{"id":"https://openalex.org/W3083068898","doi":"https://doi.org/10.1186/s13020-020-00378-y","title":"Exploring the protective effect of Modified Xiaochaihu Decoction against hepatic steatosis and inflammation by network pharmacology and validation in ageing rats","display_name":"Exploring the protective effect of Modified Xiaochaihu Decoction against hepatic steatosis and inflammation by network pharmacology and validation in ageing rats","publication_year":2020,"publication_date":"2020-09-04","ids":{"openalex":"https://openalex.org/W3083068898","doi":"https://doi.org/10.1186/s13020-020-00378-y","mag":"3083068898"},"language":"en","primary_location":{"id":"doi:10.1186/s13020-020-00378-y","doi":"https://doi.org/10.1186/s13020-020-00378-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13020-020-00378-y","pdf_url":"https://cmjournal.biomedcentral.com/counter/pdf/10.1186/s13020-020-00378-y","source":{"id":"https://openalex.org/S103976430","display_name":"Chinese Medicine","issn_l":"1749-8546","issn":["1749-8546","1991-0150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cmjournal.biomedcentral.com/counter/pdf/10.1186/s13020-020-00378-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071595650","display_name":"Siting Gao","orcid":"https://orcid.org/0009-0003-9523-0844","observed_orcids":["https://orcid.org/0009-0003-9523-0844"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siting Gao","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010215000","display_name":"Tongzhuang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongzhuang Wang","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101764752","display_name":"Xuekuan Huang","orcid":"https://orcid.org/0000-0002-9507-6678","observed_orcids":["https://orcid.org/0000-0002-9507-6678","https://orcid.org/0009-0007-2829-0395"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XueKuan Huang","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102376812","display_name":"Yaqian Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaqian Jin","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052693482","display_name":"Yu Xu","orcid":"https://orcid.org/0000-0003-3360-8998","observed_orcids":["https://orcid.org/0000-0003-3360-8998"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Xu","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yumeng Xi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yumeng Xi","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433187","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0002-6523-7573","observed_orcids":["https://orcid.org/0000-0002-6523-7573"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014789709","display_name":"Yan Luo","orcid":"https://orcid.org/0000-0002-8862-7451","observed_orcids":["https://orcid.org/0000-0002-8862-7451"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Luo","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100949764","display_name":"Hongling Xu","orcid":"https://orcid.org/0000-0001-9021-4405","observed_orcids":["https://orcid.org/0000-0001-9021-4405"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongling Xu","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091472243","display_name":"Hong\u2010Li Guo","orcid":"https://orcid.org/0000-0002-6660-8145","observed_orcids":["https://orcid.org/0000-0002-6660-8145"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongli Guo","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101401421","display_name":"Dazhi Ke","orcid":"https://orcid.org/0000-0003-0280-1234","observed_orcids":["https://orcid.org/0000-0003-0280-1234"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dazhi Ke","raw_affiliation_strings":["The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103076794","display_name":"Jianwei Wang","orcid":"https://orcid.org/0000-0002-1468-391X","observed_orcids":["https://orcid.org/0000-0002-1468-391X"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianwei Wang","raw_affiliation_strings":["Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0002-1468-391X","affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103076794"],"corresponding_institution_ids":["https://openalex.org/I87780372"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":{"value":0,"currency":"USD","value_usd":0},"fwci":0.7674,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.71705065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9879999756813049},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":0.9039999842643738},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.8190000057220459},{"id":"https://openalex.org/keywords/acaca","display_name":"ACACA","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.7630000114440918},{"id":"https://openalex.org/keywords/chrebp","display_name":"ChREBP","score":0.9190000295639038},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.6349999904632568},{"id":"https://openalex.org/keywords/bioactive-compounds","display_name":"bioactive compounds","score":0.6309999823570251},{"id":"https://openalex.org/keywords/saponins","display_name":"saponins","score":0.47999998927116394},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.859000027179718},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.8374571800231934},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7741708755493164},{"id":"https://openalex.org/C190409667","wikidata":"https://www.wikidata.org/wiki/Q1136912","display_name":"Decoction","level":2,"score":0.5721572041511536},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5308153629302979},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5108579993247986},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.49805378913879395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4626627266407013},{"id":"https://openalex.org/C2853687","wikidata":"https://www.wikidata.org/wiki/Q18039976","display_name":"Carbohydrate-responsive element-binding protein","level":4,"score":0.4580989181995392},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.42740583419799805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36657845973968506},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3397131860256195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3271023631095886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2078009843826294},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.1898149847984314},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17969396710395813},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13031718134880066},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10149076581001282},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.096169114112854}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s13020-020-00378-y","doi":"https://doi.org/10.1186/s13020-020-00378-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13020-020-00378-y","pdf_url":"https://cmjournal.biomedcentral.com/counter/pdf/10.1186/s13020-020-00378-y","source":{"id":"https://openalex.org/S103976430","display_name":"Chinese Medicine","issn_l":"1749-8546","issn":["1749-8546","1991-0150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:1caa6fa231b843188648df931ebea707","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1caa6fa231b843188648df931ebea707","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chinese Medicine, Vol 15, Iss 1, Pp 1-19 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13020-020-00378-y","doi":"https://doi.org/10.1186/s13020-020-00378-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13020-020-00378-y","pdf_url":"https://cmjournal.biomedcentral.com/counter/pdf/10.1186/s13020-020-00378-y","source":{"id":"https://openalex.org/S103976430","display_name":"Chinese Medicine","issn_l":"1749-8546","issn":["1749-8546","1991-0150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2597843785","display_name":null,"funder_award_id":"201810","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3216108415","display_name":null,"funder_award_id":"81973653","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4157479271","display_name":null,"funder_award_id":"81673659","funder_id":"https://openalex.org/F4320315254","funder_display_name":"Innovative Research Group Project of the National Natural Science Foundation of China"},{"id":"https://openalex.org/G4663675036","display_name":null,"funder_award_id":"cstc2017jcyjAX0374","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"},{"id":"https://openalex.org/G576176917","display_name":null,"funder_award_id":"81973653","funder_id":"https://openalex.org/F4320315254","funder_display_name":"Innovative Research Group Project of the National Natural Science Foundation of China"},{"id":"https://openalex.org/G5776354803","display_name":null,"funder_award_id":"81673659","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7510740030","display_name":null,"funder_award_id":"cstc2018jcyjAX0176","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"}],"funders":[{"id":"https://openalex.org/F4320315254","display_name":"Innovative Research Group Project of the National Natural Science Foundation of China","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321410","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30"},{"id":"https://openalex.org/F4320322595","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58"},{"id":"https://openalex.org/F4320323172","display_name":"Natural Science Foundation of Chongqing","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3083068898.pdf","grobid_xml":"https://content.openalex.org/works/W3083068898.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W978308701","https://openalex.org/W1553175139","https://openalex.org/W2006986840","https://openalex.org/W2029517297","https://openalex.org/W2035618305","https://openalex.org/W2038252960","https://openalex.org/W2039438652","https://openalex.org/W2063412095","https://openalex.org/W2081615565","https://openalex.org/W2093152783","https://openalex.org/W2115642439","https://openalex.org/W2116036853","https://openalex.org/W2135977031","https://openalex.org/W2146544786","https://openalex.org/W2159914115","https://openalex.org/W2210672989","https://openalex.org/W2281495395","https://openalex.org/W2401145004","https://openalex.org/W2414912053","https://openalex.org/W2496508689","https://openalex.org/W2551202923","https://openalex.org/W2562039591","https://openalex.org/W2597233011","https://openalex.org/W2601448796","https://openalex.org/W2605836813","https://openalex.org/W2606876974","https://openalex.org/W2615088204","https://openalex.org/W2621188456","https://openalex.org/W2770535330","https://openalex.org/W2784100642","https://openalex.org/W2791528117","https://openalex.org/W2793460409","https://openalex.org/W2803132482","https://openalex.org/W2810423511","https://openalex.org/W2883492434","https://openalex.org/W2888443845","https://openalex.org/W2889294609","https://openalex.org/W2897022047","https://openalex.org/W2900832683","https://openalex.org/W2912770808","https://openalex.org/W2920993566","https://openalex.org/W2948172128","https://openalex.org/W2950218642","https://openalex.org/W2951350919","https://openalex.org/W2952405432","https://openalex.org/W2954388177","https://openalex.org/W2981635739","https://openalex.org/W2997991507","https://openalex.org/W3002721650","https://openalex.org/W3031334797"],"related_works":["https://openalex.org/W2374612556","https://openalex.org/W2394435630","https://openalex.org/W2365971026","https://openalex.org/W2365252700","https://openalex.org/W2374122394","https://openalex.org/W3201333362","https://openalex.org/W4319224410","https://openalex.org/W2181711931","https://openalex.org/W2965405792","https://openalex.org/W2073432398"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Based":[2,176],"on":[3,11,79,177,193,277,290],"therapy":[4],"with":[5,233],"syndrome":[6],"differentiation":[7],"and":[8,42,53,62,82,88,99,122,147,174,191,211,213,216,246,258,267,283,301,316,337,341],"clinical":[9,359],"studies":[10],"Xiaochaihu":[12,19],"decoction":[13],"(XCHD),":[14],"we":[15,76,198,228,238],"hypothesize":[16],"that":[17,163,240,298,322],"Modified":[18],"Decoction":[20],"(MXD)":[21],"has":[22],"an":[23],"ability":[24],"to":[25,35,91,204,218,332],"ameliorate":[26],"non-alcoholic":[27],"fatty":[28],"liver":[29],"disease":[30],"(NAFLD).":[31],"This":[32],"study":[33],"aims":[34],"elucidate":[36],"the":[37,46,80,178,194,200,249,305,323,345],"pharmacological":[38],"efficacy":[39],"of":[40,48,120,151,158,180,196,252,272,285,326,334,361],"MXD":[41,61,152,164,241,309,349],"its":[43],"mechanism":[44,195],"in":[45,60,113,169,223,255,308,317,348],"treatment":[47],"NAFLD":[49,234,245,327],"by":[50,72,107,134],"network":[51,69,94,108,156],"pharmacology":[52,109],"experimental":[54,73,319],"validation.":[55,74],"Methods":[56],"The":[57,313],"active":[58],"ingredients":[59,81,150,275,288],"their":[63],"potential":[64,274,287],"targets":[65,83,105,146,161,173,202,254,279,292],"were":[66,110,125,153,293],"identified":[67,106],"using":[68,229],"analysis":[70,157],"followed":[71],"First,":[75],"used":[77],"data":[78,179,315],"obtained":[84],"from":[85,281,295],"professional":[86],"database":[87],"related":[89,203,260,331],"literature":[90],"do":[92,219],"PPI":[93,181],"analysis,":[95,98,182,186,190],"GO":[96,183],"functional":[97,184],"KEGG":[100,187],"pathway":[101,188],"enrichment":[102,185,189],"analysis.":[103],"Core":[104],"then":[111],"tested":[112],"natural":[114],"ageing":[115,231],"female":[116],"rats":[117,232],"model.":[118],"Indexes":[119],"lipid":[121,205,256,335],"glucose":[123],"homeostasis":[124],"determined":[126],"enzymatically":[127],"and/or":[128,137],"histologically.":[129],"Gene":[130],"expression":[131,251],"was":[132],"analyzed":[133],"real-time":[135],"PCR":[136],"Western":[138],"blot":[139],"(WB).":[140],"Results":[141],"In":[142,269],"total,":[143],"4009":[144],"NAFLD-related":[145],"1953":[148],"chemical":[149],"obtained.":[154],"In-depth":[155],"140":[159],"common":[160],"indicated":[162],"played":[165],"a":[166,236],"critical":[167],"role":[168,307,347],"anti-NAFLD":[170],"via":[171],"multiple":[172],"pathways.":[175],"literatures":[192],"NAFLD,":[197],"chose":[199],"core":[201,253],"metabolism":[206,257,336],"(SREBP-1c,":[207],"ChREBP,":[208],"FASN,":[209,264],"PPAR\u03b1,":[210],"ACACA)":[212],"inflammation":[214,259],"(IL-6":[215],"NF-\u03baB)":[217],"further":[220,224],"study.":[221],"Significantly,":[222],"animal":[225],"verification":[226],"experiment":[227],"naturally":[230],"as":[235,263,304,344],"model,":[237],"found":[239],"administration":[242],"ameliorated":[243],"age-related":[244],"mechanistically":[247],"down-regulated":[248],"mRNA/protein":[250],"pathways":[261],"such":[262],"ACACA,":[265],"IL-6,":[266],"NF-\u03baB.":[268],"addition,":[270],"12":[271],"24":[273,286],"acting":[276,289],"verified":[278,291],"came":[280],"BC,":[282],"11":[284],"derived":[294],"SM,":[296],"implying":[297],"both":[299],"BC":[300,340],"SM":[302,342],"served":[303],"key":[306,346],"against":[310,350],"NAFLD.":[311,351],"Conclusion":[312],"bioinformatics":[314],"vivo":[318],"results":[320,353],"suggest":[321],"MXD-induced":[324],"amelioration":[325],"may":[328,354],"be":[329],"predominantly":[330],"modulation":[333],"inflammation.":[338],"Both":[339],"serve":[343],"These":[352],"provide":[355],"novel":[356],"evidence":[357],"for":[358],"implication":[360],"MXD.":[362]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
