{"id":"https://openalex.org/W3083302155","doi":"https://doi.org/10.1158/1538-7445.am2020-6116","title":"Abstract 6116: Role of secretory factors from obese-derived omentum in supporting ovarian cancer progression","display_name":"Abstract 6116: Role of secretory factors from obese-derived omentum in supporting ovarian cancer progression","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083302155","doi":"https://doi.org/10.1158/1538-7445.am2020-6116","mag":"3083302155"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-6116","doi":"https://doi.org/10.1158/1538-7445.am2020-6116","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-6116","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028822512","display_name":"Jennifer A. Waters","orcid":"https://orcid.org/0000-0001-8687-9420","observed_orcids":["https://orcid.org/0000-0001-8687-9420"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Waters","raw_affiliation_strings":["San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021979414","display_name":"Mikella Robinson","orcid":"https://orcid.org/0000-0001-6198-7185","observed_orcids":["https://orcid.org/0000-0001-6198-7185"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikella Robinson","raw_affiliation_strings":["San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031985000","display_name":"Samuel F. Gilbert","orcid":"https://orcid.org/0000-0002-0440-1173","observed_orcids":["https://orcid.org/0000-0002-0440-1173","https://orcid.org/0000-0002-6833-6788"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel F. Gilbert","raw_affiliation_strings":["San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053968789","display_name":"Logan J. Alexander","orcid":"https://orcid.org/0000-0001-9236-4431","observed_orcids":["https://orcid.org/0000-0001-9236-4431"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Logan J. Alexander","raw_affiliation_strings":["San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059436422","display_name":"Carrie Danielle House","orcid":"https://orcid.org/0000-0002-1870-5872","observed_orcids":["https://orcid.org/0000-0002-1870-5872"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie D. House","raw_affiliation_strings":["San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I26538001"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"6116","last_page":"6116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.10689999908208847,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.08449999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/omentum","display_name":"omentum","score":0.9179999828338623},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.859000027179718},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8159999847412109},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9100000262260437},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9279999732971191},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":1.0},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6320000290870667},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6759999990463257},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.845985472202301},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6039555668830872},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5869399905204773},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.580824613571167},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5398513674736023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48052987456321716},{"id":"https://openalex.org/C2780084626","wikidata":"https://www.wikidata.org/wiki/Q11793790","display_name":"Ovarian tumor","level":4,"score":0.45521894097328186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44938862323760986},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.41704681515693665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3864884376525879},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3810994625091553},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3726637363433838}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-6116","doi":"https://doi.org/10.1158/1538-7445.am2020-6116","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-6116","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282981238","https://openalex.org/W2041237929","https://openalex.org/W2020015094","https://openalex.org/W4225258084","https://openalex.org/W4394909208","https://openalex.org/W3181138131","https://openalex.org/W7051491037","https://openalex.org/W4386045976","https://openalex.org/W1173591953","https://openalex.org/W7148844356"],"abstract_inverted_index":{"Abstract":[0],"Ovarian":[1],"cancer":[2,40,59,119,159,171,186,227,269],"is":[3,41,76,153],"the":[4,10,20,30,45,66,87,189,210,215,234,275,279],"most":[5],"lethal":[6],"gynecological":[7],"malignancy":[8],"in":[9,44,64,86,94,134,142,204,214,266],"United":[11],"States,":[12],"with":[13,35,48,117,157],"a":[14,22],"known":[15],"predilection":[16],"for":[17,130,175,193,240,282],"metastasizing":[18],"to":[19,97,200],"omentum,":[21],"sheet":[23],"of":[24,73,145,169,191,212,236,260,274,278],"fatty":[25],"peritoneal":[26],"tissue":[27],"that":[28,38,57,82,166,184,223],"encloses":[29],"abdomen.":[31],"This":[32],"finding":[33],"coincides":[34],"some":[36],"evidence":[37],"ovarian":[39,58,118,158,170,185,216,226,242,268],"more":[42,237],"aggressive":[43],"obese":[46,88,114],"setting":[47,89],"worse":[49],"overall":[50],"survival.":[51],"While":[52],"it":[53],"has":[54],"been":[55],"shown":[56],"cells":[60,96,172,187],"invade":[61],"towards":[62],"adipocytes":[63,111,152,174,192,213],"vitro,":[65],"mechanism":[67],"by":[68,151],"which":[69],"they":[70],"support":[71],"formation":[72],"secondary":[74],"tumors":[75],"not":[77],"well":[78],"understood.":[79],"We":[80],"hypothesize":[81],"soluble":[83],"factors":[84,125,203,222,262],"enriched":[85],"are":[90,198],"activating":[91],"signaling":[92,221],"pathways":[93],"tumor":[95,132,163,178,217],"drive":[98],"migration":[99],"and":[100,122,127,136,139,149,177,219,289],"proliferation.":[101],"To":[102],"evaluate":[103],"this":[104,205],"hypothesis":[105],"we":[106],"co-cultured":[107,156],"primary":[108],"human":[109],"omental":[110],"derived":[112],"from":[113,263],"female":[115],"donors":[116],"cell":[120],"lines":[121],"profiled":[123],"secretory":[124,261],"(cytokines":[126],"adipokines)":[128],"responsible":[129],"increasing":[131],"initiation":[133],"vivo":[135],"clonogenicity,":[137],"proliferation,":[138],"drug":[140],"resistance":[141],"vitro.":[143],"Secretion":[144],"cytokines":[146],"IL-6,":[147],"IL-8,":[148],"CCL2":[150],"enhanced":[154],"when":[155],"cells.":[160],"A":[161,180],"subcutaneous":[162],"model":[164],"showed":[165,183],"low":[167],"dilutions":[168],"require":[173,188],"engraftment":[176],"formation.":[179],"transplantation":[181],"assay":[182],"presence":[190],"sustained":[194],"tumor-initiation":[195],"capacity.":[196],"Studies":[197],"underway":[199],"investigate":[201],"adipocyte-secreted":[202],"process.":[206],"Our":[207],"findings":[208],"highlight":[209],"role":[211],"microenvironment":[218],"uncover":[220],"may":[224],"enhance":[225],"progression.":[228],"Understanding":[229],"these":[230],"processes":[231],"will":[232],"enable":[233],"design":[235],"effective":[238],"therapies":[239],"treating":[241],"cancer.":[243],"Citation":[244],"Format:":[245],"Jennifer":[246],"Waters,":[247],"Mikella":[248],"Robinson,":[249],"Samuel":[250],"F.":[251],"Gilbert,":[252],"Logan":[253],"J.":[254],"Alexander,":[255],"Carrie":[256],"D.":[257],"House.":[258],"Role":[259],"obese-derived":[264],"omentum":[265],"supporting":[267],"progression":[270],"[abstract].":[271],"In:":[272],"Proceedings":[273],"Annual":[276],"Meeting":[277],"American":[280],"Association":[281],"Cancer":[283,295],"Research":[284],"2020;":[285],"2020":[286],"Apr":[287],"27-28":[288],"Jun":[290],"22-24.":[291],"Philadelphia":[292],"(PA):":[293],"AACR;":[294],"Res":[296],"2020;80(16":[297],"Suppl):Abstract":[298],"nr":[299],"6116.":[300]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2020-09-11T00:00:00"}
