{"id":"https://openalex.org/W3083355275","doi":"https://doi.org/10.1097/ede.0000000000001256","title":"Risk of Renal Cell Carcinoma Associated with Calcium Channel Blockers","display_name":"Risk of Renal Cell Carcinoma Associated with Calcium Channel Blockers","publication_year":2020,"publication_date":"2020-09-02","ids":{"openalex":"https://openalex.org/W3083355275","doi":"https://doi.org/10.1097/ede.0000000000001256","mag":"3083355275","pmid":"https://pubmed.ncbi.nlm.nih.gov/32897909"},"language":"en","primary_location":{"id":"doi:10.1097/ede.0000000000001256","doi":"https://doi.org/10.1097/ede.0000000000001256","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ede.0000000000001256","pdf_url":null,"source":{"id":"https://openalex.org/S15470582","display_name":"Epidemiology","issn_l":"1044-3983","issn":["1044-3983","1531-5487"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://findresearcher.sdu.dk/ws/files/174001453/pure_unformatted.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089401828","display_name":"Kasper Bruun Kristensen","orcid":"https://orcid.org/0000-0001-6373-1386","observed_orcids":["https://orcid.org/0000-0001-6373-1386"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Kasper Bruun Kristensen","raw_affiliation_strings":["Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029294320","display_name":"Laurel A. Habel","orcid":"https://orcid.org/0000-0002-7230-587X","observed_orcids":["https://orcid.org/0000-0002-7230-587X"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurel A. Habel","raw_affiliation_strings":["Division of Research, Kaiser Permanente Northern California, Oakland, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research, Kaiser Permanente Northern California, Oakland, CA","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059157113","display_name":"Joshua J. Gagne","orcid":"https://orcid.org/0000-0001-5428-9733","observed_orcids":["https://orcid.org/0000-0001-5428-9733"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua J. Gagne","raw_affiliation_strings":["Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112343838","display_name":"S\u00f8ren Friis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148920","display_name":"Danish Cancer Society","ror":"https://ror.org/03ytt7k16","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210148920"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren Friis","raw_affiliation_strings":["Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210148920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044190214","display_name":"Klaus Kaae Andersen","orcid":"https://orcid.org/0000-0003-3573-092X","observed_orcids":["https://orcid.org/0000-0003-3573-092X"]},"institutions":[{"id":"https://openalex.org/I4210148920","display_name":"Danish Cancer Society","ror":"https://ror.org/03ytt7k16","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210148920"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Klaus Kaae Andersen","raw_affiliation_strings":["Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210148920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086275374","display_name":"Jesper Hallas","orcid":"https://orcid.org/0000-0002-8097-8708","observed_orcids":["https://orcid.org/0000-0002-8097-8708"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jesper Hallas","raw_affiliation_strings":["Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072859924","display_name":"Anton Potteg\u00e5rd","orcid":"https://orcid.org/0000-0001-9314-5679","observed_orcids":["https://orcid.org/0000-0001-9314-5679"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anton Potteg\u00e5rd","raw_affiliation_strings":["Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5089401828"],"corresponding_institution_ids":["https://openalex.org/I177969490"],"apc_list":null,"apc_paid":null,"fwci":0.7029,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73448604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"31","issue":"6","first_page":"860","last_page":"871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.052799999713897705,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dihydropyridines","display_name":"dihydropyridines","score":0.9679999947547913},{"id":"https://openalex.org/keywords/confounding-by-indication","display_name":"confounding by indication","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7419999837875366},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8766376972198486},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.7356195449829102},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6777748465538025},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6500619053840637},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.6283786296844482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6177793145179749},{"id":"https://openalex.org/C2781212610","wikidata":"https://www.wikidata.org/wiki/Q39094","display_name":"Dihydropyridine","level":3,"score":0.5113267302513123},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3837624192237854},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.19399550557136536}],"mesh":[{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003718","descriptor_name":"Denmark","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015986","descriptor_name":"Confounding Factors, Epidemiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/ede.0000000000001256","doi":"https://doi.org/10.1097/ede.0000000000001256","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ede.0000000000001256","pdf_url":null,"source":{"id":"https://openalex.org/S15470582","display_name":"Epidemiology","issn_l":"1044-3983","issn":["1044-3983","1531-5487"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epidemiology","raw_type":"journal-article"},{"id":"pmid:32897909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32897909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epidemiology (Cambridge, Mass.)","raw_type":"Journal Article"},{"id":"pmh:oai:sdu.dk:openaire/4873c09d-db45-4af8-81ec-6c2410843698","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/4873c09d-db45-4af8-81ec-6c2410843698","pdf_url":"https://findresearcher.sdu.dk/ws/files/174001453/pure_unformatted.pdf","source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Kristensen, K B, Habel, L A, Gagne, J J, Friis, S, Andersen, K K, Hallas, J & Potteg\u00e5rd, A 2020, 'Risk of renal cell carcinoma associated with calcium channel blockers : A nationwide observational study focusing on confounding by indication', Epidemiology, vol. 31, no. 6, pp. 860-871. https://doi.org/10.1097/EDE.0000000000001256","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:sdu.dk:openaire/4873c09d-db45-4af8-81ec-6c2410843698","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/4873c09d-db45-4af8-81ec-6c2410843698","pdf_url":"https://findresearcher.sdu.dk/ws/files/174001453/pure_unformatted.pdf","source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Kristensen, K B, Habel, L A, Gagne, J J, Friis, S, Andersen, K K, Hallas, J & Potteg\u00e5rd, A 2020, 'Risk of renal cell carcinoma associated with calcium channel blockers : A nationwide observational study focusing on confounding by indication', Epidemiology, vol. 31, no. 6, pp. 860-871. https://doi.org/10.1097/EDE.0000000000001256","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320308347","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94"},{"id":"https://openalex.org/F4320310388","display_name":"Novartis Pharmaceuticals Corporation","ror":"https://ror.org/028fhxy95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083355275.pdf","grobid_xml":"https://content.openalex.org/works/W3083355275.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1841486778","https://openalex.org/W1973040217","https://openalex.org/W1976043651","https://openalex.org/W1978670003","https://openalex.org/W1984262040","https://openalex.org/W1988989746","https://openalex.org/W2004140440","https://openalex.org/W2004516056","https://openalex.org/W2007495351","https://openalex.org/W2028166306","https://openalex.org/W2036898096","https://openalex.org/W2038118918","https://openalex.org/W2039844227","https://openalex.org/W2040860419","https://openalex.org/W2041889730","https://openalex.org/W2046244583","https://openalex.org/W2104860839","https://openalex.org/W2122985624","https://openalex.org/W2150071355","https://openalex.org/W2151902333","https://openalex.org/W2153383900","https://openalex.org/W2159198921","https://openalex.org/W2160208506","https://openalex.org/W2185809080","https://openalex.org/W2219591537","https://openalex.org/W2302540285","https://openalex.org/W2317301418","https://openalex.org/W2326293200","https://openalex.org/W2341453907","https://openalex.org/W2541013163","https://openalex.org/W2558289076","https://openalex.org/W2589817604","https://openalex.org/W2910054248","https://openalex.org/W7039612861"],"related_works":["https://openalex.org/W4404445657","https://openalex.org/W2026072012","https://openalex.org/W2095137788","https://openalex.org/W2038118918","https://openalex.org/W2041889730","https://openalex.org/W4223448854","https://openalex.org/W4411085662","https://openalex.org/W2083349123","https://openalex.org/W2149592503","https://openalex.org/W3101689894"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,56,72,88],"examined":[2],"whether":[3,106],"the":[4,28,125,162,206,212,242],"apparent":[5],"association":[6,243],"between":[7,244],"renal":[8],"cell":[9],"carcinoma":[10],"(RCC)":[11],"and":[12,67,114,196,246],"use":[13,80,147,222],"of":[14,130,175,223,241],"dihydropyridine":[15,247],"calcium":[16],"channel":[17],"blockers":[18],"(CCBs)":[19],"was":[20,151,214],"explained":[21],"by":[22,24,91,93,123,233],"confounding":[23,90,232],"indication":[25,30,92,234],"since":[26],"hypertension,":[27],"main":[29],"for":[31,37,77,96,141,158,186,221],"CCBs,":[32],"is":[33],"a":[34,46,176],"risk":[35],"factor":[36],"RCC.":[38],"METHODS:":[39],"Using":[40],"Danish":[41],"health":[42],"registries,":[43],"we":[44,155],"conducted":[45],"nested":[47],"case-control":[48],"study":[49,126],"including":[50],"7315":[51],"RCC":[52,83,142,245],"cases":[53],"during":[54],"2000-2015.":[55],"matched":[57],"each":[58],"case":[59],"with":[60,82,112,144,173,184,226],"up":[61],"to":[62,149,236],"20":[63],"controls":[64],"on":[65],"age":[66],"sex":[68],"using":[69,84,116],"risk-set":[70],"sampling.":[71],"estimated":[73],"odds":[74],"ratios":[75],"(ORs)":[76],"long-term":[78,145],"CCB":[79,146],"associated":[81,111,143,183],"conditional":[85],"logistic":[86],"regression.":[87],"addressed":[89],"(1)":[94],"adjusting":[95],"hypertension":[97,159],"severity":[98,160],"indicators;":[99],"(2)":[100],"evaluating":[101],"dose-response":[102,177],"patterns;":[103],"(3)":[104],"examining":[105],"other":[107],"first-line":[108],"anti-hypertensives":[109,180],"were":[110,181],"RCC;":[113],"(4)":[115],"an":[117],"active":[118,207],"comparator":[119,208],"new":[120,128,209],"user":[121,210],"design":[122],"nesting":[124],"in":[127],"users":[129],"CCBs":[131,224],"or":[132],"angiotensin-converting":[133],"enzyme":[134],"inhibitors":[135],"(ACEIs).":[136],"RESULTS:":[137],"The":[138],"adjusted":[139,157],"OR":[140,163,213],"compared":[148,225],"non-use":[150],"1.76":[152],"(1.63-1.90).":[153],"After":[154],"additionally":[156],"indicators,":[161],"remained":[164],"elevated":[165],"(OR":[166,189,198],"1.37;":[167],"confidence":[168],"interval":[169],"[CI]":[170],"1.25,":[171],"1.49)":[172],"evidence":[174],"pattern.":[178],"Other":[179],"also":[182],"RCC,":[185],"example,":[187],"ACEIs":[188],"1.27;":[190],"95%":[191,200],"CI":[192,201,217],"=":[193,202,218],"1.16,":[194],"1.39)":[195],"thiazides":[197],"1.22;":[199],"1.12,":[203],"1.34).":[204],"In":[205,229],"design,":[211],"1.21":[215],"(95%":[216],"0.95,":[219],"1.53)":[220],"ACEIs.":[227],"CONCLUSIONS:":[228],"this":[230],"population,":[231],"appeared":[235],"explain":[237],"at":[238],"least":[239],"part":[240],"CCBs.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-11T00:00:00"}