{"id":"https://openalex.org/W3083339176","doi":"https://doi.org/10.21763/tjfmpc.713208","title":"Evaluation of Potential Drug-drug Interactions in the Prescriptions in Outpatient Settings","display_name":"Evaluation of Potential Drug-drug Interactions in the Prescriptions in Outpatient Settings","publication_year":2020,"publication_date":"2020-09-06","ids":{"openalex":"https://openalex.org/W3083339176","doi":"https://doi.org/10.21763/tjfmpc.713208","mag":"3083339176"},"language":"en","primary_location":{"id":"doi:10.21763/tjfmpc.713208","doi":"https://doi.org/10.21763/tjfmpc.713208","is_oa":false,"landing_page_url":"https://doi.org/10.21763/tjfmpc.713208","pdf_url":null,"source":{"id":"https://openalex.org/S2764966086","display_name":"Turkish Journal of Family Medicine & Primary Care","issn_l":"1307-2048","issn":["1307-2048"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Family Medicine and Primary Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063114790","display_name":"Se\u00e7kin Engin","orcid":"https://orcid.org/0000-0002-1982-7820","observed_orcids":["https://orcid.org/0000-0002-1982-7820"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Se\u00e7kin ENG\u0130N","raw_affiliation_strings":["Karadeniz Technical University, Faculty of Pharmacy, Department of Pharmacology"],"raw_orcid":"https://orcid.org/0000-0002-1982-7820","affiliations":[{"raw_affiliation_string":"Karadeniz Technical University, Faculty of Pharmacy, Department of Pharmacology","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077823934","display_name":"Elif Nur Barut","orcid":"https://orcid.org/0000-0003-3284-848X","observed_orcids":["https://orcid.org/0000-0003-3284-848X"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif BARUT","raw_affiliation_strings":["Karadeniz Technical University, Faculty of Pharmacy, Department of Pharmacology"],"raw_orcid":"https://orcid.org/0000-0003-3284-848X","affiliations":[{"raw_affiliation_string":"Karadeniz Technical University, Faculty of Pharmacy, Department of Pharmacology","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090071755","display_name":"Feride Sena Sezen","orcid":"https://orcid.org/0000-0002-7379-2518","observed_orcids":["https://orcid.org/0000-0002-7379-2518"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Feride SEZEN","raw_affiliation_strings":["Karadeniz Technical University, Drug and Pharmaceutical Technology Application and Research Center"],"raw_orcid":"https://orcid.org/0000-0002-7379-2518","affiliations":[{"raw_affiliation_string":"Karadeniz Technical University, Drug and Pharmaceutical Technology Application and Research Center","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061834596","display_name":"Ersin Yari\u015f","orcid":"https://orcid.org/0000-0002-0055-8069","observed_orcids":["https://orcid.org/0000-0002-0055-8069"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ersin YARI\u015e","raw_affiliation_strings":["Karadeniz Technical University, Faculty of Medicine, Department of Medicinal Pharmacology"],"raw_orcid":"https://orcid.org/0000-0002-0055-8069","affiliations":[{"raw_affiliation_string":"Karadeniz Technical University, Faculty of Medicine, Department of Medicinal Pharmacology","institution_ids":["https://openalex.org/I162720556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I162720556"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"4","first_page":"564","last_page":"571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9710000157356262},{"id":"https://openalex.org/keywords/potential-drug-drug-interactions","display_name":"potential drug-drug interactions","score":0.8899999856948853},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/outpatient-prescriptions","display_name":"outpatient prescriptions","score":0.7459999918937683},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hydrochlorothiazide","display_name":"hydrochlorothiazide","score":0.9459999799728394},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.640999972820282},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lexi-interact","display_name":"Lexi-Interact","score":0.8479999899864197},{"id":"https://openalex.org/keywords/trabzon","display_name":"Trabzon","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9006878733634949},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.8530213832855225},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.83039391040802},{"id":"https://openalex.org/C2780361556","wikidata":"https://www.wikidata.org/wiki/Q423930","display_name":"Hydrochlorothiazide","level":3,"score":0.800690770149231},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6548218727111816},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5025231838226318},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49335089325904846},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.4391342103481293},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3659491240978241},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19520556926727295},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21763/tjfmpc.713208","doi":"https://doi.org/10.21763/tjfmpc.713208","is_oa":false,"landing_page_url":"https://doi.org/10.21763/tjfmpc.713208","pdf_url":null,"source":{"id":"https://openalex.org/S2764966086","display_name":"Turkish Journal of Family Medicine & Primary Care","issn_l":"1307-2048","issn":["1307-2048"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Family Medicine and Primary Care","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/713208","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/tr/pub/tjfmpc/issue/58023/713208","pdf_url":null,"source":{"id":"https://openalex.org/S2764966086","display_name":"Turkish Journal of Family Medicine & Primary Care","issn_l":"1307-2048","issn":["1307-2048"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1515319064","https://openalex.org/W1998055925","https://openalex.org/W2006249532","https://openalex.org/W2012370346","https://openalex.org/W2015874696","https://openalex.org/W2023036969","https://openalex.org/W2044412626","https://openalex.org/W2081117244","https://openalex.org/W2095924750","https://openalex.org/W2099457445","https://openalex.org/W2107212173","https://openalex.org/W2111945961","https://openalex.org/W2113558456","https://openalex.org/W2150116774","https://openalex.org/W2158891997","https://openalex.org/W2324536277","https://openalex.org/W2345768112","https://openalex.org/W2725454747","https://openalex.org/W2805586353","https://openalex.org/W3027790311"],"related_works":["https://openalex.org/W2150116774","https://openalex.org/W2333696945","https://openalex.org/W4316193316","https://openalex.org/W4408410256","https://openalex.org/W2993645695","https://openalex.org/W6968882466","https://openalex.org/W3036920704","https://openalex.org/W3163927395","https://openalex.org/W2316764448","https://openalex.org/W4408908508"],"abstract_inverted_index":{"Introduction:":[0],"Drug-drug":[1],"interactions":[2],"(DDIs)":[3],"are":[4,148],"an":[5],"important":[6],"component":[7],"of":[8,20,31,76,84,94,101,109,116,146,159,166,191,200,214,223],"drug-related":[9],"adverse":[10,210],"events,":[11],"leading":[12],"to":[13,25,202],"morbidity":[14],"and":[15,29,48,140,156,184,195],"mortality":[16],"worldwide.":[17],"The":[18,92,98,133,144,164],"aim":[19],"the":[21,27,36,123,157,172,189],"present":[22],"study":[23,53],"was":[24,54,96,105,122,137],"evaluate":[26],"frequency":[28],"severity":[30],"potential":[32],"DDIs":[33,215],"(pDDIs)":[34],"in":[35,39,44,57,129,171],"prescriptions":[37,59,78],"written":[38],"outpatient":[40],"primary":[41,62],"care":[42,63],"clinics":[43],"Trabzon,":[45],"Turkey.":[46],"Material":[47],"Methods:":[49],"A":[50,74,107],"retrospective":[51],"descriptive":[52],"carried":[55],"out":[56],"169":[58,77],"from":[60],"15":[61],"clinics.":[64],"pDDIs":[65,95,111,130,136,147,167,201],"were":[66,82,112,170,186],"identified":[67,113],"by":[68],"using":[69],"Lexi-Interact\u2122":[70],"software":[71],"program.":[72],"Results:":[73],"total":[75,108],"involving":[79],"506":[80],"drugs":[81,102,161],"analyzed,":[83],"which":[85],"59":[86],"had":[87],"at":[88],"least":[89],"one":[90],"pDDI.":[91],"prevalence":[93],"34.91%.":[97],"mean":[99,115],"number":[100,145,158],"per":[103,118],"prescription":[104],"2.99\u00b11.08.":[106],"124":[110],"with":[114,151,188,216,226],"0.73\u00b11.45":[117],"each":[119],"prescription.":[120],"Hydrochlorothiazide":[121],"most":[124,134],"frequently":[125],"prescribed":[126,160],"drug":[127,204,211],"involved":[128],"(n=15,":[131],"12.10%).":[132],"common":[135],"between":[138],"hydrochlorothiazide":[139],"metformin":[141],"(n=4,":[142],"3.22%).":[143],"positively":[149],"correlated":[150],"increasing":[152],"age":[153,185],"(r=0.33":[154],"p<0.01)":[155],"(r=0.41,":[162],"p<0.01).":[163],"majority":[165],"(n=96,":[168],"77.42%)":[169],"risk":[173,190],"category":[174],"C":[175],"(monitor":[176],"therapy).":[177],"Conclusion:":[178],"Our":[179],"findings":[180],"indicate":[181],"that":[182],"polypharmacy":[183],"associated":[187,225],"having":[192],"pDDIs.":[193,227],"Physicians":[194],"pharmacists":[196],"should":[197,218],"be":[198,219],"aware":[199],"improve":[203],"safety,":[205],"patient":[206],"compliance":[207],"and,":[208],"prevent":[209],"reactions.":[212],"Analyzing":[213],"softwares":[217],"effective":[220],"for":[221],"management":[222],"risks":[224]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2020-09-11T00:00:00"}