{"id":"https://openalex.org/W3083314940","doi":"https://doi.org/10.1158/1538-7445.am2020-5514","title":"Abstract 5514: Analysis of immune checkpoint receptor expression by circulating T cells and tumor specimens in patients pre- and post-neoadjuvant chemotherapy for operable breast cancer","display_name":"Abstract 5514: Analysis of immune checkpoint receptor expression by circulating T cells and tumor specimens in patients pre- and post-neoadjuvant chemotherapy for operable breast cancer","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083314940","doi":"https://doi.org/10.1158/1538-7445.am2020-5514","mag":"3083314940"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-5514","doi":"https://doi.org/10.1158/1538-7445.am2020-5514","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-5514","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060303416","display_name":"Dionisia Marie Quiroga","orcid":"https://orcid.org/0000-0003-3388-7069","observed_orcids":["https://orcid.org/0000-0003-3388-7069"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dionisia M. Quiroga","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003381938","display_name":"Andrew R. Stiff","orcid":"https://orcid.org/0000-0003-4154-4461","observed_orcids":["https://orcid.org/0000-0003-4154-4461"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Stiff","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112224171","display_name":"Christopher William McQuinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher McQuinn","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027957798","display_name":"Zaibo Li","orcid":"https://orcid.org/0000-0003-1325-1696","observed_orcids":["https://orcid.org/0000-0003-1325-1696"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaibo Li","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067876249","display_name":"Hiroaki Nitta","orcid":"https://orcid.org/0000-0001-8595-3182","observed_orcids":["https://orcid.org/0000-0001-8595-3182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroaki Nitta","raw_affiliation_strings":["2Roche Tissue Diagnostics, Oro Valley, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Roche Tissue Diagnostics, Oro Valley, AZ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059445665","display_name":"Himanshu Savardekar","orcid":"https://orcid.org/0000-0002-6811-4448","observed_orcids":["https://orcid.org/0000-0002-6811-4448"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Himanshu Savardekar","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073968481","display_name":"Brooke N. Benner","orcid":"https://orcid.org/0000-0001-7471-6886","observed_orcids":["https://orcid.org/0000-0001-7471-6886"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke Benner","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067587535","display_name":"Bhuvaneswari Ramaswamy","orcid":"https://orcid.org/0000-0002-2822-8379","observed_orcids":["https://orcid.org/0000-0002-2822-8379"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhuvaneswari Ramaswamy","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086903918","display_name":"Maryam B. Lustberg","orcid":"https://orcid.org/0000-0001-8559-5645","observed_orcids":["https://orcid.org/0000-0001-8559-5645"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Lustberg","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064168158","display_name":"Rachel M. Layman","orcid":"https://orcid.org/0000-0002-8663-0331","observed_orcids":["https://orcid.org/0000-0002-8663-0331"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Layman","raw_affiliation_strings":["3University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041674940","display_name":"Erin Renee Macrae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799782091","display_name":"Riverside Methodist Hospital","ror":"https://ror.org/02hsexy86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I127073530","https://openalex.org/I2799782091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Macrae","raw_affiliation_strings":["4OhioHealth Riverside Methodist Hospital, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4OhioHealth Riverside Methodist Hospital, Columbus, OH;","institution_ids":["https://openalex.org/I2799782091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087142771","display_name":"Mahmoud Attia Mohamed Kassem","orcid":"https://orcid.org/0000-0002-4429-961X","observed_orcids":["https://orcid.org/0000-0002-4429-961X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmoud Kassem","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039385718","display_name":"Nicole Olivia Williams","orcid":"https://orcid.org/0000-0002-0339-1612","observed_orcids":["https://orcid.org/0000-0002-0339-1612"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Williams","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064885323","display_name":"Sagar D. Sardesai","orcid":"https://orcid.org/0000-0002-2688-0486","observed_orcids":["https://orcid.org/0000-0002-2688-0486"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sagar Sardesai","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060904459","display_name":"Jeffrey Bryan VanDeusen","orcid":"https://orcid.org/0000-0002-4171-5649","observed_orcids":["https://orcid.org/0000-0002-4171-5649"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey VanDeusen","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049785882","display_name":"Daniel G. Stover","orcid":"https://orcid.org/0000-0001-9003-8165","observed_orcids":["https://orcid.org/0000-0001-9003-8165"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Stover","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072335237","display_name":"Mathew Amprayil Cherian","orcid":"https://orcid.org/0000-0002-0380-2012","observed_orcids":["https://orcid.org/0000-0002-0380-2012"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathew Cherian","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003348560","display_name":"Thomas A. Mace","orcid":"https://orcid.org/0000-0003-1070-6819","observed_orcids":["https://orcid.org/0000-0003-1070-6819"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Mace","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048499133","display_name":"Lianbo Yu","orcid":"https://orcid.org/0000-0002-2025-2585","observed_orcids":["https://orcid.org/0000-0002-2025-2585"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lianbo Yu","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080361449","display_name":"Megan Christina Duggan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Duggan","raw_affiliation_strings":["5Merck Research Laboratories, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Merck Research Laboratories, OH","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060897770","display_name":"William Edgar Carson","orcid":"https://orcid.org/0000-0001-7024-7533","observed_orcids":["https://orcid.org/0000-0001-7024-7533"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Carson","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030653735","display_name":"Robert Wesolowski","orcid":"https://orcid.org/0000-0003-0606-0648","observed_orcids":["https://orcid.org/0000-0003-0606-0648"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Wesolowski","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"5514","last_page":"5514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.824999988079071},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/immune-checkpoint-receptors","display_name":"immune checkpoint receptors","score":0.9570000171661377},{"id":"https://openalex.org/keywords/peripheral-blood-t-cells","display_name":"peripheral blood T cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ox40","display_name":"OX40","score":1.0},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7590000033378601},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7279999852180481},{"id":"https://openalex.org/keywords/breast-cancer-subtypes","display_name":"breast cancer subtypes","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7141659259796143},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.598812460899353},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.579910933971405},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5720108151435852},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.530765950679779},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5007240772247314},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4981207847595215},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.48670247197151184},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48555347323417664},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4538801908493042},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4499243497848511},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.44536155462265015},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44421249628067017},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4217546284198761},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3929672837257385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28894439339637756}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-5514","doi":"https://doi.org/10.1158/1538-7445.am2020-5514","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-5514","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5699999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2386116568","https://openalex.org/W2378135797","https://openalex.org/W2944387023","https://openalex.org/W2349441096","https://openalex.org/W2892370718","https://openalex.org/W2801222998","https://openalex.org/W2384493525","https://openalex.org/W2387425470","https://openalex.org/W3011494554","https://openalex.org/W2387430262"],"abstract_inverted_index":{"Abstract":[0],"While":[1],"combinations":[2],"of":[3,46,83,99,107,183,213,223,265,300,357,382,386],"immune":[4,358],"checkpoint":[5,115,359],"(ICP)":[6],"inhibitors":[7,50],"and":[8,56,67,88,95,109,118,149,167,194,232,240,284,366,372,397],"neo-adjuvant":[9],"chemotherapy":[10,374],"(NAC)":[11],"have":[12],"begun":[13],"to":[14,51,251,258,295],"be":[15,52,252],"tested":[16],"in":[17,28,104,142,162,303,369],"patients":[18,200,206,370],"with":[19,75,207],"breast":[20,172,198,204,377],"cancer":[21,173,199,205,378],"(BC),":[22],"chemotherapeutic":[23],"effects":[24,278],"on":[25,90,279],"ICP":[26,49,130,280],"expression":[27,82,131,222,281,361],"circulating":[29,91,135,154,184,363],"T":[30,92,111,137,156,187,230,286,364],"cells":[31,112,157,188,287,365],"are":[32],"still":[33],"unclear.":[34],"This":[35,126,243],"information":[36],"could":[37],"help":[38],"design":[39],"future":[40],"clinical":[41],"trials":[42],"including":[43,139],"the":[44,47,81,97,105,221,235,297,383,387],"selection":[45],"best":[48],"incorporated":[53],"into":[54],"NAC":[55,69,100,133,275],"finding":[57],"predictive/prognostic":[58],"biomarkers.":[59],"Peripheral":[60],"blood":[61],"samples":[62,261],"and/or":[63],"tumor":[64,225,236,247,367],"specimens":[65,248,368],"before":[66,94,239],"after":[68,132,241],"were":[70,101,120,179,237,249],"obtained":[71],"from":[72,189,203],"twenty-four":[73],"women":[74],"operable":[76,376],"BC.":[77],"Using":[78],"flow":[79],"cytometry,":[80],"CTLA4,":[84],"PD-1,":[85],"Lag3,":[86],"OX40,":[87],"Tim3":[89],"lymphocytes":[93,227],"at":[96,210],"end":[98],"measured.":[102],"Differences":[103],"percentage":[106],"CD4+":[108,136,186,283],"CD8+":[110,155,229,285],"expressing":[113,209],"various":[114],"receptors":[116],"pre-":[117,371],"post-NAC":[119,255],"determined":[121,238],"by":[122,134,282,362],"a":[123,159,263,292],"paired":[124],"t-test.":[125],"data":[127],"showed":[128,158],"decreased":[129],"cells,":[138,231],"significant":[140,160],"decreases":[141],"CTLA4":[143,163],"(p<0.001),":[144,146,148],"Lag3":[145,165],"OX40":[147,168],"PD-1":[150],"(p<0.001).":[151,169],"In":[152,170],"comparison,":[153],"increase":[161],"(p<0.003),":[164],"(p=0.001),":[166],"comparing":[171],"subtypes,":[174],"it":[175],"was":[176],"found":[177],"there":[178],"significantly":[180],"lower":[181],"amounts":[182],"Lag3+":[185],"triple-negative":[190],"(lacking":[191],"estrogen,":[192],"progesterone,":[193],"HER2":[195],"receptor":[196,360],"expression)":[197],"than":[201],"those":[202],"tumors":[208],"least":[211],"one":[212],"these":[214,301],"receptors.":[215],"Furthermore,":[216],"using":[217,262],"multi-color":[218],"immunohistochemistry":[219],"(IHC),":[220],"stromal":[224],"infiltrating":[226],"(TILs),":[228],"PD-1/PD-L1":[233],"within":[234],"NAC.":[242],"analysis":[244],"revealed":[245],"fewer":[246],"considered":[250],"PD-L1/PD-1":[253],"positive":[254],"as":[256,288,290],"compared":[257],"pre-NAC":[259],"biopsy":[260],"cutoff":[264],"1%":[266],"or":[267],"greater":[268],"expression.":[269],"Overall,":[270],"this":[271],"work":[272],"reveals":[273],"that":[274],"has":[276],"opposing":[277],"well":[289],"provides":[291],"starting":[293],"point":[294],"study":[296],"biological":[298],"significance":[299],"changes":[302],"BC":[304],"patients.Trial":[305],"registration:":[306],"NCT04022616":[307],"Citation":[308],"Format:":[309],"Dionisia":[310],"M.":[311],"Quiroga,":[312],"Andrew":[313],"Stiff,":[314],"Christopher":[315],"McQuinn,":[316],"Zaibo":[317],"Li,":[318],"Hiroaki":[319],"Nitta,":[320],"Himanshu":[321],"Savardekar,":[322],"Brooke":[323],"Benner,":[324],"Bhuvaneswari":[325],"Ramaswamy,":[326],"Maryam":[327],"Lustberg,":[328],"Rachel":[329],"Layman,":[330],"Erin":[331],"Macrae,":[332],"Mahmoud":[333],"Kassem,":[334],"Nicole":[335],"Williams,":[336],"Sagar":[337],"Sardesai,":[338],"Jeffrey":[339],"VanDeusen,":[340],"Daniel":[341],"Stover,":[342],"Mathew":[343],"Cherian,":[344],"Thomas":[345],"Mace,":[346],"Lianbo":[347],"Yu,":[348],"Megan":[349],"Duggan,":[350],"William":[351],"E.":[352],"Carson,":[353],"Robert":[354],"Wesolowski.":[355],"Analysis":[356],"post-neoadjuvant":[373],"for":[375,390],"[abstract].":[379],"In:":[380],"Proceedings":[381],"Annual":[384],"Meeting":[385],"American":[388],"Association":[389],"Cancer":[391,403],"Research":[392],"2020;":[393],"2020":[394],"Apr":[395],"27-28":[396],"Jun":[398],"22-24.":[399],"Philadelphia":[400],"(PA):":[401],"AACR;":[402],"Res":[404],"2020;80(16":[405],"Suppl):Abstract":[406],"nr":[407],"5514.":[408]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
