{"id":"https://openalex.org/W3083345478","doi":"https://doi.org/10.1016/j.redox.2020.101714","title":"Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis","display_name":"Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis","publication_year":2020,"publication_date":"2020-09-04","ids":{"openalex":"https://openalex.org/W3083345478","doi":"https://doi.org/10.1016/j.redox.2020.101714","mag":"3083345478","pmid":"https://pubmed.ncbi.nlm.nih.gov/32927319","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7494798"},"language":"en","primary_location":{"id":"doi:10.1016/j.redox.2020.101714","doi":"https://doi.org/10.1016/j.redox.2020.101714","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2020.101714","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213231720309198/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2213231720309198/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090390105","display_name":"Cody J. Schmidlin","orcid":"https://orcid.org/0000-0002-0361-5890","observed_orcids":["https://orcid.org/0000-0002-0361-5890"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cody J. Schmidlin","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA"],"raw_orcid":"https://orcid.org/0000-0002-0361-5890","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029942907","display_name":"Montserrat Rojo de la Vega","orcid":"https://orcid.org/0000-0002-4837-0671","observed_orcids":["https://orcid.org/0000-0002-4837-0671"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Montserrat Rojo de la Vega","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028553414","display_name":"Jessica Perer","orcid":"https://orcid.org/0000-0003-1838-6995","observed_orcids":["https://orcid.org/0000-0003-1838-6995"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Perer","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA"],"raw_orcid":"https://orcid.org/0000-0003-1838-6995","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009033820","display_name":"Donna D. Zhang","orcid":"https://orcid.org/0000-0002-8972-697X","observed_orcids":["https://orcid.org/0000-0002-8972-697X","https://orcid.org/0000-0003-1468-6616"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donna D. Zhang","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA; University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. Electronic address: dzhang@pharmacy.arizona.edu","Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA","University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"],"raw_orcid":"https://orcid.org/0000-0002-8972-697X","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA; University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. Electronic address: dzhang@pharmacy.arizona.edu","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081187066","display_name":"Georg T. Wondrak","orcid":"https://orcid.org/0000-0003-4799-8608","observed_orcids":["https://orcid.org/0000-0003-4799-8608"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Georg T. Wondrak","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA; University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. Electronic address: wondrak@pharmacy.arizona.edu","Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA","University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"],"raw_orcid":"https://orcid.org/0000-0003-4799-8608","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA; University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. Electronic address: wondrak@pharmacy.arizona.edu","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009033820","https://openalex.org/A5081187066"],"corresponding_institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"],"apc_list":{"value":2850,"currency":"USD","value_usd":2850},"apc_paid":{"value":2850,"currency":"USD","value_usd":2850},"fwci":1.59,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.84775021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"37","issue":null,"first_page":"101714","last_page":"101714"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.08659999817609787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.847000002861023},{"id":"https://openalex.org/keywords/radiation-dermatitis","display_name":"radiation dermatitis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/bixin","display_name":"bixin","score":0.9459999799728394},{"id":"https://openalex.org/keywords/apocarotenoids","display_name":"apocarotenoids","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.824999988079071},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9039999842643738},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8809999823570251},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9919999837875366},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9879999756813049},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.5960000157356262},{"id":"https://openalex.org/keywords/epidermal-thickening","display_name":"epidermal thickening","score":0.7689999938011169},{"id":"https://openalex.org/keywords/skh-1-mice","display_name":"SKH-1 mice","score":0.7689999938011169},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7612841129302979},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6496869325637817},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5945850610733032},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5841437578201294},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5497334003448486},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5362585783004761},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4939191937446594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47353407740592957},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.4262280762195587},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.4239349365234375},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4228174090385437},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3268929123878479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25696489214897156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24635624885559082},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23752203583717346},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.21773475408554077},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20376616716384888},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15240994095802307},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13956817984580994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12218144536018372},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11546796560287476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09131196141242981}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.redox.2020.101714","doi":"https://doi.org/10.1016/j.redox.2020.101714","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2020.101714","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213231720309198/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7494798","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7494798","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biol","raw_type":"Text"},{"id":"pmid:32927319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32927319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b47dcdf636ff4de6bfcd7a034c74d50b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b47dcdf636ff4de6bfcd7a034c74d50b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biology, Vol 37, Iss , Pp 101714- (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.redox.2020.101714","doi":"https://doi.org/10.1016/j.redox.2020.101714","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2020.101714","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213231720309198/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1756678099","display_name":"Exploring the role of HOCI in skin photodamage, immunosuppression, and carcinogenesis","funder_award_id":"R21ES029579","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G1978968590","display_name":null,"funder_award_id":"R03 CA230949","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2400634982","display_name":null,"funder_award_id":"T32 ES 007091","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G274614390","display_name":null,"funder_award_id":"T32CA009213","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3687393406","display_name":null,"funder_award_id":"ES006694","funder_id":"https://openalex.org/F4320310160","funder_display_name":"University of Arizona"},{"id":"https://openalex.org/G4534458934","display_name":null,"funder_award_id":"CA023074","funder_id":"https://openalex.org/F4320310160","funder_display_name":"University of Arizona"},{"id":"https://openalex.org/G4966691970","display_name":null,"funder_award_id":"P01CA229112","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5539457478","display_name":"Arsenic, Nrf2 and Autophagy Dysfunction in Type II Diabetes","funder_award_id":"R01DK109555","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6554886497","display_name":null,"funder_award_id":"ES007091","funder_id":"https://openalex.org/F4320310160","funder_display_name":"University of Arizona"},{"id":"https://openalex.org/G75755756","display_name":"Repurposing Clinical ACT Antimalarials for Experimental Melanoma Intervention","funder_award_id":"R01CA229418","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000867487","display_name":"Southwest Environmental Health Sciences Center","funder_award_id":"P30ES006694","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000885244","display_name":"NRF Transcription Factors in Environmental Stress and Disease Intervention","funder_award_id":"R35ES031575","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000909272","display_name":"University of Arizona Cancer Center - Cancer Center Support Grant","funder_award_id":"P30CA023074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000912344","display_name":"The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation","funder_award_id":"P42ES004940","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320310160","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083345478.pdf","grobid_xml":"https://content.openalex.org/works/W3083345478.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W214267242","https://openalex.org/W767415338","https://openalex.org/W1875103844","https://openalex.org/W1883049802","https://openalex.org/W1919655653","https://openalex.org/W1967419778","https://openalex.org/W1969843775","https://openalex.org/W1983644941","https://openalex.org/W1987235057","https://openalex.org/W1990048785","https://openalex.org/W1991631628","https://openalex.org/W1999472897","https://openalex.org/W2006960282","https://openalex.org/W2007458878","https://openalex.org/W2012338069","https://openalex.org/W2017498511","https://openalex.org/W2026327850","https://openalex.org/W2030513956","https://openalex.org/W2030749349","https://openalex.org/W2053076458","https://openalex.org/W2053650579","https://openalex.org/W2054988846","https://openalex.org/W2070982170","https://openalex.org/W2076703729","https://openalex.org/W2083675699","https://openalex.org/W2085043661","https://openalex.org/W2085975068","https://openalex.org/W2090963866","https://openalex.org/W2092263511","https://openalex.org/W2093156214","https://openalex.org/W2097300866","https://openalex.org/W2098327506","https://openalex.org/W2105559500","https://openalex.org/W2106244792","https://openalex.org/W2110639241","https://openalex.org/W2111774458","https://openalex.org/W2117591057","https://openalex.org/W2117800935","https://openalex.org/W2138754072","https://openalex.org/W2145389621","https://openalex.org/W2146734738","https://openalex.org/W2151736727","https://openalex.org/W2162117091","https://openalex.org/W2162956728","https://openalex.org/W2169145907","https://openalex.org/W2171287582","https://openalex.org/W2194468360","https://openalex.org/W2201268631","https://openalex.org/W2222899618","https://openalex.org/W2410407671","https://openalex.org/W2410790700","https://openalex.org/W2560323895","https://openalex.org/W2577866493","https://openalex.org/W2623669551","https://openalex.org/W2769884280","https://openalex.org/W2780965738","https://openalex.org/W2788972816","https://openalex.org/W2794848018","https://openalex.org/W2803448452","https://openalex.org/W2894123970","https://openalex.org/W2896078899","https://openalex.org/W2937655364","https://openalex.org/W2943576188","https://openalex.org/W2979792224","https://openalex.org/W2986456455","https://openalex.org/W3030051895","https://openalex.org/W4301488493","https://openalex.org/W6639648952","https://openalex.org/W6979108894"],"related_works":["https://openalex.org/W2410407671","https://openalex.org/W2770616846","https://openalex.org/W2798105551","https://openalex.org/W2194468360","https://openalex.org/W2794848018","https://openalex.org/W2110639241","https://openalex.org/W3194015251","https://openalex.org/W2780965738","https://openalex.org/W4410992871","https://openalex.org/W4394694877"],"abstract_inverted_index":{"Radiation":[0],"therapy":[1],"is":[2,180],"a":[3],"frontline":[4],"treatment":[5],"option":[6],"for":[7,182],"cancer":[8],"patients;":[9],"however,":[10],"the":[11,31,45,56,117,169,184],"effects":[12],"of":[13,25,33,44,59,63,69,102,108,114,122,158,171,196],"radiotherapy":[14],"on":[15],"non-tumor":[16],"tissue":[17],"(e.g.":[18],"radiation-induced":[19,161,202],"dermatitis)":[20],"often":[21],"worsen":[22],"patient":[23],"quality":[24],"life.":[26],"Previous":[27],"studies":[28,135],"have":[29],"implicated":[30],"importance":[32],"redox":[34],"balance":[35],"in":[36,40,81,104,131,168],"preventing":[37],"dermatitis,":[38,162],"specifically":[39],"reference":[41],"to":[42,55,83,96],"modulation":[43,68],"nuclear":[46],"factor":[47],"(erythroid-derived":[48],"2)-like":[49],"2":[50],"(NRF2)":[51],"signaling":[52],"pathway.":[53],"Due":[54],"cytoprotective":[57],"functions":[58],"transcriptional":[60],"target":[61],"genes":[62],"NRF2,":[64],"we":[65],"investigated":[66],"how":[67],"NRF2":[70,90,103,115,144,179,197],"expression":[71],"could":[72,200],"affect":[73],"DNA":[74,123,148],"damage,":[75],"oxidative":[76,126,166],"stress,":[77,127],"and":[78,125,165,192],"cell":[79],"viability":[80,130],"response":[82],"radiotherapy.":[84],"Specifically,":[85],"it":[86],"was":[87],"noted":[88],"that":[89,137,178,193],"knockdown":[91],"sensitized":[92],"human":[93],"skin":[94,170,186],"keratinocytes":[95],"ionizing":[97,190],"radiation;":[98],"likewise,":[99],"genetic":[100],"ablation":[101],"vivo":[105],"increased":[106],"radiosensitivity":[107],"murine":[109],"epidermis.":[110],"Oppositely,":[111],"pharmacological":[112],"induction":[113],"via":[116,198],"apocarotenoid":[118],"bixin":[119,141,159,199],"lowered":[120],"markers":[121],"damage":[124,149],"while":[128],"preserving":[129],"irradiated":[132],"keratinocytes.":[133],"Mechanistic":[134],"indicated":[136],"topical":[138,156,194],"pretreatment":[139],"using":[140],"as":[142],"an":[143],"activator":[145],"antagonized":[146],"initial":[147],"by":[150],"raising":[151],"cellular":[152],"glutathione":[153],"levels.":[154],"Additionally,":[155],"application":[157],"prevented":[160],"epidermal":[163],"thickening,":[164],"stress":[167],"SKH1":[172],"mice.":[173],"Overall,":[174],"these":[175],"data":[176],"indicate":[177],"critical":[181],"mitigating":[183],"harmful":[185],"toxicities":[187],"associated":[188],"with":[189],"radiation,":[191],"upregulation":[195],"prevent":[201],"dermatitis.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-09-11T00:00:00"}