{"id":"https://openalex.org/W3083177560","doi":"https://doi.org/10.1158/1538-7445.am2020-ng01","title":"Abstract NG01: MADR: Rapid generation of somatic mosaics to model cancer in mice and human organoids","display_name":"Abstract NG01: MADR: Rapid generation of somatic mosaics to model cancer in mice and human organoids","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3083177560","doi":"https://doi.org/10.1158/1538-7445.am2020-ng01","mag":"3083177560"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-ng01","doi":"https://doi.org/10.1158/1538-7445.am2020-ng01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-ng01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017276766","display_name":"Gi Bum Kim","orcid":"https://orcid.org/0000-0001-9671-0493","observed_orcids":["https://orcid.org/0000-0001-9671-0493"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gi Bum Kim","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033270528","display_name":"David Rincon Fernandez Pacheco","orcid":"https://orcid.org/0000-0002-6998-4920","observed_orcids":["https://orcid.org/0000-0002-6998-4920","https://orcid.org/0000-0001-6217-3757"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Rincon Fernandez Pacheco","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Saxon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Saxon","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amy Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Yang","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065437924","display_name":"Sara Sabat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Sabat","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083147123","display_name":"Marina Dutra\u2010Clarke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Dutra-Clarke","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111679239","display_name":"Rachelle Levy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachelle Levy","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017629227","display_name":"Ashley Watkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Watkins","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019248510","display_name":"Hannah Park","orcid":"https://orcid.org/0000-0001-7601-6170","observed_orcids":["https://orcid.org/0000-0001-7601-6170"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Park","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110487519","display_name":"Aslam Abbasi Akhtar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aslam Abbasi Akhtar","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026578031","display_name":"Paul W. Linesch","orcid":"https://orcid.org/0009-0006-0958-9810","observed_orcids":["https://orcid.org/0009-0006-0958-9810"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul W. Linesch","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030622148","display_name":"Naomi Kobritz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naomi Kobritz","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005406294","display_name":"Swasty S. Shandra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swasty S. Shandra","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048850369","display_name":"Katie B. Grausam","orcid":"https://orcid.org/0000-0003-0330-6622","observed_orcids":["https://orcid.org/0000-0003-0330-6622"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Grausam","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006561845","display_name":"Alberto E. Ayala\u2010Sarmiento","orcid":"https://orcid.org/0000-0002-0843-6111","observed_orcids":["https://orcid.org/0000-0002-0843-6111"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alberto Ayala-Sarmiento","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068803539","display_name":"J\u00e9ssica Molina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Molina","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022983672","display_name":"Krist\u00fdna \u0160ediv\u00e1kov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristyna Sedivakova","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009618982","display_name":"Daniel S. Gareau","orcid":"https://orcid.org/0000-0002-9759-1198","observed_orcids":["https://orcid.org/0000-0002-9759-1198"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Gareau","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002271939","display_name":"Mariella G. Filbin","orcid":"https://orcid.org/0000-0002-2613-8126","observed_orcids":["https://orcid.org/0000-0002-2613-8126"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariella G. Filbin","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073387528","display_name":"Serguei Bannykh","orcid":"https://orcid.org/0000-0002-1542-8224","observed_orcids":["https://orcid.org/0000-0002-1542-8224"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serguei Bannykh","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033682607","display_name":"Jie Tang","orcid":"https://orcid.org/0000-0003-0750-743X","observed_orcids":["https://orcid.org/0000-0003-0750-743X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Tang","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013741617","display_name":"Mario L. Suv\u00e0","orcid":"https://orcid.org/0000-0001-9898-5351","observed_orcids":["https://orcid.org/0000-0001-9898-5351"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario L. Suva","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427374","display_name":"Bin Chen","orcid":"https://orcid.org/0000-0003-1962-3593","observed_orcids":["https://orcid.org/0000-0003-1962-3593"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Chen","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057514061","display_name":"Moise Danielpour","orcid":"https://orcid.org/0000-0002-8187-9234","observed_orcids":["https://orcid.org/0000-0002-8187-9234"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moise Danielpour","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018100920","display_name":"Joshua J. Breunig","orcid":"https://orcid.org/0000-0002-3735-3390","observed_orcids":["https://orcid.org/0000-0002-3735-3390"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua J. Breunig","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA, Rockefeller University, New York, NY, Dana Farber Boston Children's Cancer and Blood Disorder Center, Boston, MA, Broad Institute of MIT and Harvard, Cambridge, MA, University of California Santa Cruz, Santa Cruz, CA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1282927834","https://openalex.org/I136199984","https://openalex.org/I185103710","https://openalex.org/I4210166317","https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"NG01","last_page":"NG01"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.3953000009059906,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.3953000009059906,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.3230000138282776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.08869999647140503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-models","display_name":"tumor models","score":0.44999998807907104},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pediatric-glioma","display_name":"pediatric glioma","score":0.8109999895095825},{"id":"https://openalex.org/keywords/h3f3a-mutation","display_name":"H3F3A mutation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ependymoma","display_name":"ependymoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/patient-derived-models","display_name":"patient-derived models","score":0.5680000185966492},{"id":"https://openalex.org/keywords/human-organoids","display_name":"human organoids","score":0.7400000095367432},{"id":"https://openalex.org/keywords/zygosity","display_name":"zygosity","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C73247094","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Transgenesis","level":5,"score":0.7955762147903442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7310366034507751},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6086917519569397},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5739983916282654},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5614879131317139},{"id":"https://openalex.org/C125929170","wikidata":"https://www.wikidata.org/wiki/Q908966","display_name":"Cre recombinase","level":5,"score":0.46087056398391724},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4260023236274719},{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.4232999384403229},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.41726964712142944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3941347002983093},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.3667029142379761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1930028200149536},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.0},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.0},{"id":"https://openalex.org/C519853106","wikidata":"https://www.wikidata.org/wiki/Q3640158","display_name":"Reproductive biology","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-ng01","doi":"https://doi.org/10.1158/1538-7445.am2020-ng01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-ng01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2002669389","https://openalex.org/W4200388279","https://openalex.org/W2014892279","https://openalex.org/W1983223950","https://openalex.org/W2017304053","https://openalex.org/W4232906488","https://openalex.org/W2141803553","https://openalex.org/W1990488096","https://openalex.org/W2057960014","https://openalex.org/W2055996927"],"abstract_inverted_index":{"Abstract":[0],"In":[1,172],"situ":[2],"transgenesis":[3,202],"methods":[4],"such":[5],"as":[6],"virus":[7],"and":[8,26,70,114,117,153,167,203,217,234,327,348],"electroporation":[9],"can":[10,235],"create":[11],"somatic":[12,204,250,320],"transgenic":[13,49,205,251],"mice":[14,326],"quickly,":[15],"but":[16],"they":[17],"lack":[18],"the":[19,80,109,177,181,247,334,338],"exquisite":[20],"control":[21],"over":[22],"copy":[23],"number,":[24],"zygosity,":[25],"locus":[27],"specificity.":[28],"We":[29],"have":[30,78,134,194],"recently":[31],"established":[32],"mosaic":[33],"analysis":[34,120],"by":[35,84],"dual":[36],"recombinase-mediated":[37],"cassette":[38],"exchange":[39],"(MADR),":[40],"which":[41],"permits":[42],"stable":[43],"labeling":[44],"of":[45,59,73,82,112,124,138,151,230,249,319,333,337],"mutant":[46],"cells":[47,197],"expressing":[48],"elements":[50,60],"from":[51,97],"precisely-defined":[52],"chromosomal":[53],"loci.":[54],"MADR":[55,83,107,182,201],"provides":[56],"a":[57,122,148,160,242],"toolkit":[58],"for":[61,200,341],"combinatorial":[62],"labeling,":[63],"inducible/reversible":[64],"transgene":[65],"manipulation,":[66],"VCre":[67],"recombinase":[68],"expression,":[69],"genetic":[71],"manipulation":[72],"human":[74,130,168,196,239,328],"cells.":[75],"Further,":[76],"we":[77,133,154,174,193],"demonstrated":[79],"versatility":[81],"creating":[85],"glioma":[86],"models":[87,137,146,158,166],"with":[88,93,106,163],"mixed,":[89],"reporter-identified":[90],"zygosity":[91],"or":[92],"\u201cpersonalized\u201d":[94],"driver":[95],"mutations":[96],"pediatric":[98],"glioma.":[99,131],"For":[100],"example,":[101],"introducing":[102],"H3f3a":[103],"mutation":[104],"variants":[105],"regulates":[108],"spatiotemporal":[110],"profile":[111],"glioma,":[113],"single-cell":[115,161],"RNA":[116],"ATAC":[118],"sequencing":[119],"demonstrates":[121],"recapitulation":[123],"developmental":[125],"hierarchy":[126],"seen":[127],"in":[128,220,325],"K27M-mutant":[129],"Moreover,":[132],"generated":[135],"novel":[136],"supratentorial":[139],"ependymoma":[140],"using":[141,188],"patient-derived":[142],"oncofusion":[143],"transgenes.":[144],"These":[145,207],"display":[147],"high":[149],"degree":[150],"fidelity":[152],"now":[155,175],"compare":[156],"these":[157],"on":[159],"level":[162],"our":[164],"previous":[165],"tumor":[169],"cell":[170],"transcriptomes.":[171],"addition,":[173],"demonstrate":[176],"ability":[178],"to":[179,184,198,213,228,238,245,322],"generalize":[180],"technology":[183],"other":[185],"non-CNS":[186],"tissues":[187],"local":[189],"plasmid":[190],"delivery.":[191],"Finally,":[192],"engineered":[195],"allow":[199],"organoids.":[206],"combined":[208],"approaches":[209],"will":[210],"enable":[211],"researchers":[212],"discovery":[214],"disease":[215,252],"mechanisms":[216],"test":[218],"therapeutics":[219],"more":[221],"physiologically":[222],"relevant":[223],"cancer":[224,324],"models.MADR":[225],"is":[226],"extensible":[227],"thousands":[229],"existing":[231],"mouse":[232],"lines":[233],"be":[236],"adapted":[237],"cells,":[240],"providing":[241],"flexible":[243],"platform":[244],"democratize":[246],"generation":[248,318],"models.":[253],"Citation":[254],"Format:":[255],"Gi":[256],"Bum":[257],"Kim,":[258],"David":[259,263],"Rincon":[260],"Fernandez":[261],"Pacheco,":[262],"Saxon,":[264],"Amy":[265],"Yang,":[266],"Sara":[267],"Sabat,":[268],"Marina":[269],"Dutra-Clarke,":[270],"Rachelle":[271],"Levy,":[272],"Ashley":[273],"Watkins,":[274],"Hannah":[275],"Park,":[276],"Aslam":[277],"Abbasi":[278],"Akhtar,":[279],"Paul":[280],"W.":[281],"Linesch,":[282],"Naomi":[283],"Kobritz,":[284],"Swasty":[285],"S.":[286,297],"Shandra,":[287],"Katie":[288],"Grausam,":[289],"Alberto":[290],"Ayala-Sarmiento,":[291],"Jessica":[292],"Molina,":[293],"Kristyna":[294],"Sedivakova,":[295],"Daniel":[296],"Gareau,":[298],"Mariella":[299],"G.":[300],"Filbin,":[301],"Serguei":[302],"Bannykh,":[303],"Jie":[304],"Tang,":[305],"Mario":[306],"L.":[307],"Suva,":[308],"Bin":[309],"Chen,":[310],"Moise":[311],"Danielpour,":[312],"Joshua":[313],"J.":[314],"Breunig.":[315],"MADR:":[316],"Rapid":[317],"mosaics":[321],"model":[323],"organoids":[329],"[abstract].":[330],"In:":[331],"Proceedings":[332],"Annual":[335],"Meeting":[336],"American":[339],"Association":[340],"Cancer":[342,354],"Research":[343],"2020;":[344],"2020":[345],"Apr":[346],"27-28":[347],"Jun":[349],"22-24.":[350],"Philadelphia":[351],"(PA):":[352],"AACR;":[353],"Res":[355],"2020;80(16":[356],"Suppl):Abstract":[357],"nr":[358],"NG01.":[359]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}