{"id":"https://openalex.org/W3083338325","doi":"https://doi.org/10.1158/1538-7445.am2020-1488","title":"Abstract 1488: A novel Notch4 neutralizing antibody inhibits angiogenesis and tumor growth via a distinct mechanism from endothelial Notch1 inhibition","display_name":"Abstract 1488: A novel Notch4 neutralizing antibody inhibits angiogenesis and tumor growth via a distinct mechanism from endothelial Notch1 inhibition","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083338325","doi":"https://doi.org/10.1158/1538-7445.am2020-1488","mag":"3083338325"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-1488","doi":"https://doi.org/10.1158/1538-7445.am2020-1488","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-1488","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3083338325"],"child_works_count":0,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008831231","display_name":"L.A. Naiche","orcid":"https://orcid.org/0000-0002-5031-4804","observed_orcids":["https://orcid.org/0000-0002-5031-4804"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. A. Naiche","raw_affiliation_strings":["1University of Illinois Chicago, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois Chicago, Chicago, IL;","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089451408","display_name":"Bhairavi Swaminathan","orcid":"https://orcid.org/0009-0009-3959-6474","observed_orcids":["https://orcid.org/0009-0009-3959-6474"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhairavi Swaminathan","raw_affiliation_strings":["1University of Illinois Chicago, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois Chicago, Chicago, IL;","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039847095","display_name":"Yu Kato","orcid":"https://orcid.org/0000-0003-1662-6983","observed_orcids":["https://orcid.org/0000-0003-1662-6983"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Kato","raw_affiliation_strings":["2Eisai Ltd, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Eisai Ltd, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048250923","display_name":"Sarita Das","orcid":"https://orcid.org/0000-0003-2153-2551","observed_orcids":["https://orcid.org/0000-0003-2153-2551"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarita Das","raw_affiliation_strings":["1University of Illinois Chicago, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois Chicago, Chicago, IL;","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066978332","display_name":"Jason W.\u2010L. Eng","orcid":"https://orcid.org/0000-0002-8219-2290","observed_orcids":["https://orcid.org/0000-0002-8219-2290"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason W. Eng","raw_affiliation_strings":["1University of Illinois Chicago, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois Chicago, Chicago, IL;","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002850706","display_name":"Qanber Raza","orcid":"https://orcid.org/0000-0001-7612-805X","observed_orcids":["https://orcid.org/0000-0001-7612-805X"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qanber Raza","raw_affiliation_strings":["1University of Illinois Chicago, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois Chicago, Chicago, IL;","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041336720","display_name":"Krishna Thakkar","orcid":"https://orcid.org/0009-0000-5029-6936","observed_orcids":["https://orcid.org/0009-0000-5029-6936"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna Thakkar","raw_affiliation_strings":["1University of Illinois Chicago, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois Chicago, Chicago, IL;","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088263981","display_name":"James H. Herts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Herts","raw_affiliation_strings":["1University of Illinois Chicago, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois Chicago, Chicago, IL;","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046736995","display_name":"Rajyasree Emmadi","orcid":"https://orcid.org/0000-0002-5056-5304","observed_orcids":["https://orcid.org/0000-0002-5056-5304"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajyasree Emmadi","raw_affiliation_strings":["1University of Illinois Chicago, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois Chicago, Chicago, IL;","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034541719","display_name":"Junji Matsui","orcid":"https://orcid.org/0000-0002-9983-9943","observed_orcids":["https://orcid.org/0000-0002-9983-9943"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junji Matsui","raw_affiliation_strings":["2Eisai Ltd, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Eisai Ltd, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018317129","display_name":"Jan Kitajewski","orcid":"https://orcid.org/0000-0003-4660-593X","observed_orcids":["https://orcid.org/0000-0003-4660-593X"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan K. Kitajewski","raw_affiliation_strings":["1University of Illinois Chicago, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois Chicago, Chicago, IL;","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"1488","last_page":"1488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch4","display_name":"Notch4","score":0.9639999866485596},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.7429999709129333},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.6230000257492065},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.7170000076293945},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.722000002861023},{"id":"https://openalex.org/keywords/retinal-angiogenesis","display_name":"retinal angiogenesis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/developmental-angiogenesis","display_name":"developmental angiogenesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/vessel-sprouting","display_name":"vessel sprouting","score":0.5139999985694885},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8730000257492065},{"id":"https://openalex.org/keywords/notch-target-genes","display_name":"Notch target genes","score":0.6809999942779541},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.39100000262260437},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/vascular-tumors","display_name":"vascular tumors","score":0.5289999842643738},{"id":"https://openalex.org/keywords/tissue-hypoxia","display_name":"tissue hypoxia","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8217518329620361},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.720119833946228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6775116920471191},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5825487971305847},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4772360324859619},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.45527005195617676},{"id":"https://openalex.org/C60781801","wikidata":"https://www.wikidata.org/wiki/Q1424593","display_name":"Vasculogenesis","level":4,"score":0.45292580127716064},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4477229714393616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4326702952384949},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4000256359577179},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.23827728629112244},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19601818919181824},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.1387825608253479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12313815951347351},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11511656641960144},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08441159129142761}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-1488","doi":"https://doi.org/10.1158/1538-7445.am2020-1488","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-1488","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282939009","https://openalex.org/W4409630685","https://openalex.org/W4400495795","https://openalex.org/W3083766958","https://openalex.org/W3019015804","https://openalex.org/W2105497000","https://openalex.org/W3003116293","https://openalex.org/W1976639605","https://openalex.org/W2054001958","https://openalex.org/W2401176028"],"abstract_inverted_index":{"Abstract":[0],"Endothelial":[1],"Notch":[2,117],"signaling":[3,109,277],"is":[4,60,350],"critical":[5],"for":[6,47,412],"tumor":[7,19,29,56,67,78,287,295,312,315,391],"angiogenesis":[8,79,389],"and":[9,55,86,100,250,264,314,345,390,419],"growth.":[10,30],"Inhibitors":[11],"of":[12,65,107,112,115,126,130,162,194,201,215,224,244,248,254,257,306,308,404,408],"Notch1":[13,50,202,213,225,229,255,263,399],"or":[14,42,188],"its":[15],"ligand":[16],"Dll4":[17],"cause":[18],"vessel":[20,25],"hypersprouting":[21,252],"but":[22],"interfere":[23],"with":[24,80,121,221,272],"perfusion":[26],"causing":[27,39],"reduced":[28,53,165],"Unfortunately,":[31],"normal":[32,84],"tissue":[33,40,85],"vessels":[34],"respond":[35],"to":[36,140,148,151,227,230,289,328],"these":[37],"inhibitors":[38],"hypoxia":[41],"vascular":[43,167,186,245],"neoplasms.":[44],"Mice":[45],"null":[46],"Notch4,":[48],"unlike":[49],"mutants,":[51],"exhibit":[52],"developmental":[54,156,270],"angiogenesis.":[57,158],"Notch4":[58,75,108,143,231,265,273,281,292,309,340,349,385],"expression":[59,111,125,282,307,341],"increased":[61,198],"in":[62,103,175,269,283,294,310,323,342],"the":[63,153,185,205,212,242,251,284,324,405,409],"endothelium":[64],"some":[66],"types.":[68],"These":[69,259],"results":[70,260],"suggest":[71,261],"that":[72,102,170,262,320,330,338,346],"specifically":[73],"targeting":[74,347],"could":[76],"reduce":[77],"fewer":[81],"effects":[82,154,319],"on":[83,155],"represents":[87],"an":[88],"unexplored":[89],"therapeutic":[90],"opportunity.":[91],"We":[92,145,279],"use":[93],"a":[94,113,127,237,275,304,351,394],"newly":[95],"developed":[96],"anti-Notch4":[97],"antibody,":[98],"E7011,":[99],"show":[101,333],"endothelial":[104,189,348,398],"cells,":[105],"inhibition":[106,400],"suppresses":[110,124],"subset":[114],"canonical":[116,135],"target":[118],"genes.":[119],"Treatment":[120],"E7011":[122,147,163,171,177,206,219,331],"also":[123],"unique":[128],"set":[129],"genes":[131],"not":[132,180],"regulated":[133],"by":[134,199],"Dll4-Notch1":[136],"signaling,":[137],"which":[138,195],"appear":[139],"be":[141],"distinct":[142,210,267,395],"targets.":[144],"administered":[146],"neonatal":[149],"mice":[150],"examine":[152],"retinal":[157,166],"A":[159,383],"single":[160],"dose":[161],"significantly":[164],"outgrowth,":[168],"demonstrating":[169],"has":[172],"anti-angiogenic":[173,318,353],"activity":[174,335],"vivo.":[176],"treatment":[178,220],"did":[179],"alter":[181],"capillary":[182],"density":[183],"within":[184],"plexus":[187],"tip":[190],"cell":[191],"number,":[192],"both":[193,241,311],"are":[196],"typically":[197],"loss":[200,214,223,243,256],"signaling.":[203],"Because":[204],"phenotype":[207],"was":[208],"markedly":[209],"from":[211,397],"function,":[216],"we":[217,321],"combined":[218],"endothelial-specific":[222],"(Notch1ECKO)":[226],"compare":[228],"function.":[232,258],"E7011-treated":[233],"Notch1ECKO":[234],"retina":[235,325],"showed":[236],"compound":[238],"phenotype,":[239],"exhibiting":[240],"outgrowth":[246],"characteristic":[247,253],"E7011/Notch4":[249],"have":[266],"roles":[268],"angiogenesis,":[271],"being":[274],"pro-angiogenic":[276],"pathway.":[278],"evaluated":[280],"breast":[285,300],"cancer":[286,301],"microenvironment":[288],"determine":[290],"if":[291],"functions":[293],"vessels.":[296],"Human":[297],"triple":[298],"negative":[299],"(TNBC)":[302],"shows":[303],"range":[305],"cells":[313],"endothelium.":[316],"The":[317],"observe":[322],"lead":[326],"us":[327],"hypothesize":[329],"will":[332],"anti-tumor":[334],"against":[336],"tumors":[337],"induce":[339],"neighboring":[343],"endothelium,":[344],"novel":[352,384],"approach.":[354],"Citation":[355],"Format:":[356],"L.":[357],"A.":[358],"Naiche,":[359],"Bhairavi":[360],"Swaminathan,":[361],"Yu":[362],"Kato,":[363],"Sarita":[364],"Das,":[365],"Jason":[366],"W.":[367],"Eng,":[368],"Qanber":[369],"Raza,":[370],"Krishna":[371],"Thakkar,":[372],"James":[373],"H.":[374],"Herts,":[375],"Rajyasree":[376],"Emmadi,":[377],"Junji":[378],"Matsui,":[379],"Jan":[380],"K.":[381],"Kitajewski.":[382],"neutralizing":[386],"antibody":[387],"inhibits":[388],"growth":[392],"via":[393],"mechanism":[396],"[abstract].":[401],"In:":[402],"Proceedings":[403],"Annual":[406],"Meeting":[407],"American":[410],"Association":[411],"Cancer":[413,425],"Research":[414],"2020;":[415],"2020":[416],"Apr":[417],"27-28":[418],"Jun":[420],"22-24.":[421],"Philadelphia":[422],"(PA):":[423],"AACR;":[424],"Res":[426],"2020;80(16":[427],"Suppl):Abstract":[428],"nr":[429],"1488.":[430]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-09-11T00:00:00"}