{"id":"https://openalex.org/W3083319362","doi":"https://doi.org/10.1158/1538-7445.am2020-330","title":"Abstract 330: Reconstructed Bone (r-Bone): A patient-derived 3D culture platform for prediction of clinical outcomes in multiple myeloma","display_name":"Abstract 330: Reconstructed Bone (r-Bone): A patient-derived 3D culture platform for prediction of clinical outcomes in multiple myeloma","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083319362","doi":"https://doi.org/10.1158/1538-7445.am2020-330","mag":"3083319362"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-330","doi":"https://doi.org/10.1158/1538-7445.am2020-330","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-330","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056194127","display_name":"Julia Kirshner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Kirshner","raw_affiliation_strings":["1zPREDICTA, San Jose, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1zPREDICTA, San Jose, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013930588","display_name":"Amrita Kirshnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita Kirshnan","raw_affiliation_strings":["2City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040738036","display_name":"Nitya Nathwani","orcid":"https://orcid.org/0000-0003-4329-8102","observed_orcids":["https://orcid.org/0000-0003-4329-8102"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitya Nathwani","raw_affiliation_strings":["2City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022766377","display_name":"Myo Htut","orcid":"https://orcid.org/0000-0001-6650-5704","observed_orcids":["https://orcid.org/0000-0001-6650-5704"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myo Htut","raw_affiliation_strings":["2City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024461673","display_name":"Michael Alan Rosenzweig","orcid":"https://orcid.org/0000-0001-5158-5131","observed_orcids":["https://orcid.org/0000-0001-5158-5131"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Rosenzweig","raw_affiliation_strings":["2City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033267787","display_name":"Chatchada Karanes","orcid":"https://orcid.org/0009-0001-8099-7802","observed_orcids":["https://orcid.org/0009-0001-8099-7802","https://orcid.org/0000-0002-9535-4981"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chatchada Karanes","raw_affiliation_strings":["2City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025887498","display_name":"Firoozeh Sahebi","orcid":"https://orcid.org/0000-0002-6504-5213","observed_orcids":["https://orcid.org/0000-0002-6504-5213"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sahebi Firoozeh","raw_affiliation_strings":["2City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013430443","display_name":"Steven T. Rosen","orcid":"https://orcid.org/0000-0002-8818-7724","observed_orcids":["https://orcid.org/0000-0002-8818-7724"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Rosen","raw_affiliation_strings":["2City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"330","last_page":"330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.7900000214576721},{"id":"https://openalex.org/keywords/clinical-outcome-prediction","display_name":"clinical outcome prediction","score":0.7670000195503235},{"id":"https://openalex.org/keywords/drug-response-prediction","display_name":"drug response prediction","score":0.4650000035762787},{"id":"https://openalex.org/keywords/bone-marrow-aspirate","display_name":"bone marrow aspirate","score":0.6179999709129333},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.5120000243186951},{"id":"https://openalex.org/keywords/treatment-selection","display_name":"treatment selection","score":0.4090000092983246},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.7080000042915344},{"id":"https://openalex.org/keywords/drug-attrition","display_name":"drug attrition","score":0.5199999809265137},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6790000200271606},{"id":"https://openalex.org/keywords/stromal-cells","display_name":"stromal cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.5230000019073486},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.3400000035762787},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.79976886510849},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7817598581314087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7055407762527466},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6298259496688843},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4233071804046631},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3913037180900574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3627147972583771},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3594118058681488}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-330","doi":"https://doi.org/10.1158/1538-7445.am2020-330","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-330","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2920947133","https://openalex.org/W3213876324","https://openalex.org/W3201909109","https://openalex.org/W2552678756","https://openalex.org/W2936822487","https://openalex.org/W2751803734","https://openalex.org/W7130238426","https://openalex.org/W3173056042","https://openalex.org/W3044063134","https://openalex.org/W4417494317"],"abstract_inverted_index":{"Abstract":[0],"Multiple":[1],"myeloma":[2,140,317],"(MM),":[3],"an":[4,110],"incurable":[5],"cancer":[6],"of":[7,28,48,90,99,119,128,207,223,226,262,276,312,321,325],"the":[8,30,46,49,91,100,106,117,150,163,169,174,179,189,205,213,221,244,259,274,322,326],"bone":[9,94,101,152,181],"marrow":[10,102,132,153,182],"plasma":[11],"cells,":[12],"is":[13],"a":[14,270],"second":[15],"most":[16],"common":[17],"hematological":[18],"malignancy.":[19],"While":[20],"considerable":[21],"progress":[22],"has":[23],"been":[24],"made":[25],"towards":[26],"treatment":[27,277],"MM,":[29],"5-year":[31],"survival":[32,81],"rate":[33],"continues":[34],"to":[35,44,54,115,122,168,254],"hover":[36],"around":[37],"50%.":[38],"In":[39],"this":[40],"study,":[41],"we":[42],"aimed":[43],"evaluate":[45,116],"capacity":[47],"Reconstructed":[50,302],"Bone":[51,131,303],"(r-Bone)":[52],"model":[53],"predict":[55],"clinical":[56,129,170,215,263,313],"outcomes":[57,314],"in":[58,112,145,315],"patients":[59,137,280],"with":[60,125,138,212,229,258,281],"multiple":[61,139,282,316],"myeloma.":[62,283],"The":[63,96],"r-Bone":[64,107,146,190,217,245],"system":[65,114,246],"incorporates":[66],"cellular":[67,88],"(hematopoietic":[68],"and":[69,71,75,84,86,143,191,197,204,236,265,336],"stromal)":[70],"extracellular":[72],"(extracellular":[73],"matrix":[74],"secretory":[76],"factors)":[77],"components,":[78],"supports":[79],"long-term":[80],"(>30":[82],"days)":[83],"proliferation,":[85],"maintains":[87],"heterogeneity":[89],"primary":[92],"human":[93],"marrow.":[95],"1-to-1":[97],"reconstruction":[98],"architecture":[103],"established":[104],"by":[105,173],"platform":[108,309],"provides":[109],"ideal":[111],"vitro":[113],"efficacy":[118],"anti-myeloma":[120],"agents":[121],"select":[123,255],"those":[124],"highest":[126,260],"probability":[127,261],"success.":[130],"aspirates":[133],"collected":[134],"from":[135,188],"21":[136,227],"were":[141,165,186,201],"processed":[142,192],"set-up":[144],"cultures.":[147],"To":[148],"establish":[149],"correct":[151],"architechture,":[154],"cultures":[155,218],"where":[156],"grown":[157],"for":[158,193,250,273,279,310,329],"5":[159],"days,":[160],"after":[161],"which":[162],"cells":[164,185],"treated":[166],"according":[167],"regimen":[171,278],"selected":[172],"treating":[175],"physician":[176],"based":[177],"on":[178],"orginal":[180],"aspirate.":[183],"Subsequently,":[184],"isolated":[187],"flow":[194],"cytometry.":[195],"Plasma":[196],"non-plasma":[198],"cell":[199,208],"populations":[200],"evaluated":[202],"post-treatment":[203],"extent":[206],"death":[209],"was":[210],"correlated":[211],"observed":[214],"response.":[216],"correctly":[219],"predicted":[220],"outcome":[222],"19":[224],"out":[225],"cases":[228],"8":[230],"true":[231,234],"positivies,":[232],"11":[233],"negatives,":[235],"2":[237],"false":[238],"positives.":[239],"This":[240],"data":[241],"demonstrate":[242],"that":[243],"could":[247],"be":[248,267],"used":[249],"pipeline":[251],"attrition":[252],"management":[253],"drug":[256],"candidates":[257],"success":[264],"can":[266],"developed":[268],"into":[269],"prognostic":[271],"tool":[272],"selection":[275],"Citation":[284],"Format:":[285],"Julia":[286],"Kirshner,":[287],"Amrita":[288],"Kirshnan,":[289],"Nitya":[290],"Nathwani,":[291],"Myo":[292],"Htut,":[293],"Michael":[294],"Rosenzweig,":[295],"Chatchada":[296],"Karanes,":[297],"Sahebi":[298],"Firoozeh,":[299],"Steven":[300],"Rosen.":[301],"(r-Bone):":[304],"A":[305],"patient-derived":[306],"3D":[307],"culture":[308],"prediction":[311],"[abstract].":[318],"In:":[319],"Proceedings":[320],"Annual":[323],"Meeting":[324],"American":[327],"Association":[328],"Cancer":[330,342],"Research":[331],"2020;":[332],"2020":[333],"Apr":[334],"27-28":[335],"Jun":[337],"22-24.":[338],"Philadelphia":[339],"(PA):":[340],"AACR;":[341],"Res":[343],"2020;80(16":[344],"Suppl):Abstract":[345],"nr":[346],"330.":[347]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2020-09-11T00:00:00"}