{"id":"https://openalex.org/W3082977330","doi":"https://doi.org/10.4324/9780367854652-17","title":"Clozapine and Treatment-Refractory Illness","display_name":"Clozapine and Treatment-Refractory Illness","publication_year":2020,"publication_date":"2020-09-02","ids":{"openalex":"https://openalex.org/W3082977330","doi":"https://doi.org/10.4324/9780367854652-17","mag":"3082977330"},"language":"en","primary_location":{"id":"doi:10.4324/9780367854652-17","doi":"https://doi.org/10.4324/9780367854652-17","is_oa":false,"landing_page_url":"https://doi.org/10.4324/9780367854652-17","pdf_url":null,"source":{"id":"https://openalex.org/S4306463855","display_name":"Routledge eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Understanding and Caring for People with Schizophrenia","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W3082915259","display_name":"Understanding and Caring for People with Schizophrenia"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074474145","display_name":"Ragy R. Girgis","orcid":"https://orcid.org/0000-0001-5715-8982","observed_orcids":["https://orcid.org/0000-0001-5715-8982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ragy R. Girgis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027733157","display_name":"Gary Brucato","orcid":"https://orcid.org/0000-0002-9796-8901","observed_orcids":["https://orcid.org/0000-0002-9796-8901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Brucato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075093461","display_name":"Jeffrey Alan Lieberman","orcid":"https://orcid.org/0000-0002-1899-1776","observed_orcids":["https://orcid.org/0000-0002-1899-1776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey A. Lieberman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21692745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"109","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":1.0},{"id":"https://openalex.org/keywords/treatment-resistant-schizophrenia","display_name":"treatment-resistant schizophrenia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/antipsychotic-side-effects","display_name":"antipsychotic adverse effects","score":0.7279999852180481},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6690000295639038},{"id":"https://openalex.org/keywords/psychiatric-hospitalization","display_name":"psychiatric hospitalization","score":0.6420000195503235},{"id":"https://openalex.org/keywords/functional-decline","display_name":"functional decline","score":0.7760000228881836},{"id":"https://openalex.org/keywords/case-studies","display_name":"case studies","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.8180006742477417},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6608844995498657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4876672029495239},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3214687407016754},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3032389283180237},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.19842281937599182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05521911382675171},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.048833489418029785}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4324/9780367854652-17","doi":"https://doi.org/10.4324/9780367854652-17","is_oa":false,"landing_page_url":"https://doi.org/10.4324/9780367854652-17","pdf_url":null,"source":{"id":"https://openalex.org/S4306463855","display_name":"Routledge eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Understanding and Caring for People with Schizophrenia","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1982720888"],"related_works":["https://openalex.org/W2887788245","https://openalex.org/W2136273051","https://openalex.org/W2005815656","https://openalex.org/W2471260821","https://openalex.org/W4401924670","https://openalex.org/W2805018983","https://openalex.org/W7171945645","https://openalex.org/W6902001690","https://openalex.org/W2038675623","https://openalex.org/W7099282377"],"abstract_inverted_index":{"Clozapine":[0],"is":[1,74],"a":[2,85,124],"miracle":[3],"drug":[4,24],"for":[5,46],"schizophrenia.":[6],"Ever":[7],"since":[8],"the":[9,34,81],"late":[10],"1980s,":[11],"it":[12,70,73],"has":[13],"been":[14,31],"treating":[15],"individuals":[16],"with":[17],"schizophrenia":[18],"who":[19,27,87],"have":[20,30],"failed":[21],"all":[22],"other":[23],"trials":[25],"and":[26,52,58,68,76,108,115],"would":[28],"otherwise":[29,120],"relegated":[32],"to":[33],"back":[35],"halls":[36],"of":[37,83,103],"psychiatric":[38,93],"units":[39],"in":[40,95],"state":[41],"hospitals.":[42],"Although":[43],"not":[44],"effective":[45],"everyone,":[47],"few":[48],"medications":[49],"are":[50],"revered,":[51],"feared,":[53],"by":[54],"as":[55,123],"many":[56],"patients":[57],"clinicians":[59],"alike.":[60],"In":[61],"this":[62],"chapter,":[63],"clozapine,":[64],"its":[65,77],"history,":[66],"how":[67,72],"why":[69],"works,":[71],"used,":[75],"side":[78],"effects":[79],"through":[80],"case":[82],"\u201cAnthony,\u201d":[84],"patient":[86],"spent":[88],"years":[89,102],"trying":[90],"nearly":[91],"every":[92],"medication":[94,106],"existence,":[96],"will":[97],"be":[98,121],"discussed.":[99],"After":[100],"15":[101],"countless":[104],"hospitalizations,":[105],"trials,":[107],"severe":[109],"functional":[110],"decline,":[111],"Anthony":[112],"began":[113],"clozapine":[114],"experienced":[116],"what":[117],"could":[118],"only":[119],"described":[122],"miracle.":[125]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2020-09-08T00:00:00"}
