcids":["https://orcid.org/0000-0002-9847-1331"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith Halks-Miller","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091013365","display_name":"Nathan M. Hunkapiller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Hunkapiller","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086036723","display_name":"Sonya T. Parpart-Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonya Parpart-Li","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061491054","display_name":"Alexander M. Aravanis","orcid":"https://orcid.org/0000-0001-7711-3124","observed_orcids":["https://orcid.org/0000-0001-7711-3124"]},"institutions":[{"id":"https://openalex.org/I4210139067","display_name":"Grail (United States)","ror":"https://ror.org/03jwhs418","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139067"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Aravanis","raw_affiliation_strings":["GRAIL, Inc., Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRAIL, Inc., Menlo Park, CA","institution_ids":["https://openalex.org/I4210139067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210139067"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"721","last_page":"721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multi-cancer-early-detection","display_name":"multi-cancer early detection","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tissue-of-origin","display_name":"tissue of origin","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tumor-fraction","display_name":"tumor fraction","score":0.4970000088214874},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.8930000066757202},{"id":"https://openalex.org/keywords/analytical-sensitivity","display_name":"analytical sensitivity","score":0.5920000076293945},{"id":"https://openalex.org/keywords/analytical-specificity","display_name":"analytical specificity","score":0.8889999985694885},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.6449999809265137},{"id":"https://openalex.org/keywords/interferents","display_name":"interferents","score":0.6110000014305115},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.5040000081062317},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/classifiers","display_name":"machine learning classifiers","score":0.5419999957084656},{"id":"https://openalex.org/keywords/methylation-markers","display_name":"methylation biomarkers","score":0.597000002861023},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.5569999814033508},{"id":"https://openalex.org/keywords/lymphoid-malignancies","display_name":"lymphoid malignancies","score":0.9139999747276306},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.6880872249603271},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5864435434341431},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5451343655586243},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5408151745796204},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5238142609596252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5039076209068298},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45656618475914},{"id":"https://openalex.org/C154020017","wikidata":"https://www.wikidata.org/wiki/Q520171","display_name":"Repeatability","level":2,"score":0.4130794405937195},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.41110581159591675},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40421298146247864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39026975631713867},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34541618824005127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25189220905303955},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2051072120666504},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13645672798156738},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12193050980567932},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09894418716430664},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-721","doi":"https://doi.org/10.1158/1538-7445.am2020-721","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-721","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W638612878","https://openalex.org/W2355957485","https://openalex.org/W1968795594","https://openalex.org/W2391646176","https://openalex.org/W2353380786","https://openalex.org/W1808777170","https://openalex.org/W2086083558","https://openalex.org/W2417306072","https://openalex.org/W3037204814","https://openalex.org/W3010158444"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"A":[2,378],"blood-based":[3],"test":[4,31,239,375,382,478],"using":[5,84,482],"cell-free":[6,484],"DNA":[7],"(cfDNA)":[8],"may":[9],"address":[10],"an":[11,196],"unmet":[12],"need":[13],"for":[14,68,271,403,500],"earlier":[15],"detection":[16,42,66,141,406,418,477],"of":[17,26,37,53,65,87,93,188,226,248,370,414,473,492,496],"multiple":[18,177,212],"cancers.":[19],"Here,":[20],"we":[21,76],"report":[22],"the":[23,104,131,148,246,262,272,327,371,493,497],"analytical":[24,58,390],"validation":[25,409,472],"a":[27,46,61,186,366,474,483],"targeted":[28,379,486],"methylation-based":[29,380],"cfDNA":[30,94,189,201,353,381],"to":[32,81,138,221,259],"detect":[33],"cancer":[34,89,99,113,170,207,274,308,319,331,336,367,387],"and":[35,100,117,159,165,172,181,216,268,292,300,312,316,320,340,384,392,394,507],"tissue":[36,480],"origin":[38],"(TOO).":[39],"Methods:":[40],"Since":[41],"was":[43,72,125,145,193,241,269,332,357],"determined":[44,146],"by":[45,60,147,163,195,250],"machine-learning":[47],"classifier":[48],"based":[49],"on":[50,238],"methylation":[51,487],"patterns":[52],">105":[54],"genomic":[55,70,236],"targets,":[56],"defining":[57],"sensitivity":[59,78,249,391],"single":[62],"common":[63],"limit":[64],"(LOD)":[67],"each":[69],"target":[71],"not":[73,219,341],"applicable.":[74],"Thus,":[75],"characterized":[77,162],"with":[79,112,200,206,305,365,388,397,479],"respect":[80],"tumor":[82,251,266],"fraction":[83,136],"dilution":[85,123],"series":[86,124],"contrived":[88],"samples":[90,155,171,175,278,322,346,364],"containing":[91],"mixtures":[92],"from":[95,202,255,279],"6":[96,101,203],"individuals":[97,218],"without":[98,156,307],"participants":[102,205],"in":[103,153,168,297,309,313,323,334,343,360],"Circulating":[105],"Cell-free":[106],"Genome":[107],"Atlas":[108],"study":[109,199,410],"(CCGA;":[110],"NCT02889978)":[111],"(breast,":[114],"colorectal,":[115],"head":[116],"neck,":[118],"lung,":[119,209],"lymphoid":[120,214],"neoplasm).":[121],"Each":[122],"performed":[126],"at":[127],"3":[128],"levels":[129,354],"near":[130],"expected":[132],"LOD95%":[133,253],"(lowest":[134],"admixture":[135],"predicted":[137],"have":[139,222],"95%":[140,288],"probability).":[142],"Analytical":[143,471],"specificity":[144,393],"false":[149],"positive":[150],"(FP)":[151],"rate":[152],"1,204":[154],"cancer.":[157,223],"Reproducibility":[158],"repeatability":[160],"were":[161,284,295],"within-":[164],"between-run":[166,324],"variability":[167],"81":[169],"45":[173],"noncancer":[174,277,321,345],"across":[176,261,350],"reagent":[178],"lots,":[179],"instruments,":[180],"operators.":[182],"Test":[183],"performance":[184,240],"as":[185],"function":[187],"input":[190,197,328,352],"(3-100":[191],"ng)":[192],"assessed":[194],"titration":[198,329],"CCGA":[204,280],"(colorectal,":[208],"esophageal,":[210],"renal,":[211],"myeloma,":[213],"neoplasm)":[215],"5":[217,263],"known":[220],"The":[224],"effect":[225],"4":[227],"potential":[228],"interferents":[229,373],"(hemoglobin,":[230],"bilirubin,":[231],"triglycerides,":[232],"white":[233],"blood":[234,273],"cell":[235],"DNA)":[237],"also":[242],"evaluated.":[243],"Results:":[244],"In":[245],"assessment":[247],"fraction,":[252],"ranged":[254],"0.2%":[256],"(upper":[257],"bound)":[258],"0.5%":[260],"individual":[264],"solid":[265],"cases":[267],"1.9%":[270],"case.":[275],"Among":[276],"participants,":[281],"9":[282],"FPs":[283],"detected":[285,333,342,386],"(99.3%":[286],"specificity;":[287],"CI,":[289],"98.6%-99.7%).":[290],"Repeatability":[291],"reproducibility":[293],"results":[294],"correct":[296],"31/34":[298],"(91.2%)":[299],"17/17":[301],"(100%)":[302,318],"sample":[303],"pairs":[304],"or":[306],"within-run":[310],"tests":[311],"77/81":[314],"(95.1%)":[315],"45/45":[317],"tests.":[325],"For":[326],"study,":[330],"5/6":[335],"specimens":[337],"(156/183":[338],"samples)":[339],"any":[344],"(n":[347],"=":[348],"62)":[349],"all":[351,361],"tested.":[355],"TOO":[356,396],"correctly":[358],"localized":[359,395],"but":[362],"2":[363],"signal.":[368],"None":[369],"tested":[372],"affected":[374],"performance.":[376],"Conclusions:":[377],"repeatedly":[383],"reproducibly":[385],"high":[389,398],"accuracy,":[399],"which":[400],"are":[401],"critical":[402],"multi-cancer":[404,416,475],"early":[405,417,476],"applications.":[407],"This":[408],"supports":[411],"clinical":[412],"development":[413],"this":[415],"test.":[419],"Citation":[420],"Format:":[421],"Gregory":[422],"Alexander,":[423],"Wendy":[424],"Lin,":[425],"Madhuvanthi":[426],"Ramaiah,":[427],"Byoungsok":[428],"Jung,":[429],"Lijuan":[430],"Ji,":[431],"Ekaterina":[432],"Revenkova,":[433],"Payal":[434],"Shah,":[435],"Christian":[436],"Croisetiere,":[437],"Jennifer":[438],"Berman,":[439],"Lane":[440],"Eubank,":[441],"Gunjan":[442],"Naik,":[443],"Jacqueline":[444],"Brooks,":[445],"Andrea":[446],"Mich,":[447],"Seyedmehdi":[448],"Shojaee,":[449],"Neda":[450],"Ronaghi,":[451],"Hemanshi":[452],"Chawla,":[453],"Xinyi":[454],"Hou,":[455],"Qinwen":[456],"Liu,":[457],"Christopher":[458],"Yakym,":[459],"Patriss":[460],"Wais":[461],"Moradi,":[462],"Meredith":[463],"Halks-Miller,":[464],"Nathan":[465],"Hunkapiller,":[466],"Sonya":[467],"Parpart-Li,":[468],"Alexander":[469],"Aravanis.":[470],"localization":[481],"DNA-based":[485],"assay":[488],"[abstract].":[489],"In:":[490],"Proceedings":[491],"Annual":[494],"Meeting":[495],"American":[498],"Association":[499],"Cancer":[501,513],"Research":[502],"2020;":[503],"2020":[504],"Apr":[505],"27-28":[506],"Jun":[508],"22-24.":[509],"Philadelphia":[510],"(PA):":[511],"AACR;":[512],"Res":[514],"2020;80(16":[515],"Suppl):Abstract":[516],"nr":[517],"721.":[518]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
