{"id":"https://openalex.org/W3083329137","doi":"https://doi.org/10.1111/gtc.12805","title":"Efficient and multiplexable genome editing using Platinum TALENs in oleaginous microalga, Nannochloropsis oceanica NIES\u20102145","display_name":"Efficient and multiplexable genome editing using Platinum TALENs in oleaginous microalga, Nannochloropsis oceanica NIES\u20102145","publication_year":2020,"publication_date":"2020-09-05","ids":{"openalex":"https://openalex.org/W3083329137","doi":"https://doi.org/10.1111/gtc.12805","mag":"3083329137","pmid":"https://pubmed.ncbi.nlm.nih.gov/32888368"},"language":"en","primary_location":{"id":"doi:10.1111/gtc.12805","doi":"https://doi.org/10.1111/gtc.12805","is_oa":false,"landing_page_url":"https://doi.org/10.1111/gtc.12805","pdf_url":null,"source":{"id":"https://openalex.org/S48908450","display_name":"Genes to Cells","issn_l":"1356-9597","issn":["1356-9597","1365-2443"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015911095","display_name":"Tomokazu Kurita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomokazu Kurita","raw_affiliation_strings":["Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056391756","display_name":"Keishi Moroi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keishi Moroi","raw_affiliation_strings":["Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049688470","display_name":"Masako Iwai","orcid":"https://orcid.org/0000-0001-6121-7543","observed_orcids":["https://orcid.org/0000-0001-6121-7543"]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masako Iwai","raw_affiliation_strings":["School of Life Science and Technology Tokyo Institute of Technology  Yokohama Japan","School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology Tokyo Institute of Technology  Yokohama Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033344048","display_name":"Kumiko Okazaki","orcid":"https://orcid.org/0000-0002-7742-2477","observed_orcids":["https://orcid.org/0000-0002-7742-2477"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumiko Okazaki","raw_affiliation_strings":["Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111357602","display_name":"S. Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinsuke Shimizu","raw_affiliation_strings":["School of Life Science and Technology Tokyo Institute of Technology  Yokohama Japan","School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology Tokyo Institute of Technology  Yokohama Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002271353","display_name":"Seiji Nomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282569916","display_name":"Mazda Motor Corporation (Japan)","ror":"https://ror.org/05hk1wv51","country_code":"JP","type":"company","lineage":["https://openalex.org/I1282569916"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Nomura","raw_affiliation_strings":["Mazda Motor Corporation  Fuchu\u2010cho Hiroshima Japan","Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazda Motor Corporation  Fuchu\u2010cho Hiroshima Japan","institution_ids":["https://openalex.org/I1282569916"]},{"raw_affiliation_string":"Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan","institution_ids":["https://openalex.org/I1282569916"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fumihiko Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282569916","display_name":"Mazda Motor Corporation (Japan)","ror":"https://ror.org/05hk1wv51","country_code":"JP","type":"company","lineage":["https://openalex.org/I1282569916"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumihiko Saito","raw_affiliation_strings":["Mazda Motor Corporation  Fuchu\u2010cho Hiroshima Japan","Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazda Motor Corporation  Fuchu\u2010cho Hiroshima Japan","institution_ids":["https://openalex.org/I1282569916"]},{"raw_affiliation_string":"Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan","institution_ids":["https://openalex.org/I1282569916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001298393","display_name":"Shinichiro Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282569916","display_name":"Mazda Motor Corporation (Japan)","ror":"https://ror.org/05hk1wv51","country_code":"JP","type":"company","lineage":["https://openalex.org/I1282569916"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichiro Maeda","raw_affiliation_strings":["Mazda Motor Corporation  Fuchu\u2010cho Hiroshima Japan","Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazda Motor Corporation  Fuchu\u2010cho Hiroshima Japan","institution_ids":["https://openalex.org/I1282569916"]},{"raw_affiliation_string":"Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan","institution_ids":["https://openalex.org/I1282569916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108718744","display_name":"Akihide Takami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282569916","display_name":"Mazda Motor Corporation (Japan)","ror":"https://ror.org/05hk1wv51","country_code":"JP","type":"company","lineage":["https://openalex.org/I1282569916"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihide Takami","raw_affiliation_strings":["Mazda Motor Corporation  Fuchu\u2010cho Hiroshima Japan","Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazda Motor Corporation  Fuchu\u2010cho Hiroshima Japan","institution_ids":["https://openalex.org/I1282569916"]},{"raw_affiliation_string":"Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan","institution_ids":["https://openalex.org/I1282569916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020948537","display_name":"Atsushi Sakamoto","orcid":"https://orcid.org/0000-0001-5710-1900","observed_orcids":["https://orcid.org/0000-0001-5710-1900"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Sakamoto","raw_affiliation_strings":["Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091691483","display_name":"Hiroyuki Ohta","orcid":"https://orcid.org/0000-0002-1068-3242","observed_orcids":["https://orcid.org/0000-0002-1068-3242","https://orcid.org/0000-0002-1816-7912"]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Ohta","raw_affiliation_strings":["School of Life Science and Technology Tokyo Institute of Technology  Yokohama Japan","School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology Tokyo Institute of Technology  Yokohama Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026826873","display_name":"Tetsushi Sakuma","orcid":"https://orcid.org/0000-0003-0396-1563","observed_orcids":["https://orcid.org/0000-0003-0396-1563"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsushi Sakuma","raw_affiliation_strings":["Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0396-1563","affiliations":[{"raw_affiliation_string":"Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078140561","display_name":"Takashi Yamamoto","orcid":"https://orcid.org/0000-0002-6516-2903","observed_orcids":["https://orcid.org/0000-0002-6516-2903","https://orcid.org/0009-0000-7380-0592","https://orcid.org/0009-0008-7027-2286"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Yamamoto","raw_affiliation_strings":["Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6516-2903","affiliations":[{"raw_affiliation_string":"Division of Integrated Sciences for Life Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026826873","https://openalex.org/A5078140561"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.4511,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.81638083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"25","issue":"10","first_page":"695","last_page":"702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-activator-like-effector-nucleases","display_name":"TALEN","score":0.9259999990463257},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nannochloropsis-oceanica","display_name":"Nannochloropsis oceanica","score":0.9729999899864197},{"id":"https://openalex.org/keywords/oleaginous-microalgae","display_name":"oleaginous microalgae","score":0.9760000109672546},{"id":"https://openalex.org/keywords/algal-lipid-production","display_name":"algal lipid production","score":0.7419999837875366},{"id":"https://openalex.org/keywords/biodiesel-feedstock","display_name":"biodiesel feedstock","score":0.6800000071525574},{"id":"https://openalex.org/keywords/nitrate-reductase","display_name":"nitrate reductase","score":0.7950000166893005},{"id":"https://openalex.org/keywords/acyltransferase","display_name":"acyltransferase","score":0.8980000019073486},{"id":"https://openalex.org/keywords/codon-optimization","display_name":"codon optimization","score":0.8429999947547913},{"id":"https://openalex.org/keywords/multiplex-genome-editing","display_name":"multiplex genome editing","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2777141785","wikidata":"https://www.wikidata.org/wiki/Q586679","display_name":"Nannochloropsis","level":3,"score":0.9163044691085815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8151934146881104},{"id":"https://openalex.org/C31909778","wikidata":"https://www.wikidata.org/wiki/Q7833921","display_name":"Transcription activator-like effector nuclease","level":5,"score":0.7542067766189575},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5313620567321777},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.4637065529823303},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.41592273116111755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3211524486541748},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.2500945031642914},{"id":"https://openalex.org/C559758991","wikidata":"https://www.wikidata.org/wiki/Q37868","display_name":"Algae","level":2,"score":0.16877481341362}],"mesh":[{"descriptor_ui":"D000069896","descriptor_name":"Transcription Activator-Like Effector Nucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000069896","descriptor_name":"Transcription Activator-Like Effector Nucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000069896","descriptor_name":"Transcription Activator-Like Effector Nucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000069896","descriptor_name":"Transcription Activator-Like Effector Nucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000069896","descriptor_name":"Transcription Activator-Like Effector Nucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000069896","descriptor_name":"Transcription Activator-Like Effector Nucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058009","descriptor_name":"Stramenopiles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058009","descriptor_name":"Stramenopiles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058009","descriptor_name":"Stramenopiles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058009","descriptor_name":"Stramenopiles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058009","descriptor_name":"Stramenopiles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058009","descriptor_name":"Stramenopiles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058086","descriptor_name":"Microalgae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058086","descriptor_name":"Microalgae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058086","descriptor_name":"Microalgae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058086","descriptor_name":"Microalgae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058086","descriptor_name":"Microalgae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058086","descriptor_name":"Microalgae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/gtc.12805","doi":"https://doi.org/10.1111/gtc.12805","is_oa":false,"landing_page_url":"https://doi.org/10.1111/gtc.12805","pdf_url":null,"source":{"id":"https://openalex.org/S48908450","display_name":"Genes to Cells","issn_l":"1356-9597","issn":["1356-9597","1365-2443"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to Cells","raw_type":"journal-article"},{"id":"pmid:32888368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32888368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to cells : devoted to molecular & cellular mechanisms","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.5666999816894531}],"sustainable_development_goals_aurora":[{"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12","score":0.47999998927116394}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2867653952","display_name":"The stress signaling effect of allantoin and its molecular mechanism of action: a new avenue to plant ureide research","funder_award_id":"19K06725","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G94035052","display_name":"Development of a novel epigenome editing technology using the expanded TREE system and its application in cancer study","funder_award_id":"19K16111","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338123","display_name":"Program on Open Innovation Platform with Enterprises, Research Institute and Academia","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1580249194","https://openalex.org/W1994360376","https://openalex.org/W2002547950","https://openalex.org/W2013253012","https://openalex.org/W2042115934","https://openalex.org/W2052430014","https://openalex.org/W2053745385","https://openalex.org/W2084322857","https://openalex.org/W2091708974","https://openalex.org/W2102450255","https://openalex.org/W2112006537","https://openalex.org/W2114838239","https://openalex.org/W2140884584","https://openalex.org/W2153922477","https://openalex.org/W2156778513","https://openalex.org/W2160586543","https://openalex.org/W2472559425","https://openalex.org/W2518075094","https://openalex.org/W2566816565","https://openalex.org/W2589309763","https://openalex.org/W2624919703","https://openalex.org/W2763271494","https://openalex.org/W2791247674","https://openalex.org/W2793263267","https://openalex.org/W2800170484","https://openalex.org/W2864031524","https://openalex.org/W2904189781","https://openalex.org/W2907138919","https://openalex.org/W2923103077","https://openalex.org/W2946957748","https://openalex.org/W3089952624","https://openalex.org/W4247025394"],"related_works":["https://openalex.org/W2604891032","https://openalex.org/W2147579536","https://openalex.org/W4388142354","https://openalex.org/W627210887","https://openalex.org/W2808076791","https://openalex.org/W2890784575","https://openalex.org/W2418424376","https://openalex.org/W2757127690","https://openalex.org/W2083779135","https://openalex.org/W4281908041"],"abstract_inverted_index":{"Algae":[0],"accumulate":[1],"large":[2],"amounts":[3],"of":[4,35,42,49,55,61,134,169],"lipids":[5,11,57],"produced":[6],"by":[7,58,103],"photosynthesis,":[8],"and":[9,97,123],"these":[10],"are":[12,28,45],"expected":[13],"to":[14],"be":[15],"utilized":[16],"as":[17,24],"feedstocks":[18],"for":[19,65,92,114,181],"sustainable":[20],"new":[21],"energies,":[22],"known":[23],"biodiesels.":[25],"Nannochloropsis":[26,87,130,185],"species":[27],"eukaryotic":[29],"microalgae":[30],"that":[31],"produce":[32],"high":[33,139],"levels":[34],"lipids.":[36],"However,":[37],"since":[38],"the":[39,52,69,118,148],"production":[40],"costs":[41],"algal":[43,56],"biodiesels":[44],"higher":[46],"than":[47],"those":[48],"fossil":[50],"fuels,":[51],"improved":[53],"productivity":[54],"molecular":[59,182],"breeding":[60,183],"algae":[62],"is":[63],"required":[64],"practical":[66],"use.":[67],"In":[68],"present":[70],"study,":[71],"we":[72,161],"developed":[73],"a":[74],"highly":[75],"efficient":[76],"genome-editing":[77,140],"system":[78],"involving":[79],"Platinum":[80,89,115,136],"transcription":[81],"activator-like":[82],"effector":[83],"nucleases":[84],"(TALENs)":[85],"in":[86,107,151,184],"oceanica.":[88,153],"TALENs":[90,157],"codon-optimized":[91],"N.":[93,152],"oceanica":[94],"were":[95,127],"synthesized,":[96],"their":[98],"DNA-binding":[99],"activity":[100],"was":[101,171],"confirmed":[102],"single-strand":[104],"annealing":[105],"assays":[106],"human":[108],"HEK293T":[109],"cells.":[110],"All-in-one":[111],"expression":[112],"vectors":[113],"TALEN":[116,137],"targeting":[117,158],"nitrate":[119],"reductase":[120],"gene,":[121,125],"NoNR,":[122],"acyltransferase":[124],"LPAT1,":[126],"transfected":[128],"into":[129],"species.":[131,186],"The":[132,166],"introduction":[133],"each":[135],"revealed":[138],"efficiency":[141],"with":[142],"no":[143],"detectable":[144],"off-target":[145],"mutations":[146],"at":[147],"candidate":[149],"sites":[150],"By":[154],"simultaneously":[155],"introducing":[156],"two":[159],"genes,":[160],"obtained":[162],"double":[163],"mutant":[164],"strains.":[165],"loss-of-function":[167],"phenotype":[168],"NoNR":[170],"also":[172],"confirmed.":[173],"These":[174],"findings":[175],"will":[176],"provide":[177],"an":[178],"essential":[179],"technology":[180]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-09-11T00:00:00"}
