{"id":"https://openalex.org/W3082670124","doi":"https://doi.org/10.1097/01.tp.0000700164.06183.b2","title":"EPIDEMIOLOGY OF NOCARDIA SPP INFECTIONS IN HEART TRANSPLANT RECIPIENTS AT A SINGLE CENTER","display_name":"EPIDEMIOLOGY OF NOCARDIA SPP INFECTIONS IN HEART TRANSPLANT RECIPIENTS AT A SINGLE CENTER","publication_year":2020,"publication_date":"2020-08-28","ids":{"openalex":"https://openalex.org/W3082670124","doi":"https://doi.org/10.1097/01.tp.0000700164.06183.b2","mag":"3082670124"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000700164.06183.b2","doi":"https://doi.org/10.1097/01.tp.0000700164.06183.b2","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000700164.06183.b2","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032579236","display_name":"Hannah H. Nam","orcid":"https://orcid.org/0000-0003-4576-287X","observed_orcids":["https://orcid.org/0000-0003-4576-287X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Nam","raw_affiliation_strings":["Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070211681","display_name":"Scott C. Roberts","orcid":"https://orcid.org/0000-0001-7348-6716","observed_orcids":["https://orcid.org/0000-0001-7348-6716"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott C. Roberts","raw_affiliation_strings":["Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046385947","display_name":"Michael Angarone","orcid":"https://orcid.org/0000-0002-3728-7864","observed_orcids":["https://orcid.org/0000-0002-3728-7864"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Angarone","raw_affiliation_strings":["Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011913674","display_name":"Valentina Stosor","orcid":"https://orcid.org/0000-0002-0388-5460","observed_orcids":["https://orcid.org/0000-0002-0388-5460"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentina Stosor","raw_affiliation_strings":["Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"S3","first_page":"S326","last_page":"S326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nocardiosis","display_name":"nocardiosis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/post-transplant-infection","display_name":"post-transplant infection","score":0.7770000100135803},{"id":"https://openalex.org/keywords/pulmonary-involvement","display_name":"pulmonary involvement","score":0.5419999957084656},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole-prophylaxis","display_name":"trimethoprim-sulfamethoxazole prophylaxis","score":0.890999972820282},{"id":"https://openalex.org/keywords/antithymocyte-globulin","display_name":"antithymocyte globulin","score":0.7730000019073486},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8130000233650208},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.5389999747276306},{"id":"https://openalex.org/keywords/co-pathogens","display_name":"co-pathogens","score":0.5440000295639038},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5709999799728394},{"id":"https://openalex.org/keywords/central-nervous-system-infection","display_name":"central nervous system infection","score":0.5019999742507935},{"id":"https://openalex.org/keywords/skin-infections","display_name":"skin infections","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2779448432","wikidata":"https://www.wikidata.org/wiki/Q135175","display_name":"Nocardia","level":3,"score":0.8566616773605347},{"id":"https://openalex.org/C2777436413","wikidata":"https://www.wikidata.org/wiki/Q4425574","display_name":"Nocardia brasiliensis","level":5,"score":0.7017503976821899},{"id":"https://openalex.org/C2776846390","wikidata":"https://www.wikidata.org/wiki/Q1856914","display_name":"Nocardiosis","level":4,"score":0.674637496471405},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.5681965947151184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5409371256828308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5206993222236633},{"id":"https://openalex.org/C2909574288","wikidata":"https://www.wikidata.org/wiki/Q1856914","display_name":"Nocardia Infections","level":5,"score":0.49315088987350464},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4730086624622345},{"id":"https://openalex.org/C2780728791","wikidata":"https://www.wikidata.org/wiki/Q422665","display_name":"Trimethoprim","level":3,"score":0.45666036009788513},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.4521418511867523},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44794678688049316},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.41497132182121277},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.357302725315094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3228394687175751},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1929466724395752},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.12010228633880615},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.tp.0000700164.06183.b2","doi":"https://doi.org/10.1097/01.tp.0000700164.06183.b2","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000700164.06183.b2","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2565133274","https://openalex.org/W2023528678","https://openalex.org/W2583472864","https://openalex.org/W2156685107","https://openalex.org/W2240125582","https://openalex.org/W1995384717","https://openalex.org/W1975289481","https://openalex.org/W7154649407","https://openalex.org/W7095804798","https://openalex.org/W2133657394"],"abstract_inverted_index":{"Introduction:":[0],"Infection":[1],"with":[2,44,71,92,152,160,211,253,272,305],"Nocardia":[3,45,72,93,199,335,363,417],"spp":[4,46,73,94,200],"is":[5],"a":[6,61,177,202,256,366],"rare":[7],"complication":[8],"after":[9,96],"heart":[10,338],"transplantation":[11],"(HT).":[12],"Risk":[13],"factors":[14],"for":[15,120,132],"acquisition,":[16],"diagnosis,":[17,329],"and":[18,39,67,83,113,155,221,242,255,286,300,311,330,381,437,445],"optimal":[19,378],"management":[20],"strategies":[21],"in":[22,48,138,204,237,246,260,298,369,383,419],"this":[23,29,306,370],"population":[24],"are":[25,289,303,314,341,374],"poorly":[26],"defined.":[27],"In":[28],"retrospective":[30],"case":[31,401],"series,":[32],"we":[33],"sought":[34],"to":[35,78,172,328,343,350,376],"characterize":[36],"the":[37,195,292,317,323,331,334,420],"epidemiology":[38],"outcomes":[40,438],"of":[41,127,143,179,187,197,209,265,296,319,333,439,443],"all":[42],"patients":[43,89,144,188,225],"infection":[47,70,95],"HT":[49,62,97],"recipients":[50,128,340],"at":[51,63,102,176,194,360],"our":[52,301,354],"institution.":[53],"Methodology:":[54],"Patients":[55],"were":[56,86,90,108,118,189,357],"included":[57,250],"if":[58],"they":[59],"received":[60,129,168,269],"Northwestern":[64],"Memorial":[65],"Hospital":[66],"developed":[68],"subsequent":[69,273],"from":[74],"January":[75],"1,":[76],"2011":[77],"December":[79],"31,":[80],"2018.":[81],"Summary":[82],"comparative":[84],"statistics":[85],"performed.":[87],"Results:5":[88],"identified":[91,137],"(Figure":[98],"1).":[99],"Mean":[100],"age":[101],"diagnosis":[103],"was":[104,136,201,280,365],"54.8":[105],"years.":[106],"80%":[107,123,139,164,205,261],"male":[109],"(n":[110,115,124,140,149,157,165,184,206,239,262,282],"=":[111,116,125,141,150,158,166,185,207,240,263,283],"4)":[112,126,142,167,208,264],"60%":[114,148,281],"3)":[117,151],"transplanted":[119,421],"ischemic":[121],"cardiomyopathy.":[122],"anti-thymocyte":[130],"globulin":[131],"induction":[133],"immunosuppression.":[134],"Rejection":[135],"preceding":[145],"microbiologic":[146],"diagnosis;":[147],"cellular":[153],"rejection":[154],"40%":[156,183],"2)":[159,186],"antibody":[161],"mediated":[162],"rejection.":[163],"pulse":[169],"steroids":[170],"prior":[171],"infection.":[173],"Diagnosis":[174],"occurred":[175,236,245],"mean":[178],"208.6":[180],"days":[181],"post-HT.":[182],"on":[190,322],"trimethoprim-sulfamethoxazole":[191],"(TMP/SMX)":[192],"prophylaxis":[193],"time":[196,327],"identification.":[198],"co-pathogen":[203,368],"cases,":[210],"other":[212,315,351],"pathogens":[213],"including":[214],"Actinomyces":[215],"ondontolyticus,":[216],"Cunninghamella":[217],"spp,":[218,220],"Alternaria":[219],"Mycobacterium":[222],"kansasii.":[223],"All":[224],"had":[226],"pulmonary":[227],"involvement":[228,297],"(n=5),":[229],"while":[230],"central":[231],"nervous":[232],"system":[233],"(CNS)":[234],"disease":[235,244,313],"20%":[238,247],"1)":[241],"skin":[243],"(n=1).":[248],"Treatments":[249],"dual":[251],"therapy":[252],"TMP/SMX":[254],"cephalosporin":[257],"or":[258],"carbapenem":[259,270],"cases.":[266],"One":[267],"patient":[268],"monotherapy":[271],"clinical":[274],"cure.":[275],"Overall":[276],"crude":[277],"mortality":[278,355],"rate":[279],"3).":[284],"Discussion":[285],"Conclusion:":[287],"Lungs":[288],"described":[290],"as":[291],"most":[293],"common":[294],"site":[295],"Nocardiosis,[1-3]":[299],"results":[302],"consistent":[304],"finding.":[307],"The":[308],"CNS,":[309],"skin,":[310],"disseminated":[312],"presentations,":[316],"likelihood":[318],"which":[320],"depends":[321],"individual\u2019s":[324],"immune":[325],"status,":[326],"virulence":[332],"spp.":[336,364],"While":[337],"transplant":[339,352],"thought":[342],"have":[344],"potentially":[345],"better":[346],"survival":[347],"when":[348],"compared":[349],"groups,[2]":[353],"rates":[356],"still":[358],"significant":[359],"60%.":[361],"Interestingly":[362],"frequent":[367],"series.":[371,402],"Further":[372],"studies":[373],"needed":[375],"determine":[377],"treatment":[379],"course":[380],"duration":[382],"Nocardiosis.":[384],"References:":[385],"1.":[386],"Aggarwal":[387],"D,":[388],"Garg":[389],"K,":[390],"Chander":[391],"J,":[392,429,431],"Saini":[393],"V,":[394],"Janmeja":[395],"AK.":[396],"Pulmonary":[397],"nocardiosis":[398],"revisited:":[399],"A":[400],"Lung":[403],"India.":[404],"2015;32(2):165-168.":[405],"2.":[406],"Hemmersbach-Miller":[407],"M,":[408],"Stout":[409],"JE,":[410],"Woodworth":[411],"MH,":[412],"Cox":[413],"GM,":[414],"Saullo":[415],"JL.":[416],"infections":[418],"host.":[422],"Transpl":[423],"Infect":[424],"Dis.":[425],"2018;20(4):e12902-e12902.":[426],"3.":[427],"Steinbrink":[428],"Leavens":[430],"Kauffman":[432],"CA,":[433],"Miceli":[434],"MH.":[435],"Manifestations":[436],"nocardia":[440],"infections:":[441],"Comparison":[442],"immunocompromised":[444],"nonimmunocompromised":[446],"adult":[447],"patients.":[448],"Medicine":[449],"(Baltimore).":[450],"2018;97(40):e12436-e12436.":[451]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-08T00:00:00"}