{"id":"https://openalex.org/W3082675720","doi":"https://doi.org/10.1158/1538-7445.am2020-5288","title":"Abstract 5288: Mechanisms of resistance to FGFR inhibitors in urothelial cancer cell lines and patients harboring FGFR3 alterations and strategies to overcome it","display_name":"Abstract 5288: Mechanisms of resistance to FGFR inhibitors in urothelial cancer cell lines and patients harboring FGFR3 alterations and strategies to overcome it","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3082675720","doi":"https://doi.org/10.1158/1538-7445.am2020-5288","mag":"3082675720"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-5288","doi":"https://doi.org/10.1158/1538-7445.am2020-5288","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-5288","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054594785","display_name":"Sergio Ruiz\u2010Llorente","orcid":"https://orcid.org/0000-0002-5003-1759","observed_orcids":["https://orcid.org/0000-0002-5003-1759"]},"institutions":[{"id":"https://openalex.org/I4210137474","display_name":"Hospital Universitario HM Sanchinarro","ror":"https://ror.org/04jep6391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338","https://openalex.org/I4210137474"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Ruiz-Llorente","raw_affiliation_strings":["1HM Sanchinarro Madrid, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1HM Sanchinarro Madrid, Madrid, Spain;","institution_ids":["https://openalex.org/I4210137474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083756218","display_name":"Elena Fern\u00e1ndez-Sevillano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137474","display_name":"Hospital Universitario HM Sanchinarro","ror":"https://ror.org/04jep6391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338","https://openalex.org/I4210137474"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Fern\u00e1ndez-Sevillano","raw_affiliation_strings":["1HM Sanchinarro Madrid, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1HM Sanchinarro Madrid, Madrid, Spain;","institution_ids":["https://openalex.org/I4210137474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068109247","display_name":"Paloma Navarro","orcid":"https://orcid.org/0000-0003-2198-6967","observed_orcids":["https://orcid.org/0000-0003-2198-6967"]},"institutions":[{"id":"https://openalex.org/I4210137474","display_name":"Hospital Universitario HM Sanchinarro","ror":"https://ror.org/04jep6391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338","https://openalex.org/I4210137474"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paloma Navarro","raw_affiliation_strings":["1HM Sanchinarro Madrid, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1HM Sanchinarro Madrid, Madrid, Spain;","institution_ids":["https://openalex.org/I4210137474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041173579","display_name":"Juan Francisco Rodr\u00edguez-Moreno","orcid":"https://orcid.org/0000-0001-7510-5059","observed_orcids":["https://orcid.org/0000-0001-7510-5059"]},"institutions":[{"id":"https://openalex.org/I4210137474","display_name":"Hospital Universitario HM Sanchinarro","ror":"https://ror.org/04jep6391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338","https://openalex.org/I4210137474"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Francisco Rodr\u00edguez-Moreno","raw_affiliation_strings":["1HM Sanchinarro Madrid, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1HM Sanchinarro Madrid, Madrid, Spain;","institution_ids":["https://openalex.org/I4210137474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047341028","display_name":"Ar\u00e1ntzazu Barqu\u00edn","orcid":"https://orcid.org/0000-0002-3701-0347","observed_orcids":["https://orcid.org/0000-0002-3701-0347"]},"institutions":[{"id":"https://openalex.org/I4210137474","display_name":"Hospital Universitario HM Sanchinarro","ror":"https://ror.org/04jep6391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338","https://openalex.org/I4210137474"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Arantzazu Barqu\u00edn-Garc\u00eda","raw_affiliation_strings":["1HM Sanchinarro Madrid, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1HM Sanchinarro Madrid, Madrid, Spain;","institution_ids":["https://openalex.org/I4210137474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035227730","display_name":"Sandra Amarilla\u2010Quintana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137474","display_name":"Hospital Universitario HM Sanchinarro","ror":"https://ror.org/04jep6391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338","https://openalex.org/I4210137474"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sandra Amarilla-Quintana","raw_affiliation_strings":["1HM Sanchinarro Madrid, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1HM Sanchinarro Madrid, Madrid, Spain;","institution_ids":["https://openalex.org/I4210137474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074730628","display_name":"M\u00f3nica Yag\u00fce-Fern\u00e1ndez","orcid":"https://orcid.org/0000-0001-9438-5703","observed_orcids":["https://orcid.org/0000-0001-9438-5703"]},"institutions":[{"id":"https://openalex.org/I4210137474","display_name":"Hospital Universitario HM Sanchinarro","ror":"https://ror.org/04jep6391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338","https://openalex.org/I4210137474"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Yag\u00fce-Fern\u00e1ndez","raw_affiliation_strings":["1HM Sanchinarro Madrid, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1HM Sanchinarro Madrid, Madrid, Spain;","institution_ids":["https://openalex.org/I4210137474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051968938","display_name":"Juan Mar\u00eda Rold\u00e1n\u2010Romero","orcid":"https://orcid.org/0000-0002-5651-4313","observed_orcids":["https://orcid.org/0000-0002-5651-4313"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Mar\u00eda Roldan-Romero","raw_affiliation_strings":["2Centro Nacional de Investigaciones Oncol\u00f3gicas, CNIO, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Centro Nacional de Investigaciones Oncol\u00f3gicas, CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049859710","display_name":"Raquel Mart\u00edn","orcid":"https://orcid.org/0009-0009-7771-550X","observed_orcids":["https://orcid.org/0009-0009-7771-550X"]},"institutions":[{"id":"https://openalex.org/I4210137474","display_name":"Hospital Universitario HM Sanchinarro","ror":"https://ror.org/04jep6391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338","https://openalex.org/I4210137474"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Mart\u00edn","raw_affiliation_strings":["1HM Sanchinarro Madrid, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1HM Sanchinarro Madrid, Madrid, Spain;","institution_ids":["https://openalex.org/I4210137474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019181961","display_name":"Cristina Rodr\u00edguez\u2010Antona","orcid":"https://orcid.org/0000-0001-8750-7338","observed_orcids":["https://orcid.org/0000-0001-8750-7338"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Rodriguez-Antona","raw_affiliation_strings":["2Centro Nacional de Investigaciones Oncol\u00f3gicas, CNIO, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Centro Nacional de Investigaciones Oncol\u00f3gicas, CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004741487","display_name":"Jes\u00fas Garc\u00eda-Don\u00e1s","orcid":"https://orcid.org/0000-0001-7731-3601","observed_orcids":["https://orcid.org/0000-0001-7731-3601"]},"institutions":[{"id":"https://openalex.org/I4210137474","display_name":"Hospital Universitario HM Sanchinarro","ror":"https://ror.org/04jep6391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338","https://openalex.org/I4210137474"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Garc\u00eda-Donas","raw_affiliation_strings":["1HM Sanchinarro Madrid, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1HM Sanchinarro Madrid, Madrid, Spain;","institution_ids":["https://openalex.org/I4210137474"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"5288","last_page":"5288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.4417000114917755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgfr-inhibitor-resistance","display_name":"FGFR inhibitor resistance","score":0.8199999928474426},{"id":"https://openalex.org/keywords/erdafitinib","display_name":"erdafitinib","score":0.824999988079071},{"id":"https://openalex.org/keywords/azd4547","display_name":"AZD4547","score":0.9459999799728394},{"id":"https://openalex.org/keywords/fgfr3-alterations","display_name":"FGFR3 alterations","score":0.8140000104904175},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.7749999761581421},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.7390000224113464},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/phospholipase-c-gamma","display_name":"phospholipase C-gamma","score":0.5440000295639038},{"id":"https://openalex.org/keywords/trametinib","display_name":"trametinib","score":0.9179999828338623},{"id":"https://openalex.org/keywords/igf1r-inhibitors","display_name":"IGF1R inhibitors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/ipatasertib","display_name":"ipatasertib","score":0.7889999747276306},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.9639999866485596},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5938606858253479},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.5773029327392578},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5415698289871216},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5290747284889221},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.4999854564666748},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.48749232292175293},{"id":"https://openalex.org/C3020745361","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial cancer","level":4,"score":0.48156479001045227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4732675552368164},{"id":"https://openalex.org/C2910041100","wikidata":"https://www.wikidata.org/wiki/Q11878994","display_name":"Urothelial Cell","level":4,"score":0.4677465260028839},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.46133410930633545},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45440831780433655},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4322047531604767},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4240856468677521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3543405830860138},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.32704317569732666},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3098580241203308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3061497211456299},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.26364606618881226},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22373759746551514},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1576797366142273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07487010955810547}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-5288","doi":"https://doi.org/10.1158/1538-7445.am2020-5288","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-5288","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362593906","https://openalex.org/W4405492323","https://openalex.org/W4382344454","https://openalex.org/W3048907562","https://openalex.org/W4386529928","https://openalex.org/W2936195076","https://openalex.org/W2907705110","https://openalex.org/W3212371407","https://openalex.org/W3022883047","https://openalex.org/W4397013168"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"The":[2,16],"Fibroblast":[3],"Growth":[4],"Factor":[5],"Receptor":[6],"(FGFR)":[7],"has":[8,21],"become":[9],"a":[10,60,299,315],"key":[11],"target":[12],"in":[13,31,62,65,110,170,203,209,234,273,280,311,318,323,338,339,374,411],"urothelial":[14,67,412],"cancer.":[15],"FGFR":[17,409],"inhibitor":[18],"(FGFRi)":[19],"erdafitinib":[20],"been":[22],"approved":[23],"for":[24,164,437],"clinical":[25,81,282,375],"use":[26],"and":[27,52,82,88,106,152,157,201,237,240,243,268,296,305,320,325,350,372,416,421,444],"many":[28],"others":[29],"are":[30,348,377],"development.":[32],"Unfortunately,":[33],"responses":[34],"have":[35],"shown":[36],"to":[37,45,55,74,103,144,173,249,408,423],"last":[38],"short.":[39],"Thus,":[40],"it":[41,425],"is":[42],"urgently":[43],"required":[44],"identify":[46],"the":[47,80,165,171,198,281,293,334,344,355,365,430,434],"underlying":[48],"mechanisms":[49,330],"of":[50,90,141,167,183,228,231,284,331,343,358,367,406,429,433],"resistance":[51,73,407],"establish":[53],"strategies":[54,422],"overcome":[56,424],"it.":[57],"We":[58],"designed":[59],"comprehensive":[61],"vitro":[63,340],"study":[64,286],"FGFR3-altered":[66],"cancer":[68,112,413],"cell":[69,113,130,176,274,414],"lines":[70,114,131,177,415],"after":[71,188],"acquiring":[72],"FGFRis.":[75],"In":[76],"parallel,":[77],"we":[78],"monitored":[79],"molecular":[83,321],"evolution":[84],"(through":[85],"tumor":[86,192,206,307],"biopsies":[87,303],"ctDNA)":[89],"three":[91],"patients":[92,277,417],"treated":[93,137,179,258],"with":[94,138,180,259,360],"FGFRi":[95,104,359],"at":[96,306,354],"our":[97,285],"institution.":[98],"Experimental":[99],"Procedures":[100],"Drug":[101],"sensitivity":[102,134],"(Erdafitinib":[105],"AZD4547)":[107],"was":[108,194,216],"evaluated":[109],"bladder":[111],"harboring":[115,418],"FGFR3":[116,319,419],"point":[117],"mutations":[118],"(pS249C)":[119],"or":[120,123,246,264],"rearrangements":[121],"(FGFR3/BAIAP2L1":[122],"TACC3).":[124],"After":[125],"performing":[126],"7-days":[127],"proliferation":[128],"assays,":[129],"showing":[132,314],"nM-range":[133],"were":[135,150,162,178,278,309],"long-term":[136],"high":[139],"concentrations":[140],"both":[142],"compounds":[143],"induce":[145],"therapeutic":[146],"resistance.":[147],"Cell":[148],"lysates":[149],"collected":[151,195],"protein":[153],"arrays":[154,224],"(Human":[155],"Phospho-RTK":[156],"Kinases":[158],"Array,":[159],"R&D":[160],"Systems)":[161],"used":[163],"identification":[166],"proteins":[168,232,247],"involved":[169,233],"desensitization":[172],"FGFRi.":[174],"Later,":[175],"selective":[181],"inhibitors":[182,410],"such":[184],"kinases.":[185],"Regarding":[186],"patients,":[187],"providing":[189],"written":[190],"consent,":[191],"tissue":[193],"retrospectively":[196],"from":[197,213],"initial":[199],"diagnosis":[200],"prospectively":[202],"any":[204],"new":[205],"resection":[207],"performed":[208],"daily":[210],"practice.":[211],"ctDNA":[212],"peripheral":[214],"blood":[215],"also":[217],"periodically":[218],"extracted.":[219],"Results":[220],"&":[221],"Conclusions":[222],"Protein":[223],"showed":[225],"an":[226],"overactivation":[227],"phosphorylated":[229],"forms":[230],"PI3K":[235],"(EGFR":[236],"AKT,":[238],"4":[239],"9-fold":[241],"increase)":[242],"MAPK":[244],"pathways":[245,327],"related":[248],"signal":[250],"transduction":[251],"(PLC\u03b3,":[252],"80-fold":[253],"increase,":[254],"among":[255],"others).":[256],"When":[257],"trametinib,":[260],"IGF1Ri,":[261],"ipatasertib,":[262],"everolimus":[263],"erlotinib,":[265],"only":[266],"trametinib":[267],"IGF1Ri":[269],"demonstrated":[270],"significant":[271],"activity":[272],"cultures.":[275],"Three":[276],"included":[279],"cohort":[283],"(2":[287],"males,":[288],"1":[289],"female).":[290],"All":[291],"harbored":[292],"mutation":[294,317],"p.S249C":[295],"initially":[297],"achieved":[298],"partial":[300],"response.":[301],"Multiple":[302],"(baseline":[304],"progression)":[308],"analyzed":[310],"case":[312],"1,":[313],"secondary":[316],"alterations":[322,420],"EGFR":[324],"IGFR":[326],"as":[328],"potential":[329],"resistance,":[332],"matching":[333],"results":[335],"previously":[336],"observed":[337],"models.":[341],"Studies":[342],"other":[345],"2":[346],"cases":[347],"ongoing":[349],"will":[351],"be":[352],"presented":[353],"meeting.":[356],"Combination":[357],"additional":[361],"TKIs":[362],"could":[363],"improve":[364],"efficacy":[366],"these":[368],"drugs.":[369],"Further":[370],"studies":[371],"validation":[373],"trials":[376],"required.":[378],"Citation":[379],"Format:":[380],"Sergio":[381],"Ruiz-Llorente,":[382],"Elena":[383],"Fern\u00e1ndez-Sevillano,":[384],"Paloma":[385],"Navarro,":[386],"Juan":[387,396],"Francisco":[388],"Rodr\u00edguez-Moreno,":[389],"Arantzazu":[390],"Barqu\u00edn-Garc\u00eda,":[391],"Sandra":[392],"Amarilla-Quintana,":[393],"M\u00f3nica":[394],"Yag\u00fce-Fern\u00e1ndez,":[395],"Mar\u00eda":[397],"Roldan-Romero,":[398],"Raquel":[399],"Mart\u00edn,":[400],"Cristina":[401],"Rodriguez-Antona,":[402],"Jes\u00fas":[403],"Garc\u00eda-Donas.":[404],"Mechanisms":[405],"[abstract].":[426],"In:":[427],"Proceedings":[428],"Annual":[431],"Meeting":[432],"American":[435],"Association":[436],"Cancer":[438,450],"Research":[439],"2020;":[440],"2020":[441],"Apr":[442],"27-28":[443],"Jun":[445],"22-24.":[446],"Philadelphia":[447],"(PA):":[448],"AACR;":[449],"Res":[451],"2020;80(16":[452],"Suppl):Abstract":[453],"nr":[454],"5288.":[455]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2020-09-08T00:00:00"}