{"id":"https://openalex.org/W3083081589","doi":null,"title":"Impact of a decrease in monocarboxylate transporter expression in the rat somatosensory cortex on synaptic plasticity and animal cognition obtained with a shRNA-dependent viral vector approach","display_name":"Impact of a decrease in monocarboxylate transporter expression in the rat somatosensory cortex on synaptic plasticity and animal cognition obtained with a shRNA-dependent viral vector approach","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3083081589","mag":"3083081589"},"language":"en","primary_location":{"id":"pmh:oai:iris.unil.ch:iris/72308","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/72308","pdf_url":"https://iris.unil.ch/bitstreams/c88afa8b-d622-4fcd-a5c7-1c1fb48d8fc8/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.unil.ch/bitstreams/c88afa8b-d622-4fcd-a5c7-1c1fb48d8fc8/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060101381","display_name":"Charlotte Joll\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Charlotte Joll\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060101381"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocyte-neuron-lactate-shuttle","display_name":"astrocyte-neuron lactate shuttle","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mct4","display_name":"MCT4","score":0.8730000257492065},{"id":"https://openalex.org/keywords/monocarboxylate-transporter-2","display_name":"MCT2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6449999809265137},{"id":"https://openalex.org/keywords/animal-cognition","display_name":"animal cognition","score":0.7129999995231628},{"id":"https://openalex.org/keywords/texture-discrimination","display_name":"texture discrimination","score":0.8360000252723694},{"id":"https://openalex.org/keywords/novel-object-recognition","display_name":"novel object recognition","score":0.9629999995231628},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.4950000047683716},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.6140000224113464},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.7620000243186951},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.640999972820282},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2781217356","wikidata":"https://www.wikidata.org/wiki/Q83426191","display_name":"Monocarboxylate transporter","level":4,"score":0.6572881937026978},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6337013840675354},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6123402118682861},{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.5945979356765747},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5620307326316833},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5572430491447449},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.5462980270385742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5242407917976379},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5063890218734741},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4616353511810303},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31110239028930664},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2029963731765747},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09028699994087219},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:iris.unil.ch:iris/72308","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/72308","pdf_url":"https://iris.unil.ch/bitstreams/c88afa8b-d622-4fcd-a5c7-1c1fb48d8fc8/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"pmh:oai:serval.unil.ch:BIB_343304501FCC","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_343304501FCC","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:3083081589","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/resource/serval:BIB_343304501FCC.P001/REF.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:iris.unil.ch:iris/72308","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/72308","pdf_url":"https://iris.unil.ch/bitstreams/c88afa8b-d622-4fcd-a5c7-1c1fb48d8fc8/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083081589.pdf","grobid_xml":"https://content.openalex.org/works/W3083081589.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2605202107","https://openalex.org/W3213164295","https://openalex.org/W2170158628","https://openalex.org/W7154617204","https://openalex.org/W3215471611","https://openalex.org/W1965302517","https://openalex.org/W2153883114","https://openalex.org/W1982422255","https://openalex.org/W4385555760","https://openalex.org/W4290725094"],"abstract_inverted_index":{"Traditionally,":[0],"it":[1,343],"was":[2,195,201],"considered":[3],"that":[4,34,75,157,178,198,261,329,345],"neurons":[5,137],"consumed":[6],"essentially":[7],"glucose":[8,43,372,409],"as":[9],"their":[10,112,146],"main":[11],"energy":[12,65],"substrate.":[13],"This":[14,232],"view":[15],"of":[16,42,98,134,139,170,182,189,214,264,275,309],"brain":[17],"metabolism":[18,103],"has":[19,72,104],"been":[20,73,105],"challenged":[21],"25":[22,392],"years":[23],"ago":[24],"with":[25,126,295],"the":[26,83,127,165,171,183,190,199,212,215,252,256,262,276,283,287,330,339],"Astrocyte-Neuron":[27],"Lactate":[28],"Shuttle":[29],"(ANLS)":[30],"hypothesis.":[31],"It":[32,71],"proposed":[33],"under":[35],"sustained":[36,68],"neuronal":[37,90],"activation,":[38],"a":[39,58,63,131,179,224,242,296,384,391,441,477,654],"major":[40],"part":[41],"is":[44,92,114,251,332,349],"taken":[45],"up":[46],"by":[47,78,94],"astrocytes,":[48],"metabolized":[49],"into":[50],"lactate":[51,59,76,102,422,446,476,601],"and":[52,67,88,138,148,152,167,197,203,321,354,360],"then":[53,208],"transferred":[54],"to":[55,129,163,210,228,281,313,351],"neurons.":[56],"Such":[57],"supply":[60],"would":[61],"allow":[62],"fast":[64],"production":[66],"synaptic":[69,317,363],"activity.":[70],"shown":[74],"release":[77],"astrocytes":[79,416],"occurs":[80],"predominantly":[81],"via":[82],"monocarboxylate":[84],"transporter":[85],"4":[86,456],"(MCT4)":[87,457],"its":[89],"uptake":[91],"facilitated":[93],"MCT2.":[95,467],"The":[96],"implication":[97,484,707],"those":[99],"transporters":[100],"in":[101,107,110,136,141,150,153,158,237,248,266,316,358,480,485,534,537,608],"demonstrated":[106],"vitro.":[108,481],"However,":[109],"vivo,":[111,175,554],"involvement":[113],"still":[115],"debated.":[116],"To":[117,219],"answer":[118],"this":[119,346],"question,":[120,497],"several":[121,310],"viral":[122],"vectors":[123],"were":[124,161,207,278],"produced":[125],"aim":[128],"induce":[130],"cell-specific":[132],"knockdown":[133,200,263],"MCT2":[135,265,320,515,653,717],"MCT4":[140,322,521],"astrocytes.":[142,524],"First,":[143],"we":[144,176,222,240,304],"validated":[145],"efficiency":[147],"specificity":[149],"vitro":[151,159,535],"vivo.":[154,538,609],"We":[155,259],"showed":[156,177],"they":[160],"able":[162,280],"decrease":[164],"mRNA":[166],"protein":[168],"expression":[169,308],"targeted":[172,184],"MCT.":[173],"In":[174,324,539,553],"large":[180,559],"majority":[181],"area":[185,234],"(the":[186],"barrel":[187],"field":[188],"somatosensory":[191],"cortex,":[192],"a.k.a.":[193],"S1BF)":[194],"transduced":[196],"significant":[202],"cell-specific.":[204],"Those":[205],"tools":[206],"used":[209],"study":[211],"importance":[213],"ANLS":[216,331],"for":[217,272,301,334],"cognition.":[218],"do":[220],"so,":[221],"established":[223],"new":[225,284],"behavioral":[226,336],"protocol":[227],"probe":[229],"S1BF":[230,267,340,607],"function.":[231],"cortical":[233],"being":[235],"involved":[236,294,315,357],"texture":[238,250,269,285],"discrimination,":[239],"developed":[241],"textured":[243],"novel":[244],"object":[245],"recognition":[246],"test,":[247],"which":[249],"only":[253],"difference":[254],"between":[255],"two":[257],"objects.":[258],"found":[260],"prevented":[268],"discrimination.":[270],"Intriguingly,":[271],"MCT4,":[273,663],"half":[274,289],"animals":[277],"not":[279],"discriminate":[282],"while":[286],"other":[288],"did,":[290],"suggesting":[291],"different":[292],"mechanisms":[293],"particular":[297],"threshold":[298],"or":[299],"compensation":[300],"MCT4.":[302,719],"Moreover,":[303],"observed":[305],"an":[306],"altered":[307],"genes":[311],"known":[312],"be":[314],"plasticity":[318],"after":[319],"knockdowns.":[323],"conclusion,":[325],"these":[326],"results":[327],"indicate":[328],"necessary":[333],"proper":[335],"performances":[337],"involving":[338],"area.":[341],"Furthermore,":[342],"suggests":[344],"metabolic":[347],"interaction":[348],"required":[350],"sustain":[352],"molecular":[353],"cellular":[355],"processes":[356],"learning":[359],"memory":[361],"(e.g.":[362],"plasticity).":[364],"--":[365],"Il":[366,440],"\u00e9tait":[367,668],"classiquement":[368],"admis":[369],"que":[370,444,459,675,738],"le":[371,374,408,419,424,445,473,574],"est":[373,411,447,646,741],"nutriment":[375],"principal":[376],"des":[377,498,571,660,666,681,698],"neurones.":[378],"Cette":[379,610],"vision":[380],"du":[381,475,561,586],"m\u00e9tabolisme":[382,474],"c\u00e9r\u00e9bral":[383],"\u00e9t\u00e9":[385,442,478,490,502,593],"remise":[386],"en":[387,421],"question":[388],"il":[389],"y":[390,678],"ans":[393],"avec":[394,504],"l\u2019hypoth\u00e8se":[395],"de":[396,404,454,469,506,514,520,547,549,565,598,606,617,624,626,652,658,670,691,702,716,726],"la":[397,599,603,615,631,637,643,664,709,713,727,754,757],"navette":[398,600,728],"lactate.":[399],"Celle-ci":[400],"propose":[401],"qu\u2019en":[402],"cas":[403],"forte":[405],"activit\u00e9":[406],"neuronale,":[407],"sanguin":[410],"majoritairement":[412],"capt\u00e9":[413],"par":[414,449],"les":[415,427,517,523,672,745],"qui":[417,429],"vont":[418,430],"transformer":[420],"et":[423,458,512,519,531,584,718,748,753],"lib\u00e9rer":[425],"pour":[426,432,595,705,729,743],"neurones":[428,518],"l\u2019utiliser":[431],"produire":[433],"rapidement":[434],"l\u2019\u00e9nergie":[435],"n\u00e9cessaire":[436,742],"\u00e0":[437,466,495,579],"l\u2019activit\u00e9":[438],"neuronale.":[439],"montr\u00e9":[443,543,557],"lib\u00e9r\u00e9":[448],"l\u2019astrocyte":[450],"gr\u00e2ce":[451,465],"au":[452,509,563],"transporteur":[453],"monocarboxylates":[455],"sa":[460],"capture":[461],"neuronale":[462],"se":[463],"fait":[464],"L\u2019implication":[468],"ces":[470,722],"transporteurs":[471],"dans":[472,516,522,573,602,614,700,708,751],"montr\u00e9e":[479],"Cependant,":[482],"leur":[483,529,532,647,706],"vivo":[486],"n\u2019a":[487],"pas":[488],"encore":[489],"d\u00e9montr\u00e9e":[491],"clairement.":[492],"Pour":[493,662,720],"r\u00e9pondre":[494],"cette":[496],"vecteurs":[499,590],"viraux":[500],"ont":[501,591],"produits":[503],"l\u2019objectif":[505],"diminuer":[507],"l\u2019expression":[508,548,701],"niveau":[510],"ARNm":[511],"prot\u00e9ique":[513],"Nous":[525],"avons":[526,542,556,620,696],"d\u2019abord":[527],"test\u00e9":[528],"sp\u00e9cificit\u00e9":[530],"efficacit\u00e9":[533],"puis":[536],"vitro,":[540],"nous":[541,555,619,695],"une":[544,558,580,656],"diminution":[545],"sp\u00e9cifique":[546,585],"notre":[550,566],"MCT":[551,587],"d\u2019int\u00e9r\u00eat.":[552],"transduction":[560],"vecteur":[562],"sein":[564],"zone":[567,570,611],"d\u2019int\u00e9r\u00eat":[568],"(la":[569],"tonneaux":[572],"cortex":[575],"somatosensoriel,":[576],"S1BF),":[577],"associ\u00e9e":[578],"r\u00e9duction":[581,650,714],"d\u2019expression":[582,651,715],"significative":[583],"vis\u00e9.":[588],"Ces":[589],"ensuite":[592],"utilis\u00e9s":[594],"\u00e9tudier":[596],"l\u2019importance":[597,725],"fonction":[604],"cognitive":[605],"\u00e9tant":[612],"impliqu\u00e9e":[613],"discrimination":[616,659],"textures,":[618],"d\u00e9velopp\u00e9":[621],"un":[622,685,689,730],"test":[623],"reconnaissance":[625],"nouvel":[627],"objet":[628],"bas\u00e9":[629],"sur":[630],"texture.":[632,648],"Ici,":[633],"l\u2019animal":[634],"doit":[635],"faire":[636],"diff\u00e9rence":[638,645],"entre":[639],"deux":[640],"objets":[641],"dont":[642],"seule":[644],"La":[649],"entrain\u00e9":[655],"absence":[657],"objets.":[661],"moiti\u00e9":[665,677],"animaux":[667],"incapable":[669],"diff\u00e9rencier":[671],"objets,":[673],"alors":[674],"l\u2019autre":[676],"arrivait,":[679],"sugg\u00e9rant":[680],"m\u00e9canismes":[682],"diff\u00e9rents":[683],"impliquant":[684,734],"seuil":[686],"particulier":[687],"ou":[688],"ph\u00e9nom\u00e8ne":[690],"compensation.":[692],"De":[693],"plus,":[694],"observ\u00e9":[697],"alt\u00e9rations":[699],"g\u00e8nes":[703],"connus":[704],"plasticit\u00e9":[710,758],"synaptique":[711],"apr\u00e8s":[712],"conclure,":[721],"r\u00e9sultats":[723],"montrent":[724],"fonctionnement":[731],"cognitif":[732],"ad\u00e9quat":[733],"S1BF.":[735],"Cela":[736],"sugg\u00e8re":[737],"cet":[739],"\u00e9change":[740],"soutenir":[744],"processus":[746],"mol\u00e9culaires":[747],"cellulaires":[749],"impliqu\u00e9s":[750],"l\u2019apprentissage":[752],"m\u00e9moire":[755],"(ex.":[756],"synaptique).":[759]},"counts_by_year":[],"updated_date":"2026-08-22T07:34:49.880490","created_date":"2020-09-11T00:00:00"}