{"id":"https://openalex.org/W3082836062","doi":"https://doi.org/10.1016/j.carbpol.2020.117007","title":"Aminated laminaran from brown alga Saccharina cichorioides: Synthesis, structure, anticancer, and radiosensitizing potential in vitro","display_name":"Aminated laminaran from brown alga Saccharina cichorioides: Synthesis, structure, anticancer, and radiosensitizing potential in vitro","publication_year":2020,"publication_date":"2020-08-29","ids":{"openalex":"https://openalex.org/W3082836062","doi":"https://doi.org/10.1016/j.carbpol.2020.117007","mag":"3082836062","pmid":"https://pubmed.ncbi.nlm.nih.gov/33049875"},"language":"en","primary_location":{"id":"doi:10.1016/j.carbpol.2020.117007","doi":"https://doi.org/10.1016/j.carbpol.2020.117007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.carbpol.2020.117007","pdf_url":null,"source":{"id":"https://openalex.org/S64311837","display_name":"Carbohydrate Polymers","issn_l":"0144-8617","issn":["0144-8617","1879-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carbohydrate Polymers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064378067","display_name":"Olesya S. Malyarenko","orcid":"https://orcid.org/0000-0002-3262-0373","observed_orcids":["https://orcid.org/0000-0002-3262-0373","https://orcid.org/0000-0002-9677-5323"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Olesya S. Malyarenko","raw_affiliation_strings":["Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. Electronic address: malyarenko_os@piboc.dvo.ru","Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. Electronic address: malyarenko_os@piboc.dvo.ru","institution_ids":["https://openalex.org/I4210120806"]},{"raw_affiliation_string":"Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090132880","display_name":"Roza V. Usoltseva","orcid":"https://orcid.org/0009-0002-1519-1519","observed_orcids":["https://orcid.org/0009-0002-1519-1519"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Roza V. Usoltseva","raw_affiliation_strings":["Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. Electronic address: usoltseva@piboc.dvo.ru","Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. Electronic address: usoltseva@piboc.dvo.ru","institution_ids":["https://openalex.org/I4210120806"]},{"raw_affiliation_string":"Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081237968","display_name":"Artem S. Silchenko","orcid":"https://orcid.org/0000-0002-3502-5692","observed_orcids":["https://orcid.org/0000-0002-3502-5692"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Artem S. Silchenko","raw_affiliation_strings":["Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. Electronic address: artem.silchencko@yandex.ru","Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. Electronic address: artem.silchencko@yandex.ru","institution_ids":["https://openalex.org/I4210120806"]},{"raw_affiliation_string":"Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042776516","display_name":"Svetlana Pavlovna Ermakova","orcid":"https://orcid.org/0000-0002-5905-2046","observed_orcids":["https://orcid.org/0000-0002-5905-2046"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Svetlana P. Ermakova","raw_affiliation_strings":["Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. Electronic address: ermakova@piboc.dvo.ru","Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation. Electronic address: ermakova@piboc.dvo.ru","institution_ids":["https://openalex.org/I4210120806"]},{"raw_affiliation_string":"Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064378067"],"corresponding_institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":null,"fwci":1.6648,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.82103572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"250","issue":null,"first_page":"117007","last_page":"117007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brown-algae-polysaccharides","display_name":"brown algae polysaccharides","score":0.7559999823570251},{"id":"https://openalex.org/keywords/beta-1-3-glucan","display_name":"\u03b2-1,3-glucan","score":0.8799999952316284},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8880000114440918},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9079999923706055},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9259999990463257},{"id":"https://openalex.org/keywords/radiation-therapy-combination","display_name":"radiation therapy combination","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6426537036895752},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.48499032855033875},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46341222524642944},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4441494047641754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4012911319732666},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3349171578884125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31411898136138916},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3005691170692444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12484732270240784}],"mesh":[{"descriptor_ui":"D000459","descriptor_name":"Phaeophyceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005936","descriptor_name":"Glucans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005936","descriptor_name":"Glucans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.carbpol.2020.117007","doi":"https://doi.org/10.1016/j.carbpol.2020.117007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.carbpol.2020.117007","pdf_url":null,"source":{"id":"https://openalex.org/S64311837","display_name":"Carbohydrate Polymers","issn_l":"0144-8617","issn":["0144-8617","1879-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carbohydrate Polymers","raw_type":"journal-article"},{"id":"pmid:33049875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33049875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carbohydrate polymers","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1508628649","display_name":null,"funder_award_id":"18-34-20013","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G6488555115","display_name":null,"funder_award_id":"16-14-10131","funder_id":"https://openalex.org/F4320306201","funder_display_name":"Russell Sage Foundation"}],"funders":[{"id":"https://openalex.org/F4320306201","display_name":"Russell Sage Foundation","ror":"https://ror.org/02yh9se80"},{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W60311618","https://openalex.org/W219952058","https://openalex.org/W1504229889","https://openalex.org/W1967466408","https://openalex.org/W1975534296","https://openalex.org/W1994930469","https://openalex.org/W1998926818","https://openalex.org/W2011754786","https://openalex.org/W2031890504","https://openalex.org/W2037690883","https://openalex.org/W2056239762","https://openalex.org/W2064488040","https://openalex.org/W2073515589","https://openalex.org/W2085856408","https://openalex.org/W2092532047","https://openalex.org/W2096439168","https://openalex.org/W2107516157","https://openalex.org/W2107588151","https://openalex.org/W2112611468","https://openalex.org/W2146629016","https://openalex.org/W2151213561","https://openalex.org/W2170885324","https://openalex.org/W2273625236","https://openalex.org/W2301887099","https://openalex.org/W2318252996","https://openalex.org/W2416563655","https://openalex.org/W2498506543","https://openalex.org/W2750692616","https://openalex.org/W2899449128","https://openalex.org/W2900321707","https://openalex.org/W3009789321","https://openalex.org/W6716546005"],"related_works":["https://openalex.org/W2900321707","https://openalex.org/W2361762641","https://openalex.org/W3041552576","https://openalex.org/W2132951277","https://openalex.org/W3032415325","https://openalex.org/W1973515019","https://openalex.org/W2054940324","https://openalex.org/W2028624353","https://openalex.org/W2432422450","https://openalex.org/W2754565030"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-09-08T00:00:00"}