{"id":"https://openalex.org/W3082570258","doi":"https://doi.org/10.12122/j.issn.1673-4254.2020.07.02","title":"[Differential expression of miR-30a-5p in post stroke depression and bioinformatics analysis of the possible mechanism].","display_name":"[Differential expression of miR-30a-5p in post stroke depression and bioinformatics analysis of the possible mechanism].","publication_year":2020,"publication_date":"2020-07-30","ids":{"openalex":"https://openalex.org/W3082570258","doi":"https://doi.org/10.12122/j.issn.1673-4254.2020.07.02","mag":"3082570258","pmid":"https://pubmed.ncbi.nlm.nih.gov/32895153","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7386218"},"language":"zh","primary_location":{"id":"pmid:32895153","doi":"https://doi.org/10.12122/j.issn.1673-4254.2020.07.02","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32895153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7386218/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101453564","display_name":"Jia Hu","orcid":"https://orcid.org/0000-0003-2227-3600","observed_orcids":["https://orcid.org/0000-0003-2227-3600"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]},{"id":"https://openalex.org/I4210167381","display_name":"First Affiliated Hospital of Wannan Medical College","ror":"https://ror.org/05wbpaf14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Hu","raw_affiliation_strings":["Department of Neurology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, China","institution_ids":["https://openalex.org/I100357981","https://openalex.org/I4210167381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000546663","display_name":"Zhiming Zhou","orcid":"https://orcid.org/0000-0002-0851-3930","observed_orcids":["https://orcid.org/0000-0002-0851-3930"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]},{"id":"https://openalex.org/I4210167381","display_name":"First Affiliated Hospital of Wannan Medical College","ror":"https://ror.org/05wbpaf14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiming Zhou","raw_affiliation_strings":["Department of Neurology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, China","institution_ids":["https://openalex.org/I100357981","https://openalex.org/I4210167381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101865274","display_name":"Qian Yang","orcid":"https://orcid.org/0000-0001-7575-6396","observed_orcids":["https://orcid.org/0000-0001-7575-6396"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]},{"id":"https://openalex.org/I4210167381","display_name":"First Affiliated Hospital of Wannan Medical College","ror":"https://ror.org/05wbpaf14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Yang","raw_affiliation_strings":["Department of Neurology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, China","institution_ids":["https://openalex.org/I100357981","https://openalex.org/I4210167381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101767440","display_name":"Ke Yang","orcid":"https://orcid.org/0000-0001-8085-8282","observed_orcids":["https://orcid.org/0000-0001-8085-8282"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]},{"id":"https://openalex.org/I4210167381","display_name":"First Affiliated Hospital of Wannan Medical College","ror":"https://ror.org/05wbpaf14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Yang","raw_affiliation_strings":["Department of Neurology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, China","institution_ids":["https://openalex.org/I100357981","https://openalex.org/I4210167381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4712,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.48823681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"40","issue":"7","first_page":"922","last_page":"929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-30a-5p","display_name":"miR-30a-5p","score":0.9810000061988831},{"id":"https://openalex.org/keywords/post-stroke-depression","display_name":"post-stroke depression","score":0.9620000123977661},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6259999871253967},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.871999979019165},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.6610000133514404},{"id":"https://openalex.org/keywords/insulin-signaling-pathway","display_name":"insulin signaling pathway","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6140000224113464},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2777198177","wikidata":"https://www.wikidata.org/wiki/Q3765927","display_name":"Hamd","level":3,"score":0.8795404434204102},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.8186392784118652},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5748252868652344},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5593368411064148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.558615505695343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5455323457717896},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.45104408264160156},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.4325272738933563},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3916356563568115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32338660955429077},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16046440601348877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13586735725402832},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.09886980056762695},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09416413307189941},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmid:32895153","doi":"https://doi.org/10.12122/j.issn.1673-4254.2020.07.02","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32895153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7386218","doi":"https://doi.org/10.12122/j.issn.1673-4254.2020.07.02","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7386218/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan Fang Yi Ke Da Xue Xue Bao","raw_type":"Text"},{"id":"mag:3171220737","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386218/","pdf_url":null,"source":{"id":"https://openalex.org/S4306545097","display_name":"\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5b66\u62a5","issn_l":"1000-2588","issn":["1000-2588","1673-4254"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1","medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Nanfang Yike Daxue xuebao","raw_type":null},{"id":"mag:3045479898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32701232/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Zhejiang University (Medical Sciences)","raw_type":null},{"id":"mag:3082570258","doi":"https://doi.org/10.12122/j.issn.1673-4254.2020.07.02","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32895153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7386218","doi":"https://doi.org/10.12122/j.issn.1673-4254.2020.07.02","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7386218/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan Fang Yi Ke Da Xue Xue Bao","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1930885864","https://openalex.org/W1996963134","https://openalex.org/W2006869556","https://openalex.org/W2012631257","https://openalex.org/W2027984042","https://openalex.org/W2050640090","https://openalex.org/W2126671780","https://openalex.org/W2132549398","https://openalex.org/W2151437295","https://openalex.org/W2215395666","https://openalex.org/W2235217262","https://openalex.org/W2309165118","https://openalex.org/W2491786871","https://openalex.org/W2510657589","https://openalex.org/W2570677359","https://openalex.org/W2619236908","https://openalex.org/W2620090474","https://openalex.org/W2621403686","https://openalex.org/W2744579607","https://openalex.org/W2767674851","https://openalex.org/W2769012187","https://openalex.org/W2795447768","https://openalex.org/W2799277391","https://openalex.org/W2810967677","https://openalex.org/W2902255849","https://openalex.org/W2922050765","https://openalex.org/W2923967191","https://openalex.org/W2944979300","https://openalex.org/W2965583817","https://openalex.org/W2983611068","https://openalex.org/W2995276319"],"related_works":["https://openalex.org/W3171220737","https://openalex.org/W4306167779","https://openalex.org/W3112487421","https://openalex.org/W4384498158","https://openalex.org/W2221152716","https://openalex.org/W3168261397","https://openalex.org/W3125674115","https://openalex.org/W2945032174","https://openalex.org/W1956697799","https://openalex.org/W4252244967"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,15,46,54,58,69,116,121,137],"differential":[4],"expression":[5],"of":[6,24,57,72,79,87,93,102,172],"miR-30a-5p":[7,25,88,151],"in":[8,155],"patients":[9],"with":[10,74,146],"poststroke":[11],"depression":[12],"and":[13,20,36,44,53,77,81,106,130,157,167],"explore":[14],"possible":[16,47,55],"mechanism.":[17],"METHODS:":[18],"=25),":[19],"their":[21],"plasma":[22],"levels":[23],"were":[26,40],"detected":[27],"using":[28],"qPCR.":[29],"The":[30,84],"STARBASE":[31],"Database":[32,39],"ENCORI":[33],"miRNA-mRNA":[34],"module":[35],"Comparative":[37],"Toxicogenomics":[38],"used":[41],"to":[42,51],"predict":[43],"screen":[45],"target":[48,59,85,117,171],"genes":[49,60,141],"related":[50],"miR-30a-5p,":[52],"mechanism":[56],"was":[61],"further":[62],"analyzed":[63],"through":[64],"bioinformatics.":[65],"RESULTS:":[66],"=0.0005)":[67],"at":[68],"cutoff":[70],"value":[71],"1.597,":[73],"a":[75,90,161,169],"sensitivity":[76],"specificity":[78],"0.727":[80],"0.840,":[82],"respectively.":[83],"proteins":[86,118],"involved":[89],"wide":[91],"range":[92],"biological":[94],"processes,":[95],"including":[96],"signal":[97],"transduction,":[98],"intercellular":[99],"communication,":[100],"regulation":[101],"nucleobase,":[103],"nucleoside,":[104],"nucleotide":[105],"nucleic":[107],"acid":[108],"metabolism.":[109],"KEGG":[110],"pathway":[111,129],"enrichment":[112],"analysis":[113],"showed":[114],"that":[115,142],"affected":[119],"mainly":[120],"neural":[122],"nutrient":[123],"signaling":[124,128,132],"pathway,":[125],"axon":[126],"guidance":[127],"insulin":[131],"system.":[133],"We":[134],"also":[135,168],"identified":[136],"top":[138],"20":[139],"HUB":[140],"might":[143],"be":[144],"associated":[145],"post-stroke":[147],"depression.":[148],"CONCLUSIONS:":[149],"Plasma":[150],"is":[152],"differentially":[153],"expressed":[154],"PSD":[156],"can":[158],"serve":[159],"as":[160],"new":[162],"blood":[163],"marker":[164],"for":[165],"diagnosis":[166],"therapeutic":[170],"PSD.":[173]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-09-08T00:00:00"}