{"id":"https://openalex.org/W3083173565","doi":"https://doi.org/10.1186/s12929-020-00682-7","title":"Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank","display_name":"Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank","publication_year":2020,"publication_date":"2020-09-04","ids":{"openalex":"https://openalex.org/W3083173565","doi":"https://doi.org/10.1186/s12929-020-00682-7","mag":"3083173565","pmid":"https://pubmed.ncbi.nlm.nih.gov/32887585"},"language":"en","primary_location":{"id":"doi:10.1186/s12929-020-00682-7","doi":"https://doi.org/10.1186/s12929-020-00682-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12929-020-00682-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12929-020-00682-7.pdf","source":{"id":"https://openalex.org/S52607827","display_name":"Journal of Biomedical Science","issn_l":"1021-7770","issn":["1021-7770","1423-0127"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1186/s12929-020-00682-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108089946","display_name":"Ching-Ying Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ching-Ying Huang","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113558035","display_name":"Ling-Hui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ling-Hui Li","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064377880","display_name":"Wan-Tseng Hsu","orcid":"https://orcid.org/0000-0001-6358-999X","observed_orcids":["https://orcid.org/0000-0001-6358-999X"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wan-Tseng Hsu","raw_affiliation_strings":["School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 100, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 100, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077937525","display_name":"Yu\u2010Che Cheng","orcid":"https://orcid.org/0000-0002-5346-3610","observed_orcids":["https://orcid.org/0000-0002-5346-3610"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Che Cheng","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012123033","display_name":"Martin W. Nicholson","orcid":"https://orcid.org/0009-0001-8031-3407","observed_orcids":["https://orcid.org/0009-0001-8031-3407"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Martin W. Nicholson","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113915749","display_name":"Chun-Lin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Lin Liu","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067157802","display_name":"Chien-Yu Ting","orcid":"https://orcid.org/0000-0002-9168-5820","observed_orcids":["https://orcid.org/0000-0002-9168-5820"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chien-Yu Ting","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110460797","display_name":"Hui-Wen Ko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Wen Ko","raw_affiliation_strings":["Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I4210157834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042506963","display_name":"Shih\u2010Han Syu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Han Syu","raw_affiliation_strings":["Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I4210157834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113620357","display_name":"Cheng-Hao Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Hao Wen","raw_affiliation_strings":["Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I4210157834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025504883","display_name":"Yan Zhuge","orcid":"https://orcid.org/0000-0003-1620-6743","observed_orcids":["https://orcid.org/0000-0003-1620-6743"]},"institutions":[{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuge Yan","raw_affiliation_strings":["Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065054918","display_name":"Hsiang\u2013Po Huang","orcid":"https://orcid.org/0000-0002-3382-305X","observed_orcids":["https://orcid.org/0000-0002-3382-305X"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiang-Po Huang","raw_affiliation_strings":["Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, 100, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, 100, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110553384","display_name":"Hong-Lin Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hong-Lin Su","raw_affiliation_strings":["Department of Life Sciences, National Chung-Hsing University, Taichung, 402, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, National Chung-Hsing University, Taichung, 402, Taiwan","institution_ids":["https://openalex.org/I162838928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043429176","display_name":"Po\u2010Min Chiang","orcid":"https://orcid.org/0000-0002-4950-9292","observed_orcids":["https://orcid.org/0000-0002-4950-9292"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Min Chiang","raw_affiliation_strings":["Institute of Clinical Medicine, National Cheng Kung University, Tainan, 701, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine, National Cheng Kung University, Tainan, 701, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061050276","display_name":"Chia\u2010Ning Shen","orcid":"https://orcid.org/0000-0002-0747-217X","observed_orcids":["https://orcid.org/0000-0002-0747-217X"]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Ning Shen","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210087491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102876214","display_name":"Hsin\u2010Fu Chen","orcid":"https://orcid.org/0000-0002-7748-4440","observed_orcids":["https://orcid.org/0000-0002-7748-4440"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Fu Chen","raw_affiliation_strings":["Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, 100, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, 100, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072353128","display_name":"Betty Linju Yen","orcid":"https://orcid.org/0000-0002-6905-3018","observed_orcids":["https://orcid.org/0000-0002-6905-3018"]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"B. Lin Ju Yen","raw_affiliation_strings":["Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, 350, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, 350, Taiwan","institution_ids":["https://openalex.org/I165441096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044416994","display_name":"Huai-En Lu","orcid":"https://orcid.org/0000-0003-0875-9321","observed_orcids":["https://orcid.org/0000-0003-0875-9321"]},"institutions":[{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Huai-En Lu","raw_affiliation_strings":["Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I4210157834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103725161","display_name":"Shiaw\u2010Min Hwang","orcid":"https://orcid.org/0009-0004-9085-9675","observed_orcids":["https://orcid.org/0009-0004-9085-9675"]},"institutions":[{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shiaw-Min Hwang","raw_affiliation_strings":["Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I4210157834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047465008","display_name":"Shih\u2010Hwa Chiou","orcid":"https://orcid.org/0000-0002-8651-5755","observed_orcids":["https://orcid.org/0000-0002-8651-5755","https://orcid.org/0000-0002-2481-5357"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Hwa Chiou","raw_affiliation_strings":["Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, 112, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058840846","display_name":"Hong\u2010Nerng Ho","orcid":"https://orcid.org/0000-0002-7207-0089","observed_orcids":["https://orcid.org/0000-0002-7207-0089"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hong-Nerng Ho","raw_affiliation_strings":["Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107825977","display_name":"Jer-Yuarn Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Jer-Yuarn Wu","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055084338","display_name":"Timothy J. Kamp","orcid":"https://orcid.org/0000-0003-2103-7876","observed_orcids":["https://orcid.org/0000-0003-2103-7876"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Kamp","raw_affiliation_strings":["Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI, 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI, 53705, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047561254","display_name":"Joseph C. Wu","orcid":"https://orcid.org/0000-0002-6068-8041","observed_orcids":["https://orcid.org/0000-0002-6068-8041","https://orcid.org/0000-0002-2217-1674","https://orcid.org/0000-0003-4274-0413"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Joseph C. Wu","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072228476","display_name":"Patrick C.H. Hsieh","orcid":"https://orcid.org/0000-0002-8910-3596","observed_orcids":["https://orcid.org/0000-0002-8910-3596"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Patrick C. H. Hsieh","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan. phsieh@ibms.sinica.edu.tw","Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-8910-3596","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan. phsieh@ibms.sinica.edu.tw","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5072228476"],"corresponding_institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.484,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56166951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"27","issue":"1","first_page":"92","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ipsc-differentiation-protocols","display_name":"iPSC differentiation protocols","score":0.7110000252723694},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.9257879853248596},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.8888981938362122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6231451034545898},{"id":"https://openalex.org/C122060243","wikidata":"https://www.wikidata.org/wiki/Q7391885","display_name":"SNP array","level":5,"score":0.5303992033004761},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47647377848625183},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.47359445691108704},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4363468885421753},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4309362471103668},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41184067726135254},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3291255235671997},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3072762191295624},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30530112981796265},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2835337519645691},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25292789936065674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23593759536743164},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1683143973350525},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1556820571422577},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0992591381072998},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013624","descriptor_name":"Taiwan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013624","descriptor_name":"Taiwan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013624","descriptor_name":"Taiwan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12929-020-00682-7","doi":"https://doi.org/10.1186/s12929-020-00682-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12929-020-00682-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12929-020-00682-7.pdf","source":{"id":"https://openalex.org/S52607827","display_name":"Journal of Biomedical Science","issn_l":"1021-7770","issn":["1021-7770","1423-0127"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Science","raw_type":"journal-article"},{"id":"pmid:32887585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32887585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7487458","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7487458","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biomed Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:de67dc5bc3d844d98e58ec1317f016bd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/de67dc5bc3d844d98e58ec1317f016bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-15 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12929-020-00682-7","doi":"https://doi.org/10.1186/s12929-020-00682-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12929-020-00682-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12929-020-00682-7.pdf","source":{"id":"https://openalex.org/S52607827","display_name":"Journal of Biomedical Science","issn_l":"1021-7770","issn":["1021-7770","1423-0127"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1289113730","display_name":"Taiwan Heart Tissue Chip Project( III )","funder_award_id":"MOST108-2321-B001-017","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4400250899","display_name":"Taiwan Heart Tissue Chip Project( II )","funder_award_id":"MOST107-2321-B001-029","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G6357088243","display_name":"Human Disease Induced Pluripotent Stem Cells Service Consortium","funder_award_id":"MOST109-2740-B001-002","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G822938513","display_name":"Human Disease Induced Pluripotent Stem Cells (Ipsc) Service Consortium","funder_award_id":"MOST107-2319-B001-003","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G8286100892","display_name":"Human Disease Induced Pluripotent Stem Cells Service Consortium","funder_award_id":"MOST108-2319-B001-004","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083173565.pdf","grobid_xml":"https://content.openalex.org/works/W3083173565.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1436283894","https://openalex.org/W1600024584","https://openalex.org/W1968504109","https://openalex.org/W1987523847","https://openalex.org/W1997482445","https://openalex.org/W2014477412","https://openalex.org/W2022534144","https://openalex.org/W2038455004","https://openalex.org/W2045150892","https://openalex.org/W2048975453","https://openalex.org/W2049358079","https://openalex.org/W2050160133","https://openalex.org/W2052159842","https://openalex.org/W2059017712","https://openalex.org/W2063135302","https://openalex.org/W2088152986","https://openalex.org/W2108234281","https://openalex.org/W2119741858","https://openalex.org/W2121507445","https://openalex.org/W2125577657","https://openalex.org/W2125987139","https://openalex.org/W2129385319","https://openalex.org/W2135757824","https://openalex.org/W2138977668","https://openalex.org/W2163404991","https://openalex.org/W2278743348","https://openalex.org/W2278911990","https://openalex.org/W2411564276","https://openalex.org/W2419046874","https://openalex.org/W2558758033","https://openalex.org/W2593312496","https://openalex.org/W2601350462","https://openalex.org/W2604155358","https://openalex.org/W2765190063","https://openalex.org/W2782828571","https://openalex.org/W2952488094","https://openalex.org/W3149364280"],"related_works":["https://openalex.org/W3029540856","https://openalex.org/W2418603484","https://openalex.org/W4254937032","https://openalex.org/W2744405843","https://openalex.org/W2415743749","https://openalex.org/W3032669875","https://openalex.org/W2992250893","https://openalex.org/W1888433033","https://openalex.org/W2479215566","https://openalex.org/W2990520546"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,33,165],"Taiwan":[2,220],"Human":[3],"Disease":[4],"iPSC":[5,40,47,91,137,191,204],"Service":[6],"Consortium":[7],"was":[8,199],"established":[9,131],"to":[10,146,200,211,213],"accelerate":[11],"Taiwan's":[12],"growing":[13],"stem":[14,29,216],"cell":[15,30,162,170,217],"research":[16],"initiatives":[17],"and":[18,37,44,93,117,149,221],"provide":[19],"a":[20,186,202],"platform":[21],"for":[22,135,189,193],"researchers":[23],"interested":[24],"in":[25,60,73,161,176,219],"utilizing":[26],"induced":[27,168],"pluripotent":[28],"(iPSC)":[31],"technology.":[32],"consortium":[34],"has":[35],"generated":[36],"characterized":[38],"83":[39,88],"lines:":[41],"11":[42],"normal":[43],"72":[45],"disease":[46],"lines":[48,92],"covering":[49],"21":[50],"different":[51],"diseases,":[52],"several":[53,132],"of":[54,57,87],"which":[55],"are":[56,64,123],"high":[58],"incidence":[59],"Taiwan.":[61],"Whether":[62],"there":[63],"any":[65],"reprogramming-induced":[66],"recurrent":[67],"copy":[68,83],"number":[69,84],"variant":[70,85],"(CNV)":[71],"hotspots":[72,167],"iPSCs":[74],"is":[75],"still":[76],"largely":[77],"unknown.":[78],"METHODS:":[79],"We":[80,139],"performed":[81],"genome-wide":[82,103],"screening":[86],"Han":[89],"Taiwanese":[90],"compared":[94],"them":[95],"with":[96,125],"1093":[97],"control":[98],"subjects":[99],"using":[100],"an":[101],"Affymetrix":[102],"human":[104],"SNP":[105],"array.":[106],"RESULTS:":[107],"In":[108],"the":[109,126,154,177,215,223],"iPSCs,":[110,208],"we":[111,130],"identified":[112,175],"ten":[113],"specific":[114],"CNV":[115,120,166],"loci":[116],"seven":[118],"\"polymorphic\"":[119],"regions":[121],"that":[122,141],"associated":[124],"reprogramming":[127,171],"process.":[128],"Additionally,":[129],"differentiation":[133],"protocols":[134],"our":[136,142],"lines.":[138],"demonstrated":[140],"iPSC-derived":[143],"cardiomyocytes":[144],"respond":[145],"pharmacological":[147],"agents":[148],"were":[150],"successfully":[151,173],"engrafted":[152],"into":[153],"mouse":[155],"myocardium":[156],"demonstrating":[157],"their":[158],"potential":[159],"application":[160],"therapy.":[163],"CONCLUSIONS:":[164],"by":[169],"have":[172],"been":[174],"current":[178],"study.":[179],"This":[180],"finding":[181],"may":[182],"be":[183],"used":[184],"as":[185],"reference":[187],"index":[188],"evaluating":[190],"quality":[192],"future":[194],"clinical":[195],"applications.":[196],"Our":[197],"aim":[198],"establish":[201],"national":[203],"resource":[205],"center":[206],"generating":[207],"made":[209],"available":[210],"researchers,":[212],"benefit":[214],"community":[218],"throughout":[222],"world.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}