{"id":"https://openalex.org/W3083322195","doi":"https://doi.org/10.1158/1538-7445.am2020-2253","title":"Abstract 2253: Lymphangiogenesis augments the anti-tumor efficacy of radiotherapy in mouse melanoma","display_name":"Abstract 2253: Lymphangiogenesis augments the anti-tumor efficacy of radiotherapy in mouse melanoma","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083322195","doi":"https://doi.org/10.1158/1538-7445.am2020-2253","mag":"3083322195"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-2253","doi":"https://doi.org/10.1158/1538-7445.am2020-2253","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-2253","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029074046","display_name":"Nikolaos Mitrousis","orcid":"https://orcid.org/0000-0002-6451-5180","observed_orcids":["https://orcid.org/0000-0002-6451-5180"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolaos Mitrousis","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016088495","display_name":"Maria Stella Sasso","orcid":"https://orcid.org/0000-0002-4625-9486","observed_orcids":["https://orcid.org/0000-0002-4625-9486"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Stella Sasso","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054855052","display_name":"Ralph R. Weichselbaum","orcid":"https://orcid.org/0000-0002-5643-8939","observed_orcids":["https://orcid.org/0000-0002-5643-8939"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph R. Weichselbaum","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031517705","display_name":"Jeffrey A. Hubbell","orcid":"https://orcid.org/0000-0003-0276-5456","observed_orcids":["https://orcid.org/0000-0003-0276-5456"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Hubbell","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088767177","display_name":"Melody A. Swartz","orcid":"https://orcid.org/0000-0001-5484-1903","observed_orcids":["https://orcid.org/0000-0001-5484-1903"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melody A. Swartz","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"2253","last_page":"2253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphangiogenesis","display_name":"lymphangiogenesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/vegf-c","display_name":"VEGF-C","score":0.9520000219345093},{"id":"https://openalex.org/keywords/vegfr-3","display_name":"VEGFR-3","score":0.9739999771118164},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.9120000004768372},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9259999990463257},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.4830000102519989},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.8190000057220459},{"id":"https://openalex.org/keywords/combination-therapy-with-immunotherapy","display_name":"combination therapy with immunotherapy","score":0.6200000047683716},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.8227546215057373},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6373564004898071},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6371626257896423},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6049542427062988},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5940492749214172},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5927566289901733},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5858802199363708},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4655032753944397},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45383715629577637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3915759027004242},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2558797001838684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2197151482105255}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-2253","doi":"https://doi.org/10.1158/1538-7445.am2020-2253","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-2253","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3013008721","https://openalex.org/W4379984001","https://openalex.org/W4388083659","https://openalex.org/W2885287481","https://openalex.org/W2914399440","https://openalex.org/W2955722147","https://openalex.org/W3083481024","https://openalex.org/W4220850675","https://openalex.org/W2809887423","https://openalex.org/W3137286939"],"abstract_inverted_index":{"Abstract":[0],"Radiotherapy":[1],"(RT)":[2],"constitutes":[3],"a":[4,33,49,154,167,218,236,257,297,316],"significant":[5,219],"component":[6],"of":[7,16,25,41,60,82,148,178,205,221,260,278,300,346,354,358],"cancer":[8,18],"therapy":[9],"in":[10,209,303,348],"the":[11,23,39,58,72,135,149,161,202,261,272,283,343,355,359],"clinic,":[12],"with":[13,97,230,282],"approximately":[14],"50%":[15],"all":[17],"patients":[19],"receiving":[20],"treatment":[21,99],"over":[22],"course":[24],"their":[26],"disease.":[27],"In":[28,228],"addition":[29],"to":[30,38,68,76,92,107,159,213,323],"acting":[31],"as":[32,102,215],"DNA-damaging":[34],"agent,":[35],"RT":[36,87,180,206],"leads":[37],"release":[40],"tumor":[42,184,222,273,321],"antigens,":[43],"damage-associated":[44],"molecular":[45],"patterns,":[46],"and":[47,84,95,112,126,138,166,181,186,197,224,243,275,294,369],"cytokines,":[48],"process":[50],"termed":[51],"immunogenic":[52],"cell":[53,241,286],"death.":[54],"This":[55],"phenomenon":[56],"triggers":[57],"initiation":[59],"anti-tumor":[61,123,139,189,344],"immune":[62,124,136,190],"responses,":[63],"which":[64],"have":[65,114],"been":[66],"shown":[67],"be":[69,315],"essential":[70],"for":[71,183,362],"complete":[73],"therapeutic":[74,203],"response":[75,137],"RT.":[77,143,250,307,324],"Despite":[78],"its":[79],"diverse":[80],"mechanisms":[81],"action":[83],"broad":[85],"applicability,":[86],"does":[88],"not":[89],"typically":[90],"lead":[91],"curative":[93],"responses":[94,125,191,252],"combinations":[96],"other":[98],"modalities":[100],"such":[101],"immunotherapy":[103],"are":[104],"being":[105],"explored":[106],"improve":[108],"efficacy.":[109],"Our":[110],"laboratory":[111],"others":[113],"previously":[115],"established":[116],"that":[117,156,201,290,312],"tumor-associated":[118],"lymphatics":[119],"can":[120],"actively":[121],"modulate":[122],"potentiate":[127],"immunotherapy.":[128],"Here,":[129],"we":[130,270,288],"asked":[131],"whether":[132],"lymphangiogenesis":[133],"influences":[134],"efficacy":[140,204,345],"elicited":[141],"by":[142,175,194,217,256],"We":[144,199],"employed":[145],"two":[146],"variants":[147],"aggressive":[150],"B16F10":[151],"melanoma":[152,350],"model:":[153],"variant":[155],"was":[157,207],"transduced":[158],"overexpress":[160],"lymphangiogenic":[162],"factor":[163,319],"VEGF-C":[164,263],"(B16-VEGF-C),":[165],"mock-transduced":[168],"(B16-ctrl)":[169],"variant.":[170],"Tumor-bearing":[171],"animals":[172],"were":[173,192,253],"treated":[174],"ablative":[176],"doses":[177],"localized":[179],"monitored":[182],"growth":[185,223],"survival,":[187],"while":[188],"assessed":[193,271],"flow":[195],"cytometry":[196],"ELISA.":[198],"observed":[200,284],"greater":[208,298],"B16-VEGF-C":[210,233,304],"melanomas":[211,234,305],"compared":[212],"B16-ctrl,":[214],"evidenced":[216],"inhibition":[220],"extended":[225],"animal":[226],"survival.":[227],"line":[229],"this":[231],"finding,":[232],"exhibited":[235,296],"significantly":[237],"higher":[238],"CD8+":[239],"T":[240,285],"infiltration":[242,274],"activation":[244,276],"upon":[245],"ex":[246],"vivo":[247],"restimulation":[248],"after":[249,306],"These":[251],"partially":[254],"inhibited":[255],"function-blocking":[258],"antibody":[259],"main":[262],"receptor,":[264],"VEGFR3.":[265],"To":[266],"gain":[267],"further":[268],"insight,":[269],"status":[277],"antigen-presenting":[279],"cells.":[280],"Consistent":[281],"response,":[287],"found":[289],"both":[291],"dendritic":[292],"cells":[293],"macrophages":[295],"expression":[299],"co-stimulatory":[301],"molecules":[302],"Together,":[308],"our":[309],"findings":[310],"demonstrate":[311],"lymhangiogenesis":[313],"may":[314],"key":[317],"contributing":[318],"underlying":[320],"responsiveness":[322],"Citation":[325],"Format:":[326],"Nikolaos":[327],"Mitrousis,":[328],"Maria":[329],"Stella":[330],"Sasso,":[331],"Ralph":[332],"R.":[333],"Weichselbaum,":[334],"Jeffrey":[335],"A.":[336,339],"Hubbell,":[337],"Melody":[338],"Swartz.":[340],"Lymphangiogenesis":[341],"augments":[342],"radiotherapy":[347],"mouse":[349],"[abstract].":[351],"In:":[352],"Proceedings":[353],"Annual":[356],"Meeting":[357],"American":[360],"Association":[361],"Cancer":[363,375],"Research":[364],"2020;":[365],"2020":[366],"Apr":[367],"27-28":[368],"Jun":[370],"22-24.":[371],"Philadelphia":[372],"(PA):":[373],"AACR;":[374],"Res":[376],"2020;80(16":[377],"Suppl):Abstract":[378],"nr":[379],"2253.":[380]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2020-09-11T00:00:00"}