{"id":"https://openalex.org/W3082883151","doi":"https://doi.org/10.1016/j.bbrc.2020.07.055","title":"Beneficial effect of erlotinib and trastuzumab emtansine combination in lung tumors harboring EGFR mutations","display_name":"Beneficial effect of erlotinib and trastuzumab emtansine combination in lung tumors harboring EGFR mutations","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W3082883151","doi":"https://doi.org/10.1016/j.bbrc.2020.07.055","mag":"3082883151","pmid":"https://pubmed.ncbi.nlm.nih.gov/32888648"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2020.07.055","doi":"https://doi.org/10.1016/j.bbrc.2020.07.055","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2020.07.055","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091805928","display_name":"Hiroe Kayatani","orcid":"https://orcid.org/0009-0001-4418-3131","observed_orcids":["https://orcid.org/0009-0001-4418-3131"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroe Kayatani","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002407044","display_name":"Kadoaki Ohashi","orcid":"https://orcid.org/0000-0002-5180-3933","observed_orcids":["https://orcid.org/0000-0002-5180-3933"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kadoaki Ohashi","raw_affiliation_strings":["Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan. Electronic address: kohashi@cc.okayama-u.ac.jp","Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan. Electronic address: kohashi@cc.okayama-u.ac.jp","institution_ids":["https://openalex.org/I4210100185"]},{"raw_affiliation_string":"Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014194149","display_name":"Kiichiro Ninomiya","orcid":"https://orcid.org/0000-0002-2134-2865","observed_orcids":["https://orcid.org/0000-0002-2134-2865","https://orcid.org/0000-0001-5072-3061"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiichiro Ninomiya","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036685872","display_name":"Go Makimoto","orcid":"https://orcid.org/0000-0002-0638-8435","observed_orcids":["https://orcid.org/0000-0002-0638-8435"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Go Makimoto","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076072180","display_name":"Kazuya Nishii","orcid":"https://orcid.org/0000-0002-1591-1937","observed_orcids":["https://orcid.org/0000-0002-1591-1937"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Nishii","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068740298","display_name":"Hisao Higo","orcid":"https://orcid.org/0000-0003-4946-0123","observed_orcids":["https://orcid.org/0000-0003-4946-0123"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisao Higo","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4946-0123","affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077188939","display_name":"Hiromi Watanabe","orcid":"https://orcid.org/0000-0002-4094-9080","observed_orcids":["https://orcid.org/0000-0002-4094-9080"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Watanabe","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062219464","display_name":"Hirohisa Kano","orcid":"https://orcid.org/0000-0003-4327-7547","observed_orcids":["https://orcid.org/0000-0003-4327-7547"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirohisa Kano","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4327-7547","affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022480619","display_name":"Yuka Kato","orcid":"https://orcid.org/0000-0003-3349-4847","observed_orcids":["https://orcid.org/0000-0003-3349-4847","https://orcid.org/0009-0006-0538-5052"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Kato","raw_affiliation_strings":["Center of Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101531161","display_name":"Takashi Ninomiya","orcid":"https://orcid.org/0000-0001-6581-9277","observed_orcids":["https://orcid.org/0000-0001-6581-9277"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Ninomiya","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056975051","display_name":"Toshio Kubo","orcid":"https://orcid.org/0000-0002-2545-3052","observed_orcids":["https://orcid.org/0000-0002-2545-3052"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Kubo","raw_affiliation_strings":["Center for Clinical Oncology, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Oncology, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061557628","display_name":"Kammei Rai","orcid":"https://orcid.org/0000-0001-5637-0762","observed_orcids":["https://orcid.org/0000-0001-5637-0762"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kammei Rai","raw_affiliation_strings":["Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5637-0762","affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050389295","display_name":"Eiki Ichihara","orcid":"https://orcid.org/0000-0002-2966-106X","observed_orcids":["https://orcid.org/0000-0002-2966-106X"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiki Ichihara","raw_affiliation_strings":["Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2966-106X","affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062920555","display_name":"Katsuyuki Hotta","orcid":"https://orcid.org/0000-0002-0112-0843","observed_orcids":["https://orcid.org/0000-0002-0112-0843"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyuki Hotta","raw_affiliation_strings":["Center for Clinical Oncology, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Oncology, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039723911","display_name":"Masahiro Tabata","orcid":"https://orcid.org/0000-0002-0008-2275","observed_orcids":["https://orcid.org/0000-0002-0008-2275"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Tabata","raw_affiliation_strings":["Center for Clinical Oncology, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Oncology, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025889209","display_name":"Yoshinobu Maeda","orcid":"https://orcid.org/0000-0003-1634-5487","observed_orcids":["https://orcid.org/0000-0003-1634-5487"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinobu Maeda","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066700160","display_name":"Katsuyuki Kiura","orcid":"https://orcid.org/0000-0002-9172-9379","observed_orcids":["https://orcid.org/0000-0002-9172-9379"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyuki Kiura","raw_affiliation_strings":["Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9172-9379","affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I4210100185"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002407044"],"corresponding_institution_ids":["https://openalex.org/I4210100185"],"apc_list":{"value":2450,"currency":"USD","value_usd":2450},"apc_paid":null,"fwci":1.1592,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.80951344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"532","issue":"3","first_page":"341","last_page":"346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9909999966621399},{"id":"https://openalex.org/keywords/trastuzumab-emtansine","display_name":"trastuzumab emtansine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/her2-expression","display_name":"HER2 expression","score":0.7480000257492065},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8080000281333923},{"id":"https://openalex.org/keywords/drug-tolerant-persister-cells","display_name":"drug-tolerant persister cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/egfr-l858r-mutation","display_name":"L858R mutation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/exon-19-deletion","display_name":"exon 19 deletion","score":0.9599999785423279},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.9195049405097961},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.6768057346343994},{"id":"https://openalex.org/C2778087150","wikidata":"https://www.wikidata.org/wiki/Q3997863","display_name":"Trastuzumab emtansine","level":5,"score":0.5939635038375854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5401548147201538},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5170012712478638},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.49021631479263306},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38369274139404297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35886287689208984},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.3557681441307068},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2121245563030243},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.09744688868522644}],"mesh":[{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000080044","descriptor_name":"Ado-Trastuzumab Emtansine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2020.07.055","doi":"https://doi.org/10.1016/j.bbrc.2020.07.055","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2020.07.055","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:32888648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32888648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2999533081","display_name":"Development of innovative immunotherapy for lung cancer using tumor immune-activating gene REIC","funder_award_id":"19H03667","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1984007340","https://openalex.org/W2048662229","https://openalex.org/W2081801534","https://openalex.org/W2096540669","https://openalex.org/W2106391833","https://openalex.org/W2114918609","https://openalex.org/W2119870604","https://openalex.org/W2133208325","https://openalex.org/W2143913849","https://openalex.org/W2159192794","https://openalex.org/W2184959883","https://openalex.org/W2272802268","https://openalex.org/W2275679174","https://openalex.org/W2735084022","https://openalex.org/W2766316939","https://openalex.org/W2767597066","https://openalex.org/W2772606138","https://openalex.org/W2805550471","https://openalex.org/W2883256340","https://openalex.org/W2885224353","https://openalex.org/W2889957730","https://openalex.org/W2910264472","https://openalex.org/W2937223370","https://openalex.org/W2943671268","https://openalex.org/W2947076462","https://openalex.org/W2967398721","https://openalex.org/W2978677918","https://openalex.org/W2987053327","https://openalex.org/W3020500179"],"related_works":["https://openalex.org/W4321793909","https://openalex.org/W2154100643","https://openalex.org/W4282941375","https://openalex.org/W2119870604","https://openalex.org/W1997656349","https://openalex.org/W2772606138","https://openalex.org/W3207218234","https://openalex.org/W2964016456","https://openalex.org/W2011026203","https://openalex.org/W2339915715"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-09-08T00:00:00"}