{"id":"https://openalex.org/W3082270090","doi":"https://doi.org/10.1158/1538-7445.am2020-1625","title":"Abstract 1625: Lung and kidney metabolism altered by cancer-induced cachexia","display_name":"Abstract 1625: Lung and kidney metabolism altered by cancer-induced cachexia","publication_year":2020,"publication_date":"2020-08-15","ids":{"openalex":"https://openalex.org/W3082270090","doi":"https://doi.org/10.1158/1538-7445.am2020-1625","mag":"3082270090"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2020-1625","doi":"https://doi.org/10.1158/1538-7445.am2020-1625","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-1625","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050171498","display_name":"Raj Kumar Sharma","orcid":"https://orcid.org/0000-0003-0623-3238","observed_orcids":["https://orcid.org/0000-0003-0623-3238"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj Kumar Sharma","raw_affiliation_strings":["The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051494356","display_name":"Santosh Kumar Bharti","orcid":"https://orcid.org/0000-0002-0627-6433","observed_orcids":["https://orcid.org/0000-0002-0627-6433"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santosh K. Bharti","raw_affiliation_strings":["The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109131667","display_name":"Paul T. Winnard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul T. Winnard","raw_affiliation_strings":["The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026291909","display_name":"Marie\u2010France Penet","orcid":"https://orcid.org/0000-0002-9132-7433","observed_orcids":["https://orcid.org/0000-0002-9132-7433"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie-France Penet","raw_affiliation_strings":["The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009487218","display_name":"Zaver M. Bhujwalla","orcid":"https://orcid.org/0000-0002-6617-9360","observed_orcids":["https://orcid.org/0000-0002-6617-9360"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaver M. Bhujwalla","raw_affiliation_strings":["The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"16_Supplement","first_page":"1625","last_page":"1625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.07509999722242355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lung-metabolism","display_name":"lung metabolism","score":0.9300000071525574},{"id":"https://openalex.org/keywords/renal-metabolism","display_name":"renal metabolism","score":0.996999979019165},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.7350000143051147},{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9980000257492065},{"id":"https://openalex.org/keywords/histidine","display_name":"histidine","score":0.6000000238418579},{"id":"https://openalex.org/keywords/phenylalanine","display_name":"phenylalanine","score":0.890999972820282},{"id":"https://openalex.org/keywords/tyrosine","display_name":"tyrosine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.8560000061988831},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.5410000085830688},{"id":"https://openalex.org/keywords/1h-magnetic-resonance-spectroscopy","display_name":"1H magnetic resonance spectroscopy","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.9486128091812134},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.678274929523468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6682866811752319},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6249607801437378},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5376269817352295},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4436124265193939},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.43137574195861816},{"id":"https://openalex.org/C3020092424","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cancer cachexia","level":4,"score":0.4290669858455658},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4280027151107788},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.4249260127544403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42240506410598755},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.41646474599838257},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36675408482551575},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3331584334373474},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.09296420216560364}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2020-1625","doi":"https://doi.org/10.1158/1538-7445.am2020-1625","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2020-1625","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4234127133","https://openalex.org/W4230582045","https://openalex.org/W2740679029","https://openalex.org/W4410973264","https://openalex.org/W2742055748","https://openalex.org/W2885175974","https://openalex.org/W4393096166","https://openalex.org/W2313234375","https://openalex.org/W2886652422","https://openalex.org/W3213717026"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Cachexia":[2],"is":[3],"a":[4,242,280],"complex":[5],"metabolic":[6,50,71,103,325,345],"syndrome":[7],"that":[8,366,377],"affects":[9],"nearly":[10],"80%":[11],"of":[12,20,26,73,86,93,178,274,310,351,360,467,471],"pancreatic":[13],"ductal":[14],"adenocarcinoma":[15],"(PDAC)":[16],"patients.":[17],"Major":[18],"symptoms":[19],"cancer":[21,374],"induced":[22,75],"cachexia":[23,42,76,371,463],"include":[24],"loss":[25,34,143],"skeletal":[27],"muscle":[28],"weight":[29,142],"with":[30,124,130,255,263,369,373],"or":[31],"without":[32],"fat":[33],"and":[35,49,109,134,163,190,195,198,218,251,268,276,295,308,321,337,342,372,382,394,457,482],"reduced":[36],"physical":[37],"activity":[38],"[1,":[39],"2].":[40],"Cancer":[41,170,411,429,476,488],"may":[43,367,378],"lead":[44],"to":[45,89,128,150,180,223,289,316,380],"multiple":[46],"organ":[47,87,120,364],"dysfunction":[48],"abnormalities":[51],"[3].":[52],"To":[53],"date":[54],"there":[55],"are":[56],"no":[57],"known":[58],"cures":[59],"for":[60,475],"this":[61,94],"condition.":[62],"Our":[63,354],"ongoing":[64],"studies":[65],"have":[66,98,138],"focused":[67,99],"on":[68,100,231,241],"understanding":[69,92,101,359],"the":[70,102,107,175,232,284,290,306,340,349,361,468,472],"impact":[72],"PDAC":[74,115],"in":[77,106,122,144,174,300,305,329,339,363,375],"vital":[78],"organs":[79],"using":[80,111],"1H":[81,227,236],"magnetic":[82],"resonance":[83],"spectroscopy":[84],"(MRS)":[85],"extracts":[88],"expand":[90],"our":[91,112],"syndrome.":[95],"Here":[96],"we":[97],"changes":[104,121,346,362],"occurring":[105],"lungs":[108,191,307],"kidneys":[110,309],"well":[113],"established":[114,140],"xenograft":[116],"models.":[117],"We":[118,137],"compared":[119,149,288,315],"mice":[123,129,148,154,194,202,209,314,320],"cachexia-inducing":[125],"xenografts":[126,132],"(Pa04C)":[127],"non-cachexia-inducing":[131],"(Panc1)":[133],"normal":[135,193,296,322],"mice.":[136,188,297,323],"previously":[139],"significant":[141],"Pa04C":[145,168,197,285,311],"tumor":[146,152,200,292,312,318],"bearing":[147,153,201,293,313,319],"Panc1":[151,157,199,291,317],"[4].":[155],"Methods:":[156],"cells":[158,171],"were":[159,172,212,215,239,253,303,327],"obtained":[160],"from":[161,192,196,207],"ATCC":[162],"Dr.":[164],"Maitra":[165],"kindly":[166],"provided":[167],"cells.":[169],"inoculated":[173],"right":[176],"flank":[177],"six":[179],"eight":[181],"week":[182],"old":[183],"male":[184],"severe":[185],"combined":[186],"immunodeficient":[187],"Kidneys":[189],"(n=5":[203],"per":[204],"group),":[205],"excised":[206],"euthanized":[208],"once":[210],"tumors":[211],"~300":[213],"mm3,":[214],"snap":[216],"frozen":[217],"stored":[219],"at":[220],"-80\u00b0C":[221],"prior":[222],"dual":[224],"phase":[225],"extraction.":[226],"MRS":[228],"was":[229,261,389],"performed":[230,254,262],"water":[233],"phase.":[234],"All":[235,247],"MR":[237,245],"spectra":[238],"acquired":[240],"750":[243],"MHz":[244],"spectrometer.":[246],"data":[248,278],"processing":[249],"analyses":[250],"quantification":[252],"TOPSPIN":[256],"3.5":[257],"software.":[258],"Statistical":[259],"analysis":[260,273],"MetaboAnalyst":[264],"software":[265],"[5].":[266],"Result":[267],"Discussion":[269],"Multivariate":[270],"principal":[271],"component":[272],"lung":[275,341],"kidney":[277,458],"identified":[279],"clear":[281],"separation":[282],"between":[283],"tumor-bearing":[286],"group":[287,294],"Significant":[298,324],"differences":[299,326],"several":[301],"metabolites":[302],"observed":[304],"detected":[328],"amino":[330],"acids,":[331],"BCAA,":[332],"glutathione,":[333],"acetate,":[334],"histidine,":[335],"phenylalanine":[336],"tyrosine":[338],"kidney.":[343],"These":[344],"can":[347],"influence":[348],"function":[350],"these":[352],"organs.":[353],"results":[355],"support":[356],"an":[357],"expanded":[358],"metabolism":[365,459],"occur":[368],"cancer-induced":[370,462],"general":[376],"contribute":[379],"morbidity":[381],"poor":[383],"treatment":[384],"response.":[385],"Acknowledgement:":[386],"This":[387],"work":[388],"supported":[390],"by":[391,461],"NIH":[392],"R35CA209960":[393],"R01CA193365.":[395],"Ref:":[396],"1.":[397],"Fearon":[398],"K":[399],"et":[400,417,427],"al,":[401,418,428],"The":[402],"Lancet":[403],"Oncology.":[404],"2011;":[405],"2.":[406],"Penet":[407],"MF,":[408],"Bhujwalla":[409],"ZM.":[410],"journal.":[412],"2015;":[413],"3.":[414],"Argiles":[415],"JM":[416],"Nature":[419,437],"reviews":[420],"Cancer.":[421],"2014;":[422],"4.":[423],"Winnard":[424],"PT,":[425],"Jr.":[426],"research.":[430],"2016;":[431],"5.":[432],"Xia":[433],"J,":[434],"Wishart":[435],"DS.":[436],"protocols.":[438],"2011.":[439],"Citation":[440],"Format:":[441],"Raj":[442],"Kumar":[443],"Sharma,":[444],"Santosh":[445],"K.":[446],"Bharti,":[447],"Paul":[448],"T.":[449],"Winnard,":[450],"Marie-France":[451],"Penet,":[452],"Zaver":[453],"M.":[454],"Bhujwalla.":[455],"Lung":[456],"altered":[460],"[abstract].":[464],"In:":[465],"Proceedings":[466],"Annual":[469],"Meeting":[470],"American":[473],"Association":[474],"Research":[477],"2020;":[478],"2020":[479],"Apr":[480],"27-28":[481],"Jun":[483],"22-24.":[484],"Philadelphia":[485],"(PA):":[486],"AACR;":[487],"Res":[489],"2020;80(16":[490],"Suppl):Abstract":[491],"nr":[492],"1625.":[493]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-08T00:00:00"}
