{"id":"https://openalex.org/W3083149685","doi":"https://doi.org/10.1097/cm9.0000000000001039","title":"How neural stem cells promote the repair of brain injury through immunoregulation","display_name":"How neural stem cells promote the repair of brain injury through immunoregulation","publication_year":2020,"publication_date":"2020-09-03","ids":{"openalex":"https://openalex.org/W3083149685","doi":"https://doi.org/10.1097/cm9.0000000000001039","mag":"3083149685","pmid":"https://pubmed.ncbi.nlm.nih.gov/32889903","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7546833"},"language":"en","primary_location":{"id":"doi:10.1097/cm9.0000000000001039","doi":"https://doi.org/10.1097/cm9.0000000000001039","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cm9.0000000000001039","pdf_url":null,"source":{"id":"https://openalex.org/S22240167","display_name":"Chinese Medical Journal","issn_l":"0366-6999","issn":["0366-6999","2542-5641"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/cm9.0000000000001039","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006503848","display_name":"Cheng Shi Jiang","orcid":"https://orcid.org/0000-0003-4583-3295","observed_orcids":["https://orcid.org/0000-0003-4583-3295"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Jiang","raw_affiliation_strings":["Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","institution_ids":["https://openalex.org/I4210124531"]},{"raw_affiliation_string":"133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bo-Ru Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo-Ru Hou","raw_affiliation_strings":["Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","institution_ids":["https://openalex.org/I4210124531"]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075817419","display_name":"Ze-Ning Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze-Ning Wang","raw_affiliation_strings":["Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","institution_ids":["https://openalex.org/I4210124531"]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419230","display_name":"Yi Chen","orcid":"https://orcid.org/0000-0002-0528-5776","observed_orcids":["https://orcid.org/0000-0002-0528-5776"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Chen","raw_affiliation_strings":["Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","institution_ids":["https://openalex.org/I4210124531"]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039561937","display_name":"Dong Wang","orcid":"https://orcid.org/0000-0002-5245-3074","observed_orcids":["https://orcid.org/0000-0002-5245-3074"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Wang","raw_affiliation_strings":["Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","institution_ids":["https://openalex.org/I4210124531"]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101021159","display_name":"Haijun Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai-Jun Ren","raw_affiliation_strings":["Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","Dr. Hai-Jun Ren, Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, ChinaE-Mail: [email\u00a0protected]","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, China","institution_ids":["https://openalex.org/I4210124531"]},{"raw_affiliation_string":"Dr. Hai-Jun Ren, Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, ChinaE-Mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I4210124531"]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020;133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"133:2365\u20132367. doi: 10.1097/CM9.0000000000001039","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Jiang C, Hou BR, Wang ZN, Chen Y, Wang D, Ren HJ. How neural stem cells promote the repair of brain injury through immunoregulation. Chin Med J 2020","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101021159"],"corresponding_institution_ids":["https://openalex.org/I4210124531"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.0951,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.41382827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"133","issue":"19","first_page":"2365","last_page":"2367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/brain-injury","display_name":"brain injury","score":0.6029999852180481},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cx3cl1","display_name":"fractalkine","score":0.7699999809265137},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bystander-effect","display_name":"bystander effect","score":0.6610000133514404},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.746999979019165},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6100000143051147},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.7379999756813049},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.35199999809265137},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7630788087844849},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.5632376670837402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5195653438568115},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5093956589698792},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5079744458198547},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4982452392578125},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.47802624106407166},{"id":"https://openalex.org/C91682701","wikidata":"https://www.wikidata.org/wiki/Q41797304","display_name":"Immunoglobulin superfamily","level":3,"score":0.47305646538734436},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.47288861870765686},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4673348665237427},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4637494683265686},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45028549432754517},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4196888506412506},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.30115386843681335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2818349003791809},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22434192895889282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06946095824241638},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1097/cm9.0000000000001039","doi":"https://doi.org/10.1097/cm9.0000000000001039","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cm9.0000000000001039","pdf_url":null,"source":{"id":"https://openalex.org/S22240167","display_name":"Chinese Medical Journal","issn_l":"0366-6999","issn":["0366-6999","2542-5641"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7546833","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7546833","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chin Med J (Engl)","raw_type":"Text"},{"id":"pmid:32889903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32889903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"pmh:oai:/ir.lzu.edu.cn/:262010/442498","doi":null,"is_oa":true,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/442498","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/431283","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/431283","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/439676","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/439676","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"pmh:oai:doaj.org/article:32d18043b2f94cd99553a02ac91d2677","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/32d18043b2f94cd99553a02ac91d2677","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chinese Medical Journal, Vol 133, Iss 19, Pp 2365-2367 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1097/cm9.0000000000001039","doi":"https://doi.org/10.1097/cm9.0000000000001039","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cm9.0000000000001039","pdf_url":null,"source":{"id":"https://openalex.org/S22240167","display_name":"Chinese Medical Journal","issn_l":"0366-6999","issn":["0366-6999","2542-5641"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2028321082","https://openalex.org/W2059844545","https://openalex.org/W2099005297","https://openalex.org/W2116505148","https://openalex.org/W2164905816","https://openalex.org/W2523586902","https://openalex.org/W2552454010","https://openalex.org/W2775366010","https://openalex.org/W2803377995","https://openalex.org/W2810236669","https://openalex.org/W2887371008","https://openalex.org/W2896245391","https://openalex.org/W2899657202","https://openalex.org/W2907635870","https://openalex.org/W2911189893","https://openalex.org/W2940337896","https://openalex.org/W3013259899"],"related_works":["https://openalex.org/W3031573892","https://openalex.org/W2095783207","https://openalex.org/W2523586902","https://openalex.org/W7120785776","https://openalex.org/W7096420916","https://openalex.org/W2297402353","https://openalex.org/W2413701608","https://openalex.org/W3030271763","https://openalex.org/W7096572755","https://openalex.org/W2002902649"],"abstract_inverted_index":{"Brain":[0],"injury,":[1],"such":[2,263,912,971,1054,1240],"as":[3,185,187,264,417,422,730,913,972,1055,1139,1241],"traumatic":[4],"brain":[5,31,518,562,1015,1035,1123,1146,1257,1327,1388],"injury":[6,29,453,805,867,1016],"and":[7,14,73,115,182,195,226,231,241,270,279,332,400,406,430,434,554,584,588,592,628,657,674,692,726,744,793,832,847,857,879,886,908,962,964,978,994,1027,1048,1061,1071,1081,1097,1118,1135,1142,1148,1165,1199,1230,1243,1286,1375,1401,1409,1417],"stroke,":[8],"are":[9,37,717,752,1171,1281,1305],"important":[10,299,1268],"causes":[11],"of":[12,87,97,105,118,132,163,171,206,246,250,259,268,275,311,315,329,457,483,489,502,547,560,570,582,590,615,650,655,740,760,771,816,845,854,861,877,889,896,899,942,955,968,986,997,1003,1021,1031,1039,1088,1094,1099,1114,1121,1131,1177,1182,1210,1237,1254,1297,1326,1340,1350,1358,1363,1369,1387,1421,1429],"death":[13,604],"long-term":[15,212],"disability":[16],"all":[17],"over":[18,64],"the":[19,59,65,83,100,103,116,129,135,140,147,159,172,211,243,257,309,312,326,409,447,455,461,478,484,487,514,544,558,568,580,586,616,625,632,648,704,710,723,769,782,843,852,859,875,883,914,946,952,966,992,995,1004,1019,1024,1028,1132,1180,1183,1202,1208,1252,1263,1271,1295,1300,1309,1313,1324,1337,1344,1348,1356,1361,1366,1385,1398],"world.[1]":[20],"Inflammation":[21],"may":[22,76,296,306,533,700,778,917,1215],"play":[23,77,297,918,1266],"an":[24,298,576,833,1267,1319],"essential":[25],"role":[26,80,640,920,1269],"in":[27,139,146,277,281,292,308,404,408,446,460,492,572,594,631,641,659,754,768,795,800,809,849,869,882,921,958,980,991,1023,1145,1251,1270,1312,1342],"secondary":[28],"after":[30,481,806,1008,1083,1105],"injury.":[32,1036,1258,1328,1389],"Neural":[33,371],"stem":[34,372,750,943,987,1106,1192,1238,1245],"cells":[35,39,751,944,988,1078,1117,1193,1239,1246],"(NSCs)":[36],"pluripotent":[38],"with":[40,252,319,538,606,781,1160,1173,1256],"self-renewal":[41],"ability.":[42],"It":[43,413,598],"is":[44,93,168,286,393,401,441,520,575,609,902,1128,1214,1318,1352,1377],"initially":[45],"assumed":[46],"that":[47,236,284,304,536,578,720,842],"NSCs":[48,88,269,278,305,324,405,532,566,713,821,848,929,1242,1285,1288,1341,1351,1370],"transplantation":[49,645,873],"promotes":[50,585],"tissue":[51,519,563,642,686,755],"restoration":[52],"by":[53,427,444,620,663,695,749,811,820,1014,1051,1076,1186,1206,1218,1395],"direct":[54],"structural":[55],"cell":[56,384,603,1063,1107,1277],"replacement.":[57],"However,":[58,82,1279],"view":[60],"has":[61,1136],"been":[62,763,1249],"recalibrated":[63],"past":[66],"decade.":[67],"Bystander":[68],"effect":[69,92,1030,1213,1273,1368],"providing":[70],"immunomodulatory,":[71],"neurotrophic,":[72],"reparative":[74],"support":[75],"a":[78,95,169,202,287,394,418,423,428,530,638,731,827,919,983,1129,1140,1381],"major":[79],"instead.[2]":[81],"specific":[84],"action":[85],"mode":[86],"to":[89,157,200,222,273,436,438,470,496,526,542,684,703,714,765,776,925,1018,1111,1201,1307,1322,1335,1379],"exert":[90,1289],"immunomodulatory":[91,148],"still":[94],"lack":[96],"knowledge.":[98],"On":[99,134],"one":[101],"hand,":[102,137],"secretion":[104,456,488,589],"CD200,":[106],"CX3":[107],"chemokine":[108,343],"ligand":[109,425],"1":[110,389,1059],"(CX3CL1),":[111],"NSC-derived":[112],"exosomes":[113,798],"(NSC-Exos),":[114],"regulation":[117,898,1296],"nucleotide":[119],"oligomerization":[120,365],"domain":[121],"(NOD)-like":[122],"receptor":[123,224,344,367],"protein":[124,255,368,420,1221],"3":[125],"(NLRP3)":[126],"can":[127,414,646,786,802,949,1194,1371],"inhibit":[128,325,471,543],"inflammatory":[130,233,244,327,358,452,475,629,672,1029,1073,1077,1084,1231],"effects":[131,213,328,759,1292],"microglia.":[133,207,863],"other":[136,232,909],"changes":[138],"systemic":[141,334,937],"immune":[142,178,335,596,938,1006,1310],"response":[143,1007,1311],"also":[144,599,935],"function":[145,1349],"process.":[149],"This":[150,1391],"article":[151],"will":[152],"focus":[153],"on":[154,176,188,197,468,540,1360],"these":[155],"aspects":[156],"discuss":[158],"potential":[160],"immunoregulation":[161],"mechanisms":[162,1265],"NSCs.":[164,189],"CD200-CD200R":[165],"Axis":[166,391],"CD200":[167,194,237,253,276],"member":[170,1130],"immunoglobulin":[173],"superfamily":[174],"expressed":[175,403,442],"most":[177,1166],"cells,":[179,184],"including":[180,505,1152],"T":[181],"B":[183],"well":[186],"The":[190,266,612,758,894,1175,1212],"ligand-receptor":[191],"interaction":[192,289,318],"between":[193,214,290,1045,1284],"CD200R":[196,251,280,320],"microglia":[198,218,271,316,330,445,469,493,541,661,668,777,825,846,856,881,933,1298],"helps":[199],"maintain":[201],"relatively":[203],"static":[204],"state":[205,314,830,836],"In":[208,477,513,529,864],"CD200-deficient":[209],"mice,":[210,870],"neurons":[215,407],"were":[216,989],"reduced,":[217],"responded":[219],"more":[220],"strongly":[221],"Toll-like":[223],"2":[225],"4":[227],"agonists,":[228],"interferon":[229],"(IFN)-gamma,":[230],"factors,":[234],"suggesting":[235,283,1001],"enhances":[238],"synaptic":[239],"plasticity":[240],"inhibits":[242],"activity":[245,473],"microglia.[3]":[247],"Conversely,":[248],"activation":[249,261,581],"fusion":[254],"reduced":[256,1092],"expression":[258,649,953,967,1087,1209],"microglial":[260,527,690,791,813,900],"markers":[262],"CD40.[4]":[265],"co-culture":[267,844],"leads":[272],"overexpression":[274,1176],"microglia,":[282,698],"there":[285,1280],"significant":[288,1141],"them,":[291],"which":[293,440,608,699,1109],"interleukin":[294,490],"(IL)-4":[295],"role.[5]":[300],"These":[301],"phenomena":[302],"suggest":[303],"participate":[307],"maintenance":[310],"resting":[313],"through":[317,945,1294],"[Figure":[321,564],"1A].Figure":[322],"1:":[323],"(A)":[331],"regulate":[333,932,936],"responses":[336],"(B).":[337],"BBB:":[338],"Blood-brain":[339],"barrier;":[340],"CX3CR1:":[341],"CX3C":[342],"1;":[345],"ICAM:":[346],"Intercellular":[347],"adhesion":[348,385,1057,1064,1095],"molecule;":[349],"IL:":[350],"Interleukin;":[351],"MCP:":[352],"Monocyte":[353],"chemoattractant":[354,1069],"protein;":[355,359],"MIP:":[356],"Macrophage":[357],"MMP:":[360],"Matrix":[361,1125],"metalloproteinase-9;":[362],"NLRP3:":[363],"Nucleotide":[364],"domain-like":[366],"3;":[369],"NSC:":[370],"cell;":[373],"TGF:":[374],"Tumor":[375,379],"growth":[376,891,974],"factor;":[377,381],"TNF:":[378],"necrosis":[380,507],"VCAM:":[382],"Vascular":[383],"molecule.CX3CL1-CX3C":[386],"Chemokine":[387],"Receptor":[388],"(CX3CR1)":[390],"CX3CL1":[392,459,466,522,535],"cytokine":[395],"containing":[396],"373":[397],"amino":[398],"acids":[399],"primarily":[402],"central":[410],"nervous":[411],"system.":[412],"be":[415,701,779,1216,1333,1372],"used":[416],"membrane-binding":[419],"or":[421,451],"soluble":[424,458],"decomposed":[426],"disintegrin":[429],"metalloproteinase":[431],"10":[432],"(ADAM10)":[433],"ADAM17":[435],"bind":[437],"CX3CR1,":[439],"only":[443,931],"brain.[6]":[448],"When":[449],"excitotoxicity":[450],"occurs,":[454],"extracellular":[462],"fluid":[463],"increases.":[464],"Soluble":[465],"acts":[467],"their":[472,1290],"under":[474],"conditions.[7]":[476],"physiological":[479],"state,":[480,516],"interruption":[482],"CX3CL1-CX3CR1":[485],"axis,":[486],"(IL)-1-beta":[491],"increased,":[494],"leading":[495,525],"increased":[497,887],"nuclear":[498],"factor":[499,508,975],"kappa-B-dependent":[500],"transcription":[501],"pro-inflammatory":[503,829,956],"cytokines":[504,1232],"tumor":[506,973],"(TNF)-alpha,":[509],"IL-6":[510],"and,":[511],"IFN-gamma.[8]":[512],"pathological":[515],"when":[517],"damaged,":[521],"levels":[523,654,876,888,954],"decrease,":[524],"activation.[7]":[528],"word,":[531],"secrete":[534],"interacts":[537],"CX3CR1":[539],"excessive":[545],"production":[546],"inducible":[548],"nitric":[549],"oxide":[550],"synthase,":[551],"IL-1,":[552],"TNF-alpha,":[553],"IL-6,":[555],"thereby":[556,666],"promoting":[557,693],"repair":[559,756,1120,1163,1325,1386],"damaged":[561,1025],"1B].":[565],"Reduce":[567],"Expression":[569],"NLRP3":[571,574,617,636,651,706],"Microglia":[573,715,817],"inflammasome":[577],"regulates":[579],"caspase-1":[583,656],"maturation":[587],"pro-IL-1-beta":[591],"pro-IL-18":[593],"innate":[595],"defence.":[597],"induces":[600],"caspase-1-dependent":[601],"programmed":[602],"associated":[605,780,1172],"inflammation,":[607],"called":[610],"pyroptosis.[9]":[611],"selective":[613],"blockade":[614],"inflammation":[618,1198],"pathway":[619,725],"MCC950":[621],"(NLRP3-specific":[622],"inhibitor)":[623],"alleviates":[624],"behavioral":[626],"deficits":[627],"injuries":[630],"injured":[633,884,1122],"sites.[10]":[634],"Therefore,":[635],"plays":[637],"negative":[639],"repair.":[643],"NSC":[644,679,872,897],"attenuate":[647],"inflammasome,":[652],"reduce":[653,788,951,1195],"IL-1\u03b2":[658],"BV2":[660],"stimulated":[662],"phosphate":[664],"polysaccharide,":[665],"preventing":[667],"from":[669,712,722,774,1397],"releasing":[670],"neurotoxic":[671],"factors":[673,957,970],"exerting":[675],"neuroprotective":[676],"effects.[11]":[677],"Besides,":[678,1067],"transplants":[680],"could":[681],"confer":[682],"neuroprotection":[683,767],"alleviate":[685],"loss":[687],"via":[688],"inhibiting":[689,1207],"pyroptosis":[691],"phagocytosis":[694],"surviving":[696],"activated":[697],"related":[702],"decreased":[705,874],"activation.[12]":[707],"NSC-Exos":[708,761,775,785,801],"Mediate":[709],"Signals":[711,773],"Exosomes":[716,747],"membrane-bound":[718],"nanovesicles":[719],"originate":[721],"endocytic":[724],"recently":[727,1137],"have":[728,762,840,1248],"emerged":[729,1138],"new":[732,1382],"avenue":[733],"for":[734,1384],"cell-to-cell":[735],"communication.":[736],"They":[737],"usually":[738],"consist":[739],"proteins,":[741],"lipids,":[742],"microRNA,":[743],"messenger":[745],"RNA.":[746],"generated":[748],"involved":[753],"theoretically.":[757],"shown":[764],"promote":[766,1323],"models":[770],"stroke.":[772],"beneficial":[783],"effects.":[784],"significantly":[787],"neuronal":[789,1154],"apoptosis,":[790,1156],"activation,":[792],"neuroinflammation":[794],"rats.":[796],"MiR-26b-5p":[797],"enriched":[799],"relieve":[803],"nerve":[804],"cerebral":[807,960],"ischemia/reperfusion":[808],"mice":[810],"suppressing":[812],"activation.[13]":[814],"Regulation":[815,924],"Phenotypic":[818],"Polarization":[819],"Present":[822],"studies":[823,839],"divide":[824],"into":[826],"classical":[828],"(M1)":[831],"alternative":[834],"anti-inflammatory":[835,969],"(M2).":[837],"Numerous":[838],"confirmed":[841],"vitro":[850],"reduces":[851],"number":[853,860,985],"M1":[855],"increases":[858,1179],"M2":[862],"closed":[865],"craniocerebral":[866],"model":[868],"induced":[871],"ED1":[878],"TNF-alpha-positive":[880],"cortex":[885],"insulin":[890],"factor-1-positive":[892],"microglia.[14]":[893],"mechanism":[895,1362],"polarization":[901],"unclear.":[903],"Inflammatory":[904,1011],"inhibitors":[905],"referred":[906],"above":[907],"signaling":[910],"pathways":[911],"CXCL12-CXCR4":[915],"axis":[916],"this":[922,1376],"effect.[14]":[923],"Systemic":[926,940],"Immune":[927],"Responses":[928],"not":[930],"but":[934],"responses.":[939],"application":[941],"intravenous":[947,1009],"injection":[948],"help":[950],"ischemic":[959],"hemisphere":[961],"blood,":[963],"increase":[965],"(TGF)":[976],"beta":[977],"IL-10":[979],"blood.":[981],"Furthermore,":[982],"large":[984],"found":[990],"spleen,":[993],"contraction":[996],"spleen":[998],"was":[999,1103,1393],"blocked,":[1000],"suppression":[1002],"peripheral":[1005,1040],"transplantation.[15]":[1010],"reactions":[1012],"caused":[1013],"lead":[1017],"accumulation":[1020],"leukocytes":[1022,1032,1042],"area,":[1026],"further":[1033,1330],"aggravates":[1034],"Intracerebral":[1037],"infiltration":[1038,1113,1229],"blood":[1041,1116],"requires":[1043],"interactions":[1044],"vascular":[1046,1062],"endothelium":[1047],"leukocytes,":[1049],"mediated":[1050,1217],"cell-surface":[1052],"proteins":[1053],"intercellular":[1056],"molecule":[1058,1065],"(ICAM-1)":[1060],"1.":[1066],"monocyte":[1068,1089],"protein-1":[1070],"macrophage":[1072],"protein-1\u03b1":[1074],"secreted":[1075],"recruit":[1079],"monocytes":[1080],"neutrophils":[1082],"stimulation.":[1085],"Decreased":[1086],"chemotactic":[1090],"protein,":[1091],"level":[1093],"molecules,":[1096],"amelioration":[1098],"blood-brain":[1100,1168,1184,1203],"barrier":[1101,1169,1185,1204],"damage":[1102,1200],"observed":[1104],"transplantation,":[1108],"contributes":[1110],"lower":[1112],"white":[1115],"better":[1119,1373],"tissue.[16]":[1124],"metalloproteinase-9":[1126],"(MMP-9)":[1127],"metzincin":[1133],"family":[1134],"unique":[1143],"player":[1144],"physiology":[1147],"pathology.":[1149],"Various":[1150],"complications,":[1151],"excitotoxicity,":[1153],"damage,":[1155],"oxidative":[1157,1161],"stress,":[1158],"interference":[1159],"DNA":[1162],"mechanisms,":[1164],"importantly":[1167],"opening,":[1170],"MMP-9.":[1174],"MMP-9":[1178],"permeability":[1181],"degrading":[1187],"tight":[1188],"junction":[1189],"proteins.[17]":[1190],"Transplanted":[1191],"both":[1196,1260],"microvascular":[1197],"(BBB)":[1205],"MPP-9.":[1211],"adenosine":[1219],"monophosphate-activated":[1220],"kinase-dependent":[1222],"ICAM-1":[1223],"downregulation":[1224],"potentially,":[1225],"thus":[1226],"alleviated":[1227],"neutrophil":[1228],"release.[16]":[1233],"Conclusions":[1234],"Different":[1235],"types":[1236],"mesenchymal":[1244],"(MSCs)":[1247],"researched":[1250],"treatment":[1253],"patients":[1255],"For":[1259],"SC":[1261],"types,":[1262],"bystander":[1264],"therapeutic":[1272],"rather":[1274],"than":[1275],"simple":[1276],"substitution.":[1278],"some":[1282],"differences":[1283],"MSCs.":[1287],"immunoregulatory":[1291],"mainly":[1293],"around":[1299],"lesion":[1301],"site,":[1302],"while":[1303],"MSCs":[1304],"prone":[1306],"control":[1308],"periphery.":[1314],"Jointly,":[1315],"NSC-based":[1316,1364],"therapy":[1317],"attractive":[1320],"approach":[1321],"Although":[1329],"efforts":[1331],"should":[1332],"made":[1334],"understand":[1336],"biological":[1338],"roles":[1339],"immunoregulation,":[1343],"basic":[1345],"concept":[1346],"about":[1347],"becoming":[1353],"clear.":[1354],"With":[1355],"development":[1357],"research":[1359],"therapy,":[1365],"curative":[1367],"exploited,":[1374],"expected":[1378],"bring":[1380],"dawn":[1383],"Funding":[1390],"study":[1392],"supported":[1394],"grants":[1396],"Lanzhou":[1399,1407,1422],"Science":[1400,1408],"Technology":[1402,1410],"Bureau":[1403],"Project":[1404,1412],"(No.":[1405,1413,1426],"2018-4-68),":[1406],"Plan":[1411],"2018SHFZ0062),":[1414],"Cuiying":[1415],"Scientific":[1416],"Technological":[1418],"Innovation":[1419],"Program":[1420],"University":[1423],"Second":[1424],"Hospital":[1425],"CY2018-MS08).":[1427],"Conflicts":[1428],"interest":[1430],"None.":[1431]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-11T00:00:00"}
