{"id":"https://openalex.org/W3083220152","doi":"https://doi.org/10.1016/j.ejmech.2020.112793","title":"Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors","display_name":"Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors","publication_year":2020,"publication_date":"2020-09-06","ids":{"openalex":"https://openalex.org/W3083220152","doi":"https://doi.org/10.1016/j.ejmech.2020.112793","mag":"3083220152","pmid":"https://pubmed.ncbi.nlm.nih.gov/32961480"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmech.2020.112793","doi":"https://doi.org/10.1016/j.ejmech.2020.112793","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2020.112793","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100324484","display_name":"Ziyang Chen","orcid":"https://orcid.org/0000-0002-3357-5412","observed_orcids":["https://orcid.org/0000-0002-3357-5412"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210160314","display_name":"Shenzhen Pingle Orthopedic Hospital","ror":"https://ror.org/04ppv2c95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160314"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyang Chen","raw_affiliation_strings":["Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China; Shenzhen Pingle Orthopaedic Hospital (Shenzhen Pingshan Traditional Chinese Medicine Hospital), Shenzhen, 518118, China","Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","Shenzhen Pingle Orthopaedic Hospital (Shenzhen Pingshan Traditional Chinese Medicine Hospital), Shenzhen, 518118, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China; Shenzhen Pingle Orthopaedic Hospital (Shenzhen Pingshan Traditional Chinese Medicine Hospital), Shenzhen, 518118, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210160314"]},{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Shenzhen Pingle Orthopaedic Hospital (Shenzhen Pingshan Traditional Chinese Medicine Hospital), Shenzhen, 518118, China","institution_ids":["https://openalex.org/I4210160314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101655343","display_name":"Hao Chen","orcid":"https://orcid.org/0000-0003-3577-2345","observed_orcids":["https://orcid.org/0000-0003-3577-2345"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Chen","raw_affiliation_strings":["Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100751706","display_name":"Zizhen Zhang","orcid":"https://orcid.org/0000-0002-9992-5956","observed_orcids":["https://orcid.org/0000-0002-9992-5956"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zizhen Zhang","raw_affiliation_strings":["Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China"],"raw_orcid":"https://orcid.org/0000-0002-9992-5956","affiliations":[{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000589365","display_name":"Peng Ding","orcid":"https://orcid.org/0000-0002-1765-0988","observed_orcids":["https://orcid.org/0000-0002-1765-0988","https://orcid.org/0009-0003-0095-4090"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Ding","raw_affiliation_strings":["Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101539992","display_name":"Xin Yan","orcid":"https://orcid.org/0000-0002-4744-7905","observed_orcids":["https://orcid.org/0000-0002-4744-7905"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Yan","raw_affiliation_strings":["Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China"],"raw_orcid":"https://orcid.org/0000-0002-4744-7905","affiliations":[{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101524129","display_name":"Yanwen Li","orcid":"https://orcid.org/0000-0002-7709-6085","observed_orcids":["https://orcid.org/0000-0002-7709-6085"]},"institutions":[{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanwen Li","raw_affiliation_strings":["School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014866676","display_name":"Songxuan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songxuan Zhang","raw_affiliation_strings":["Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070005587","display_name":"Qiong Gu","orcid":"https://orcid.org/0000-0001-6011-3697","observed_orcids":["https://orcid.org/0000-0001-6011-3697"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Gu","raw_affiliation_strings":["Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005573082","display_name":"Huihao Zhou","orcid":"https://orcid.org/0000-0002-9675-5007","observed_orcids":["https://orcid.org/0000-0002-9675-5007"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huihao Zhou","raw_affiliation_strings":["Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address: zhuihao@mail.sysu.edu.cn","Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China"],"raw_orcid":"https://orcid.org/0000-0002-9675-5007","affiliations":[{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address: zhuihao@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100380894","display_name":"Jun Xu","orcid":"https://orcid.org/0000-0002-1075-0337","observed_orcids":["https://orcid.org/0000-0002-1075-0337"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Xu","raw_affiliation_strings":["Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China. Electronic address: junxu@biochemomes.com","Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China. Electronic address: junxu@biochemomes.com","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210151615","https://openalex.org/I98834328"]},{"raw_affiliation_string":"Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005573082","https://openalex.org/A5100380894"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210151615","https://openalex.org/I98834328"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":1.3578,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.80123908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"206","issue":null,"first_page":"112793","last_page":"112793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.12189999967813492,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-x-receptor-beta","display_name":"liver X receptor beta","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lxr-agonists","display_name":"LXR agonists","score":0.8939999938011169},{"id":"https://openalex.org/keywords/co-crystal-structure","display_name":"co-crystal structure","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ncor1","display_name":"NCOR1","score":0.625},{"id":"https://openalex.org/keywords/hydrophobic-groove","display_name":"hydrophobic groove","score":0.7120000123977661},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":0.8029999732971191},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase","display_name":"acetyl-CoA carboxylase","score":0.8989999890327454},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase-1","display_name":"stearoyl-CoA desaturase 1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lipogenesis-inhibition","display_name":"lipogenesis inhibition","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.6340000033378601},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.8665492534637451},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7722344398498535},{"id":"https://openalex.org/C89951826","wikidata":"https://www.wikidata.org/wiki/Q1671731","display_name":"Inverse agonist","level":4,"score":0.7671364545822144},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.6136401891708374},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.481356680393219},{"id":"https://openalex.org/C14527384","wikidata":"https://www.wikidata.org/wiki/Q4693403","display_name":"Agonism","level":3,"score":0.4677465260028839},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4558519124984741},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37777355313301086},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3505462110042572},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3342583179473877},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1885916292667389},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.14433389902114868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11691680550575256},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10857045650482178},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050155","descriptor_name":"Lipogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054314","descriptor_name":"Drug Inverse Agonism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejmech.2020.112793","doi":"https://doi.org/10.1016/j.ejmech.2020.112793","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2020.112793","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:32961480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32961480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3387814226","display_name":null,"funder_award_id":"2017YFB0203403","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3676460847","display_name":null,"funder_award_id":"81903540","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4548140080","display_name":null,"funder_award_id":"201604020109","funder_id":"https://openalex.org/F4320326685","funder_display_name":"Guangzhou Science, Technology and Innovation Commission"},{"id":"https://openalex.org/G6875406522","display_name":null,"funder_award_id":"81773636","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326685","display_name":"Guangzhou Science, Technology and Innovation Commission","ror":"https://ror.org/05t4nb462"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1541739901","https://openalex.org/W1975070287","https://openalex.org/W1976499671","https://openalex.org/W1985927721","https://openalex.org/W2004822259","https://openalex.org/W2009423060","https://openalex.org/W2014864566","https://openalex.org/W2015688756","https://openalex.org/W2026958742","https://openalex.org/W2029177106","https://openalex.org/W2054557659","https://openalex.org/W2108483033","https://openalex.org/W2110046079","https://openalex.org/W2112632255","https://openalex.org/W2113624181","https://openalex.org/W2118233996","https://openalex.org/W2118552522","https://openalex.org/W2121564839","https://openalex.org/W2145991777","https://openalex.org/W2174107467","https://openalex.org/W2196209555","https://openalex.org/W2506013634","https://openalex.org/W2735562440","https://openalex.org/W2789257932","https://openalex.org/W2808548053","https://openalex.org/W2949755240","https://openalex.org/W2951012101","https://openalex.org/W2951952237","https://openalex.org/W2954050367","https://openalex.org/W3000704614","https://openalex.org/W3012296242"],"related_works":["https://openalex.org/W4318762019","https://openalex.org/W4200373508","https://openalex.org/W6991254855","https://openalex.org/W2806935388","https://openalex.org/W3000704614","https://openalex.org/W2011306587","https://openalex.org/W2000231222","https://openalex.org/W2034339368","https://openalex.org/W2905104601","https://openalex.org/W4410934652"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-11T00:00:00"}