{"id":"https://openalex.org/W3082885180","doi":"https://doi.org/10.1158/1538-7445.am2020-4365","title":"Abstract 4365: Estrogen receptor \u03b2 agonists reverses letrozole therapy resistance of breast cancer through FOXO3 and FOXM1 mediated actions","display_name":"Abstract 4365: Estrogen receptor \u03b2 agonists reverses letrozole therapy resistance of breast cancer through FOXO3 and FOXM1 mediated actions","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3082885180","doi":"https://doi.org/10.1158/1538-7445.am2020-4365","mag":"3082885180"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-4365","doi":"https://doi.org/10.1158/1538-7445.am2020-4365","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-4365","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051673604","display_name":"Kumaraguruparan Ramasamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kumaraguruparan Ramasamy","raw_affiliation_strings":["1UT Health San Antonio, San Antonio, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health San Antonio, San Antonio, TX;","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043867874","display_name":"Suryavathi Viswanadhapalli","orcid":"https://orcid.org/0000-0002-7381-6962","observed_orcids":["https://orcid.org/0000-0002-7381-6962"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suryavathi Viswanadhapalli","raw_affiliation_strings":["1UT Health San Antonio, San Antonio, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health San Antonio, San Antonio, TX;","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038344333","display_name":"M.A. Sureshkumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A. Sureshkumar","raw_affiliation_strings":["1UT Health San Antonio, San Antonio, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health San Antonio, San Antonio, TX;","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005466573","display_name":"Susan T. Weintraub","orcid":"https://orcid.org/0000-0002-8328-7814","observed_orcids":["https://orcid.org/0000-0002-8328-7814"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Weintraub","raw_affiliation_strings":["1UT Health San Antonio, San Antonio, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health San Antonio, San Antonio, TX;","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090010000","display_name":"Ratna K. Vadlamudi","orcid":"https://orcid.org/0000-0003-2849-4076","observed_orcids":["https://orcid.org/0000-0003-2849-4076"]},"institutions":[{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ratna K. Vadlamudi","raw_affiliation_strings":["2UT Health San Antonio & Mays Cancer Center, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UT Health San Antonio & Mays Cancer Center, San Antonio, TX","institution_ids":["https://openalex.org/I4390039360"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054763940","display_name":"RAJESHWAR RAO TEKMAL","orcid":"https://orcid.org/0000-0002-3770-6811","observed_orcids":["https://orcid.org/0000-0002-3770-6811"]},"institutions":[{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajeshwar R. Tekmal","raw_affiliation_strings":["2UT Health San Antonio & Mays Cancer Center, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UT Health San Antonio & Mays Cancer Center, San Antonio, TX","institution_ids":["https://openalex.org/I4390039360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"4365","last_page":"4365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-beta-agonist","display_name":"estrogen receptor beta agonist","score":0.9620000123977661},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7749999761581421},{"id":"https://openalex.org/keywords/letrozole-resistance","display_name":"letrozole resistance","score":0.9679999947547913},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.9700000286102295},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.8309999704360962},{"id":"https://openalex.org/keywords/foxm1","display_name":"FOXM1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/s-equol","display_name":"S-equol","score":0.9620000123977661},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.718999981880188},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.46299999952316284},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.9779999852180481},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cell-death-pathways","display_name":"cell death pathways","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7170339226722717},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6289539337158203},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6217223405838013},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5627517700195312},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5092321634292603},{"id":"https://openalex.org/C2778812593","wikidata":"https://www.wikidata.org/wiki/Q194974","display_name":"Letrozole","level":5,"score":0.4808112382888794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4643459916114807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4331231117248535},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.41009652614593506},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33838027715682983},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.33151674270629883},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3273160755634308}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-4365","doi":"https://doi.org/10.1158/1538-7445.am2020-4365","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-4365","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3007681198","https://openalex.org/W2794000015","https://openalex.org/W2594835306","https://openalex.org/W2945394772","https://openalex.org/W1965559549","https://openalex.org/W2323397737","https://openalex.org/W2094906472","https://openalex.org/W4224547507","https://openalex.org/W2006818056","https://openalex.org/W2051406949"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Breast":[2],"cancer":[3,9,17,223,233,391,423,452],"(BC)":[4],"is":[5,46],"the":[6,55,71,88,111,120,194,213,236,257,284,301,312,316,331,335,369,384,463,467],"most":[7],"common":[8],"in":[10,105,119,242,262,288,351,379,389],"women":[11],"worldwide":[12],"and":[13,84,117,130,135,148,179,184,210,220,245,265,275,291,298,419,455,477],"leading":[14],"cause":[15],"of":[16,22,73,91,102,113,122,157,197,215,229,238,304,337,371,387,450,462,466],"death.":[18],"More":[19],"than":[20],"70%":[21],"cancers":[23,92],"are":[24],"estrogen":[25,80],"receptor":[26,81,443],"alpha":[27],"(ER\u03b1)":[28],"positive.":[29],"Despite":[30],"effective":[31],"therapeutic":[32,100],"strategies":[33],"for":[34,69,99,162,407,470],"treating":[35],"hormone":[36,268],"receptor-positive":[37],"(HR+)":[38],"breast":[39,106,123,222,232,390,411,451],"cancer,":[40,124],"resistance":[41,62,266,449],"to":[42,60,65,192,267],"endocrine":[43,74,217,408],"therapy":[44,127,218,406,409,448],"that":[45,58,79,204,252,280,329,345,361,398],"either":[47],"de":[48],"novo":[49],"or":[50,154],"acquired":[51],"still":[52],"occurs.":[53],"Understanding":[54],"molecular":[56],"pathways":[57],"contribute":[59],"BC":[61,187,339],"will":[63],"enable":[64],"develop":[66],"new":[67,404],"treatments":[68],"improving":[70],"efficacy":[72],"therapy.":[75],"Studies":[76],"have":[77,327],"shown":[78],"beta":[82],"(ER\u03b2)":[83],"its":[85],"agonists":[86,104,115,159,296,333,366,400,445],"inhibits":[87],"different":[89],"types":[90],"including":[93],"BC.":[94],"Herein,":[95],"we":[96,125,326],"investigated":[97],"mechanism(s)":[98],"efficacies":[101],"ER\u03b2":[103,114,136,149,158,198,207,258,295,332,365,380,388,399],"cancer.":[107],"Methods:":[108],"To":[109],"investigate":[110],"mechanisms":[112],"(S-Equol":[116],"LY500307),":[118],"treatment":[121,156,205,253,282],"used":[126,191],"sensitive":[128,219],"(MCF7-Aro)":[129],"letrozole":[131,356,447],"resistant":[132,221,410],"(MCF7-Aro-LTLT)":[133],"cells":[134,152,234,306,353,382],"knock":[137,150,317],"down":[138,151],"cell":[139,163,243,246,292,302],"lines,":[140],"generated":[141],"by":[142,349,364,414],"CRISPR-Cas9":[143],"technology.":[144],"The":[145],"wild":[146],"type":[147],"with":[153,206,254],"without":[155],"were":[160,190,376],"analyzed,":[161],"proliferation,":[164],"protein":[165],"(Western),":[166],"Gene":[167,225],"expression":[168,226],"array":[169,227],"analysis,":[170,172],"RNA-seq":[171,249],"data-independent":[173],"acquisition":[174],"(DIA)":[175],"mass":[176],"spectrometry":[177,271],"analyses":[178],"RNA":[180],"(RT-qPCR)":[181],"analysis.":[182],"Xenograft":[183],"patient":[185],"derived":[186],"explants":[188],"(PDEX)":[189],"test":[193],"antiproliferative":[195],"activity":[196],"agonists.":[199],"Results:":[200],"Our":[201,341,358],"results":[202,359,396],"demonstrated":[203,328],"agonists,":[208],"S-Equol":[209,297],"LY500307":[211,230,299],"inhibited":[212,300,334],"growth":[214],"both":[216,330],"cells.":[224,319,373],"analysis":[228,250,274,278],"treated":[231],"showed":[235,251,360],"modulation":[237],"signaling":[239],"molecules":[240],"involved":[241,261,287],"death":[244],"cycle":[247],"pathways.":[248],"S-equol":[255,281,350],"modulated":[256,283],"target":[259],"genes":[260],"tumor":[263],"progression":[264],"therapies.":[269],"Mass":[270],"based":[272],"DIA":[273],"Reactome":[276],"pathway":[277],"revealed":[279],"key":[285],"proteins":[286],"DNA":[289],"replication":[290],"cycle.":[293],"Both":[294],"proliferation":[303,336,370],"parental":[305],"whereas":[307],"they":[308],"could":[309],"not":[310,377],"elicits":[311],"inhibitory":[313],"effect":[314],"on":[315],"out":[318],"By":[320],"using":[321],"ER\u03b1":[322],"positive":[323],"PDX":[324],"tumors,":[325],"human":[338],"tumors.":[340,412],"mechanistic":[342],"studies":[343],"confirmed":[344],"increased":[346],"FOXO3":[347,454],"activation":[348],"LTLT":[352],"can":[354],"reverse":[355],"resistance.":[357],"inhibiting":[362],"FOXM1":[363,456],"significantly":[367],"reduce":[368],"letrozole-resistant":[372],"These":[374],"changes":[375],"observed":[378],"knockdown":[381],"confirming":[383],"anti-proliferative":[385],"role":[386],"progression.":[392],"Conclusions:":[393],"Collectively,":[394],"our":[395],"suggest":[397],"may":[401],"offer":[402],"a":[403],"targeted":[405],"(Supported":[413],"BCRP":[415],"151884/DOD":[416],"grant":[417],"W81XWH-16-1-0294":[418],"P30":[420],"CA-54174":[421],"NCI-Mays":[422],"center":[424],"grant).":[425],"Citation":[426],"Format:":[427],"Kumaraguruparan":[428],"Ramasamy,":[429],"Suryavathi":[430],"Viswanadhapalli,":[431],"M.A.":[432],"Sureshkumar,":[433],"Susan":[434],"Weintraub,":[435],"Ratna":[436],"K.":[437],"Vadlamudi,":[438],"Rajeshwar":[439],"R.":[440],"Tekmal.":[441],"Estrogen":[442],"\u03b2":[444],"reverses":[446],"through":[453],"mediated":[457],"actions":[458],"[abstract].":[459],"In:":[460],"Proceedings":[461],"Annual":[464],"Meeting":[465],"American":[468],"Association":[469],"Cancer":[471,483],"Research":[472],"2020;":[473],"2020":[474],"Apr":[475],"27-28":[476],"Jun":[478],"22-24.":[479],"Philadelphia":[480],"(PA):":[481],"AACR;":[482],"Res":[484],"2020;80(16":[485],"Suppl):Abstract":[486],"nr":[487],"4365.":[488]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-09-08T00:00:00"}
