{"id":"https://openalex.org/W3082882489","doi":"https://doi.org/10.1186/s41232-020-00130-x","title":"Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy","display_name":"Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy","publication_year":2020,"publication_date":"2020-08-31","ids":{"openalex":"https://openalex.org/W3082882489","doi":"https://doi.org/10.1186/s41232-020-00130-x","mag":"3082882489","pmid":"https://pubmed.ncbi.nlm.nih.gov/32922570","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7461317"},"language":"en","primary_location":{"id":"doi:10.1186/s41232-020-00130-x","doi":"https://doi.org/10.1186/s41232-020-00130-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41232-020-00130-x","pdf_url":"https://inflammregen.biomedcentral.com/track/pdf/10.1186/s41232-020-00130-x","source":{"id":"https://openalex.org/S143716263","display_name":"Inflammation and Regeneration","issn_l":"1346-8022","issn":["1346-8022","1880-5795","1880-8190","1880-9693"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://inflammregen.biomedcentral.com/track/pdf/10.1186/s41232-020-00130-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101593624","display_name":"Katsu Takahashi","orcid":"https://orcid.org/0000-0003-2395-4715","observed_orcids":["https://orcid.org/0000-0003-2395-4715"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Katsu Takahashi","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029405949","display_name":"Honoka Kiso","orcid":"https://orcid.org/0000-0001-5719-3008","observed_orcids":["https://orcid.org/0000-0001-5719-3008"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Honoka Kiso","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070722376","display_name":"Akiko Murashima-Suginami","orcid":"https://orcid.org/0000-0003-2485-8637","observed_orcids":["https://orcid.org/0000-0003-2485-8637"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Murashima-Suginami","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050643731","display_name":"Yoshihito Tokita","orcid":"https://orcid.org/0000-0001-8598-3525","observed_orcids":["https://orcid.org/0000-0001-8598-3525"]},"institutions":[{"id":"https://openalex.org/I4210160234","display_name":"Aichi Human Service Center","ror":"https://ror.org/00c4ncp37","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210160234"]},{"id":"https://openalex.org/I4405287295","display_name":"Institute for Developmental Research","ror":"https://ror.org/04qywsk58","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210166504","https://openalex.org/I4405287295"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihito Tokita","raw_affiliation_strings":["Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan","institution_ids":["https://openalex.org/I4210160234","https://openalex.org/I4405287295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040414662","display_name":"Manabu Sugai","orcid":"https://orcid.org/0000-0003-1668-7647","observed_orcids":["https://orcid.org/0000-0003-1668-7647"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manabu Sugai","raw_affiliation_strings":["Department of Molecular Genetics, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055033211","display_name":"Yasuhiko Tabata","orcid":"https://orcid.org/0000-0001-8974-277X","observed_orcids":["https://orcid.org/0000-0001-8974-277X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Tabata","raw_affiliation_strings":["Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027664108","display_name":"Kazuhisa Bessho","orcid":"https://orcid.org/0000-0002-7731-6738","observed_orcids":["https://orcid.org/0000-0002-7731-6738"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhisa Bessho","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101593624"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":1230,"currency":"USD","value_usd":1230},"apc_paid":{"value":1230,"currency":"USD","value_usd":1230},"fwci":0.2902,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.37296037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"40","issue":"1","first_page":"21","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tooth-regeneration","display_name":"tooth regeneration","score":0.9620000123977661},{"id":"https://openalex.org/keywords/supernumerary-teeth","display_name":"supernumerary teeth","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tooth-agenesis","display_name":"tooth agenesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.8949999809265137},{"id":"https://openalex.org/keywords/usag-1","display_name":"USAG-1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cebpb","display_name":"CEBPB","score":0.9070000052452087},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9940000176429749},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.734000027179718},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.6600000262260437},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tooth-development","display_name":"tooth development","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.651614248752594},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5645238161087036},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5463552474975586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5454639792442322},{"id":"https://openalex.org/C147642095","wikidata":"https://www.wikidata.org/wiki/Q5259423","display_name":"Dental lamina","level":3,"score":0.4351491630077362},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38357049226760864},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3332158327102661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2746613323688507},{"id":"https://openalex.org/C2778125672","wikidata":"https://www.wikidata.org/wiki/Q769266","display_name":"Odontogenic","level":2,"score":0.2702706456184387}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s41232-020-00130-x","doi":"https://doi.org/10.1186/s41232-020-00130-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41232-020-00130-x","pdf_url":"https://inflammregen.biomedcentral.com/track/pdf/10.1186/s41232-020-00130-x","source":{"id":"https://openalex.org/S143716263","display_name":"Inflammation and Regeneration","issn_l":"1346-8022","issn":["1346-8022","1880-5795","1880-8190","1880-9693"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal-article"},{"id":"pmid:32922570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32922570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and regeneration","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7461317","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7461317/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflamm Regen","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6df984da5359472497a0e5d6d7596fe5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6df984da5359472497a0e5d6d7596fe5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Inflammation and Regeneration, Vol 40, Iss 1, Pp 1-9 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s41232-020-00130-x","doi":"https://doi.org/10.1186/s41232-020-00130-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41232-020-00130-x","pdf_url":"https://inflammregen.biomedcentral.com/track/pdf/10.1186/s41232-020-00130-x","source":{"id":"https://openalex.org/S143716263","display_name":"Inflammation and Regeneration","issn_l":"1346-8022","issn":["1346-8022","1880-5795","1880-8190","1880-9693"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4221779099","display_name":"Intracellular labile heme: signaling function in cell differentiation and proliferation","funder_award_id":"18K19423","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5728127429","display_name":"Development of a novel heart failure therapy by in vivo subtype modulation of macrophages using DDS","funder_award_id":"20K09147","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8752426913","display_name":"Feasibility of Molecularly Targeted Therapy for Tooth Regeneration","funder_award_id":"25463081","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3082882489.pdf","grobid_xml":"https://content.openalex.org/works/W3082882489.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W118441463","https://openalex.org/W1516530870","https://openalex.org/W1526523208","https://openalex.org/W1963641861","https://openalex.org/W1963698034","https://openalex.org/W1971303929","https://openalex.org/W1973004999","https://openalex.org/W1975991200","https://openalex.org/W1982506781","https://openalex.org/W1984177164","https://openalex.org/W1985792161","https://openalex.org/W1992635050","https://openalex.org/W1995069459","https://openalex.org/W1996212838","https://openalex.org/W2000784382","https://openalex.org/W2015270157","https://openalex.org/W2022963105","https://openalex.org/W2023952918","https://openalex.org/W2026084562","https://openalex.org/W2034888081","https://openalex.org/W2041657681","https://openalex.org/W2042585687","https://openalex.org/W2046175767","https://openalex.org/W2053584868","https://openalex.org/W2055824128","https://openalex.org/W2058225094","https://openalex.org/W2067070827","https://openalex.org/W2068227259","https://openalex.org/W2070979219","https://openalex.org/W2072106278","https://openalex.org/W2073517371","https://openalex.org/W2073591912","https://openalex.org/W2076637239","https://openalex.org/W2076872741","https://openalex.org/W2076973648","https://openalex.org/W2085013069","https://openalex.org/W2089388208","https://openalex.org/W2096819604","https://openalex.org/W2099518672","https://openalex.org/W2110156587","https://openalex.org/W2110703061","https://openalex.org/W2113198452","https://openalex.org/W2114712805","https://openalex.org/W2118469770","https://openalex.org/W2120506431","https://openalex.org/W2124490674","https://openalex.org/W2126525177","https://openalex.org/W2131928488","https://openalex.org/W2132940683","https://openalex.org/W2141772350","https://openalex.org/W2149813369","https://openalex.org/W2150133795","https://openalex.org/W2160775747","https://openalex.org/W2160995250","https://openalex.org/W2163126983","https://openalex.org/W2186400656","https://openalex.org/W2257500932","https://openalex.org/W2261076064","https://openalex.org/W2324949612","https://openalex.org/W2330373002","https://openalex.org/W2371658808","https://openalex.org/W2409862648","https://openalex.org/W2508482379","https://openalex.org/W2737082409","https://openalex.org/W2745036497","https://openalex.org/W2755490196","https://openalex.org/W2767737238","https://openalex.org/W2790965500","https://openalex.org/W2810909862","https://openalex.org/W2811276089","https://openalex.org/W2889701886","https://openalex.org/W2953671637","https://openalex.org/W4230545082"],"related_works":["https://openalex.org/W7028662198","https://openalex.org/W2070979219","https://openalex.org/W7162029071","https://openalex.org/W1516530870","https://openalex.org/W2349260050","https://openalex.org/W2110156587","https://openalex.org/W7118478921","https://openalex.org/W1988343816","https://openalex.org/W2622037142","https://openalex.org/W1971978299"],"abstract_inverted_index":{"Abstract":[0],"Analysis":[1],"of":[2,22,34,39,59,66,72,77,87,97,170,177,184,202,219,272,280],"various":[3],"genetically":[4],"modified":[5],"mice,":[6,83],"with":[7,121,284],"supernumerary":[8,28,107,178],"teeth,":[9],"has":[10,192,275],"revealed":[11],"the":[12,20,32,57,64,67,137,144,168,171,182,200,220,270,277],"following":[13],"two":[14],"intrinsic":[15],"molecular":[16,111,155],"mechanisms":[17],"that":[18],"increase":[19],"number":[21],"teeth.":[23],"One":[24],"plausible":[25],"explanation":[26],"for":[27,269,287,292],"tooth":[29,35,46,52,60,78,89,123,128,147],"formation":[30,47,180],"is":[31,54,91,105,141],"rescue":[33],"rudiments.":[36],"Topical":[37],"application":[38,279],"candidate":[40],"molecules":[41],"could":[42,113],"lead":[43],"to":[44,63,116,134,159,195,250,261],"whole":[45],"under":[48],"suitable":[49,162],"conditions.":[50],"Congenital":[51],"agenesis":[53,124],"caused":[55],"by":[56,125,167,238],"cessation":[58],"development":[61,79,271],"due":[62],"deletion":[65],"causative":[68],"gene":[69],"and":[70,99,150,207,228,245],"suppression":[71],"its":[73],"function.":[74],"The":[75,101,130],"arrest":[76],"in":[80,93,119,148,164,189,198,265],"Runx2":[81,98],"knockout":[82,95,103],"a":[84,106,161],"mouse":[85,104],"model":[86,108],"congenital":[88,122],"agenesis,":[90],"rescued":[92],"double":[94],"mice":[96],"Usag-1.":[100],"Usag-1":[102],"mouse.":[109],"Targeted":[110,154],"therapy":[112],"be":[114,160,196],"used":[115],"generate":[117],"teeth":[118,179,252,264],"patients":[120],"stimulating":[126],"arrested":[127],"germs.":[129],"third":[131,172],"dentition":[132],"begins":[133],"develop":[135],"when":[136],"second":[138,175],"successional":[139],"lamina":[140],"formed":[142,233],"from":[143,217,234,253],"developing":[145],"permanent":[146],"humans":[149],"usually":[151],"regresses":[152],"apoptotically.":[153],"therapy,":[156],"therefore,":[157],"seems":[158],"approach":[163,268],"whole-tooth":[165],"regeneration":[166],"stimulation":[169],"dentition.":[173],"A":[174],"mechanism":[176],"involves":[181],"contribution":[183],"odontogenic":[185,203,229,235,242,246],"epithelial":[186,204,212,225,236,243,255],"stem":[187,205,213,222,226,256],"cells":[188,206,214,231,237,244,248,257],"adults.":[190,266],"Cebpb":[191],"been":[193,276],"shown":[194],"involved":[197],"maintaining":[199],"stemness":[201],"suppressing":[208],"epithelial-mesenchymal":[209,239],"transition.":[210,240],"Odontogenic":[211],"are":[215,232],"differentiated":[216],"one":[218],"tissue":[221],"cells,":[223,227],"enamel":[224,254],"mesenchymal":[230,247],"Both":[241],"required":[249],"form":[251,262],"were":[258],"directly":[259],"induced":[260],"excess":[263],"An":[267],"targeted":[273],"therapeutics":[274],"local":[278],"monoclonal":[281],"neutralizing":[282],"antibody/siRNA":[283],"cationic":[285],"gelatin":[286],"USAG-1":[288],"or":[289],"small":[290],"molecule":[291],"Cebpb.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-09-08T00:00:00"}
